| Titre : |
Synthèse de Chalcones adamantylées, de dérivés Thiazolylpyrazolines et évaluation de leurs activités antimicrobienne et anticancéreuse. |
| Type de document : |
texte imprimé |
| Auteurs : |
Aouatef Tabbi-Benmerkhi, Auteur ; Dahmane Tebbani, Directeur de thèse |
| Editeur : |
جامعة الإخوة منتوري قسنطينة |
| Année de publication : |
2017 |
| Importance : |
192 f. |
| Format : |
30 cm. |
| Note générale : |
2 copies imprimées disponibles
|
| Langues : |
Français (fre) |
| Catégories : |
Français - Anglais
Chimie
|
| Tags : |
Chalcones adamantylées Thiazolylpyrazolines activité antimicrobienne activité
anti cancéreuse MiaPaca2 A549 NIH/3T3 RMN adamantylated Chalcones Thiazolylpyrazoline antimirobial activity anticancer
activity NMR الشالكونات الادمونتلية تيازوليل بيرازولين مضادات الميكروبات النشاط المضاد للسرطان |
| Index. décimale : |
540 Chimie et sciences connexes |
| Résumé : |
In the first part, a new variety of adamantyl chalcones was efficiently prepared by ClaisenSchmidt reaction of 4-adamantyl acetophenone with a series of aromatic aldehydes in good
yields. Their structures were confirmed by spectroscopic data, and the relative configuration
of compound 3d was confirmed by X-ray crystallography. All synthesized chalcones were
tested against a panel of Gram-positive and Gram-negative bacteria and pathogenic fungus.
They displayed a strong antibacterial activity against Enterococcus faecali 29212,
Pseudomonas aeruginosa ATCC27853, Escherichia coli, as well as an interesting antifungal
activity against Candida glabrata ATCC 90030. The effect of these compounds was also
tested in vitro as antitumor on Miapaca2 cells. The compounds also showed anticancer
activity against human pancreas cancer cell MiaPaca2.
In the second part, several thiazolyl-pyrazoline derivatives were synthesized by reacting
substituted 3, 5-diaryl-1-thiocarbamoyl-2-pyrazolines with phenacylbromides. The structures
of the synthesized compounds were confirmed by IR, 1H NMR, 13C NMR, and MS spectral
data. Their antimicrobial, anticancer activities and cytotoxicity were investigated. A
significant level of antimicrobial activity and anticancer activity against A549 human lung
carcinoma cell line and low cytotoxicity were observed. |
| Diplôme : |
Doctorat |
| En ligne : |
../theses/chimie/TAB7068.pdf |
| Format de la ressource électronique : |
pdf |
| Permalink : |
index.php?lvl=notice_display&id=10533 |
Synthèse de Chalcones adamantylées, de dérivés Thiazolylpyrazolines et évaluation de leurs activités antimicrobienne et anticancéreuse. [texte imprimé] / Aouatef Tabbi-Benmerkhi, Auteur ; Dahmane Tebbani, Directeur de thèse . - جامعة الإخوة منتوري قسنطينة, 2017 . - 192 f. ; 30 cm. 2 copies imprimées disponibles
Langues : Français ( fre)
| Catégories : |
Français - Anglais
Chimie
|
| Tags : |
Chalcones adamantylées Thiazolylpyrazolines activité antimicrobienne activité
anti cancéreuse MiaPaca2 A549 NIH/3T3 RMN adamantylated Chalcones Thiazolylpyrazoline antimirobial activity anticancer
activity NMR الشالكونات الادمونتلية تيازوليل بيرازولين مضادات الميكروبات النشاط المضاد للسرطان |
| Index. décimale : |
540 Chimie et sciences connexes |
| Résumé : |
In the first part, a new variety of adamantyl chalcones was efficiently prepared by ClaisenSchmidt reaction of 4-adamantyl acetophenone with a series of aromatic aldehydes in good
yields. Their structures were confirmed by spectroscopic data, and the relative configuration
of compound 3d was confirmed by X-ray crystallography. All synthesized chalcones were
tested against a panel of Gram-positive and Gram-negative bacteria and pathogenic fungus.
They displayed a strong antibacterial activity against Enterococcus faecali 29212,
Pseudomonas aeruginosa ATCC27853, Escherichia coli, as well as an interesting antifungal
activity against Candida glabrata ATCC 90030. The effect of these compounds was also
tested in vitro as antitumor on Miapaca2 cells. The compounds also showed anticancer
activity against human pancreas cancer cell MiaPaca2.
In the second part, several thiazolyl-pyrazoline derivatives were synthesized by reacting
substituted 3, 5-diaryl-1-thiocarbamoyl-2-pyrazolines with phenacylbromides. The structures
of the synthesized compounds were confirmed by IR, 1H NMR, 13C NMR, and MS spectral
data. Their antimicrobial, anticancer activities and cytotoxicity were investigated. A
significant level of antimicrobial activity and anticancer activity against A549 human lung
carcinoma cell line and low cytotoxicity were observed. |
| Diplôme : |
Doctorat |
| En ligne : |
../theses/chimie/TAB7068.pdf |
| Format de la ressource électronique : |
pdf |
| Permalink : |
index.php?lvl=notice_display&id=10533 |
|
Synthèse de Chalcones adamantylées, de dérivés Thiazolylpyrazolines et évaluation de leurs activités antimicrobienne et anticancéreuse.
