| Titre : |
Metals debenzylation of tetrazoles, and high convergent straightforward stereoselective synthesis of (+)-C(9a)-Epiepiquinamide. |
| Type de document : |
texte imprimé |
| Auteurs : |
Meriem Benlahrech, Auteur ; Cherif Behloul, Directeur de thèse |
| Editeur : |
جامعة الإخوة منتوري قسنطينة |
| Année de publication : |
2018 |
| Importance : |
131 f. |
| Format : |
30 cm. |
| Note générale : |
Doctorat 3éme CYCLE.
2 copies imprimées disponibles
|
| Langues : |
Anglais (eng) |
| Catégories : |
Français - Anglais
Chimie
|
| Tags : |
Organic chemistry :Organic synthesis Protégés (+)-C(9a)-epiepiquinamide alcaloide aza-Henry N-tert-butanesulfinyl imine Protected alkaloid N-tertbutanesulfinyl imine تيتراوزول المحمية )+( ايببكناميد ازاءهنري ترسيبوتيل سلفينيل ايمين |
| Index. décimale : |
540 Chimie et sciences connexes |
| Résumé : |
This manuscript encloses two principal parts:
In the first part, We report the use of three metals for debenzylation of protected tetrazoles: indium, magnesium and zinc, comparing the process of using metals, and taking into account financial aspects, the use of zinc show to be the most effective for substrates non-sensitive to acidic conditions. For substrates sensitive to acid, magnesium or indium metal can be used, can we say that zinc being preferable considering reaction conditions and metal prices. In the second part, We have synthesis from commercially available compounds, the (+)-C(9a)- epiepiquinamide the reaction was carried out in six synthetic operations starting from a diastereoselective aza-Henry reaction of a chiral N-tert-butanesulfinyl imine and ethyl 4- nitrobutanoate, the configuration of the sulfur atom of the sulfinyl group determining the configuration of C(9a) stereocenter in this transformation. |
| Note de contenu : |
Annexes. |
| Diplôme : |
Doctorat |
| En ligne : |
../theses/chimie/BEN7441.pdf |
| Format de la ressource électronique : |
pdf |
| Permalink : |
index.php?lvl=notice_display&id=11219 |
Metals debenzylation of tetrazoles, and high convergent straightforward stereoselective synthesis of (+)-C(9a)-Epiepiquinamide. [texte imprimé] / Meriem Benlahrech, Auteur ; Cherif Behloul, Directeur de thèse . - جامعة الإخوة منتوري قسنطينة, 2018 . - 131 f. ; 30 cm. Doctorat 3éme CYCLE.
2 copies imprimées disponibles
Langues : Anglais ( eng)
| Catégories : |
Français - Anglais
Chimie
|
| Tags : |
Organic chemistry :Organic synthesis Protégés (+)-C(9a)-epiepiquinamide alcaloide aza-Henry N-tert-butanesulfinyl imine Protected alkaloid N-tertbutanesulfinyl imine تيتراوزول المحمية )+( ايببكناميد ازاءهنري ترسيبوتيل سلفينيل ايمين |
| Index. décimale : |
540 Chimie et sciences connexes |
| Résumé : |
This manuscript encloses two principal parts:
In the first part, We report the use of three metals for debenzylation of protected tetrazoles: indium, magnesium and zinc, comparing the process of using metals, and taking into account financial aspects, the use of zinc show to be the most effective for substrates non-sensitive to acidic conditions. For substrates sensitive to acid, magnesium or indium metal can be used, can we say that zinc being preferable considering reaction conditions and metal prices. In the second part, We have synthesis from commercially available compounds, the (+)-C(9a)- epiepiquinamide the reaction was carried out in six synthetic operations starting from a diastereoselective aza-Henry reaction of a chiral N-tert-butanesulfinyl imine and ethyl 4- nitrobutanoate, the configuration of the sulfur atom of the sulfinyl group determining the configuration of C(9a) stereocenter in this transformation. |
| Note de contenu : |
Annexes. |
| Diplôme : |
Doctorat |
| En ligne : |
../theses/chimie/BEN7441.pdf |
| Format de la ressource électronique : |
pdf |
| Permalink : |
index.php?lvl=notice_display&id=11219 |
|
Metals debenzylation of tetrazoles, and high convergent straightforward stereoselective synthesis of (+)-C(9a)-Epiepiquinamide.
