Titre :	Profil inflammatoire systémique des fumeurs atteints de bronchopneumopathie chronique obstructive comparés aux fumeurs indemnes de bronchopneumopathie chronique obstructive.
Type de document :	texte imprimé
Auteurs :	Yousra Mosrane, Auteur ; Mohamed Bougrida, Directeur de thèse
Editeur :	جامعة الإخوة منتوري قسنطينة
Année de publication :	2018
Importance :	130 f.
Format :	30 cm.
Note générale :	Doctorat 3éme CYCLE LMD. 2 copies imprimées disponibles
Langues :	Français (fre)
Catégories :	Français - Anglais Biologie
Tags :	Biochimie et Biologie Cellulaire et Moléculaire:Biologie et Santé  Tabac  spirométrie  BPCO  inflammation systémique, VEMS, VEMS/CVF.  Tobacco  spirometry  COPD  systemic inflammation, FEV1, FEV1/FVC.  تبغ  قياس التنفس
Index. décimale :	570 Sciences de la vie. Biologie
Résumé :	Studies comparing the systemic inflammatory profiles of smokers with and without COPD present discordant findings. The aim of our study is to compare the systemic inflammatory profile of smokers with and without COPD. This is a cross-sectional comparative study. Two groups of active smokers of more than 10 pack-years were included: 56 consecutives stable COPD (postbronchodilator FEV1/FVC < 0.70) and 32 consecutives non-COPD (postbronchodilator FEV1/FVC ≥ 0.70). Smoking and clinical, anthropometric and spirometric data were noted. The following blood biomarkers were identified: leukocytes, hemoglobin, tumor necrosis factor- (TNF-), nterleukin-6 (IL- 6), C reactive protein (CRP), erythrocyte sedimentation rate (ESR). According to the levels (normal/abnormal) of these markers, two groups of smokers were formed. Quantitative and qualitative data were expressed, respectively, as means±SD and percentages. Compared to the non-COPD group, the COPD group was older (56±12 vs. 65±8 years) and had a higher smoking consumption (30±18 vs. 52±31 pack-years). Compared to the nonCOPD group, the COPD group had higher values of CRP (2.06±1.24 vs. 11.32±11.03 mg/L), of ESR (9.59±8.29 vs. 15.96±11.56), of IL-6 (9.28±4.69 vs. 20.27±5.31 ng/L) and of TNF- (18.38±7.98 vs. 8.62±3.72 ng/L). Compared to the non-COPD group, the COPD group included higher percentages of smokers with elevated CRP (0 vs. 32%), with leukocytosis (6 vs. 16%), with higher levels of IL-6 (81 vs. 98%) or TNF-α (91 vs. 100%). Smokers with COPD, compared to smokers free from COPD, have a marked systemic inflammation.
Note de contenu :	Annexes.
Diplôme :	Doctorat
En ligne :	../theses/biologie/MOS7483.pdf
Format de la ressource électronique :	pdf
Permalink :	index.php?lvl=notice_display&id=11315

Profil inflammatoire systémique des fumeurs atteints de bronchopneumopathie chronique obstructive comparés aux fumeurs indemnes de bronchopneumopathie chronique obstructive. [texte imprimé] / Yousra Mosrane, Auteur ; Mohamed Bougrida, Directeur de thèse . - جامعة الإخوة منتوري قسنطينة, 2018 . - 130 f. ; 30 cm.
Doctorat 3éme CYCLE LMD.
2 copies imprimées disponibles

Langues : Français (fre)

Catégories :	Français - Anglais Biologie
Tags :	Biochimie et Biologie Cellulaire et Moléculaire:Biologie et Santé  Tabac  spirométrie  BPCO  inflammation systémique, VEMS, VEMS/CVF.  Tobacco  spirometry  COPD  systemic inflammation, FEV1, FEV1/FVC.  تبغ  قياس التنفس
Index. décimale :	570 Sciences de la vie. Biologie
Résumé :	Studies comparing the systemic inflammatory profiles of smokers with and without COPD present discordant findings. The aim of our study is to compare the systemic inflammatory profile of smokers with and without COPD. This is a cross-sectional comparative study. Two groups of active smokers of more than 10 pack-years were included: 56 consecutives stable COPD (postbronchodilator FEV1/FVC < 0.70) and 32 consecutives non-COPD (postbronchodilator FEV1/FVC ≥ 0.70). Smoking and clinical, anthropometric and spirometric data were noted. The following blood biomarkers were identified: leukocytes, hemoglobin, tumor necrosis factor- (TNF-), nterleukin-6 (IL- 6), C reactive protein (CRP), erythrocyte sedimentation rate (ESR). According to the levels (normal/abnormal) of these markers, two groups of smokers were formed. Quantitative and qualitative data were expressed, respectively, as means±SD and percentages. Compared to the non-COPD group, the COPD group was older (56±12 vs. 65±8 years) and had a higher smoking consumption (30±18 vs. 52±31 pack-years). Compared to the nonCOPD group, the COPD group had higher values of CRP (2.06±1.24 vs. 11.32±11.03 mg/L), of ESR (9.59±8.29 vs. 15.96±11.56), of IL-6 (9.28±4.69 vs. 20.27±5.31 ng/L) and of TNF- (18.38±7.98 vs. 8.62±3.72 ng/L). Compared to the non-COPD group, the COPD group included higher percentages of smokers with elevated CRP (0 vs. 32%), with leukocytosis (6 vs. 16%), with higher levels of IL-6 (81 vs. 98%) or TNF-α (91 vs. 100%). Smokers with COPD, compared to smokers free from COPD, have a marked systemic inflammation.
Note de contenu :	Annexes.
Diplôme :	Doctorat
En ligne :	../theses/biologie/MOS7483.pdf
Format de la ressource électronique :	pdf
Permalink :	index.php?lvl=notice_display&id=11315