Titre :	Effet de la propolis sur les bactéries résistantes aux antibiotiques par inhibition des pompes à efflux.
Type de document :	texte imprimé
Auteurs :	Sagia Moussaoui, Auteur ; Mesbah Lahouel, Directeur de thèse
Mention d'édition :	02-mai-19
Editeur :	جامعة الإخوة منتوري قسنطينة
Année de publication :	2019
Importance :	64 f.
Format :	30 cm.
Note générale :	1 copies imprimées disponibles
Langues :	Français (fre)
Catégories :	Français - Anglais Biologie
Tags :	Sciences biologiques : Microbiologie  Propolis  Bactéries  Pompes d’efflux  inhibition  CMIs  Infection in vivo  Bacteria  efflux pumps  MICs  in vivo infection  العكبر  بكتيريا  مضخات التدفق  تثبيط  التركيز الأدنى المثبط  عدوى بكتيرية
Index. décimale :	570 Sciences de la vie. Biologie
Résumé :	The resistance of bacteria to various anti-infectious chemotherapies has become a real public health problem. Bacteria ovoid antibiotics through the development of antimicrobiol resistance by draining grugs out the cells. Drug efflux is a key mechanism of resistance mechanism using pump systems located on the surface of bacterial membranes. For this, genetically modified bacteria carrying different types of efflux pumps were chosen as the study model on which Algerian propolis was tested. The tests in vitro performed on different bacterial strains have shown results comparable to those reported in the literature and confirm that Gram-positive bacteria are more sensitive to the effect of propolis than Gram-negative bacteria. In addition, the effectiveness of propolis also extends to resistant strains by efflux pump mechanisms The satisfactory results obtained encouraged us to carry out in vivo studies on wistar rats. The effects on a model of induced infection in rats were studied and evaluated by different laboratory parameters. Restoring the parameters tested in vivo after treatment of the infection with propolis, could confirm the interest of using it as a natural agent capable of countering the effects of oxidative stress linked to infections such as sepsis. As few information, on the clinical efficacy of Algerian propolis, is available, for this, a new step would be interesting to complete the research and thus develop the clinical investigations obtained which would make it possible to evaluate the beneficial effect of propolis in patients. Also the results obtained in this modest work could be used to justify the place that Algerian propolis may have for alternative therapies in the search.
Note de contenu :	Annexe.
Diplôme :	Doctorat en sciences
En ligne :	../theses/biologie/MOU7694.pdf
Format de la ressource électronique :	pdf
Permalink :	index.php?lvl=notice_display&id=11528

Effet de la propolis sur les bactéries résistantes aux antibiotiques par inhibition des pompes à efflux. [texte imprimé] / Sagia Moussaoui, Auteur ; Mesbah Lahouel, Directeur de thèse  . -  02-mai-19 . - جامعة الإخوة منتوري قسنطينة, 2019 . - 64 f. ; 30 cm.
1 copies imprimées disponibles

Langues : Français (fre)

Catégories :	Français - Anglais Biologie
Tags :	Sciences biologiques : Microbiologie  Propolis  Bactéries  Pompes d’efflux  inhibition  CMIs  Infection in vivo  Bacteria  efflux pumps  MICs  in vivo infection  العكبر  بكتيريا  مضخات التدفق  تثبيط  التركيز الأدنى المثبط  عدوى بكتيرية
Index. décimale :	570 Sciences de la vie. Biologie
Résumé :	The resistance of bacteria to various anti-infectious chemotherapies has become a real public health problem. Bacteria ovoid antibiotics through the development of antimicrobiol resistance by draining grugs out the cells. Drug efflux is a key mechanism of resistance mechanism using pump systems located on the surface of bacterial membranes. For this, genetically modified bacteria carrying different types of efflux pumps were chosen as the study model on which Algerian propolis was tested. The tests in vitro performed on different bacterial strains have shown results comparable to those reported in the literature and confirm that Gram-positive bacteria are more sensitive to the effect of propolis than Gram-negative bacteria. In addition, the effectiveness of propolis also extends to resistant strains by efflux pump mechanisms The satisfactory results obtained encouraged us to carry out in vivo studies on wistar rats. The effects on a model of induced infection in rats were studied and evaluated by different laboratory parameters. Restoring the parameters tested in vivo after treatment of the infection with propolis, could confirm the interest of using it as a natural agent capable of countering the effects of oxidative stress linked to infections such as sepsis. As few information, on the clinical efficacy of Algerian propolis, is available, for this, a new step would be interesting to complete the research and thus develop the clinical investigations obtained which would make it possible to evaluate the beneficial effect of propolis in patients. Also the results obtained in this modest work could be used to justify the place that Algerian propolis may have for alternative therapies in the search.
Note de contenu :	Annexe.
Diplôme :	Doctorat en sciences
En ligne :	../theses/biologie/MOU7694.pdf
Format de la ressource électronique :	pdf
Permalink :	index.php?lvl=notice_display&id=11528