| Titre : |
L’intérêt des biomarqueurs osseux dans le diagnostic, le suivi et l’évaluation des tumeurs osseuses : L’ostéosarcome et le sarcome d’Ewing. |
| Type de document : |
texte imprimé |
| Auteurs : |
Samy Kabouche, Auteur ; Leïla Rouabah, Directeur de thèse ; Rabah Maza, Directeur de thèse |
| Editeur : |
جامعة الإخوة منتوري قسنطينة |
| Année de publication : |
2019 |
| Importance : |
153 f. |
| Format : |
30 cm. |
| Note générale : |
1 copies imprimées disponibles
|
| Langues : |
Français (fre) |
| Catégories : |
Français - Anglais
Biologie
|
| Tags : |
Biochimie et Biologie Moléculaire et Cellulaire: Biologie Moléculaire et Cellulaire Ostéosarcome Sarcome d’Ewing Les biomarqueurs osseux DiagnosticTumeurs osseuses primaire Osteosarcoma Ewing sarcoma Bone biomarquers Diagnostic Primary bone
tumors ساركوما العظمیة ساركوما یوینغ العلامات البیوكیمیائیة في العظام تشخیص الاورام الاولیة السرطانیة |
| Index. décimale : |
570 Sciences de la vie. Biologie |
| Résumé : |
Primary bone tumors are a major public health problem. Osteosarcoma and Ewing's sarcoma are rare diseases that affect children and young adults, and are the result of impaired bone remodeling. Biochemical markers of bone remodeling are used in the diagnosis, prognosis and evaluation of bone metastases, osteoporosis in combination with imaging techniques. However, bone biomarkers of P1NP and PAO formation and those of CTX and TRAP5b bone resorption may be useful in the diagnosis, evaluation and monitoring of osteosarcoma and Ewing's sarcoma. Firstly, we described the epidemiological and therapeutic aspects of bone tumors by a retrospective study at the level of Ibn Badis -Constantine Hospital-University Center in eastern Algeria. In a second step, we assessed serum biochemical markers of PAO and P1NP bone formation and CTX and TRAP5b bone resorption in patients with osteosarcoma (40 cases) and Ewing's sarcoma (34 cases) by the ELISA assay of these biomarkers. The latter showed good performance in the diagnosis of osteosarcoma and Ewing's sarcoma in terms of precision before treatment, and in evaluation and follow-up after neoadjuvant chemotherapy-based treatment. On the other hand, the correlations of these biochemical markers with each other before and after treatment have allowed effective clinical evaluation of patients with both of these most common types of primary bone tumors. All of our work shows a new aspect of the diagnosis, evaluation and monitoring of osteosarcoma and Ewing's sarcoma before these are detectable by medical imaging. |
| Note de contenu : |
Annexes. |
| Diplôme : |
Doctorat en sciences |
| En ligne : |
../theses/biologie/KAB7427.pdf |
| Format de la ressource électronique : |
pdf |
| Permalink : |
index.php?lvl=notice_display&id=11081 |
L’intérêt des biomarqueurs osseux dans le diagnostic, le suivi et l’évaluation des tumeurs osseuses : L’ostéosarcome et le sarcome d’Ewing. [texte imprimé] / Samy Kabouche, Auteur ; Leïla Rouabah, Directeur de thèse ; Rabah Maza, Directeur de thèse . - جامعة الإخوة منتوري قسنطينة, 2019 . - 153 f. ; 30 cm. 1 copies imprimées disponibles
Langues : Français ( fre)
| Catégories : |
Français - Anglais
Biologie
|
| Tags : |
Biochimie et Biologie Moléculaire et Cellulaire: Biologie Moléculaire et Cellulaire Ostéosarcome Sarcome d’Ewing Les biomarqueurs osseux DiagnosticTumeurs osseuses primaire Osteosarcoma Ewing sarcoma Bone biomarquers Diagnostic Primary bone
tumors ساركوما العظمیة ساركوما یوینغ العلامات البیوكیمیائیة في العظام تشخیص الاورام الاولیة السرطانیة |
| Index. décimale : |
570 Sciences de la vie. Biologie |
| Résumé : |
Primary bone tumors are a major public health problem. Osteosarcoma and Ewing's sarcoma are rare diseases that affect children and young adults, and are the result of impaired bone remodeling. Biochemical markers of bone remodeling are used in the diagnosis, prognosis and evaluation of bone metastases, osteoporosis in combination with imaging techniques. However, bone biomarkers of P1NP and PAO formation and those of CTX and TRAP5b bone resorption may be useful in the diagnosis, evaluation and monitoring of osteosarcoma and Ewing's sarcoma. Firstly, we described the epidemiological and therapeutic aspects of bone tumors by a retrospective study at the level of Ibn Badis -Constantine Hospital-University Center in eastern Algeria. In a second step, we assessed serum biochemical markers of PAO and P1NP bone formation and CTX and TRAP5b bone resorption in patients with osteosarcoma (40 cases) and Ewing's sarcoma (34 cases) by the ELISA assay of these biomarkers. The latter showed good performance in the diagnosis of osteosarcoma and Ewing's sarcoma in terms of precision before treatment, and in evaluation and follow-up after neoadjuvant chemotherapy-based treatment. On the other hand, the correlations of these biochemical markers with each other before and after treatment have allowed effective clinical evaluation of patients with both of these most common types of primary bone tumors. All of our work shows a new aspect of the diagnosis, evaluation and monitoring of osteosarcoma and Ewing's sarcoma before these are detectable by medical imaging. |
| Note de contenu : |
Annexes. |
| Diplôme : |
Doctorat en sciences |
| En ligne : |
../theses/biologie/KAB7427.pdf |
| Format de la ressource électronique : |
pdf |
| Permalink : |
index.php?lvl=notice_display&id=11081 |
|
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