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Auteur Abdlkader Rouabah |
Documents disponibles écrits par cet auteur (2)
Affiner la recherche Interroger des sources externesInfertilité liée à la qualité du génome spermatique et impact en Procréation Médicalement Assistée. / Maroua Hachemi
Titre : Infertilité liée à la qualité du génome spermatique et impact en Procréation Médicalement Assistée. Type de document : texte imprimé Auteurs : Maroua Hachemi, Auteur ; Abdlkader Rouabah, Directeur de thèse Editeur : جامعة الإخوة منتوري قسنطينة Année de publication : 2019 Importance : 202 f. Format : 30 cm. Note générale : Doctorat 3éme CYCLE LMD.
2 copies imprimées disponiblesLangues : Français (fre) Catégories : Français - Anglais
BiologieTags : Biochimie et Biologie Cellulaire et Moléculaire: Biologie et Santé Infertilité masculine Qualité du génome spermatique Fragmentation de l’ADN spermatique Décondensation de la chromatine spermatique Male infertility Spermatic genome quality Sperm DNA fragmentation Sperm chromatin decondensation العقم عند الرجال نوعية الجينوم المنوي تجزئة الحمض النووي للحيوانات المنوية تفكيك بنية كروماتين الحيوانات المنوية Index. décimale : 570 Sciences de la vie. Biologie Résumé : Male infertility is a relatively common pathology; the genetic etiology may be a cause of this abnormality for these males presumed sterile. Thanks to new techniques of Medically Assisted Procreation that infertile men could become biological fathers. However, some questions about the genetic and epigenetic information transmitted to the offspring as well as the modalities of this transmission are raised. A genetic study was carried out over 101 infertile male patients candidates for the Medically Assisted Procreation, these subjects are registered with their spouses in a schedule of intra-cytoplasmic microinjection of the spermatozoon. This study was performed in a prospective setting using cytogenetic tools. Two approaches have been tried in order to assess the quality of the sperm genome. One by analyzing the quality of sperm DNA by measuring the rate of degradation and fragmentation of the latter, another by exploring the quality of spermatic chromatin by measuring its decondensation rate. The study of the association between the quality of the spermatic genome and the various classical spermiological factors shows that the alteration of spermatogenesis is related to a deterioration of the spermatic genome. Regarding the behavioral, toxic and environmental factors, our study showed that these factors did not act on the quality of the spermatic genome. Nevertheless, smoking intoxication seems to alter the chromatin structure of a specific category of patients (p = 0.03). The evaluation of the various parameters was related to the status of Medically Assisted Reproduction especially those of microinjection into cytoplasmic sperm. Our results showed that alterations in the quality of the spermatic genome do not influence either the fertilization process or preimplantation embryonic development (p > 0.05). Our findings indicate also that the quality of the spermatic genome is not related to pregnancy. Nonetheless, it may have an impact on abortions. Regarding births, the integrity of the spermatic nucleus may influence the birth rate (p = 0.064). Moreover, a differentiated sperm cell with an unaltered DNA can give birth even if its chromatin is poorly structured or even decondensed.
Note de contenu : Annexes.
Diplôme : Doctorat En ligne : ../theses/biologie/HAC7520.pdf Format de la ressource électronique : Permalink : index.php?lvl=notice_display&id=11359 Infertilité liée à la qualité du génome spermatique et impact en Procréation Médicalement Assistée. [texte imprimé] / Maroua Hachemi, Auteur ; Abdlkader Rouabah, Directeur de thèse . - جامعة الإخوة منتوري قسنطينة, 2019 . - 202 f. ; 30 cm.
Doctorat 3éme CYCLE LMD.
2 copies imprimées disponibles
Langues : Français (fre)
Catégories : Français - Anglais
BiologieTags : Biochimie et Biologie Cellulaire et Moléculaire: Biologie et Santé Infertilité masculine Qualité du génome spermatique Fragmentation de l’ADN spermatique Décondensation de la chromatine spermatique Male infertility Spermatic genome quality Sperm DNA fragmentation Sperm chromatin decondensation العقم عند الرجال نوعية الجينوم المنوي تجزئة الحمض النووي للحيوانات المنوية تفكيك بنية كروماتين الحيوانات المنوية Index. décimale : 570 Sciences de la vie. Biologie Résumé : Male infertility is a relatively common pathology; the genetic etiology may be a cause of this abnormality for these males presumed sterile. Thanks to new techniques of Medically Assisted Procreation that infertile men could become biological fathers. However, some questions about the genetic and epigenetic information transmitted to the offspring as well as the modalities of this transmission are raised. A genetic study was carried out over 101 infertile male patients candidates for the Medically Assisted Procreation, these subjects are registered with their spouses in a schedule of intra-cytoplasmic microinjection of the spermatozoon. This study was performed in a prospective setting using cytogenetic tools. Two approaches have been tried in order to assess the quality of the sperm genome. One by analyzing the quality of sperm DNA by measuring the rate of degradation and fragmentation of the latter, another by exploring the quality of spermatic chromatin by measuring its decondensation rate. The study of the association between the quality of the spermatic genome and the various classical spermiological factors shows that the alteration of spermatogenesis is related to a deterioration of the spermatic genome. Regarding the behavioral, toxic and environmental factors, our study showed that these factors did not act on the quality of the spermatic genome. Nevertheless, smoking intoxication seems to alter the chromatin structure of a specific category of patients (p = 0.03). The evaluation of the various parameters was related to the status of Medically Assisted Reproduction especially those of microinjection into cytoplasmic sperm. Our results showed that alterations in the quality of the spermatic genome do not influence either the fertilization process or preimplantation embryonic development (p > 0.05). Our findings indicate also that the quality of the spermatic genome is not related to pregnancy. Nonetheless, it may have an impact on abortions. Regarding births, the integrity of the spermatic nucleus may influence the birth rate (p = 0.064). Moreover, a differentiated sperm cell with an unaltered DNA can give birth even if its chromatin is poorly structured or even decondensed.
Note de contenu : Annexes.
Diplôme : Doctorat En ligne : ../theses/biologie/HAC7520.pdf Format de la ressource électronique : Permalink : index.php?lvl=notice_display&id=11359 Exemplaires (1)
Code-barres Cote Support Localisation Section Disponibilité HAC/7520 HAC/7520 Thèse Bibliothèque principale Thèses Disponible
Titre : Profil épidémiologique et balance pro / antioxydants de la surcharge pondérale chez les adultes de la localité d'Ain - Fakroun : Est Algérien Type de document : texte imprimé Auteurs : Saida Karouche, Auteur ; Abdlkader Rouabah, Directeur de thèse Editeur : constantine [Algérie] : Université Constantine 1 Année de publication : 2015 Importance : 198 f. Format : 30 cm. Note générale : 2 copies imprimées disponibles
Langues : Français (fre) Catégories : Français - Anglais
BiologieTags : Adiposité pro / antioxydants jeunes adultes séniors Algérie Adiposity pro / antioxidants young adults seniors Algeria
السمنة المضاد للأكسدة/أكسدة الشباب الكبار الجزائرIndex. décimale : 570 Sciences de la vie. Biologie Résumé : The use of data on the health status of populations throughout the world, and their importance in the development of protocols and strategies for care and prevention are currently the subject of great interest. In Algeria, the increasing prevalence of overweight and obesity continues significantly. It is the consequence of a radical change in the mode
of life.
A cross-sectional survey of 273 households from 12 districts located in urban areas in 1091 and introducing people, aged 18-75 years, helped describe the epidemiological profile and enjoy the oxidant / antioxidant status of the population overweight in the town of Ain Fakroun located in eastern Algeria.
The epidemiological approach shows that over one third (1/3) of the recruited population is overweight (BMI> 25 kg / m²). The prevalence increased significantly (p = 0.0014) in adult women and then gradually decreases with age and drops significantly among seniors over 60 years. The study of the association between BMI levels and risk factors reinforces conventional notions. From a descriptive point of view, among both men and women, overweight seems strongly linked to social, biological and environmental factors.
The evaluation of various parameters related to oxidative / antioxidant status indicates an imbalance in the obese. The imbalance seems more pronounced among women. A negative relationship was observed between adiposity and antioxidant capacity for the presence of oxidative stress in obese individuals from our study sample. Indeed, we found reduced levels of antioxidant systems, proved through in reduced plasma levels of vitamin E and vitamin A, glutathione, trace elements linked to the system in this case zinc, even where enzymes, particularly the CAT. Added to the significant concomitant increase in the levels of oxidizing system including lipid peroxidation and copper in the blood plasma of obese compared to overweight individuals.
With the advent of industrialization, bank loans and medical care, the situation remains a concern in our country since the trend is for a development that alarmed plagues. Also, a prevention strategy is urgent to undertake.
Diplôme : Doctorat En ligne : ../theses/biologie/KAR6672.pdf Format de la ressource électronique : Permalink : index.php?lvl=notice_display&id=9802 Profil épidémiologique et balance pro / antioxydants de la surcharge pondérale chez les adultes de la localité d'Ain - Fakroun : Est Algérien [texte imprimé] / Saida Karouche, Auteur ; Abdlkader Rouabah, Directeur de thèse . - constantine [Algérie] : Université Constantine 1, 2015 . - 198 f. ; 30 cm.
2 copies imprimées disponibles
Langues : Français (fre)
Catégories : Français - Anglais
BiologieTags : Adiposité pro / antioxydants jeunes adultes séniors Algérie Adiposity pro / antioxidants young adults seniors Algeria
السمنة المضاد للأكسدة/أكسدة الشباب الكبار الجزائرIndex. décimale : 570 Sciences de la vie. Biologie Résumé : The use of data on the health status of populations throughout the world, and their importance in the development of protocols and strategies for care and prevention are currently the subject of great interest. In Algeria, the increasing prevalence of overweight and obesity continues significantly. It is the consequence of a radical change in the mode
of life.
A cross-sectional survey of 273 households from 12 districts located in urban areas in 1091 and introducing people, aged 18-75 years, helped describe the epidemiological profile and enjoy the oxidant / antioxidant status of the population overweight in the town of Ain Fakroun located in eastern Algeria.
The epidemiological approach shows that over one third (1/3) of the recruited population is overweight (BMI> 25 kg / m²). The prevalence increased significantly (p = 0.0014) in adult women and then gradually decreases with age and drops significantly among seniors over 60 years. The study of the association between BMI levels and risk factors reinforces conventional notions. From a descriptive point of view, among both men and women, overweight seems strongly linked to social, biological and environmental factors.
The evaluation of various parameters related to oxidative / antioxidant status indicates an imbalance in the obese. The imbalance seems more pronounced among women. A negative relationship was observed between adiposity and antioxidant capacity for the presence of oxidative stress in obese individuals from our study sample. Indeed, we found reduced levels of antioxidant systems, proved through in reduced plasma levels of vitamin E and vitamin A, glutathione, trace elements linked to the system in this case zinc, even where enzymes, particularly the CAT. Added to the significant concomitant increase in the levels of oxidizing system including lipid peroxidation and copper in the blood plasma of obese compared to overweight individuals.
With the advent of industrialization, bank loans and medical care, the situation remains a concern in our country since the trend is for a development that alarmed plagues. Also, a prevention strategy is urgent to undertake.
Diplôme : Doctorat En ligne : ../theses/biologie/KAR6672.pdf Format de la ressource électronique : Permalink : index.php?lvl=notice_display&id=9802 Exemplaires (1)
Code-barres Cote Support Localisation Section Disponibilité KAR/6672 KAR/6672 Thèse Bibliothèque principale Thèses Disponible
