| Titre : |
Effect of bioactive molecules extracted from medicinal plants on inflammation induced by hyperhomocysteinemia and tumoral process |
| Type de document : |
texte imprimé |
| Auteurs : |
Assia Benmebarek, Auteur ; S Zerizer, Directeur de thèse |
| Editeur : |
جامعة الإخوة منتوري قسنطينة |
| Année de publication : |
2014 |
| Importance : |
231 f. |
| Note générale : |
2 copies imprimées disponibles
|
| Langues : |
Anglais (eng) |
| Catégories : |
Français - Anglais
Biologie
|
| Tags : |
Hyperhomocysteinemia atherogenesis inflammation carcinogenesis Stachys mialhesi Stachys ocymastrum immunomodulatory activity Hyperhomocysteinémie athérogénèse carcinogénèse activité immunomodulatrice زیادة الھوموسستیین البلازمي تصلب الشرایین الالتھاب السرطان التنبیھ المناعي |
| Index. décimale : |
570 Sciences de la vie. Biologie |
| Résumé : |
Hyperhomocysteinemia is an important risk factor in cardiovascular diseases and may also be implicated in cancer biology. Elevated plasma homocysteine (Hcy) levels may mediate long-term oxidative damage at the vascular interface and there appear to be a mechanism by which they may also be carcinogenic. In addition, immunostimulatory therapy is one solution to enhance the immunity, however, the immunopharmacologic activities of herbal extracts may be antagonistic, they can be immunosupressive or immunostimulating. In the present study, we evaluated the in vivo effect of S. mialhesi extract on the inflammation induced by hyperhomocysteinemia and damages induced to the aorta, heart, liver, thymus and spleen. Another study was carried on the immunomodulatory potential of S. mialhesi
and S. ocymastrum on the phagocytic activity which was evaluated using the Carbon Clearance Assay. The results obtained showed that plasma hs-CRP concentrations were elevated significantly after the administration of L-methionine in high doses to mice (200mg/kg). Also, the loss and degeneration of endothelium, fenestration, foam cells formation, and a change in the appearance of smooth muscle cells nuclei from a fusiform nuclei aspect to a rounded one, were observed in the media of the aorta as well as the alteration of the cardiac muscle, liver necrosis, lymphocytes membrane destruction in the thymus, and a hypertrophy of the spleen white pulp. Our research also revealed that at different doses, S. mialhesi extract increased the reticuloendothelial system (RES)
phagocytic activity in a dose dependant manner, in contrast to S. ocymastrum who exhibited a biphasic dose response effect. Hcy initiated inflammation and mediated early atherogenesis lesions through increased oxidant stress, and the treatment with S. mialhesi extract at a dose of (50mg/kg) prevented the alterations. Also, S. mialhesi extract exhibited a dose-dependent immunostimulatory effect on the RES and S. ocymastrum extract appeared immunostimulatory at low concentrations and immunosuppressive at high concentrations. Moreover, in the present thesis, we performed a review study which demonstrated that Hcy may mediate carcinogenesis namely through folate deficiency, oxidative stress, aberrant DNA methylation and the production of homocysteine thiolactone.
|
| Diplôme : |
Doctorat |
| En ligne : |
../theses/biologie/BEN6973.pdf |
| Format de la ressource électronique : |
pdf |
| Permalink : |
index.php?lvl=notice_display&id=10371 |
Effect of bioactive molecules extracted from medicinal plants on inflammation induced by hyperhomocysteinemia and tumoral process [texte imprimé] / Assia Benmebarek, Auteur ; S Zerizer, Directeur de thèse . - جامعة الإخوة منتوري قسنطينة, 2014 . - 231 f. 2 copies imprimées disponibles
Langues : Anglais ( eng)
| Catégories : |
Français - Anglais
Biologie
|
| Tags : |
Hyperhomocysteinemia atherogenesis inflammation carcinogenesis Stachys mialhesi Stachys ocymastrum immunomodulatory activity Hyperhomocysteinémie athérogénèse carcinogénèse activité immunomodulatrice زیادة الھوموسستیین البلازمي تصلب الشرایین الالتھاب السرطان التنبیھ المناعي |
| Index. décimale : |
570 Sciences de la vie. Biologie |
| Résumé : |
Hyperhomocysteinemia is an important risk factor in cardiovascular diseases and may also be implicated in cancer biology. Elevated plasma homocysteine (Hcy) levels may mediate long-term oxidative damage at the vascular interface and there appear to be a mechanism by which they may also be carcinogenic. In addition, immunostimulatory therapy is one solution to enhance the immunity, however, the immunopharmacologic activities of herbal extracts may be antagonistic, they can be immunosupressive or immunostimulating. In the present study, we evaluated the in vivo effect of S. mialhesi extract on the inflammation induced by hyperhomocysteinemia and damages induced to the aorta, heart, liver, thymus and spleen. Another study was carried on the immunomodulatory potential of S. mialhesi
and S. ocymastrum on the phagocytic activity which was evaluated using the Carbon Clearance Assay. The results obtained showed that plasma hs-CRP concentrations were elevated significantly after the administration of L-methionine in high doses to mice (200mg/kg). Also, the loss and degeneration of endothelium, fenestration, foam cells formation, and a change in the appearance of smooth muscle cells nuclei from a fusiform nuclei aspect to a rounded one, were observed in the media of the aorta as well as the alteration of the cardiac muscle, liver necrosis, lymphocytes membrane destruction in the thymus, and a hypertrophy of the spleen white pulp. Our research also revealed that at different doses, S. mialhesi extract increased the reticuloendothelial system (RES)
phagocytic activity in a dose dependant manner, in contrast to S. ocymastrum who exhibited a biphasic dose response effect. Hcy initiated inflammation and mediated early atherogenesis lesions through increased oxidant stress, and the treatment with S. mialhesi extract at a dose of (50mg/kg) prevented the alterations. Also, S. mialhesi extract exhibited a dose-dependent immunostimulatory effect on the RES and S. ocymastrum extract appeared immunostimulatory at low concentrations and immunosuppressive at high concentrations. Moreover, in the present thesis, we performed a review study which demonstrated that Hcy may mediate carcinogenesis namely through folate deficiency, oxidative stress, aberrant DNA methylation and the production of homocysteine thiolactone.
|
| Diplôme : |
Doctorat |
| En ligne : |
../theses/biologie/BEN6973.pdf |
| Format de la ressource électronique : |
pdf |
| Permalink : |
index.php?lvl=notice_display&id=10371 |
|
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