| Titre : |
Etude analytique et épidémiologique de la toxicité des pesticides utilisés dans l’Est Algérien. |
| Type de document : |
texte imprimé |
| Auteurs : |
Awatif Boumaza, Auteur ; Korichi Lalaoui, Directeur de thèse |
| Editeur : |
جامعة الإخوة منتوري قسنطينة |
| Année de publication : |
2017 |
| Importance : |
99 f. |
| Format : |
30 cm. |
| Note générale : |
2 copies imprimées disponibles
|
| Langues : |
Français (fre) |
| Catégories : |
Français - Anglais
Biologie
|
| Tags : |
Exposition aux pesticides génotoxicité biosurveillance stress oxydatif hématotoxicité troubles biochimiques pesticides exposure genotoxicity biomonitoring oxidative stress hematotoxicity biochemical disturbances |
| Index. décimale : |
570 Sciences de la vie. Biologie |
| Résumé : |
Various pesticides have demonstrated hazardous, genotoxic and carcinogenic potential
via different mechanisms, among of which oxidative stress. Until now, biomonitoring and
epidemiological studies have been carried out to assess toxic and genotoxic risk to exposed
human populations. In this sense, the present study was carried out to determine cytotoxic and
genotoxic effects of some pesticides used in Algeria. First, six pesticides have been tested for
their potential genotoxicity using micronucleus test and chromosome aberration test in
cultured human lymphocytes, and Allium cepa test. Results of both types of tests, in vitro and
in situ, showed positive cytotoxic and genotoxic effects with the different tested pesticides. In
the second part of the present study, a population of pesticide-exposed farmers has been
monitored for possible health disturbances. Here, we focused on people exposed to complex
mixtures of pesticides. The exposure of farm workers from Constantine to these hazardous
chemicals was assessed and cytogenetic alterations were evaluated using blood lymphocytes
micronucleus assay, chromosome aberration assay, hematological and lipid parameters,
Butyrylcholinesterase (BChE) activity and oxidative stress enzymes and biomarkers involved
in the pathogenesis of pesticides. The group of farm workers exposed to different types of
pesticides was evaluated and compared to matched non-exposed control group. A significant
increase was observed in the frequencies of micronuclei, and chromosome aberrations in
blood lymphocytes in the exposed groups (n = 21) compared to controls (n = 21). Some
differences were detected regarding the hematological parameters, lipid profile and BChE
activity. A significant difference was observed regarding oxidative stress parameters and
biochemical parameters. These results suggest possible disrupting effect and genotoxic harms
of pesticides. |
| Diplôme : |
Doctorat en sciences |
| En ligne : |
../theses/biologie/BOU7075.pdf |
| Format de la ressource électronique : |
pdf |
| Permalink : |
index.php?lvl=notice_display&id=10526 |
Etude analytique et épidémiologique de la toxicité des pesticides utilisés dans l’Est Algérien. [texte imprimé] / Awatif Boumaza, Auteur ; Korichi Lalaoui, Directeur de thèse . - جامعة الإخوة منتوري قسنطينة, 2017 . - 99 f. ; 30 cm. 2 copies imprimées disponibles
Langues : Français ( fre)
| Catégories : |
Français - Anglais
Biologie
|
| Tags : |
Exposition aux pesticides génotoxicité biosurveillance stress oxydatif hématotoxicité troubles biochimiques pesticides exposure genotoxicity biomonitoring oxidative stress hematotoxicity biochemical disturbances |
| Index. décimale : |
570 Sciences de la vie. Biologie |
| Résumé : |
Various pesticides have demonstrated hazardous, genotoxic and carcinogenic potential
via different mechanisms, among of which oxidative stress. Until now, biomonitoring and
epidemiological studies have been carried out to assess toxic and genotoxic risk to exposed
human populations. In this sense, the present study was carried out to determine cytotoxic and
genotoxic effects of some pesticides used in Algeria. First, six pesticides have been tested for
their potential genotoxicity using micronucleus test and chromosome aberration test in
cultured human lymphocytes, and Allium cepa test. Results of both types of tests, in vitro and
in situ, showed positive cytotoxic and genotoxic effects with the different tested pesticides. In
the second part of the present study, a population of pesticide-exposed farmers has been
monitored for possible health disturbances. Here, we focused on people exposed to complex
mixtures of pesticides. The exposure of farm workers from Constantine to these hazardous
chemicals was assessed and cytogenetic alterations were evaluated using blood lymphocytes
micronucleus assay, chromosome aberration assay, hematological and lipid parameters,
Butyrylcholinesterase (BChE) activity and oxidative stress enzymes and biomarkers involved
in the pathogenesis of pesticides. The group of farm workers exposed to different types of
pesticides was evaluated and compared to matched non-exposed control group. A significant
increase was observed in the frequencies of micronuclei, and chromosome aberrations in
blood lymphocytes in the exposed groups (n = 21) compared to controls (n = 21). Some
differences were detected regarding the hematological parameters, lipid profile and BChE
activity. A significant difference was observed regarding oxidative stress parameters and
biochemical parameters. These results suggest possible disrupting effect and genotoxic harms
of pesticides. |
| Diplôme : |
Doctorat en sciences |
| En ligne : |
../theses/biologie/BOU7075.pdf |
| Format de la ressource électronique : |
pdf |
| Permalink : |
index.php?lvl=notice_display&id=10526 |
|
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