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Auteur Korichi Lalaoui |
Documents disponibles écrits par cet auteur (2)
Affiner la recherche Interroger des sources externesEtude analytique et épidémiologique de la toxicité des pesticides utilisés dans l’Est Algérien. / Awatif Boumaza
Titre : Etude analytique et épidémiologique de la toxicité des pesticides utilisés dans l’Est Algérien. Type de document : texte imprimé Auteurs : Awatif Boumaza, Auteur ; Korichi Lalaoui, Directeur de thèse Editeur : جامعة الإخوة منتوري قسنطينة Année de publication : 2017 Importance : 99 f. Format : 30 cm. Note générale : 2 copies imprimées disponibles
Langues : Français (fre) Catégories : Français - Anglais
BiologieTags : Exposition aux pesticides génotoxicité biosurveillance stress oxydatif hématotoxicité troubles biochimiques pesticides exposure genotoxicity biomonitoring oxidative stress hematotoxicity biochemical disturbances Index. décimale : 570 Sciences de la vie. Biologie Résumé : Various pesticides have demonstrated hazardous, genotoxic and carcinogenic potential
via different mechanisms, among of which oxidative stress. Until now, biomonitoring and
epidemiological studies have been carried out to assess toxic and genotoxic risk to exposed
human populations. In this sense, the present study was carried out to determine cytotoxic and
genotoxic effects of some pesticides used in Algeria. First, six pesticides have been tested for
their potential genotoxicity using micronucleus test and chromosome aberration test in
cultured human lymphocytes, and Allium cepa test. Results of both types of tests, in vitro and
in situ, showed positive cytotoxic and genotoxic effects with the different tested pesticides. In
the second part of the present study, a population of pesticide-exposed farmers has been
monitored for possible health disturbances. Here, we focused on people exposed to complex
mixtures of pesticides. The exposure of farm workers from Constantine to these hazardous
chemicals was assessed and cytogenetic alterations were evaluated using blood lymphocytes
micronucleus assay, chromosome aberration assay, hematological and lipid parameters,
Butyrylcholinesterase (BChE) activity and oxidative stress enzymes and biomarkers involved
in the pathogenesis of pesticides. The group of farm workers exposed to different types of
pesticides was evaluated and compared to matched non-exposed control group. A significant
increase was observed in the frequencies of micronuclei, and chromosome aberrations in
blood lymphocytes in the exposed groups (n = 21) compared to controls (n = 21). Some
differences were detected regarding the hematological parameters, lipid profile and BChE
activity. A significant difference was observed regarding oxidative stress parameters and
biochemical parameters. These results suggest possible disrupting effect and genotoxic harms
of pesticides.Diplôme : Doctorat en sciences En ligne : ../theses/biologie/BOU7075.pdf Format de la ressource électronique : Permalink : index.php?lvl=notice_display&id=10526 Etude analytique et épidémiologique de la toxicité des pesticides utilisés dans l’Est Algérien. [texte imprimé] / Awatif Boumaza, Auteur ; Korichi Lalaoui, Directeur de thèse . - جامعة الإخوة منتوري قسنطينة, 2017 . - 99 f. ; 30 cm.
2 copies imprimées disponibles
Langues : Français (fre)
Catégories : Français - Anglais
BiologieTags : Exposition aux pesticides génotoxicité biosurveillance stress oxydatif hématotoxicité troubles biochimiques pesticides exposure genotoxicity biomonitoring oxidative stress hematotoxicity biochemical disturbances Index. décimale : 570 Sciences de la vie. Biologie Résumé : Various pesticides have demonstrated hazardous, genotoxic and carcinogenic potential
via different mechanisms, among of which oxidative stress. Until now, biomonitoring and
epidemiological studies have been carried out to assess toxic and genotoxic risk to exposed
human populations. In this sense, the present study was carried out to determine cytotoxic and
genotoxic effects of some pesticides used in Algeria. First, six pesticides have been tested for
their potential genotoxicity using micronucleus test and chromosome aberration test in
cultured human lymphocytes, and Allium cepa test. Results of both types of tests, in vitro and
in situ, showed positive cytotoxic and genotoxic effects with the different tested pesticides. In
the second part of the present study, a population of pesticide-exposed farmers has been
monitored for possible health disturbances. Here, we focused on people exposed to complex
mixtures of pesticides. The exposure of farm workers from Constantine to these hazardous
chemicals was assessed and cytogenetic alterations were evaluated using blood lymphocytes
micronucleus assay, chromosome aberration assay, hematological and lipid parameters,
Butyrylcholinesterase (BChE) activity and oxidative stress enzymes and biomarkers involved
in the pathogenesis of pesticides. The group of farm workers exposed to different types of
pesticides was evaluated and compared to matched non-exposed control group. A significant
increase was observed in the frequencies of micronuclei, and chromosome aberrations in
blood lymphocytes in the exposed groups (n = 21) compared to controls (n = 21). Some
differences were detected regarding the hematological parameters, lipid profile and BChE
activity. A significant difference was observed regarding oxidative stress parameters and
biochemical parameters. These results suggest possible disrupting effect and genotoxic harms
of pesticides.Diplôme : Doctorat en sciences En ligne : ../theses/biologie/BOU7075.pdf Format de la ressource électronique : Permalink : index.php?lvl=notice_display&id=10526 Exemplaires (1)
Code-barres Cote Support Localisation Section Disponibilité BOU/7075 BOU/7075 Thèse Bibliothèque principale Thèses Disponible
Titre : Le rôle de Thymelaea microphylla dans l’amélioration du stress oxydant et du taux de la métallothionéine induits par le cadmium dans le rein chez le rat. Type de document : texte imprimé Auteurs : Samira Laib, Auteur ; Korichi Lalaoui, Directeur de thèse Editeur : جامعة الإخوة منتوري قسنطينة Année de publication : 2018 Importance : 94 f. Format : 30 cm. Note générale : 2 copies imprimées disponibles
Langues : Français (fre) Catégories : Français - Anglais
BiologieTags : chlorure de cadmium rein stress oxydatif Thymelaea microphylla métallothionéine cadmium chloride kidney oxidative stress metallothionein لوريد الكادميوم الكلية والإجهاد التأكسدي Thymelaea microphyllaميتالوثيونيين Index. décimale : 570 Sciences de la vie. Biologie Résumé : The present investigation was performed to evaluate the protective effect and the antioxidant power of Thymelaea microphylla against cadmium chloride induced oxidative stress and renal toxicity in Wistar rats. First, antioxidant and radical scavenging effect of Thymelaea microphylla was evaluated in vitro with 2,2- diphenyl-1-picrylhydrazyl (DPPH) and hydroxyl (OH) radicals assays. Then, Wistar rats were subjected to oral pretreatment with n-butanolic
extract of Thymelaea microphylla (BETM) (200 mg/kg) against the renal toxicity induced by oral administration of cadmium chloride CdCl2 (5 mg/kg) for 28 days, vitamin E (250 mg/Kg) was used similarly as standard. Efficiency of Thymelaea microphylla against the renal toxicity was evaluated in terms of biochemical estimation of renal function parameters, antioxidant enzymes activities, metallothionein levels and histopathological modifications. Thymelaea
microphylla anti-inflammatory effect was evaluated by carrageenan (1%) induced rat paw edema. Thymelaea microphylla revealed a high scavenging ability of DPPH and OH radicals.
Also, Thymelaea microphylla (200 mg/Kg) pretreatment prevented deteriorative effects caused by cadmium chloride through a protective mechanism that included significant decrease in the levels of Blood Urea Nitrogen, creatinine, gamma-glutamyltranspeptidase (GGT), potassium,sodium, Myeloperoxidase, Nitric Oxide and Thiobarbituric Acid Reactive Species as well as by restoration of antioxidant enzymes in the cytosol, metallothionein levels and
histopathological changes induced by cadmium. Additionally, Thymelaea microphylla revealed an important anti-inflammatory effect reducing carrageenan induced paw edema. This study proved the antioxidant and protective effect of Thymelaea microphylla against cadmium chloride induced oxidative stress and kidney injury.
Diplôme : Doctorat En ligne : ../theses/biologie/LAI7250.pdf Format de la ressource électronique : Permalink : index.php?lvl=notice_display&id=10842 Le rôle de Thymelaea microphylla dans l’amélioration du stress oxydant et du taux de la métallothionéine induits par le cadmium dans le rein chez le rat. [texte imprimé] / Samira Laib, Auteur ; Korichi Lalaoui, Directeur de thèse . - جامعة الإخوة منتوري قسنطينة, 2018 . - 94 f. ; 30 cm.
2 copies imprimées disponibles
Langues : Français (fre)
Catégories : Français - Anglais
BiologieTags : chlorure de cadmium rein stress oxydatif Thymelaea microphylla métallothionéine cadmium chloride kidney oxidative stress metallothionein لوريد الكادميوم الكلية والإجهاد التأكسدي Thymelaea microphyllaميتالوثيونيين Index. décimale : 570 Sciences de la vie. Biologie Résumé : The present investigation was performed to evaluate the protective effect and the antioxidant power of Thymelaea microphylla against cadmium chloride induced oxidative stress and renal toxicity in Wistar rats. First, antioxidant and radical scavenging effect of Thymelaea microphylla was evaluated in vitro with 2,2- diphenyl-1-picrylhydrazyl (DPPH) and hydroxyl (OH) radicals assays. Then, Wistar rats were subjected to oral pretreatment with n-butanolic
extract of Thymelaea microphylla (BETM) (200 mg/kg) against the renal toxicity induced by oral administration of cadmium chloride CdCl2 (5 mg/kg) for 28 days, vitamin E (250 mg/Kg) was used similarly as standard. Efficiency of Thymelaea microphylla against the renal toxicity was evaluated in terms of biochemical estimation of renal function parameters, antioxidant enzymes activities, metallothionein levels and histopathological modifications. Thymelaea
microphylla anti-inflammatory effect was evaluated by carrageenan (1%) induced rat paw edema. Thymelaea microphylla revealed a high scavenging ability of DPPH and OH radicals.
Also, Thymelaea microphylla (200 mg/Kg) pretreatment prevented deteriorative effects caused by cadmium chloride through a protective mechanism that included significant decrease in the levels of Blood Urea Nitrogen, creatinine, gamma-glutamyltranspeptidase (GGT), potassium,sodium, Myeloperoxidase, Nitric Oxide and Thiobarbituric Acid Reactive Species as well as by restoration of antioxidant enzymes in the cytosol, metallothionein levels and
histopathological changes induced by cadmium. Additionally, Thymelaea microphylla revealed an important anti-inflammatory effect reducing carrageenan induced paw edema. This study proved the antioxidant and protective effect of Thymelaea microphylla against cadmium chloride induced oxidative stress and kidney injury.
Diplôme : Doctorat En ligne : ../theses/biologie/LAI7250.pdf Format de la ressource électronique : Permalink : index.php?lvl=notice_display&id=10842 Exemplaires (1)
Code-barres Cote Support Localisation Section Disponibilité LAI/7250 LAI/7250 Thèse Bibliothèque principale Thèses Disponible
