Titre : |
Comportement électrochimiques des hétérocycles azotés et des biomolécules biologiquement actifs. |
Type de document : |
texte imprimé |
Auteurs : |
Fatima Zohra Issaad, Auteur ; Chaabane Mouats, Directeur de thèse ; Ana Maria Oliveira Brett, Directeur de thèse |
Editeur : |
جامعة الإخوة منتوري قسنطينة |
Année de publication : |
2017 |
Importance : |
190 f. |
Format : |
30 cm. |
Note générale : |
2 copies imprimées disponibles. |
Langues : |
Français (fre) |
Catégories : |
Français - Anglais Chimie
|
Tags : |
Hétérocycles Bevacizumab dénaturation flavonoïde électrode de carbone vitreux activité antioxydante Heterocyclic compound Bevacizumab, denaturation flavonoid glassy carbon electrode antioxidant activity المركبات الحلقية غير المتجانسة بيفاسيزوماب تغيير شكل الفلافونويد قطب الكاربون الزجاجي القدرة المضادة لأكسدة |
Index. décimale : |
540 Chimie et sciences connexes |
Résumé : |
This work presents the electrochemical behavior of three types of molecules: synthetic, biosynthetic and natural.
Heterocyclic compounds from nitrophenyl acetic acid were synthetized and evaluated for their electroactivities and cytotoxic properties.
The electrochemical oxidation of native and denatured BEVA was investigated in solution over a wide pH range and using BEVA-thin film voltammetry on a glassy carbon electrode.
For native BEVA, only one pH-dependent oxidation peak, corresponding to tyrosine and tryptophan amino acid residues oxidation, was observed. On the other hand, the electrochemical oxidation of denatured BEVA thin film on GCE showed additional cysteine and histidine residues oxidation peaks.
Flavonoids present in the extracts of Mediterranean freeze-dried fruits: apricot, cherry, plum, pomegranate, date, prickly pear and nectarine were detected by high-performance liquidphase chromatography with inverse phase (RP-HPLC) coupled with photodiode array (PDA) and electrochemical detection (ED).
The total antioxidant activity of these extracts was investigated by differential pulse voltammetry (electrochemical index-EI and peak area-Parea) and chronoamperometry (peak intensity-Ia). A comparative study was carried out by free radical scavenger efficient concentration (EC50), using 2, 2-diphenyl-1-picrylhydrazyl (DPPH) assay. |
Diplôme : |
Doctorat en sciences |
En ligne : |
../theses/chimie/ISS7183.pdf |
Format de la ressource électronique : |
pdf |
Permalink : |
index.php?lvl=notice_display&id=10737 |
Comportement électrochimiques des hétérocycles azotés et des biomolécules biologiquement actifs. [texte imprimé] / Fatima Zohra Issaad, Auteur ; Chaabane Mouats, Directeur de thèse ; Ana Maria Oliveira Brett, Directeur de thèse . - جامعة الإخوة منتوري قسنطينة, 2017 . - 190 f. ; 30 cm. 2 copies imprimées disponibles. Langues : Français ( fre)
Catégories : |
Français - Anglais Chimie
|
Tags : |
Hétérocycles Bevacizumab dénaturation flavonoïde électrode de carbone vitreux activité antioxydante Heterocyclic compound Bevacizumab, denaturation flavonoid glassy carbon electrode antioxidant activity المركبات الحلقية غير المتجانسة بيفاسيزوماب تغيير شكل الفلافونويد قطب الكاربون الزجاجي القدرة المضادة لأكسدة |
Index. décimale : |
540 Chimie et sciences connexes |
Résumé : |
This work presents the electrochemical behavior of three types of molecules: synthetic, biosynthetic and natural.
Heterocyclic compounds from nitrophenyl acetic acid were synthetized and evaluated for their electroactivities and cytotoxic properties.
The electrochemical oxidation of native and denatured BEVA was investigated in solution over a wide pH range and using BEVA-thin film voltammetry on a glassy carbon electrode.
For native BEVA, only one pH-dependent oxidation peak, corresponding to tyrosine and tryptophan amino acid residues oxidation, was observed. On the other hand, the electrochemical oxidation of denatured BEVA thin film on GCE showed additional cysteine and histidine residues oxidation peaks.
Flavonoids present in the extracts of Mediterranean freeze-dried fruits: apricot, cherry, plum, pomegranate, date, prickly pear and nectarine were detected by high-performance liquidphase chromatography with inverse phase (RP-HPLC) coupled with photodiode array (PDA) and electrochemical detection (ED).
The total antioxidant activity of these extracts was investigated by differential pulse voltammetry (electrochemical index-EI and peak area-Parea) and chronoamperometry (peak intensity-Ia). A comparative study was carried out by free radical scavenger efficient concentration (EC50), using 2, 2-diphenyl-1-picrylhydrazyl (DPPH) assay. |
Diplôme : |
Doctorat en sciences |
En ligne : |
../theses/chimie/ISS7183.pdf |
Format de la ressource électronique : |
pdf |
Permalink : |
index.php?lvl=notice_display&id=10737 |
|