| Titre : |
Synthesis and anticancer properties of some novel Cyanopyridines-based hybrid molecules bearing pyrazole, oxadiazole, and N-acylhydrazone moieties. |
| Type de document : |
texte imprimé |
| Auteurs : |
Zineddine Zebbiche, Auteur ; Boudjemaa Boumoud, Directeur de thèse |
| Mention d'édition : |
15 July 2021 |
| Editeur : |
جامعة الإخوة منتوري قسنطينة |
| Année de publication : |
2021 |
| Importance : |
197 f. |
| Format : |
30 cm. |
| Note générale : |
Doctorat 3éme CYCLE LMD.
1 copies imprimées disponibles
|
| Langues : |
Anglais (eng) |
| Catégories : |
Français - Anglais
Chimie
|
| Tags : |
Chimie Organique:Bioactive molecule Cyanopyridine pyrazole Oxadiazole N-acylhydrazone anticancéreuses test MTT anticancer MTT assay سيانوبيريدين بيرازول أوكساديازول إن-أسيل هيدرازون مضادات السرطان اختبار MTT |
| Index. décimale : |
540 Chimie et sciences connexes |
| Résumé : |
In order to decrease the level of toxicity and improve the selectivity of drugs toward cancer targets, hybrid drugs are designed to simultaneously modulate multiple targets of multifactorial diseases to overcome the side effects associated with a single target-drugs. As a result, the development of hybrid molecules has become the centre of research. Owing to the pharmacological data of pyridine, 1,3,4 oxadiazole, and pyrazole rings, we are
interested in synthesizing new hybrid molecules and examining their anti-cancer activities. In the first chapter of the manuscript, a bibliographical study described the biological interests and synthesis methods of four heterocyclic systems, namely cyanopridines, pyrazoles, oxadiazoles, and N-acylhydrazones. In the second chapter, we developed novel conditions to prepare a well-furnished library of acetohydrazides from cyanopyridones as starting materials. The reactivity of the formers was used to synthesize three novel series bearing pyarzoles, 1,3,4 oxadiazoles, and hydrazones containing isatin moieties. in the final chapter of the thesis, as the main objective, was evaluating and discussing the synthesized molecules' anticancer properties against different cancer cell lines (A‐2780, MCF‐7, and Caco-2) using MTT assay.
|
| Note de contenu : |
Annexes. |
| Diplôme : |
Doctorat |
| En ligne : |
../theses/chimie/ZEB7791.pdf |
| Format de la ressource électronique : |
pdf |
| Permalink : |
index.php?lvl=notice_display&id=11623 |
Synthesis and anticancer properties of some novel Cyanopyridines-based hybrid molecules bearing pyrazole, oxadiazole, and N-acylhydrazone moieties. [texte imprimé] / Zineddine Zebbiche, Auteur ; Boudjemaa Boumoud, Directeur de thèse . - 15 July 2021 . - جامعة الإخوة منتوري قسنطينة, 2021 . - 197 f. ; 30 cm. Doctorat 3éme CYCLE LMD.
1 copies imprimées disponibles
Langues : Anglais ( eng)
| Catégories : |
Français - Anglais
Chimie
|
| Tags : |
Chimie Organique:Bioactive molecule Cyanopyridine pyrazole Oxadiazole N-acylhydrazone anticancéreuses test MTT anticancer MTT assay سيانوبيريدين بيرازول أوكساديازول إن-أسيل هيدرازون مضادات السرطان اختبار MTT |
| Index. décimale : |
540 Chimie et sciences connexes |
| Résumé : |
In order to decrease the level of toxicity and improve the selectivity of drugs toward cancer targets, hybrid drugs are designed to simultaneously modulate multiple targets of multifactorial diseases to overcome the side effects associated with a single target-drugs. As a result, the development of hybrid molecules has become the centre of research. Owing to the pharmacological data of pyridine, 1,3,4 oxadiazole, and pyrazole rings, we are
interested in synthesizing new hybrid molecules and examining their anti-cancer activities. In the first chapter of the manuscript, a bibliographical study described the biological interests and synthesis methods of four heterocyclic systems, namely cyanopridines, pyrazoles, oxadiazoles, and N-acylhydrazones. In the second chapter, we developed novel conditions to prepare a well-furnished library of acetohydrazides from cyanopyridones as starting materials. The reactivity of the formers was used to synthesize three novel series bearing pyarzoles, 1,3,4 oxadiazoles, and hydrazones containing isatin moieties. in the final chapter of the thesis, as the main objective, was evaluating and discussing the synthesized molecules' anticancer properties against different cancer cell lines (A‐2780, MCF‐7, and Caco-2) using MTT assay.
|
| Note de contenu : |
Annexes. |
| Diplôme : |
Doctorat |
| En ligne : |
../theses/chimie/ZEB7791.pdf |
| Format de la ressource électronique : |
pdf |
| Permalink : |
index.php?lvl=notice_display&id=11623 |
|
Affiner la recherche Interroger des sources externesSynthesis and anticancer properties of some novel Cyanopyridines-based hybrid molecules bearing pyrazole, oxadiazole, and N-acylhydrazone moieties. / Zineddine Zebbiche
