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Auteur Nadra Debbache |
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Affiner la recherche Interroger des sources externesComportement d’un oxyhydroxyde de Fe(III) vis-à-vis d’un produit pharmaceutique en solution aqueuse en présence de lumières naturelle et simulée. / Mohamed el Mehdi Benacherine
Titre : Comportement d’un oxyhydroxyde de Fe(III) vis-à-vis d’un produit pharmaceutique en solution aqueuse en présence de lumières naturelle et simulée. Type de document : texte imprimé Auteurs : Mohamed el Mehdi Benacherine, Auteur ; Nadra Debbache, Directeur de thèse Editeur : جامعة الإخوة منتوري قسنطينة Année de publication : 2017 Importance : 167 f. Format : 30 cm. Note générale : 2 copies imprimées disponibles
Langues : Français (fre) Catégories : Français - Anglais
ChimieTags : Amoxicilline Photodégradation Radicaux hydroxyle Goethite Fenton Amoxicillin photodegradation hydroxyl radicals hydrogen peroxide oxalic acid أموكسیسیلین التفكك الضوئي الجذور الھیدروكسیلیة •OH فانتون الجیوثیت (GOE) (like Fenton) نوﺘﻧﺎﻔﻟﺎﺑ ﮫﯿﺒﺸﻟا Index. décimale : 540 Chimie et sciences connexes Résumé : Our objectives in this thesis were to demonstrate the effectiveness of Goethite (GOE) in the
amoxicillin (AMX) photodegradation process under artificial and solar irradiation by different
systems, as well as the optimization of experimental parameters affecting the rate of the
degradation. Different analytical methods have been used in the characterization of AMX and
GOE. In the absence of light, the transformation of AMX was studied in different mixtures
(AMX-GOE, AMX-GOE-H2O2 and AMX-GOE-Carboxylic Acid). An interaction between
AMX and GOE was demonstrated; H2O2 significantly improved the degradation of AMX
while no effect was mentioned in the case of the presence of carboxylic acids. Under
irradiation and in the absence of GOE, AMX was found to be photolysed at 254 nm and
refractory to photolysis at 365 nm (monochromatic and polychromatic); this is due to the
overlap between the absorption spectrum of AMX and the light source.
The photodegradation of AMX by heterogeneous photocatalysis in the presence of GOE has
been studied. Results show that the photodegradation is dependent on several parameters such
as pH, substrate and catalyst concentration. The use of free radical inhibitors has shown that
the reaction mechanism is dominated by •OH radicals where oxygen plays an important role.
The addition of H2O2 to the solution improves the degradation of AMX and increases its rate
of mineralization in terms of chemical oxygen demand. The degradation is effected by the
contribution of the •OH radicals and also by oxidation on the surface of GOE. The AMXGOE-carboxylic acid system has been tested, among the used acids, oxalic acid was the only
one that showed a photo-activity. By comparing the degradation kinetics of AMX in natural
and artificial light in the three studied systems, it is found that the degradation rate is higher
under solar irradiation.
Diplôme : Doctorat En ligne : ../theses/chimie/BEN7137.pdf Format de la ressource électronique : Permalink : index.php?lvl=notice_display&id=10465 Comportement d’un oxyhydroxyde de Fe(III) vis-à-vis d’un produit pharmaceutique en solution aqueuse en présence de lumières naturelle et simulée. [texte imprimé] / Mohamed el Mehdi Benacherine, Auteur ; Nadra Debbache, Directeur de thèse . - جامعة الإخوة منتوري قسنطينة, 2017 . - 167 f. ; 30 cm.
2 copies imprimées disponibles
Langues : Français (fre)
Catégories : Français - Anglais
ChimieTags : Amoxicilline Photodégradation Radicaux hydroxyle Goethite Fenton Amoxicillin photodegradation hydroxyl radicals hydrogen peroxide oxalic acid أموكسیسیلین التفكك الضوئي الجذور الھیدروكسیلیة •OH فانتون الجیوثیت (GOE) (like Fenton) نوﺘﻧﺎﻔﻟﺎﺑ ﮫﯿﺒﺸﻟا Index. décimale : 540 Chimie et sciences connexes Résumé : Our objectives in this thesis were to demonstrate the effectiveness of Goethite (GOE) in the
amoxicillin (AMX) photodegradation process under artificial and solar irradiation by different
systems, as well as the optimization of experimental parameters affecting the rate of the
degradation. Different analytical methods have been used in the characterization of AMX and
GOE. In the absence of light, the transformation of AMX was studied in different mixtures
(AMX-GOE, AMX-GOE-H2O2 and AMX-GOE-Carboxylic Acid). An interaction between
AMX and GOE was demonstrated; H2O2 significantly improved the degradation of AMX
while no effect was mentioned in the case of the presence of carboxylic acids. Under
irradiation and in the absence of GOE, AMX was found to be photolysed at 254 nm and
refractory to photolysis at 365 nm (monochromatic and polychromatic); this is due to the
overlap between the absorption spectrum of AMX and the light source.
The photodegradation of AMX by heterogeneous photocatalysis in the presence of GOE has
been studied. Results show that the photodegradation is dependent on several parameters such
as pH, substrate and catalyst concentration. The use of free radical inhibitors has shown that
the reaction mechanism is dominated by •OH radicals where oxygen plays an important role.
The addition of H2O2 to the solution improves the degradation of AMX and increases its rate
of mineralization in terms of chemical oxygen demand. The degradation is effected by the
contribution of the •OH radicals and also by oxidation on the surface of GOE. The AMXGOE-carboxylic acid system has been tested, among the used acids, oxalic acid was the only
one that showed a photo-activity. By comparing the degradation kinetics of AMX in natural
and artificial light in the three studied systems, it is found that the degradation rate is higher
under solar irradiation.
Diplôme : Doctorat En ligne : ../theses/chimie/BEN7137.pdf Format de la ressource électronique : Permalink : index.php?lvl=notice_display&id=10465 Exemplaires (1)
Code-barres Cote Support Localisation Section Disponibilité BEN/7137 BEN/7137 Thèse Bibliothèque principale Thèses Disponible
Titre : Comportements thermique et photochimique du paracétamol et de l’aspirine par la goethite en solution aqueuse en phase hétérogène Type de document : texte imprimé Auteurs : Yazid Mameri, Auteur ; Nadra Debbache, Directeur de thèse Editeur : جامعة الإخوة منتوري قسنطينة Année de publication : 2018 Importance : 177 f. Format : 30 cm. Note générale : 2 copies imprimées disponibles
Langues : Français (fre) Catégories : Français - Anglais
ChimieTags : Paracétamol Aspirine Photodégradation Radicaux hydroxyle Goethite Fenton Paracetamol Aspirin Photodegradation Hydroxyl radicals الباراسيتامول الأسبرين التفكك الضوئي جذور الهيدروكسيل فانتون Index. décimale : 540 Chimie et sciences connexes Résumé : The photodegradation of two pharmaceuticals (PP), paracetamol (PC) and aspirin (ASP), induced by an iron (III) oxyhydroxide (Goethite) was studied in aqueous solution in heterogeneous phase. The phototransformation of the substrates was followed by spectrophotometry and HPLC in various mixtures namely: PP-Goethite, PP-Goethite-H2O2 and PP-Goethite-carboxylic acid. In absence of light both substrates showed different behavior with regard to Goethite in aqueous solution. Indeed, no interaction was observed in the case of the PC whereas a particular reaction was highlighted in the case of the ASP. Under irradiation, photodegradation of PP induced by Goethite shows slow kinetics and is dependent on several parameters such as pH, substrate concentration and catalyst. Fe (II) formed exclusively in the ASP-Goethite mixture shows the photocatalytic dissolution of Goethite. The mechanistic study reveals that hydroxyl radicals are not involved in the photocatalytic process of PC, however they govern on the photodegradation mechanism of ASP. The addition of hydrogen peroxide in the PP-Goethite mixture improves significantly the rate of disappearance of the substrates following a large production of ●OH radicals generated by a heterogeneous photo Fenton reaction. Different parameters have been studied, the effect of pH, as well as the concentration of H2O2.
The addition of carboxylic acid to the PP-Goethite system has also been studied and shows that oxalic acid has the most important photoactivity following the involvement of the eterogeneous like-Fenton process resulting from the photoreductive dissolution of the complex surface formed between Fe (III) of Goethite and oxalic acid. The following of the mineralization shows that the life of intermediates reaction is much greater than the starting product. In order to verify the feasibility of the photochemical process in the environment, the same systems were studied under solar irradiation. The results show that such systems operate with kinetics of the same order as those observed in artificial irradiations. These results provide some knowledge about the fate of PP in the aquatic environment as well as the photocatalytic treatment with oxy (hydroxides) of Fe (III). These results are very promising for the application of this system under pH conditions close to those met in the environment.
Diplôme : Doctorat en sciences En ligne : ../theses/chimie/MAM7351.pdf Format de la ressource électronique : Permalink : index.php?lvl=notice_display&id=11001 Comportements thermique et photochimique du paracétamol et de l’aspirine par la goethite en solution aqueuse en phase hétérogène [texte imprimé] / Yazid Mameri, Auteur ; Nadra Debbache, Directeur de thèse . - جامعة الإخوة منتوري قسنطينة, 2018 . - 177 f. ; 30 cm.
2 copies imprimées disponibles
Langues : Français (fre)
Catégories : Français - Anglais
ChimieTags : Paracétamol Aspirine Photodégradation Radicaux hydroxyle Goethite Fenton Paracetamol Aspirin Photodegradation Hydroxyl radicals الباراسيتامول الأسبرين التفكك الضوئي جذور الهيدروكسيل فانتون Index. décimale : 540 Chimie et sciences connexes Résumé : The photodegradation of two pharmaceuticals (PP), paracetamol (PC) and aspirin (ASP), induced by an iron (III) oxyhydroxide (Goethite) was studied in aqueous solution in heterogeneous phase. The phototransformation of the substrates was followed by spectrophotometry and HPLC in various mixtures namely: PP-Goethite, PP-Goethite-H2O2 and PP-Goethite-carboxylic acid. In absence of light both substrates showed different behavior with regard to Goethite in aqueous solution. Indeed, no interaction was observed in the case of the PC whereas a particular reaction was highlighted in the case of the ASP. Under irradiation, photodegradation of PP induced by Goethite shows slow kinetics and is dependent on several parameters such as pH, substrate concentration and catalyst. Fe (II) formed exclusively in the ASP-Goethite mixture shows the photocatalytic dissolution of Goethite. The mechanistic study reveals that hydroxyl radicals are not involved in the photocatalytic process of PC, however they govern on the photodegradation mechanism of ASP. The addition of hydrogen peroxide in the PP-Goethite mixture improves significantly the rate of disappearance of the substrates following a large production of ●OH radicals generated by a heterogeneous photo Fenton reaction. Different parameters have been studied, the effect of pH, as well as the concentration of H2O2.
The addition of carboxylic acid to the PP-Goethite system has also been studied and shows that oxalic acid has the most important photoactivity following the involvement of the eterogeneous like-Fenton process resulting from the photoreductive dissolution of the complex surface formed between Fe (III) of Goethite and oxalic acid. The following of the mineralization shows that the life of intermediates reaction is much greater than the starting product. In order to verify the feasibility of the photochemical process in the environment, the same systems were studied under solar irradiation. The results show that such systems operate with kinetics of the same order as those observed in artificial irradiations. These results provide some knowledge about the fate of PP in the aquatic environment as well as the photocatalytic treatment with oxy (hydroxides) of Fe (III). These results are very promising for the application of this system under pH conditions close to those met in the environment.
Diplôme : Doctorat en sciences En ligne : ../theses/chimie/MAM7351.pdf Format de la ressource électronique : Permalink : index.php?lvl=notice_display&id=11001 Exemplaires (1)
Code-barres Cote Support Localisation Section Disponibilité MAM/7351 MAM/7351 Thèse Bibliothèque principale Thèses Disponible
Titre : Contribution à l’étude de la dégradation photochimique de polluants organiques par les oxyhydroxydes de Fe (III) en solution aqueuse en phase hétérogène. Type de document : texte imprimé Auteurs : Sara Belattar, Auteur ; Nadra Debbache, Directeur de thèse Editeur : جامعة الإخوة منتوري قسنطينة Année de publication : 2018 Importance : 161 f. Format : 30 cm. Note générale : 2 copies imprimées disponibles
Langues : Français (fre) Catégories : Français - Anglais
ChimieTags : Photodégradation La GOE Dérivés phénoliques Radicaux hydroxyle Fenton Photodegradation GOE Phenolic derivatives Hydroxyl radicals التحلل الضوئي GOمشتقات الفینول ، جذور الھیدروكسیل فنتون Index. décimale : 540 Chimie et sciences connexes Résumé : The effectiveness of Goethite (GOE) in inducing the photodegradation of organic pollutants under artificial and solar irradiation in a heterogeneous medium and in aqueous solution was the main objective of this study. We used four organic pollutants of the phenol family (RP, BBP, BCP, phenol) whose chemical structure differs depending on the substitute nature. In the absence of light and in our experimental conditions, two distinct behaviors were observed as a function of the pollutants studied during the mixing of the GOE-substrate. Indeed, in the Phenol-GOE mixture, no interaction was observed whereas a slow reaction, in the presence of the GOE, was demonstrated with RP, BBP and BCP. This interaction can be attributed to a low adsorption of the substrate on the GOE in the following order: BCP (15%)> BBP (12%)> RP (5%)> Phenol (1%), and this phenomenon is optimal in acidic medium. The addition of H2O2 accelerates the thermal process in RP-GOE system while an inhibitory effect was observed for the other two substrates (BBP, BCP) in the presence of GOE. The presence of carboxylic acids in the substrate-GOE system has shown that oxalic acid has a positive effect on the kinetics of BCP and RP eliminations under our experimental conditions. Under irradiation at 365 nm, the photodegradation of these pollutants by the GOE, was characterized by slow kinetics and seems to be dependent on several parameters such as the pH, the concentration of the substrate, the catalyst concentration, the oxygen and the molecular structure of the substrates. The mechanistic study reveals that the radicals HO • do not intervene in the mechanism of degradation of the phenol on the other hand they govern the reaction in the case of RP, BBP and BCP. The addition of H2O2 in a GOE suspension significantly improves the rate of photodegradation due to additional production of HO• radicals generated by the Fenton photo process. Different parameters have been studied to optimize this process. In the same way, the efficiency of the photochemical process is improved by the presence of carboxylic acid in a GOE suspension following the involvement of the heterogeneous like-Fenton process resulting from the reductive photo dissolution of the surface complex formed between the Fe (III) Goethite and oxalic acid. In order to verify the feasibility of the photochemical process in the
environment, the same systems were studied under solar irradiation. The results show that such systems operate with kinetics of the same order as those observed in artificial irradiation, which can reduce the energy costs of the photochemical process.Diplôme : Doctorat en sciences En ligne : ../theses/chimie/BEL7350.pdf Format de la ressource électronique : Permalink : index.php?lvl=notice_display&id=11000 Contribution à l’étude de la dégradation photochimique de polluants organiques par les oxyhydroxydes de Fe (III) en solution aqueuse en phase hétérogène. [texte imprimé] / Sara Belattar, Auteur ; Nadra Debbache, Directeur de thèse . - جامعة الإخوة منتوري قسنطينة, 2018 . - 161 f. ; 30 cm.
2 copies imprimées disponibles
Langues : Français (fre)
Catégories : Français - Anglais
ChimieTags : Photodégradation La GOE Dérivés phénoliques Radicaux hydroxyle Fenton Photodegradation GOE Phenolic derivatives Hydroxyl radicals التحلل الضوئي GOمشتقات الفینول ، جذور الھیدروكسیل فنتون Index. décimale : 540 Chimie et sciences connexes Résumé : The effectiveness of Goethite (GOE) in inducing the photodegradation of organic pollutants under artificial and solar irradiation in a heterogeneous medium and in aqueous solution was the main objective of this study. We used four organic pollutants of the phenol family (RP, BBP, BCP, phenol) whose chemical structure differs depending on the substitute nature. In the absence of light and in our experimental conditions, two distinct behaviors were observed as a function of the pollutants studied during the mixing of the GOE-substrate. Indeed, in the Phenol-GOE mixture, no interaction was observed whereas a slow reaction, in the presence of the GOE, was demonstrated with RP, BBP and BCP. This interaction can be attributed to a low adsorption of the substrate on the GOE in the following order: BCP (15%)> BBP (12%)> RP (5%)> Phenol (1%), and this phenomenon is optimal in acidic medium. The addition of H2O2 accelerates the thermal process in RP-GOE system while an inhibitory effect was observed for the other two substrates (BBP, BCP) in the presence of GOE. The presence of carboxylic acids in the substrate-GOE system has shown that oxalic acid has a positive effect on the kinetics of BCP and RP eliminations under our experimental conditions. Under irradiation at 365 nm, the photodegradation of these pollutants by the GOE, was characterized by slow kinetics and seems to be dependent on several parameters such as the pH, the concentration of the substrate, the catalyst concentration, the oxygen and the molecular structure of the substrates. The mechanistic study reveals that the radicals HO • do not intervene in the mechanism of degradation of the phenol on the other hand they govern the reaction in the case of RP, BBP and BCP. The addition of H2O2 in a GOE suspension significantly improves the rate of photodegradation due to additional production of HO• radicals generated by the Fenton photo process. Different parameters have been studied to optimize this process. In the same way, the efficiency of the photochemical process is improved by the presence of carboxylic acid in a GOE suspension following the involvement of the heterogeneous like-Fenton process resulting from the reductive photo dissolution of the surface complex formed between the Fe (III) Goethite and oxalic acid. In order to verify the feasibility of the photochemical process in the
environment, the same systems were studied under solar irradiation. The results show that such systems operate with kinetics of the same order as those observed in artificial irradiation, which can reduce the energy costs of the photochemical process.Diplôme : Doctorat en sciences En ligne : ../theses/chimie/BEL7350.pdf Format de la ressource électronique : Permalink : index.php?lvl=notice_display&id=11000 Exemplaires (1)
Code-barres Cote Support Localisation Section Disponibilité BEL/7350 BEL/7350 Thèse Bibliothèque principale Thèses Disponible
Titre : Photodegradation du naproxene induite par un Oxyde de Fer (III) (Goethite) sous forme particulaire et nanoparticulaire. Type de document : texte imprimé Auteurs : Nessrine Setifi, Auteur ; Nadra Debbache, Directeur de thèse Editeur : جامعة الإخوة منتوري قسنطينة Année de publication : 2019 Importance : 196 f. Format : 30 cm. Note générale : Doctorat 3éme CYCLE LMD.
2 copies imprimées disponiblesLangues : Français (fre) Catégories : Français - Anglais
ChimieTags : Chimie: Chimie Analytique et Environnement Naproxène Photodégradation Nanoparticule Nanocomposite Goethite Fenton نابروكسين التحلل الضوئي جسيمات متناهية الصغر بمركب متناهي في الصغر الجيوثايت فنتون Index. décimale : 540 Chimie et sciences connexes Résumé :
The photodegradation under artificial and solar irradiation of Naproxen (NPX, induced by 3 iron (III) oxy (hydroxide) based semiconductors (Goethite) was studied in aqueous solution in heterogeneous phase. The phototransformation of the substrate was followed by spectrophotometry and HPLC in the different systems. Semiconductors including particulate Goethite (GO), nanoparticle (nGO) and nanocomposite montmorillonite - Goethite (MGO) were synthesized at laboratory, and characterized by different methods (RDX, BET, SEM, TEM ...). The results of the XRD show good crystallinity. In addition, SEM and TEM analysis revealed that the particle sizes of GO, nGO and MGO are: 5 μm, 37.64 nm and 45.79 nm respectively. The removal of NPX in the presence of GO, in the absence and in the presence of light, has shown that the NPX is eliminated by both processes with a faster rate in the presence of light and seems closely dependent on the PH. The optimization of important parameters in the photochemical process was also undertaken in order to quantify the reagents necessary for the completion of the reaction. The addition of activators such as hydrogen peroxide and oxalic acid in the NPX-GO mixture significantly improves the disappearance of the substrate. In a second part, the degradation of NPX by nGO was undertaken in a similar way comparing with GO. It appeared in the systems nGO-H2O2-UV and nGO- AOx-UV are more efficient than the corresponding simple system. Finally, the performance of the new MGO catalyst has been demonstrated in the degradation of NPX. In the absence of light, an interaction between NPX and MGO was found where 33% of NPX was eliminated for a quantity of MGO of 1 g / L. Under light irradiation, 96.5% of NPX was degraded after 5 hours. The Fe (II) formed exclusively in the mixture shows the photocatalytic dissolution of the MGO. The influence of some parameters has been treated. The degradation efficiency of NPX in mixture (NPX-MGO- H2O2, pH = 3) made it possible to improve the rate of degradation to 100% NPX in 60 minutes. The formation of iron (II) in the H2O2- containing mixture creates the Fenton process under these conditions. The hydroxyl radicals have been demonstrated by the use of 1% isopropanol. Illumination of this mixture significantly advanced the reaction with 100% substrate degradation in only 10 minutes. Several parameters affecting this process have been optimized: pH, MGO dosage and H2O2 concentration. Under solar irradiation, the results showed that 30 minutes were sufficient for complete degradation of NPX at free pH. The effect of pH and some cationic metals allows considering this low-cost process in the elimination of this kind of emerging pollutants.Diplôme : Doctorat En ligne : ../theses/chimie/SET7532.pdf Format de la ressource électronique : Permalink : index.php?lvl=notice_display&id=11371 Photodegradation du naproxene induite par un Oxyde de Fer (III) (Goethite) sous forme particulaire et nanoparticulaire. [texte imprimé] / Nessrine Setifi, Auteur ; Nadra Debbache, Directeur de thèse . - جامعة الإخوة منتوري قسنطينة, 2019 . - 196 f. ; 30 cm.
Doctorat 3éme CYCLE LMD.
2 copies imprimées disponibles
Langues : Français (fre)
Catégories : Français - Anglais
ChimieTags : Chimie: Chimie Analytique et Environnement Naproxène Photodégradation Nanoparticule Nanocomposite Goethite Fenton نابروكسين التحلل الضوئي جسيمات متناهية الصغر بمركب متناهي في الصغر الجيوثايت فنتون Index. décimale : 540 Chimie et sciences connexes Résumé :
The photodegradation under artificial and solar irradiation of Naproxen (NPX, induced by 3 iron (III) oxy (hydroxide) based semiconductors (Goethite) was studied in aqueous solution in heterogeneous phase. The phototransformation of the substrate was followed by spectrophotometry and HPLC in the different systems. Semiconductors including particulate Goethite (GO), nanoparticle (nGO) and nanocomposite montmorillonite - Goethite (MGO) were synthesized at laboratory, and characterized by different methods (RDX, BET, SEM, TEM ...). The results of the XRD show good crystallinity. In addition, SEM and TEM analysis revealed that the particle sizes of GO, nGO and MGO are: 5 μm, 37.64 nm and 45.79 nm respectively. The removal of NPX in the presence of GO, in the absence and in the presence of light, has shown that the NPX is eliminated by both processes with a faster rate in the presence of light and seems closely dependent on the PH. The optimization of important parameters in the photochemical process was also undertaken in order to quantify the reagents necessary for the completion of the reaction. The addition of activators such as hydrogen peroxide and oxalic acid in the NPX-GO mixture significantly improves the disappearance of the substrate. In a second part, the degradation of NPX by nGO was undertaken in a similar way comparing with GO. It appeared in the systems nGO-H2O2-UV and nGO- AOx-UV are more efficient than the corresponding simple system. Finally, the performance of the new MGO catalyst has been demonstrated in the degradation of NPX. In the absence of light, an interaction between NPX and MGO was found where 33% of NPX was eliminated for a quantity of MGO of 1 g / L. Under light irradiation, 96.5% of NPX was degraded after 5 hours. The Fe (II) formed exclusively in the mixture shows the photocatalytic dissolution of the MGO. The influence of some parameters has been treated. The degradation efficiency of NPX in mixture (NPX-MGO- H2O2, pH = 3) made it possible to improve the rate of degradation to 100% NPX in 60 minutes. The formation of iron (II) in the H2O2- containing mixture creates the Fenton process under these conditions. The hydroxyl radicals have been demonstrated by the use of 1% isopropanol. Illumination of this mixture significantly advanced the reaction with 100% substrate degradation in only 10 minutes. Several parameters affecting this process have been optimized: pH, MGO dosage and H2O2 concentration. Under solar irradiation, the results showed that 30 minutes were sufficient for complete degradation of NPX at free pH. The effect of pH and some cationic metals allows considering this low-cost process in the elimination of this kind of emerging pollutants.Diplôme : Doctorat En ligne : ../theses/chimie/SET7532.pdf Format de la ressource électronique : Permalink : index.php?lvl=notice_display&id=11371 Exemplaires (1)
Code-barres Cote Support Localisation Section Disponibilité SET/7532 SET/7532 Thèse Bibliothèque principale Thèses Disponible
Titre : Photodegradation des produits pharmaceutiques induite par les complexes organiques de Fer(III) en solution aqueuse. Type de document : texte imprimé Auteurs : Imane Ghoul, Auteur ; Nadra Debbache, Directeur de thèse Mention d'édition : 15-janv-20 Editeur : جامعة الإخوة منتوري قسنطينة Année de publication : 2020 Importance : 226 f. Format : 30 cm. Note générale : Doctorat 3éme CYCLE LMD.
1 copies imprimées disponibles
Langues : Français (fre) Catégories : Français - Anglais
ChimieTags : Chimie: Chimie Analytique et Environnement Diclofénac Aspirine Carbamazépine Fe(III)Cit Fenton photolyse Diclofenac Aspirin Photolysis ديكلوفيناك الأسبرين كاربامازيبين التحلل الضوئي Index. décimale : 540 Chimie et sciences connexes Résumé :
This work is a contribution to the photodegradation of three pharmaceutical compounds:
diclofenac (DCF), aspirin (ASP) and carbamazepine (CBZ) induced by organic complex of Fe(III) (Fe(III)Cit) in homogeneous phase under simulated and sunlight. A first part was devoted to the synthesis and characterization of Fe(III)Cit complex, which confirms its stability, its stoichiometry, while the effect of light irradiation revealed its photolysis, which generated the HO• radical. This oxidizing species has shown its effectiveness in the elimination of PP. In the second part of the work, the study of PP-Fe(III)Cit mixtures in aqueous solution was undertaken in the absence and presence of light. Indeed, in the dark, the three substrates showed no interaction with Fe(III)Cit complex in aqueous solution when the mixture ages at room temperature. Under irradiation, the photodegradation of substrates induced by Fe(III)Cit complex, followed by spectrophotometry and HPLC, shows rapid kinetics in the beginning of reaction and then slowed down during the irradiation. This reaction appears to be dependent on several parameters such as pH, substrate and complex concentration. The Fe(II) and the hydrogen peroxide resulting from the photolysis of the complex have been quantified and highlight the involvement of the Fenton reaction in the oxidation process of PP. The mechanistic study reveals that hydroxyl radicals are involved in the photocatalytic process and this whatever the substrate used. The identification of the reaction intermediates by LC-MS made it possible to establish a degradation mechanism for each substrate. The following of the mineralization shows that the life of intermediates reaction is much greater than the starting product. To activate the photocatalytic process, the addition of hydrogen peroxide in the mixture DCFFe(III)Cit improves significantly the rate of disappearance of the substrate. To get closer to the environmental conditions, the effect of main elements present naturally in the aquatic ecosystem such as humic substances, bicarbonates and metals was examined and shows the need to take into account the impact of these elements. In order to verify the feasibility of the photochemical process in the environment, the same systems were studied under solar irradiation. The results show that such systems operate with higher kinetics as those observed in artificial irradiations..
Note de contenu : Annexe. Diplôme : Doctorat En ligne : ../theses/chimie/GHO7668.pdf Format de la ressource électronique : Permalink : index.php?lvl=notice_display&id=11502 Photodegradation des produits pharmaceutiques induite par les complexes organiques de Fer(III) en solution aqueuse. [texte imprimé] / Imane Ghoul, Auteur ; Nadra Debbache, Directeur de thèse . - 15-janv-20 . - جامعة الإخوة منتوري قسنطينة, 2020 . - 226 f. ; 30 cm.
Doctorat 3éme CYCLE LMD.
1 copies imprimées disponibles
Langues : Français (fre)
Catégories : Français - Anglais
ChimieTags : Chimie: Chimie Analytique et Environnement Diclofénac Aspirine Carbamazépine Fe(III)Cit Fenton photolyse Diclofenac Aspirin Photolysis ديكلوفيناك الأسبرين كاربامازيبين التحلل الضوئي Index. décimale : 540 Chimie et sciences connexes Résumé :
This work is a contribution to the photodegradation of three pharmaceutical compounds:
diclofenac (DCF), aspirin (ASP) and carbamazepine (CBZ) induced by organic complex of Fe(III) (Fe(III)Cit) in homogeneous phase under simulated and sunlight. A first part was devoted to the synthesis and characterization of Fe(III)Cit complex, which confirms its stability, its stoichiometry, while the effect of light irradiation revealed its photolysis, which generated the HO• radical. This oxidizing species has shown its effectiveness in the elimination of PP. In the second part of the work, the study of PP-Fe(III)Cit mixtures in aqueous solution was undertaken in the absence and presence of light. Indeed, in the dark, the three substrates showed no interaction with Fe(III)Cit complex in aqueous solution when the mixture ages at room temperature. Under irradiation, the photodegradation of substrates induced by Fe(III)Cit complex, followed by spectrophotometry and HPLC, shows rapid kinetics in the beginning of reaction and then slowed down during the irradiation. This reaction appears to be dependent on several parameters such as pH, substrate and complex concentration. The Fe(II) and the hydrogen peroxide resulting from the photolysis of the complex have been quantified and highlight the involvement of the Fenton reaction in the oxidation process of PP. The mechanistic study reveals that hydroxyl radicals are involved in the photocatalytic process and this whatever the substrate used. The identification of the reaction intermediates by LC-MS made it possible to establish a degradation mechanism for each substrate. The following of the mineralization shows that the life of intermediates reaction is much greater than the starting product. To activate the photocatalytic process, the addition of hydrogen peroxide in the mixture DCFFe(III)Cit improves significantly the rate of disappearance of the substrate. To get closer to the environmental conditions, the effect of main elements present naturally in the aquatic ecosystem such as humic substances, bicarbonates and metals was examined and shows the need to take into account the impact of these elements. In order to verify the feasibility of the photochemical process in the environment, the same systems were studied under solar irradiation. The results show that such systems operate with higher kinetics as those observed in artificial irradiations..
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Code-barres Cote Support Localisation Section Disponibilité GHO/7668 GHO/7668 Thèse Bibliothèque principale Thèses Disponible
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