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Auteur Dahmane Tebbani |
Documents disponibles écrits par cet auteur (4)
Affiner la recherche Interroger des sources externesSynthèse de Chalcones adamantylées, de dérivés Thiazolylpyrazolines et évaluation de leurs activités antimicrobienne et anticancéreuse. / Aouatef Tabbi-Benmerkhi
Titre : Synthèse de Chalcones adamantylées, de dérivés Thiazolylpyrazolines et évaluation de leurs activités antimicrobienne et anticancéreuse. Type de document : texte imprimé Auteurs : Aouatef Tabbi-Benmerkhi, Auteur ; Dahmane Tebbani, Directeur de thèse Editeur : جامعة الإخوة منتوري قسنطينة Année de publication : 2017 Importance : 192 f. Format : 30 cm. Note générale : 2 copies imprimées disponibles
Langues : Français (fre) Catégories : Français - Anglais
ChimieTags : Chalcones adamantylées Thiazolylpyrazolines activité antimicrobienne activité
anti cancéreuse MiaPaca2 A549 NIH/3T3 RMN adamantylated Chalcones Thiazolylpyrazoline antimirobial activity anticancer
activity NMR الشالكونات الادمونتلية تيازوليل بيرازولين مضادات الميكروبات النشاط المضاد للسرطانIndex. décimale : 540 Chimie et sciences connexes Résumé : In the first part, a new variety of adamantyl chalcones was efficiently prepared by ClaisenSchmidt reaction of 4-adamantyl acetophenone with a series of aromatic aldehydes in good
yields. Their structures were confirmed by spectroscopic data, and the relative configuration
of compound 3d was confirmed by X-ray crystallography. All synthesized chalcones were
tested against a panel of Gram-positive and Gram-negative bacteria and pathogenic fungus.
They displayed a strong antibacterial activity against Enterococcus faecali 29212,
Pseudomonas aeruginosa ATCC27853, Escherichia coli, as well as an interesting antifungal
activity against Candida glabrata ATCC 90030. The effect of these compounds was also
tested in vitro as antitumor on Miapaca2 cells. The compounds also showed anticancer
activity against human pancreas cancer cell MiaPaca2.
In the second part, several thiazolyl-pyrazoline derivatives were synthesized by reacting
substituted 3, 5-diaryl-1-thiocarbamoyl-2-pyrazolines with phenacylbromides. The structures
of the synthesized compounds were confirmed by IR, 1H NMR, 13C NMR, and MS spectral
data. Their antimicrobial, anticancer activities and cytotoxicity were investigated. A
significant level of antimicrobial activity and anticancer activity against A549 human lung
carcinoma cell line and low cytotoxicity were observed.Diplôme : Doctorat En ligne : ../theses/chimie/TAB7068.pdf Format de la ressource électronique : Permalink : index.php?lvl=notice_display&id=10533 Synthèse de Chalcones adamantylées, de dérivés Thiazolylpyrazolines et évaluation de leurs activités antimicrobienne et anticancéreuse. [texte imprimé] / Aouatef Tabbi-Benmerkhi, Auteur ; Dahmane Tebbani, Directeur de thèse . - جامعة الإخوة منتوري قسنطينة, 2017 . - 192 f. ; 30 cm.
2 copies imprimées disponibles
Langues : Français (fre)
Catégories : Français - Anglais
ChimieTags : Chalcones adamantylées Thiazolylpyrazolines activité antimicrobienne activité
anti cancéreuse MiaPaca2 A549 NIH/3T3 RMN adamantylated Chalcones Thiazolylpyrazoline antimirobial activity anticancer
activity NMR الشالكونات الادمونتلية تيازوليل بيرازولين مضادات الميكروبات النشاط المضاد للسرطانIndex. décimale : 540 Chimie et sciences connexes Résumé : In the first part, a new variety of adamantyl chalcones was efficiently prepared by ClaisenSchmidt reaction of 4-adamantyl acetophenone with a series of aromatic aldehydes in good
yields. Their structures were confirmed by spectroscopic data, and the relative configuration
of compound 3d was confirmed by X-ray crystallography. All synthesized chalcones were
tested against a panel of Gram-positive and Gram-negative bacteria and pathogenic fungus.
They displayed a strong antibacterial activity against Enterococcus faecali 29212,
Pseudomonas aeruginosa ATCC27853, Escherichia coli, as well as an interesting antifungal
activity against Candida glabrata ATCC 90030. The effect of these compounds was also
tested in vitro as antitumor on Miapaca2 cells. The compounds also showed anticancer
activity against human pancreas cancer cell MiaPaca2.
In the second part, several thiazolyl-pyrazoline derivatives were synthesized by reacting
substituted 3, 5-diaryl-1-thiocarbamoyl-2-pyrazolines with phenacylbromides. The structures
of the synthesized compounds were confirmed by IR, 1H NMR, 13C NMR, and MS spectral
data. Their antimicrobial, anticancer activities and cytotoxicity were investigated. A
significant level of antimicrobial activity and anticancer activity against A549 human lung
carcinoma cell line and low cytotoxicity were observed.Diplôme : Doctorat En ligne : ../theses/chimie/TAB7068.pdf Format de la ressource électronique : Permalink : index.php?lvl=notice_display&id=10533 Exemplaires (1)
Code-barres Cote Support Localisation Section Disponibilité TAB/7068 TAB/7068 Thèse Bibliothèque principale Thèses Disponible
Titre : Synthèse de nouveaux 1,2,3-triazoles adamantylés et de chalcones dérivés du diméthyle-3,5-adamantane. Type de document : texte imprimé Auteurs : Oussama Bencheikh Lehocine, Auteur ; Dahmane Tebbani, Directeur de thèse Mention d'édition : 06/07/2019 Editeur : جامعة الإخوة منتوري قسنطينة Année de publication : 2019 Importance : 121 f. Format : 30 cm. Note générale : 2 copies imprimées disponibles
Langues : Français (fre) Catégories : Français - Anglais
ChimieTags : Chimie: chimie organique chimie clic adamantine cycloaddtion triazole chalcone pyrazoline activité biologique click chemistry cycloaddition chalcone pyrazoline biological activity كيمياء النقرة الاضافة الحلقية 3-1ثنائية القطب تريازول شالكون بيرازولين الادمنتان .النشاط البيولوجي Index. décimale : 540 Chimie et sciences connexes Résumé :
The work described in this thesis is part of a program to develop new heterocyclic molecules with therapeutic potential, including adamantane, triazoles, chalcones and pyrazolines. Several types of reactions are involved, in particular one of the variant of the click chemistry that is the copper-catalyzed (I) 1,3-dipole cycloaddition [3 + 2] of Huisgen where our choice is carried after several tests on copper acetate Cu(OAc)2, H2O as a catalyst.
The thesis is divided into 2 chapters. The first is a bibliographic overview on the chemistry ""click"" and the importance of 1,2,3-triazoles in medecine and biotechnology, before the description of our work concerning the synthesis of 4-substituted 1,2,3-triazoles 1- (4- adamantylbenzyl),. In the second chapter, we presented some examples on the biological importance of chalcones, the methods of their synthesis as well as their reactivity then the work done for the elaboration of a series of new compounds. One party will then do the reactivity study plan
with respect to 1,4-addition; which gave with the hydrazine some new derivatives with pyrazoline cycle. The adamantane nucleus making a branch common to all the products of our synthesis, we devoted to it a bibliographic preview before the first chapter. The structural characterization was carried out using one-dimensional and twodimensional NMR( COSY, HSQC, HMBC ), mass spectrometry and XRD. Returns are generally satisfactory. Given the nature of the synthesized molecules, their originality, they will be the subject of various biological tests.
Note de contenu :
Annexes.
Diplôme : Doctorat en sciences En ligne : ../theses/chimie/BEN7548.pdf Format de la ressource électronique : Permalink : index.php?lvl=notice_display&id=11386 Synthèse de nouveaux 1,2,3-triazoles adamantylés et de chalcones dérivés du diméthyle-3,5-adamantane. [texte imprimé] / Oussama Bencheikh Lehocine, Auteur ; Dahmane Tebbani, Directeur de thèse . - 06/07/2019 . - جامعة الإخوة منتوري قسنطينة, 2019 . - 121 f. ; 30 cm.
2 copies imprimées disponibles
Langues : Français (fre)
Catégories : Français - Anglais
ChimieTags : Chimie: chimie organique chimie clic adamantine cycloaddtion triazole chalcone pyrazoline activité biologique click chemistry cycloaddition chalcone pyrazoline biological activity كيمياء النقرة الاضافة الحلقية 3-1ثنائية القطب تريازول شالكون بيرازولين الادمنتان .النشاط البيولوجي Index. décimale : 540 Chimie et sciences connexes Résumé :
The work described in this thesis is part of a program to develop new heterocyclic molecules with therapeutic potential, including adamantane, triazoles, chalcones and pyrazolines. Several types of reactions are involved, in particular one of the variant of the click chemistry that is the copper-catalyzed (I) 1,3-dipole cycloaddition [3 + 2] of Huisgen where our choice is carried after several tests on copper acetate Cu(OAc)2, H2O as a catalyst.
The thesis is divided into 2 chapters. The first is a bibliographic overview on the chemistry ""click"" and the importance of 1,2,3-triazoles in medecine and biotechnology, before the description of our work concerning the synthesis of 4-substituted 1,2,3-triazoles 1- (4- adamantylbenzyl),. In the second chapter, we presented some examples on the biological importance of chalcones, the methods of their synthesis as well as their reactivity then the work done for the elaboration of a series of new compounds. One party will then do the reactivity study plan
with respect to 1,4-addition; which gave with the hydrazine some new derivatives with pyrazoline cycle. The adamantane nucleus making a branch common to all the products of our synthesis, we devoted to it a bibliographic preview before the first chapter. The structural characterization was carried out using one-dimensional and twodimensional NMR( COSY, HSQC, HMBC ), mass spectrometry and XRD. Returns are generally satisfactory. Given the nature of the synthesized molecules, their originality, they will be the subject of various biological tests.
Note de contenu :
Annexes.
Diplôme : Doctorat en sciences En ligne : ../theses/chimie/BEN7548.pdf Format de la ressource électronique : Permalink : index.php?lvl=notice_display&id=11386 Exemplaires (1)
Code-barres Cote Support Localisation Section Disponibilité BEN/7548 BEN/7548 Thèse Bibliothèque principale Thèses Disponible
Titre : Synthese de nouveaux complexes de carbenes nhc adamantyles : Evolution de leurs activites catalytiques dans les reactions de Suzuki-Miyaura Et Sonogashira. Type de document : texte imprimé Auteurs : Zineb Imene Dehimat, Auteur ; Dahmane Tebbani, Directeur de thèse Editeur : جامعة الإخوة منتوري قسنطينة Année de publication : 2018 Importance : 166 f. Format : 30 cm. Note générale : 1 copies imprimées disponibles
Langues : Français (fre) Catégories : Français - Anglais
ChimieTags : la réaction de Suzuki-Miyaura la réaction de Sonogashira carbenes Nhétérocycliques substitués par benzyladamantyle (NHC) the Suzuki-Miyaura coupling reaction Sonogashira cross-coupling reaction bulky benzyladamantyl substituted N-heterocyclic carbenes (NHC) تفاعل Suzuki-Miyaura تفاعل Sonogashira Index. décimale : 540 Chimie et sciences connexes Résumé : The Suzuki-Miyaura cross-coupling reaction is one of the most important synthetic transformations that has been developed for the synthesis of biaryls and alkenes derivatives.
In this thesis, NHC-Pd-Pyridine complexes with bulky benzyladamantyl substituted Nheterocyclic carbenes (NHC) were synthesized and then used for Suzuki-Miyaura coupling reactions between aryl bromides and phenylboronic acid. With low catalyst loading, all palladium complexes were stable and had high catalytic activity for the Suzuki-Miyaura
coupling reaction.
The sonogashira cross-coupling reaction is well-known as being one of the most important and utilized reactions for the coupling of vinyl or aryl halides with terminal alkynes to form conjugated enynes or aryl alkynes. In this study we used new bulky benzyladamantyl substited N-heterocyclic carbene with NHC-Pd-PPh3 complexes and various aryl bromides were coupled with alkynes to afford coupled products.
Diplôme : Doctorat En ligne : ../theses/chimie/DEH7254.pdf Format de la ressource électronique : Permalink : index.php?lvl=notice_display&id=10846 Synthese de nouveaux complexes de carbenes nhc adamantyles : Evolution de leurs activites catalytiques dans les reactions de Suzuki-Miyaura Et Sonogashira. [texte imprimé] / Zineb Imene Dehimat, Auteur ; Dahmane Tebbani, Directeur de thèse . - جامعة الإخوة منتوري قسنطينة, 2018 . - 166 f. ; 30 cm.
1 copies imprimées disponibles
Langues : Français (fre)
Catégories : Français - Anglais
ChimieTags : la réaction de Suzuki-Miyaura la réaction de Sonogashira carbenes Nhétérocycliques substitués par benzyladamantyle (NHC) the Suzuki-Miyaura coupling reaction Sonogashira cross-coupling reaction bulky benzyladamantyl substituted N-heterocyclic carbenes (NHC) تفاعل Suzuki-Miyaura تفاعل Sonogashira Index. décimale : 540 Chimie et sciences connexes Résumé : The Suzuki-Miyaura cross-coupling reaction is one of the most important synthetic transformations that has been developed for the synthesis of biaryls and alkenes derivatives.
In this thesis, NHC-Pd-Pyridine complexes with bulky benzyladamantyl substituted Nheterocyclic carbenes (NHC) were synthesized and then used for Suzuki-Miyaura coupling reactions between aryl bromides and phenylboronic acid. With low catalyst loading, all palladium complexes were stable and had high catalytic activity for the Suzuki-Miyaura
coupling reaction.
The sonogashira cross-coupling reaction is well-known as being one of the most important and utilized reactions for the coupling of vinyl or aryl halides with terminal alkynes to form conjugated enynes or aryl alkynes. In this study we used new bulky benzyladamantyl substited N-heterocyclic carbene with NHC-Pd-PPh3 complexes and various aryl bromides were coupled with alkynes to afford coupled products.
Diplôme : Doctorat En ligne : ../theses/chimie/DEH7254.pdf Format de la ressource électronique : Permalink : index.php?lvl=notice_display&id=10846 Exemplaires (1)
Code-barres Cote Support Localisation Section Disponibilité DEH/7254 DEH/7254 Thèse Bibliothèque principale Thèses Disponible
Titre : Synthèses stereocontr?lées de métabolites hydroxyles d'acides gras polyinsatures en C18 C22 : dérives de l'acide linoléique et de l'acide cervonique Type de document : texte imprimé Auteurs : Dahmane Tebbani ; Univ. de Constantine, Éditeur scientifique ; P.Mosset Gree, Directeur de thèse Année de publication : 2002 Importance : 79 f. Note générale : 01 Disponible dans la salle de recherche
02 Disponibles au magasin de la bibliothèque centraleLangues : Français (fre) Catégories : Français - Anglais
ChimieIndex. décimale : 540 Chimie et sciences connexes Permalink : index.php?lvl=notice_display&id=4067 Synthèses stereocontr?lées de métabolites hydroxyles d'acides gras polyinsatures en C18 C22 : dérives de l'acide linoléique et de l'acide cervonique [texte imprimé] / Dahmane Tebbani ; Univ. de Constantine, Éditeur scientifique ; P.Mosset Gree, Directeur de thèse . - 2002 . - 79 f.
01 Disponible dans la salle de recherche
02 Disponibles au magasin de la bibliothèque centrale
Langues : Français (fre)
Catégories : Français - Anglais
ChimieIndex. décimale : 540 Chimie et sciences connexes Permalink : index.php?lvl=notice_display&id=4067 Exemplaires (1)
Code-barres Cote Support Localisation Section Disponibilité TEB/3686 TEB/3686 Thèse Bibliothèque principale Thèses Disponible
