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Partager le résultat de cette recherche Interroger des sources externesدراسة الدور الوقائي لبعض المركبات النشطة بيولوجيا اتجاه الأثر السمي للمبيدات الهيدروكربونات على الجهاز العصبي و المناعي عند الجرذان / زهورة لقرون
Titre : دراسة الدور الوقائي لبعض المركبات النشطة بيولوجيا اتجاه الأثر السمي للمبيدات الهيدروكربونات على الجهاز العصبي و المناعي عند الجرذان Type de document : texte imprimé Auteurs : زهورة لقرون, Auteur ; جميلة زعمة, Directeur de thèse Editeur : جامعة الإخوة منتوري قسنطينة Année de publication : 2016 Importance : 122 ورقة. Format : 30 سم. Note générale : 2نسخ موجودة مكتبة المركزية
Langues : Arabe (ara) Catégories : Arabe
5 البيولوجياTags : ??????? ??????????????? ??????????? ????????? ?????? ?????? ?????? ??????? ????? ??????? ??????? ???????? ?????
????? ???????? ??????? C ??????? E ???????? ?????????????? ??????? ????????Index. décimale : 570 بيولوجيا Résumé : Environmental toxicology is nowadays facing a great challenge especially as it is addressing
to study the impact of toxic pollutants on the living organism of the general population, in
contrast to professional pharmacology or toxicology which target limited groups in their
professional and medical milieu with well-known diagnostic and therapeutic approaches.
Indeed, many food biological matrixes are contaminated with pesticides, polycyclic aromatic
hydrocarbons and heavy metals with very little concentrations that we consider such
negligible daily doses but which could accumulate with the time because their solubility in
different organs. This study focuses on the preventive effect of some bioactive compounds
such as vitamin C, vitamin E, quercetin and phenolic extract from orange peel Citrus
Senensis, against the toxic impact of a polycyclic aromatic hydrocarbon, the naphthalene and
endosulfan, as organochlorine pesticide on brain and immune systems. The results showed a
significant change in neuronal redox status in cytosol and brain mitochondria. Indeed,
endosulfan and naphthalene administered alone or in mixture at the respective doses of 2mg /
kg and 50 mg / kg, showed a disturbance in the balance prooxidant / antioxidant in cell
compartmentalization since they caused a significant fall in the level of GSH, GST, SOD and
CAT cytosolic rats treated with these chemicals. The results of these studies have also shown
a significant increase in MDA cytosolic and a highly significant reduction of cytosolic
proteins level was also recorded compared to the control group. Furthermore, the results of
this work have showed a very significant decrease in mitochondrial enzymatic activity of
SOD and CAT parallel to fall of GSH rate. Increased peroxidation was recorded via the
significant increase in mitochondrial MDA following animal exposure to endosulfan alone at
a dose of 2 mg / kg, reflecting a loss of integrity mitochondrial membranes. Conversely, the
administration of quercetin (10 mg / kg) associated with endosulfan (2mg / kg) was able to
prevent this neuro-mitochondrial toxicity in rats. The in vitro study of the mitochondrial
integrity showed, in the presence of increasing concentrations of endosulfan, a decrease in
absorbance of mitochondrial suspensions, demonstrating that mitochondria were received
massive internalization of water via the opening giant mitochondrial pores (MPTP), causing
them to swell. Inversely, the tubes containing endosulfan and quercetin showed similar
absorbance to the control tube, which provides information on the maintenance of intact
mitochondrial integrity which not allowed undergoing this swelling.
This study also showed a toxic effect on the immune and blood systems through a very
significant increase in the overall number of lymphocytic cells in rats of groups treated with
the mixture endosulfan and naphthalene. It was also found that in the same study, a significant
and very significant respective reduction in granulocytes and monocytes rates. The evaluation
of some blood biochemical parameters did appear impairment of liver function, kidney and
pancreas via the significant increase in transaminases enzymes in the blood serum (TGO and
TGP), cholesterol, triglycerides, urea, creatinin and blood glucose compared to the control
group. Meanwhile, bioactive substances used in these studies, warned the occurrence of these
disturbances in the function of these organs in animals exposed to these persistent organic
products. In conclusion, the results of this present study showed that endosulfan and
naphthalene have neurotoxic power and immunomodulator effect in environmental doses
which have been administered individually or associated in rats. Moreover, it appears that
these persistent organic products significantly alter liver and kidney function.Diplôme : Doctorat en sciences En ligne : ../theses/biologie/ALEK4139.pdf Format de la ressource électronique : Permalink : https://bu.umc.edu.dz/md/index.php?lvl=notice_display&id=10310 دراسة الدور الوقائي لبعض المركبات النشطة بيولوجيا اتجاه الأثر السمي للمبيدات الهيدروكربونات على الجهاز العصبي و المناعي عند الجرذان [texte imprimé] / زهورة لقرون, Auteur ; جميلة زعمة, Directeur de thèse . - [S.l.] : جامعة الإخوة منتوري قسنطينة, 2016 . - 122 ورقة. ; 30 سم.
2نسخ موجودة مكتبة المركزية
Langues : Arabe (ara)
Catégories : Arabe
5 البيولوجياTags : ??????? ??????????????? ??????????? ????????? ?????? ?????? ?????? ??????? ????? ??????? ??????? ???????? ?????
????? ???????? ??????? C ??????? E ???????? ?????????????? ??????? ????????Index. décimale : 570 بيولوجيا Résumé : Environmental toxicology is nowadays facing a great challenge especially as it is addressing
to study the impact of toxic pollutants on the living organism of the general population, in
contrast to professional pharmacology or toxicology which target limited groups in their
professional and medical milieu with well-known diagnostic and therapeutic approaches.
Indeed, many food biological matrixes are contaminated with pesticides, polycyclic aromatic
hydrocarbons and heavy metals with very little concentrations that we consider such
negligible daily doses but which could accumulate with the time because their solubility in
different organs. This study focuses on the preventive effect of some bioactive compounds
such as vitamin C, vitamin E, quercetin and phenolic extract from orange peel Citrus
Senensis, against the toxic impact of a polycyclic aromatic hydrocarbon, the naphthalene and
endosulfan, as organochlorine pesticide on brain and immune systems. The results showed a
significant change in neuronal redox status in cytosol and brain mitochondria. Indeed,
endosulfan and naphthalene administered alone or in mixture at the respective doses of 2mg /
kg and 50 mg / kg, showed a disturbance in the balance prooxidant / antioxidant in cell
compartmentalization since they caused a significant fall in the level of GSH, GST, SOD and
CAT cytosolic rats treated with these chemicals. The results of these studies have also shown
a significant increase in MDA cytosolic and a highly significant reduction of cytosolic
proteins level was also recorded compared to the control group. Furthermore, the results of
this work have showed a very significant decrease in mitochondrial enzymatic activity of
SOD and CAT parallel to fall of GSH rate. Increased peroxidation was recorded via the
significant increase in mitochondrial MDA following animal exposure to endosulfan alone at
a dose of 2 mg / kg, reflecting a loss of integrity mitochondrial membranes. Conversely, the
administration of quercetin (10 mg / kg) associated with endosulfan (2mg / kg) was able to
prevent this neuro-mitochondrial toxicity in rats. The in vitro study of the mitochondrial
integrity showed, in the presence of increasing concentrations of endosulfan, a decrease in
absorbance of mitochondrial suspensions, demonstrating that mitochondria were received
massive internalization of water via the opening giant mitochondrial pores (MPTP), causing
them to swell. Inversely, the tubes containing endosulfan and quercetin showed similar
absorbance to the control tube, which provides information on the maintenance of intact
mitochondrial integrity which not allowed undergoing this swelling.
This study also showed a toxic effect on the immune and blood systems through a very
significant increase in the overall number of lymphocytic cells in rats of groups treated with
the mixture endosulfan and naphthalene. It was also found that in the same study, a significant
and very significant respective reduction in granulocytes and monocytes rates. The evaluation
of some blood biochemical parameters did appear impairment of liver function, kidney and
pancreas via the significant increase in transaminases enzymes in the blood serum (TGO and
TGP), cholesterol, triglycerides, urea, creatinin and blood glucose compared to the control
group. Meanwhile, bioactive substances used in these studies, warned the occurrence of these
disturbances in the function of these organs in animals exposed to these persistent organic
products. In conclusion, the results of this present study showed that endosulfan and
naphthalene have neurotoxic power and immunomodulator effect in environmental doses
which have been administered individually or associated in rats. Moreover, it appears that
these persistent organic products significantly alter liver and kidney function.Diplôme : Doctorat en sciences En ligne : ../theses/biologie/ALEK4139.pdf Format de la ressource électronique : Permalink : https://bu.umc.edu.dz/md/index.php?lvl=notice_display&id=10310 Exemplaires (1)
Code-barres Cote Support Localisation Section Disponibilité لقر/4139 لقر/4139 Thèse Bibliothèque principale Thèses Disponible
Titre : Nouvelles voies de Synthèse des 1,4-dihydropyridines, polyhydroquinoléines et 1,4-benzoxazines Type de document : texte imprimé Auteurs : Louisa Chouguiat, Auteur ; Abdelmadjid Debache, Directeur de thèse Editeur : جامعة الإخوة منتوري قسنطينة Année de publication : 2015 Importance : 201 f. Format : 30 cm. Note générale : 2 copies imprimées disponibles
Langues : Français (fre) Catégories : Français - Anglais
ChimieTags : 1,4-dihydropyridine polyhydroquinoléine Hantzsch t-BuOK tétrahydropyridines Bi(OTf)3 4-hydroxy-1,4-benzoxazine amines secondaire amination réductrice Petasis polyhydroquinoline tetrahydropyridines secondary amines reductive amination ?????????????? ???????????????? ????? ????? ????????? ?????????? ???????
???????? - 4????????- -4,1?????????? ???????? ???????? ????? ????? ?????, ???????Index. décimale : 540 Chimie et sciences connexes Résumé :
The work undertaken through this thesis is part of the development of new synthetic methods leading to biologically interesting molecules, whose main objective was to carry out multicomponent reactions resulting in original molecules.
This thesis is divided into three main chapters: the first and the second were the
subject of the study of new synthetic routes to 1,4-dihydropyridine via Hantzsch reaction, and the synthesis of highly functionalized tetrahydropyridines respectively and using two new catalysts for these syntheses. However, the third chapter contains two parts: in the first part we realized the synthesis of a range of secondary amines which have served as the starting material for the second part, which deals with the preparation of a series of new derivatives 4-hydroxy-1,4-benzoxazine synthesized via the reaction Petasis.
In the first chapter, we have described the use of a novel catalyst in the multicomponent Hantzsch reaction. The t-BuOK which is a basic catalyst was used with a catalytic amount of 10 mol% and led to a series of 1,4-dihydropyridine and
polyhydroquinolines with good to excellent yields.
Like in the second chapter, we studied the synthesis of tetrahydropyridine but using a Lewis acid catalyst. It is a derivative of triflates: Bi (OTf) 3, which showed good catalytic activity envres this synthesis and leads to the production of desired molecules in good yields.
Finally, in the first part of the last chapter we have synthesized a series of secondary amines via reductive amination rection. However, in the second part of this chapter we have prepared a series of 2-hydroxy-1,4-benzoxazine in a Petasis type reaction, where the reaction is a cyclocondensation between the amino alcohol previously prepared in the first Part, boronic acid, and glyoxal. This reaction has allowed us to get nine new products with good to excellent yields, which were the subject of a paper.Diplôme : Doctorat en sciences En ligne : ../theses/chimie/CHO6890.pdf Format de la ressource électronique : Permalink : https://bu.umc.edu.dz/md/index.php?lvl=notice_display&id=10219 Nouvelles voies de Synthèse des 1,4-dihydropyridines, polyhydroquinoléines et 1,4-benzoxazines [texte imprimé] / Louisa Chouguiat, Auteur ; Abdelmadjid Debache, Directeur de thèse . - [S.l.] : جامعة الإخوة منتوري قسنطينة, 2015 . - 201 f. ; 30 cm.
2 copies imprimées disponibles
Langues : Français (fre)
Catégories : Français - Anglais
ChimieTags : 1,4-dihydropyridine polyhydroquinoléine Hantzsch t-BuOK tétrahydropyridines Bi(OTf)3 4-hydroxy-1,4-benzoxazine amines secondaire amination réductrice Petasis polyhydroquinoline tetrahydropyridines secondary amines reductive amination ?????????????? ???????????????? ????? ????? ????????? ?????????? ???????
???????? - 4????????- -4,1?????????? ???????? ???????? ????? ????? ?????, ???????Index. décimale : 540 Chimie et sciences connexes Résumé :
The work undertaken through this thesis is part of the development of new synthetic methods leading to biologically interesting molecules, whose main objective was to carry out multicomponent reactions resulting in original molecules.
This thesis is divided into three main chapters: the first and the second were the
subject of the study of new synthetic routes to 1,4-dihydropyridine via Hantzsch reaction, and the synthesis of highly functionalized tetrahydropyridines respectively and using two new catalysts for these syntheses. However, the third chapter contains two parts: in the first part we realized the synthesis of a range of secondary amines which have served as the starting material for the second part, which deals with the preparation of a series of new derivatives 4-hydroxy-1,4-benzoxazine synthesized via the reaction Petasis.
In the first chapter, we have described the use of a novel catalyst in the multicomponent Hantzsch reaction. The t-BuOK which is a basic catalyst was used with a catalytic amount of 10 mol% and led to a series of 1,4-dihydropyridine and
polyhydroquinolines with good to excellent yields.
Like in the second chapter, we studied the synthesis of tetrahydropyridine but using a Lewis acid catalyst. It is a derivative of triflates: Bi (OTf) 3, which showed good catalytic activity envres this synthesis and leads to the production of desired molecules in good yields.
Finally, in the first part of the last chapter we have synthesized a series of secondary amines via reductive amination rection. However, in the second part of this chapter we have prepared a series of 2-hydroxy-1,4-benzoxazine in a Petasis type reaction, where the reaction is a cyclocondensation between the amino alcohol previously prepared in the first Part, boronic acid, and glyoxal. This reaction has allowed us to get nine new products with good to excellent yields, which were the subject of a paper.Diplôme : Doctorat en sciences En ligne : ../theses/chimie/CHO6890.pdf Format de la ressource électronique : Permalink : https://bu.umc.edu.dz/md/index.php?lvl=notice_display&id=10219 Exemplaires (1)
Code-barres Cote Support Localisation Section Disponibilité CHO/6890 CHO/6890 Thèse Bibliothèque principale Thèses Disponible
Titre : تحسين القمح الصلب(Triticum durum Desf.) : دراسة الميكانيزمات المورفوفيزيولوجية واالبيوكيميائية لتحمل الإجهاد المائي Type de document : texte imprimé Auteurs : راضية بوشارب, Auteur ; حسين غروشة, Directeur de thèse Editeur : جامعة الإخوة منتوري قسنطينة Année de publication : 2016 Format : 30 سم. Note générale : 2نسخ موجودة مكتبة المركزية
Langues : Arabe (ara) Catégories : Arabe
5 البيولوجياTags : ??????? ?????? ????? ????? ?????????????? ???????????????? ??????????? ??????? water stress durum wheat biochemical morphophysiological phenological yield stress hydrique blé dur biochimique morphophysiologique phénologiques rendement Index. décimale : 570 بيولوجيا Résumé : Although drought stress has been well documented as an effective parameter in decreasing crop production in semi arid regions. The objectives of this study were to detect the effect of water stress in durum wheat (Triticum durum Desf).
The present study was carried out to study the performance of durum wheat. We used in this study ten durum wheat varieties from different sources with two different experiences. The first was on the ground, and the second was conducted in semi-controler conditions.
The first experiment was performed during the agricultural seasons 2011-12, 2012-13, 2013-2014 at the experimental field of the Technical Institute of Field Crops (ITGC) El khroub Constantine, the objectif of this work to study the effect of water stress in natural field conditions, different measures have been taken during plant growth, morphological parameters, phenological, yield and its components. The results showed that the durum wheat response to water stress is associated with the variety, intensity and duration of water stress, the analysis of variance showed highly significant results in most parameters studied. It remains local varieties Bousselem Cirta and more productive compared to other variéties. the second experiment is conducted in a Glass House was located at Chaab el Ressas Constantine University, where we practice different physiological, biochemical measurements and analysis of variance where very significant between genotypes, we recorded a lack of chlorophyll with an increase in the resistance of the stoma by increasing the content of abscisic acid, sodium and potassium, during local varieties showed high adaptation compared to the varieties imported especially the variety Ter-1/3. The results also showed that the drought leads to a lack of water content with respect to the varieties studied, which have been modified by the accumulation of sugars and proline as well as significant differences in molecular weight of the proteins, while the majority of the response to drought stress was different for each variety. The study showed also that the varieties studied responded to water stress by different mechanisms and in proportions between introduced varieties and improved to maintain the vital functions of durum wheat
Diplôme : Doctorat en sciences En ligne : ../theses/biologie/ABOU4135.pdf Format de la ressource électronique : Permalink : https://bu.umc.edu.dz/md/index.php?lvl=notice_display&id=10303 تحسين القمح الصلب(Triticum durum Desf.) : دراسة الميكانيزمات المورفوفيزيولوجية واالبيوكيميائية لتحمل الإجهاد المائي [texte imprimé] / راضية بوشارب, Auteur ; حسين غروشة, Directeur de thèse . - [S.l.] : جامعة الإخوة منتوري قسنطينة, 2016 . - ; 30 سم.
2نسخ موجودة مكتبة المركزية
Langues : Arabe (ara)
Catégories : Arabe
5 البيولوجياTags : ??????? ?????? ????? ????? ?????????????? ???????????????? ??????????? ??????? water stress durum wheat biochemical morphophysiological phenological yield stress hydrique blé dur biochimique morphophysiologique phénologiques rendement Index. décimale : 570 بيولوجيا Résumé : Although drought stress has been well documented as an effective parameter in decreasing crop production in semi arid regions. The objectives of this study were to detect the effect of water stress in durum wheat (Triticum durum Desf).
The present study was carried out to study the performance of durum wheat. We used in this study ten durum wheat varieties from different sources with two different experiences. The first was on the ground, and the second was conducted in semi-controler conditions.
The first experiment was performed during the agricultural seasons 2011-12, 2012-13, 2013-2014 at the experimental field of the Technical Institute of Field Crops (ITGC) El khroub Constantine, the objectif of this work to study the effect of water stress in natural field conditions, different measures have been taken during plant growth, morphological parameters, phenological, yield and its components. The results showed that the durum wheat response to water stress is associated with the variety, intensity and duration of water stress, the analysis of variance showed highly significant results in most parameters studied. It remains local varieties Bousselem Cirta and more productive compared to other variéties. the second experiment is conducted in a Glass House was located at Chaab el Ressas Constantine University, where we practice different physiological, biochemical measurements and analysis of variance where very significant between genotypes, we recorded a lack of chlorophyll with an increase in the resistance of the stoma by increasing the content of abscisic acid, sodium and potassium, during local varieties showed high adaptation compared to the varieties imported especially the variety Ter-1/3. The results also showed that the drought leads to a lack of water content with respect to the varieties studied, which have been modified by the accumulation of sugars and proline as well as significant differences in molecular weight of the proteins, while the majority of the response to drought stress was different for each variety. The study showed also that the varieties studied responded to water stress by different mechanisms and in proportions between introduced varieties and improved to maintain the vital functions of durum wheat
Diplôme : Doctorat en sciences En ligne : ../theses/biologie/ABOU4135.pdf Format de la ressource électronique : Permalink : https://bu.umc.edu.dz/md/index.php?lvl=notice_display&id=10303 Exemplaires (1)
Code-barres Cote Support Localisation Section Disponibilité بوش/4135 بوش/4135 Thèse Bibliothèque principale Thèses Disponible
Titre : موسى الأحمدي نويوات : حياته و آثاره Type de document : texte imprimé Auteurs : العارم عزابي ; جامعة قسنطينة, Editeur scientifique ; لخضر عيكوس, Directeur de thèse Année de publication : 1998 Importance : 156 ورقة Note générale : 3 نسخ موجودة في مخزن المكتبة المركزية 2 نسخ محولة الى مكتبة العلوم الإنسانية Langues : Arabe (ara) Catégories : Arabe
الأدب العربيTags : ????? ?????????????? Index. décimale : 810 أدب عربي Permalink : https://bu.umc.edu.dz/md/index.php?lvl=notice_display&id=7154 موسى الأحمدي نويوات : حياته و آثاره [texte imprimé] / العارم عزابي ; جامعة قسنطينة, Editeur scientifique ; لخضر عيكوس, Directeur de thèse . - 1998 . - 156 ورقة.
3 نسخ موجودة في مخزن المكتبة المركزية 2 نسخ محولة الى مكتبة العلوم الإنسانية
Langues : Arabe (ara)
Catégories : Arabe
الأدب العربيTags : ????? ?????????????? Index. décimale : 810 أدب عربي Permalink : https://bu.umc.edu.dz/md/index.php?lvl=notice_display&id=7154 Exemplaires (1)
Code-barres Cote Support Localisation Section Disponibilité عزا/ 1226 عزا/ 1226 Thèse Bibliothèque principale Thèses Disponible
Titre : تمدرس البنت في الوسط الريفي ببلدية العنصر ولاية جيجل مقاربة أنثوروبولوجية Type de document : texte imprimé Auteurs : يونس لعوبي ; جامعة منتوري, Editeur scientifique ; موسى هاروني, Directeur de thèse Année de publication : 2005 Importance : 156 ورقة Note générale : 1 نسخة موجودة في قاعة المطالعة 2 نسخ موجودة في مخزن المكتبة المركزية 1 قرص مرن Langues : Arabe (ara) Catégories : Arabe
علم الإجتماعTags : ????? ????? ?? ????? ?????? ?????????????? ???? Index. décimale : 300 علم الإجتماع Permalink : https://bu.umc.edu.dz/md/index.php?lvl=notice_display&id=7806 تمدرس البنت في الوسط الريفي ببلدية العنصر ولاية جيجل مقاربة أنثوروبولوجية [texte imprimé] / يونس لعوبي ; جامعة منتوري, Editeur scientifique ; موسى هاروني, Directeur de thèse . - 2005 . - 156 ورقة.
1 نسخة موجودة في قاعة المطالعة 2 نسخ موجودة في مخزن المكتبة المركزية 1 قرص مرن
Langues : Arabe (ara)
Catégories : Arabe
علم الإجتماعTags : ????? ????? ?? ????? ?????? ?????????????? ???? Index. décimale : 300 علم الإجتماع Permalink : https://bu.umc.edu.dz/md/index.php?lvl=notice_display&id=7806 Exemplaires (1)
Code-barres Cote Support Localisation Section Disponibilité لعو/1854 لعو/1854 Thèse Bibliothèque principale Thèses Disponible PermalinkPermalink
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