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Partager le résultat de cette recherche Interroger des sources externesContribution phytochimique à la valorisation de deux plantes médicinales / Manel Boumaraf Ep Djendli
Titre : Contribution phytochimique à la valorisation de deux plantes médicinales : Echinops spinosus et Pulicaria undulata. Recherche et détermination structurale de leurs principales substances bioactives. Type de document : texte imprimé Auteurs : Manel Boumaraf Ep Djendli, Auteur ; Samira Benyahia, Directeur de thèse Editeur : جامعة الإخوة منتوري قسنطينة Année de publication : 2016 Importance : 176 f. Format : 30 cm. Note générale : 2 copies imprimées disponibles
Langues : Français (fre) Tags : Echinops spinosus Pulicaria undulata Asteraceae huile essentielle flavonoides glycosylé sesquiterpène lactone asteriscunolide activité antioxydante activité antiinflamatoire Pulicaria undulata L. essential oil flavonoids glycosids sesquiterpens lactons antioxidant activity anti-inflammatory activity ??????? ??????? ???? ???????? ?????????? ?????????? ????????????? ????????- ?????? ????? ??????? ?????? ????? ???????? Index. décimale : 540 Chimie et sciences connexes Résumé :
In this thesis, aerial parts of two plants belong to Asteraceae family were studied. The first is Echinops spinosus, species distributed around the world and is commonly used in the treatment of various diseases. The second one is Pulicaria undulata, species present in desert areas of North Africa and all of the Middle East regions and mainly used in the treatment of various diseases.
For experimental purposes, the Echinops spinosus sample plants were collected from the
north-eastern part of Algeria in a region near Annaba, whereas the Pulicaria undulate, was harvested in the Djanet region (Tassili ) in the southeastern part of Algeria.
During the laboratory work, different extraction and separation methods were used as
maceration, chromatographic column, TLC and HPLC preparations. Additionally, and in
order to determine the structures of the isolated compounds, deferent spectroscopic methods were combined: nuclear magnetic resonance and its different applications (1H-NMR, 13C NMR, DEPT, COSY, HSQC, HMBC, NOESY and NOE difference) as well as spectrometry of mass high resolution, UV, IR and chiroptical spectroscopy (Polarimetry, Electronic Circular Dichroïsm ECD).
Seven phenolics compounds from Echinops spinosus were isolated and identified: One
aglycone flavonoid, five glycosids flavonoids and one quinic acid. For the first time, ten sesquiterpenes were obtained from the chloroformic extract of Pulicaria undulata (nine sesquiterpenes lactones belong to the Asteriscunolide type and one humulene)
The biological study includes the antioxidant activity of CHCl3, AcOEt and n-BuOH extracts for Echnops spinosus L.and the anti-inflammatory activity of the CHCl3 extract for Pulicaria undulata L., and that of two isolated compounds.
Analysis GC and GC/MS of the essential oil of Pulicaria undulata L. identified 31
compounds. The main components are carvotanacetone (14,8%), δ-cadinene (8,2%),
α-cadinol (4,7%), epi-α-cadinol (3,4%) and thujanol (4,7%).
Diplôme : Doctorat en sciences En ligne : ../theses/chimie/BOU6999.pdf Format de la ressource électronique : Permalink : https://bu.umc.edu.dz/md/index.php?lvl=notice_display&id=10394 Contribution phytochimique à la valorisation de deux plantes médicinales : Echinops spinosus et Pulicaria undulata. Recherche et détermination structurale de leurs principales substances bioactives. [texte imprimé] / Manel Boumaraf Ep Djendli, Auteur ; Samira Benyahia, Directeur de thèse . - [S.l.] : جامعة الإخوة منتوري قسنطينة, 2016 . - 176 f. ; 30 cm.
2 copies imprimées disponibles
Langues : Français (fre)
Tags : Echinops spinosus Pulicaria undulata Asteraceae huile essentielle flavonoides glycosylé sesquiterpène lactone asteriscunolide activité antioxydante activité antiinflamatoire Pulicaria undulata L. essential oil flavonoids glycosids sesquiterpens lactons antioxidant activity anti-inflammatory activity ??????? ??????? ???? ???????? ?????????? ?????????? ????????????? ????????- ?????? ????? ??????? ?????? ????? ???????? Index. décimale : 540 Chimie et sciences connexes Résumé :
In this thesis, aerial parts of two plants belong to Asteraceae family were studied. The first is Echinops spinosus, species distributed around the world and is commonly used in the treatment of various diseases. The second one is Pulicaria undulata, species present in desert areas of North Africa and all of the Middle East regions and mainly used in the treatment of various diseases.
For experimental purposes, the Echinops spinosus sample plants were collected from the
north-eastern part of Algeria in a region near Annaba, whereas the Pulicaria undulate, was harvested in the Djanet region (Tassili ) in the southeastern part of Algeria.
During the laboratory work, different extraction and separation methods were used as
maceration, chromatographic column, TLC and HPLC preparations. Additionally, and in
order to determine the structures of the isolated compounds, deferent spectroscopic methods were combined: nuclear magnetic resonance and its different applications (1H-NMR, 13C NMR, DEPT, COSY, HSQC, HMBC, NOESY and NOE difference) as well as spectrometry of mass high resolution, UV, IR and chiroptical spectroscopy (Polarimetry, Electronic Circular Dichroïsm ECD).
Seven phenolics compounds from Echinops spinosus were isolated and identified: One
aglycone flavonoid, five glycosids flavonoids and one quinic acid. For the first time, ten sesquiterpenes were obtained from the chloroformic extract of Pulicaria undulata (nine sesquiterpenes lactones belong to the Asteriscunolide type and one humulene)
The biological study includes the antioxidant activity of CHCl3, AcOEt and n-BuOH extracts for Echnops spinosus L.and the anti-inflammatory activity of the CHCl3 extract for Pulicaria undulata L., and that of two isolated compounds.
Analysis GC and GC/MS of the essential oil of Pulicaria undulata L. identified 31
compounds. The main components are carvotanacetone (14,8%), δ-cadinene (8,2%),
α-cadinol (4,7%), epi-α-cadinol (3,4%) and thujanol (4,7%).
Diplôme : Doctorat en sciences En ligne : ../theses/chimie/BOU6999.pdf Format de la ressource électronique : Permalink : https://bu.umc.edu.dz/md/index.php?lvl=notice_display&id=10394 Exemplaires
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Titre : Etude phytochimique et evaluation biologique de l’espèce senecio delphinifolius Vahl Type de document : texte imprimé Auteurs : Soukaina Tidjani, Auteur ; Salah Rhouati, Directeur de thèse Editeur : جامعة الإخوة منتوري قسنطينة Année de publication : 2016 Importance : 187 f. Format : 30 cm. Langues : Français (fre) Tags : Asteraceae Senecio delphinifolius Alcaloïdes pyrrolizidiniques Flavonoïdes Furanoeremophilane quinone CGMS Chromatographie activité antioxydante cytotoxicité activité antibactérienne Senecio delphinifolius Vahl Pyrrolizidine alkaloids Flavonoïds GCMS Chromatography antibacterial Antioxidant Cytotoxic ??????? ??????????? ??????????? ???????? ??????? ?????????????? ????? ?????? ???????? ???????? ?????? (SM/CG) ?????? ????? ??????? ?????? ????? ????????? Index. décimale : 540 Chimie et sciences connexes Résumé : Although Senecio species are known as sources of potentially toxic pyrrolizidine alkaloids (PAs), some species of this genus are traditionally used as remedies. In this work the evaluation of biological activities and the analysis of PAs of Algerian specimens of Senecio delphinifolius Vahl (its vernacular name in Algeria is ""Hachichetettolba"") are reported. Thus it was possible to identify six APs by GC and GC-MS analysis: (1) senecionine (2) seneciphylline (3) integerrimine (4) senkirkine (5) dehydrosenkirkine and (6) neosenkirkine, this technique is frequently used for complex mixtures of such compounds. The species S.
delphinifolius, contains 140 ppm of PAs belong to the toxic series (1, 2-unsaturation in the pyrrolizidine cycle and macrocyclic diester), the use of S. delphinifolius should be discouraged in traditional medicine.
Our research has also led to the isolation by conventional purification techniques of three compounds from the n-butanol extract of the specie S. delphinifolius Vahl two of them are glycosylated flavonols, (7) Quercetine 3-O-α-(rhamnopyrannosyl (1-6) glucopyrannose) [rutine], (8) Kaempferol 3,7-di-O-α-Lrhamnopyranoside [Kaempferitin], the third is a derivative of 1, 4-benzoquinone that are common in the
genus Senecio (9) 2, 5 Cyclohexadiene-1-acetic acid, 1-methyl-4-oxo, methyl ester. A fourth product was isolated from the dichloromethane extract, the structure is being identified. The structures of the isolated compounds were elucidated through the use of NMR techniques 1D and 2D, mass spectroscopy, UV spectroscopy and acid hydrolysis. (10) Chlorogenic acid was identified by co-chromatography with standards.
Diplôme : Doctorat en sciences En ligne : ../theses/chimie/TID7016.pdf Format de la ressource électronique : Permalink : https://bu.umc.edu.dz/md/index.php?lvl=notice_display&id=10395 Etude phytochimique et evaluation biologique de l’espèce senecio delphinifolius Vahl [texte imprimé] / Soukaina Tidjani, Auteur ; Salah Rhouati, Directeur de thèse . - [S.l.] : جامعة الإخوة منتوري قسنطينة, 2016 . - 187 f. ; 30 cm.
Langues : Français (fre)
Tags : Asteraceae Senecio delphinifolius Alcaloïdes pyrrolizidiniques Flavonoïdes Furanoeremophilane quinone CGMS Chromatographie activité antioxydante cytotoxicité activité antibactérienne Senecio delphinifolius Vahl Pyrrolizidine alkaloids Flavonoïds GCMS Chromatography antibacterial Antioxidant Cytotoxic ??????? ??????????? ??????????? ???????? ??????? ?????????????? ????? ?????? ???????? ???????? ?????? (SM/CG) ?????? ????? ??????? ?????? ????? ????????? Index. décimale : 540 Chimie et sciences connexes Résumé : Although Senecio species are known as sources of potentially toxic pyrrolizidine alkaloids (PAs), some species of this genus are traditionally used as remedies. In this work the evaluation of biological activities and the analysis of PAs of Algerian specimens of Senecio delphinifolius Vahl (its vernacular name in Algeria is ""Hachichetettolba"") are reported. Thus it was possible to identify six APs by GC and GC-MS analysis: (1) senecionine (2) seneciphylline (3) integerrimine (4) senkirkine (5) dehydrosenkirkine and (6) neosenkirkine, this technique is frequently used for complex mixtures of such compounds. The species S.
delphinifolius, contains 140 ppm of PAs belong to the toxic series (1, 2-unsaturation in the pyrrolizidine cycle and macrocyclic diester), the use of S. delphinifolius should be discouraged in traditional medicine.
Our research has also led to the isolation by conventional purification techniques of three compounds from the n-butanol extract of the specie S. delphinifolius Vahl two of them are glycosylated flavonols, (7) Quercetine 3-O-α-(rhamnopyrannosyl (1-6) glucopyrannose) [rutine], (8) Kaempferol 3,7-di-O-α-Lrhamnopyranoside [Kaempferitin], the third is a derivative of 1, 4-benzoquinone that are common in the
genus Senecio (9) 2, 5 Cyclohexadiene-1-acetic acid, 1-methyl-4-oxo, methyl ester. A fourth product was isolated from the dichloromethane extract, the structure is being identified. The structures of the isolated compounds were elucidated through the use of NMR techniques 1D and 2D, mass spectroscopy, UV spectroscopy and acid hydrolysis. (10) Chlorogenic acid was identified by co-chromatography with standards.
Diplôme : Doctorat en sciences En ligne : ../theses/chimie/TID7016.pdf Format de la ressource électronique : Permalink : https://bu.umc.edu.dz/md/index.php?lvl=notice_display&id=10395 Exemplaires
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Titre : Étude phytochimique et évaluation des activités antioxydante, antibactérienne et cytotoxique de deux plantes du genre Phagnalon (Asteraceae) Type de document : texte imprimé Auteurs : Hanene Cherchar ép Saadi, Auteur ; Djemaa Berrehal, Directeur de thèse Editeur : جامعة الإخوة منتوري قسنطينة Année de publication : 2018 Importance : 190 f. Format : 30 cm. Note générale : 2 copies imprimées disponibles
Langues : Français (fre) Tags : Asteraceae Phagnalon saxatile Phagnalon sordidum activité antioxydante activité antibactérienne cytotoxicité antioxidant activity antibacterial activity cytotoxicity ?????? ????? ??????? ?????? ????? ????????? ?????? ??????? Index. décimale : 540 Chimie et sciences connexes Résumé : Our phytochemical and biological works concerned the aerial parts of two species belonging to Asteraeae family : Phagnalon saxatile (L) Cass. and Phagnalon sordidum L.
Several chromatographic methods allowed us to isolate ten products from the n-butanol and ethyl acetate extracts of Phagnalon saxatile from which one is new, and twenty one products from Phagnalon sordidum.
Structures were determined by different spectral methods: nuclear magnetic resonance with different applications (NMR 1H, NMR 13C, COSY, HSQC and HMBC), the mass spectrometry, UV, acid hydrolysis as well as comparison with literature data.
4 methods were used to evaluate the antioxidant activity of Phagnalon sordidum and Phagnalon saxatile. The latter showed a good activity by the use of 4 methods: DPPH, ABTS, CUPRAC and superoxide radical scavenging activity by alkaline DMSO whereas Phagnalon sordidum exhibited a moderate activity with DPPH and CUPRAC tests.
Furthermore, petroleum ether and chloroform extracts from Phagnalon saxatile showed moderate antibacterial activity against the tested strains. The isolated products (1-O- β-D-glucopyranosyl-1,4-dihydroxy-2-((E) 2-oxo-3-butenyl) benzene, 1-O-β-glucopyranosyl- 2(3’,3’-diméthylallyl) hydroquinone and Potassium 4-hydroxy-3-methoxybenzoique acide
methyl ester-5-sulfate) from Phagnalon saxatile showed a moderate cytotoxic activity by the use of MTT method.
Diplôme : Doctorat En ligne : ../theses/chimie/CHE7249.pdf Format de la ressource électronique : Permalink : https://bu.umc.edu.dz/md/index.php?lvl=notice_display&id=10841 Étude phytochimique et évaluation des activités antioxydante, antibactérienne et cytotoxique de deux plantes du genre Phagnalon (Asteraceae) [texte imprimé] / Hanene Cherchar ép Saadi, Auteur ; Djemaa Berrehal, Directeur de thèse . - [S.l.] : جامعة الإخوة منتوري قسنطينة, 2018 . - 190 f. ; 30 cm.
2 copies imprimées disponibles
Langues : Français (fre)
Tags : Asteraceae Phagnalon saxatile Phagnalon sordidum activité antioxydante activité antibactérienne cytotoxicité antioxidant activity antibacterial activity cytotoxicity ?????? ????? ??????? ?????? ????? ????????? ?????? ??????? Index. décimale : 540 Chimie et sciences connexes Résumé : Our phytochemical and biological works concerned the aerial parts of two species belonging to Asteraeae family : Phagnalon saxatile (L) Cass. and Phagnalon sordidum L.
Several chromatographic methods allowed us to isolate ten products from the n-butanol and ethyl acetate extracts of Phagnalon saxatile from which one is new, and twenty one products from Phagnalon sordidum.
Structures were determined by different spectral methods: nuclear magnetic resonance with different applications (NMR 1H, NMR 13C, COSY, HSQC and HMBC), the mass spectrometry, UV, acid hydrolysis as well as comparison with literature data.
4 methods were used to evaluate the antioxidant activity of Phagnalon sordidum and Phagnalon saxatile. The latter showed a good activity by the use of 4 methods: DPPH, ABTS, CUPRAC and superoxide radical scavenging activity by alkaline DMSO whereas Phagnalon sordidum exhibited a moderate activity with DPPH and CUPRAC tests.
Furthermore, petroleum ether and chloroform extracts from Phagnalon saxatile showed moderate antibacterial activity against the tested strains. The isolated products (1-O- β-D-glucopyranosyl-1,4-dihydroxy-2-((E) 2-oxo-3-butenyl) benzene, 1-O-β-glucopyranosyl- 2(3’,3’-diméthylallyl) hydroquinone and Potassium 4-hydroxy-3-methoxybenzoique acide
methyl ester-5-sulfate) from Phagnalon saxatile showed a moderate cytotoxic activity by the use of MTT method.
Diplôme : Doctorat En ligne : ../theses/chimie/CHE7249.pdf Format de la ressource électronique : Permalink : https://bu.umc.edu.dz/md/index.php?lvl=notice_display&id=10841 Exemplaires
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Titre : Le centre historique de constantine la conservation integree : une nécessité impérieuse vers la reconstruction du quartier Souika. Type de document : texte imprimé Auteurs : Nasser-Eddine Touam, Auteur ; Abdelouahab Bouchareb, Directeur de thèse Editeur : Constantine : Université Mentouri Constantine Année de publication : 2012 Importance : 206 f. Format : 31 cm. Note générale : 2 copies imprimées disponibles Langues : Français (fre) Tags : Patrimoine- Reconstruction Processus de Réhabilitation Conservation intégrée Secteur Sauvegardé Centre Historique Souika de Constantine Heritage-Reconstruction Rehabilitation Process Integrated conservation saved sector Historical Center Souika Constantine ???? ????? ?????? ?????? ????? ??????? ?????? ??????? ???? ???? ???? ?????? ????? ??????? Index. décimale : 720 Architecture Résumé : From the observation of neighborhood Souika within the conservation area of the historic center of Constantine three thousand and national heritage, we approach our subject. Due to its state of degradation and our position as a citizen and resident, as well as due to our function of architect of sites and historic monuments, this quarter concerns us, and we derive a hypothesis and objectives for its reconstruction.
The hypothetical response to safeguard the historic center of Constantine is in the reconstruction of the Souika listed in a process of rehabilitation and conservation integrated (to promote a balance between living environment and lifestyle), as lever and action unavoidable.
Our goal is to strengthen the value to store in this quarter. For this purpose, a diagnosis in its diversities dimensions, is a prerequisite; for an inventor and analysis of prevailing architectural and constructive typologies, as well as urban morphology whose degree of permanence persist and affect the plot, the street layout and the frame By basing us on the tools-concepts, the normative acts, the analysis of models and the studies performed, and finally the diagnosis by the typo morphological analysis, we tend to answer the question of how to reconstruct.
Finally, in this action research, qualitative and explanatory which has limits, our intervention is focused on the recovery of the urban fabric of traditional by the return of the street layout, and its plot its significant architectural and construction types. Our diagnostic of the built environment and its stages in a process of rehabilitation and by the use of traditional building techniques reveals identification sheets of construction systems for the recovery the frame that can be used for reconstruction studies in an alternative conservation integrated in conservation areas.Diplôme : Magistère En ligne : ../theses/architecture/TOU6160.pdf Format de la ressource électronique : Permalink : https://bu.umc.edu.dz/md/index.php?lvl=notice_display&id=6092 Le centre historique de constantine la conservation integree : une nécessité impérieuse vers la reconstruction du quartier Souika. [texte imprimé] / Nasser-Eddine Touam, Auteur ; Abdelouahab Bouchareb, Directeur de thèse . - Constantine : Université Mentouri Constantine, 2012 . - 206 f. ; 31 cm.
2 copies imprimées disponibles
Langues : Français (fre)
Tags : Patrimoine- Reconstruction Processus de Réhabilitation Conservation intégrée Secteur Sauvegardé Centre Historique Souika de Constantine Heritage-Reconstruction Rehabilitation Process Integrated conservation saved sector Historical Center Souika Constantine ???? ????? ?????? ?????? ????? ??????? ?????? ??????? ???? ???? ???? ?????? ????? ??????? Index. décimale : 720 Architecture Résumé : From the observation of neighborhood Souika within the conservation area of the historic center of Constantine three thousand and national heritage, we approach our subject. Due to its state of degradation and our position as a citizen and resident, as well as due to our function of architect of sites and historic monuments, this quarter concerns us, and we derive a hypothesis and objectives for its reconstruction.
The hypothetical response to safeguard the historic center of Constantine is in the reconstruction of the Souika listed in a process of rehabilitation and conservation integrated (to promote a balance between living environment and lifestyle), as lever and action unavoidable.
Our goal is to strengthen the value to store in this quarter. For this purpose, a diagnosis in its diversities dimensions, is a prerequisite; for an inventor and analysis of prevailing architectural and constructive typologies, as well as urban morphology whose degree of permanence persist and affect the plot, the street layout and the frame By basing us on the tools-concepts, the normative acts, the analysis of models and the studies performed, and finally the diagnosis by the typo morphological analysis, we tend to answer the question of how to reconstruct.
Finally, in this action research, qualitative and explanatory which has limits, our intervention is focused on the recovery of the urban fabric of traditional by the return of the street layout, and its plot its significant architectural and construction types. Our diagnostic of the built environment and its stages in a process of rehabilitation and by the use of traditional building techniques reveals identification sheets of construction systems for the recovery the frame that can be used for reconstruction studies in an alternative conservation integrated in conservation areas.Diplôme : Magistère En ligne : ../theses/architecture/TOU6160.pdf Format de la ressource électronique : Permalink : https://bu.umc.edu.dz/md/index.php?lvl=notice_display&id=6092 Exemplaires
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Titre : الصحافة الإستعمارية في عمالة قسنطينة خلال الفترة مابين الحربين 1919-1939 : بطاقات تعريفية Type de document : texte imprimé Auteurs : عزوز ديلمي ; جامعة منتوري, Editeur scientifique ; مصطفى حداد, Directeur de thèse Année de publication : 2002 Importance : 225 ورقة Format : 30 سم Note générale : 1 نسخة موجودة في قاعة المطالعة 2 نسخة موجودة في مخزن المكتبة المركزية Langues : Arabe (ara) Tags : ??????? ?????? ??????? ??????????? ????? ??????? ?????? ????? ??????? ?????? ??????? Index. décimale : 900 تاريخ و جغرافيا Permalink : https://bu.umc.edu.dz/md/index.php?lvl=notice_display&id=6653 الصحافة الإستعمارية في عمالة قسنطينة خلال الفترة مابين الحربين 1919-1939 : بطاقات تعريفية [texte imprimé] / عزوز ديلمي ; جامعة منتوري, Editeur scientifique ; مصطفى حداد, Directeur de thèse . - 2002 . - 225 ورقة ; 30 سم.
1 نسخة موجودة في قاعة المطالعة 2 نسخة موجودة في مخزن المكتبة المركزية
Langues : Arabe (ara)
Tags : ??????? ?????? ??????? ??????????? ????? ??????? ?????? ????? ??????? ?????? ??????? Index. décimale : 900 تاريخ و جغرافيا Permalink : https://bu.umc.edu.dz/md/index.php?lvl=notice_display&id=6653 Exemplaires
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