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Titre : Phytochemical and biological studies of two Algerian medicinal plants : Cytisus villosus Pourr. (Fabaceae) and Hypericum afrum Lam. (Hypericaceae) Type de document : texte imprimé Auteurs : Farida Larit, Auteur ; Samira Benyahia, Directeur de thèse Editeur : جامعة الإخوة منتوري قسنطينة Année de publication : 2017 Importance : 353 f. Format : 30 cm. Note générale : 2 copies imprimées disponibles
Langues : Anglais (eng) Tags : Hypericum Cytisus Secondary metabolites Total phenolics Antioxidant Cytotoxicity Antifungal Antibacterial Antimalarial Antileishmanial Activity MAO-A and MAO-B Docking Simulation Métabolites secondaires Total phénoliques Cytotoxicité Antifongique Antibactérienne Antipaludique Antileishmanienne MAO-A et MAO-B "MAO-A MAO-B Cytisus Hypericum ?????? ????????? ???????? ???? ??????? ???? ????????? ???? ???????? ???? ?????????????" Index. décimale : 540 Chimie et sciences connexes Résumé : Natural products are important sources of novel therapeutic agents. Bioactive secondary metabolites
isolated from natural sources, can act as drugs or as lead compounds for synthetic drugs. In our work, two plants
have been studied; the endemic species of Hypericum afrum Lam.(Hypericaceae) and Cytisus villosus Pourr.
(Fabaceae). Fractions of the aerial parts of these two plants have been screened in vitro for several biological
assays including cannabinoid and opioid receptors agonist assays, antifungal, antibacterial, antimalarial,
antileishmanial, antiproliferative, antioxidant, anti-inflammatory and MAO inhibition.
The chloroform, ethyl acetate and n-butanol fractions of H. afrum showed significant antioxidant activity and
potent antitrypanosomal activity against T. brucei. The n-butanol fraction of C. villosus showed highly potent
antitrypanosomal activity against T. brucei. In addition, the ethyl acetate fractions of both plants showed potent
inhibition of recombinant human monoamine oxidases (MAO-A and -B).
A bioassay-guided fractionation paradigm has been used for the isolation of bioactive compounds of these plants
and hence the subfractions that showed significant activity were further purified.
This study led to the isolation and identification of 20 compounds, three of which belonging to phloroglucinols,
terpenoids and isoflavonoids are new. The structures of the isolated compounds were elucidated through various
spectroscopic methods, including high- resolution mass spectrometry, one and two-dimensional nuclear magnetic
resonance spectroscopy.
Computational study was carried out by conformational search and docking techniques to provide insight into the
binding mode of molecules on the active site of MAO’s isoenzymes.
Diplôme : Doctorat en sciences En ligne : ../theses/chimie/LAR7157.pdf Format de la ressource électronique : Permalink : http://bu.umc.edu.dz/md/index.php?lvl=notice_display&id=10430 Phytochemical and biological studies of two Algerian medicinal plants : Cytisus villosus Pourr. (Fabaceae) and Hypericum afrum Lam. (Hypericaceae) [texte imprimé] / Farida Larit, Auteur ; Samira Benyahia, Directeur de thèse . - [S.l.] : جامعة الإخوة منتوري قسنطينة, 2017 . - 353 f. ; 30 cm.
2 copies imprimées disponibles
Langues : Anglais (eng)
Tags : Hypericum Cytisus Secondary metabolites Total phenolics Antioxidant Cytotoxicity Antifungal Antibacterial Antimalarial Antileishmanial Activity MAO-A and MAO-B Docking Simulation Métabolites secondaires Total phénoliques Cytotoxicité Antifongique Antibactérienne Antipaludique Antileishmanienne MAO-A et MAO-B "MAO-A MAO-B Cytisus Hypericum ?????? ????????? ???????? ???? ??????? ???? ????????? ???? ???????? ???? ?????????????" Index. décimale : 540 Chimie et sciences connexes Résumé : Natural products are important sources of novel therapeutic agents. Bioactive secondary metabolites
isolated from natural sources, can act as drugs or as lead compounds for synthetic drugs. In our work, two plants
have been studied; the endemic species of Hypericum afrum Lam.(Hypericaceae) and Cytisus villosus Pourr.
(Fabaceae). Fractions of the aerial parts of these two plants have been screened in vitro for several biological
assays including cannabinoid and opioid receptors agonist assays, antifungal, antibacterial, antimalarial,
antileishmanial, antiproliferative, antioxidant, anti-inflammatory and MAO inhibition.
The chloroform, ethyl acetate and n-butanol fractions of H. afrum showed significant antioxidant activity and
potent antitrypanosomal activity against T. brucei. The n-butanol fraction of C. villosus showed highly potent
antitrypanosomal activity against T. brucei. In addition, the ethyl acetate fractions of both plants showed potent
inhibition of recombinant human monoamine oxidases (MAO-A and -B).
A bioassay-guided fractionation paradigm has been used for the isolation of bioactive compounds of these plants
and hence the subfractions that showed significant activity were further purified.
This study led to the isolation and identification of 20 compounds, three of which belonging to phloroglucinols,
terpenoids and isoflavonoids are new. The structures of the isolated compounds were elucidated through various
spectroscopic methods, including high- resolution mass spectrometry, one and two-dimensional nuclear magnetic
resonance spectroscopy.
Computational study was carried out by conformational search and docking techniques to provide insight into the
binding mode of molecules on the active site of MAO’s isoenzymes.
Diplôme : Doctorat en sciences En ligne : ../theses/chimie/LAR7157.pdf Format de la ressource électronique : Permalink : http://bu.umc.edu.dz/md/index.php?lvl=notice_display&id=10430 Exemplaires
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Titre : سلوك المستهلك إتجاه المنتجات المقلدة : - دراسة حالة الجزائر- Type de document : texte imprimé Auteurs : راضية لسود ; جامعة منتوري, Editeur scientifique ; عيسى بن ناصر, Directeur de thèse Année de publication : 2009 Importance : 199 ورقة Format : 30 سم Note générale : 1 نسخة موجودة في قاعة المطالعة 1 نسخة موجودة في مخزن المكتبة المركزية+01 قرص مضغوط Langues : Arabe (ara) Tags : ???? ???????? ???????? ??????? Index. décimale : 330 علم الإقتصاد En ligne : ../theses/economie/ALSO2965.pdf Permalink : http://bu.umc.edu.dz/md/index.php?lvl=notice_display&id=6692 سلوك المستهلك إتجاه المنتجات المقلدة : - دراسة حالة الجزائر- [texte imprimé] / راضية لسود ; جامعة منتوري, Editeur scientifique ; عيسى بن ناصر, Directeur de thèse . - 2009 . - 199 ورقة ; 30 سم.
1 نسخة موجودة في قاعة المطالعة 1 نسخة موجودة في مخزن المكتبة المركزية+01 قرص مضغوط
Langues : Arabe (ara)
Tags : ???? ???????? ???????? ??????? Index. décimale : 330 علم الإقتصاد En ligne : ../theses/economie/ALSO2965.pdf Permalink : http://bu.umc.edu.dz/md/index.php?lvl=notice_display&id=6692 Exemplaires
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Titre : منهج الألباني في تصحيح الحديث وتضعيفه Type de document : texte imprimé Auteurs : عائشة غرابلي ; سلمان نصر, Directeur de thèse ; جامعة الحاج الأخضر, Editeur scientifique Année de publication : 2008 Importance : 358و. Format : 30 سم Note générale : النسخة بمخزن المكتبة هدية من جامعة باتنة Langues : Arabe (ara) Tags : ?????? ????? ???? ???????? ?????? ???? ????? ?????? Index. décimale : 200 الديانـــات Permalink : http://bu.umc.edu.dz/md/index.php?lvl=notice_display&id=7070 منهج الألباني في تصحيح الحديث وتضعيفه [texte imprimé] / عائشة غرابلي ; سلمان نصر, Directeur de thèse ; جامعة الحاج الأخضر, Editeur scientifique . - 2008 . - 358و. ; 30 سم.
النسخة بمخزن المكتبة هدية من جامعة باتنة
Langues : Arabe (ara)
Tags : ?????? ????? ???? ???????? ?????? ???? ????? ?????? Index. décimale : 200 الديانـــات Permalink : http://bu.umc.edu.dz/md/index.php?lvl=notice_display&id=7070 Exemplaires
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Titre : شركة المضاربة وتطبيقاتها المعاصرة Type de document : texte imprimé Auteurs : يمينة سلماني ; محمد محدة, Directeur de thèse ; جامعة الحاج الأخضر, Editeur scientifique Année de publication : 30سم Importance : 381 و. Format : 30سم Note générale : نسخة بمخزن المكتبة هدية من جامعة باتنة Langues : Arabe (ara) Tags : ?????? ????????? ????? ???? ???????? ???????? ????? ????? ?????? ???????? ????????? Index. décimale : 200 الديانـــات Permalink : http://bu.umc.edu.dz/md/index.php?lvl=notice_display&id=7072 شركة المضاربة وتطبيقاتها المعاصرة [texte imprimé] / يمينة سلماني ; محمد محدة, Directeur de thèse ; جامعة الحاج الأخضر, Editeur scientifique . - 30سم . - 381 و. ; 30سم.
نسخة بمخزن المكتبة هدية من جامعة باتنة
Langues : Arabe (ara)
Tags : ?????? ????????? ????? ???? ???????? ???????? ????? ????? ?????? ???????? ????????? Index. décimale : 200 الديانـــات Permalink : http://bu.umc.edu.dz/md/index.php?lvl=notice_display&id=7072 Exemplaires
Code-barres Cote Support Localisation Section Disponibilité aucun exemplaire Etude phytochimique et valorisation biologique des deux plantes, Genista quadriflora Munby (Fabaceae) et Convolvulus tricolor L. (Convolvulaceae) / Nassira Kacem
Titre : Etude phytochimique et valorisation biologique des deux plantes, Genista quadriflora Munby (Fabaceae) et Convolvulus tricolor L. (Convolvulaceae) Type de document : texte imprimé Auteurs : Nassira Kacem, Auteur ; Salah Rhouati, Directeur de thèse ; Kurt Hostettmann, Directeur de thèse Editeur : constantine [Algérie] : Université Constantine 1 Année de publication : 2015 Importance : 299 f. Format : 30 cm. Note générale : 2 copies imprimées disponibles
Langues : Français (fre) Tags : Genista Convolvulus alcaloïdes acides caféoylquiniques sesquiterpènes flavonoïdes HPLC MPLC CPC ESIMS GC/EIMS HR-MS/TOF Q-TRAP MSn RMN-2D leishmanicide antipaludique antibactérienne antifongique antiradicalaire acétylcholinestérase alkaloids caffeoylquinic acids sesquiterpenoids flavonoids antileishmanial antimalarial antibacterial antifungal antiradical acetylcholinesterase ??????? ????? ??????????? ???????????? ?????????? ???? ???????
???? ???????? ???? ????? ???? ??????? ?????????????? ???? ???????? ???? ?????????Index. décimale : 540 Chimie et sciences connexes Résumé : This work was focused on two Algerian plants, the endemic species Genista quadriflora Munby (Fabaceae) and the species Convolvulus tricolor (Convolvulaceae). The study of the alkaloid profile of G. quadriflora by GC/EIMS allowed the identification of twenty compounds, among which ten are newly registered for the genus. We indicate the presence of:
• Thirteen quinolizidine alkaloids
• Five piperidine alkaloids
• One nicotinic alkaloid, in addition to a nicotinic acid derivative.
The investigation of the G. quadriflora essential oil has lead to the identification of 222 compounds,of which 197 are reported for the first time in the genus. This oil is mainly composed of terpenoids(66.85%) with a prevalence of sesquiterpenoids (65.18%). The major compounds are cited as:
• Salvial-4 (14) - in-1-one; germacra-4 (15), 5, 10 (14) - trien-1-α-ol; amorpha-4, 9-dien-2-
ol; muurolan-4, 7-peroxide.
Also, twenty two compounds (caffeoylquinic acids, flavonoids, coumarin, phenol acid) were isolated from C. tricolor and G. quadriflora. All these compounds are reported for the first time in the studied species. The structural determination was carried out by mass spectrometry in electronic impact EIMS, by electrospray ESIMS, by high-resolution mass spectrometry HRMS, by time of flight HR-TOFMS, and by mass spectrometry high-resolution tandem MSn. In addition, we used NMR-1D and 2D spectroscopy.
The second part of our work was an in vitro evaluation of the biological activities such as:
• antileishmanial activity, antimalarial activity, antifungal and antibacterial activities, antioxidant activity against the DPPH, and the activity towards the enzyme acetylcholinesterase.
The various tests carried out during this work have leads to tracks quite interesting especially for:
• Samples of Convolvulus tricolor with inhibitions of the parasitic activity going from 89 to 99% by quite low rates of toxicity indicating their good selective activity on the parasites.
• The alkaloids extract resulting from the air parts of Genista quadriflora for which the bacteria type Pseudomonas aeruginosa had a very particular sensitivity.
Diplôme : Doctorat en sciences En ligne : ../theses/chimie/KAC6789.pdf Format de la ressource électronique : Permalink : http://bu.umc.edu.dz/md/index.php?lvl=notice_display&id=9979 Etude phytochimique et valorisation biologique des deux plantes, Genista quadriflora Munby (Fabaceae) et Convolvulus tricolor L. (Convolvulaceae) [texte imprimé] / Nassira Kacem, Auteur ; Salah Rhouati, Directeur de thèse ; Kurt Hostettmann, Directeur de thèse . - constantine (Route ain el bey, Algérie) : Université Constantine 1, 2015 . - 299 f. ; 30 cm.
2 copies imprimées disponibles
Langues : Français (fre)
Tags : Genista Convolvulus alcaloïdes acides caféoylquiniques sesquiterpènes flavonoïdes HPLC MPLC CPC ESIMS GC/EIMS HR-MS/TOF Q-TRAP MSn RMN-2D leishmanicide antipaludique antibactérienne antifongique antiradicalaire acétylcholinestérase alkaloids caffeoylquinic acids sesquiterpenoids flavonoids antileishmanial antimalarial antibacterial antifungal antiradical acetylcholinesterase ??????? ????? ??????????? ???????????? ?????????? ???? ???????
???? ???????? ???? ????? ???? ??????? ?????????????? ???? ???????? ???? ?????????Index. décimale : 540 Chimie et sciences connexes Résumé : This work was focused on two Algerian plants, the endemic species Genista quadriflora Munby (Fabaceae) and the species Convolvulus tricolor (Convolvulaceae). The study of the alkaloid profile of G. quadriflora by GC/EIMS allowed the identification of twenty compounds, among which ten are newly registered for the genus. We indicate the presence of:
• Thirteen quinolizidine alkaloids
• Five piperidine alkaloids
• One nicotinic alkaloid, in addition to a nicotinic acid derivative.
The investigation of the G. quadriflora essential oil has lead to the identification of 222 compounds,of which 197 are reported for the first time in the genus. This oil is mainly composed of terpenoids(66.85%) with a prevalence of sesquiterpenoids (65.18%). The major compounds are cited as:
• Salvial-4 (14) - in-1-one; germacra-4 (15), 5, 10 (14) - trien-1-α-ol; amorpha-4, 9-dien-2-
ol; muurolan-4, 7-peroxide.
Also, twenty two compounds (caffeoylquinic acids, flavonoids, coumarin, phenol acid) were isolated from C. tricolor and G. quadriflora. All these compounds are reported for the first time in the studied species. The structural determination was carried out by mass spectrometry in electronic impact EIMS, by electrospray ESIMS, by high-resolution mass spectrometry HRMS, by time of flight HR-TOFMS, and by mass spectrometry high-resolution tandem MSn. In addition, we used NMR-1D and 2D spectroscopy.
The second part of our work was an in vitro evaluation of the biological activities such as:
• antileishmanial activity, antimalarial activity, antifungal and antibacterial activities, antioxidant activity against the DPPH, and the activity towards the enzyme acetylcholinesterase.
The various tests carried out during this work have leads to tracks quite interesting especially for:
• Samples of Convolvulus tricolor with inhibitions of the parasitic activity going from 89 to 99% by quite low rates of toxicity indicating their good selective activity on the parasites.
• The alkaloids extract resulting from the air parts of Genista quadriflora for which the bacteria type Pseudomonas aeruginosa had a very particular sensitivity.
Diplôme : Doctorat en sciences En ligne : ../theses/chimie/KAC6789.pdf Format de la ressource électronique : Permalink : http://bu.umc.edu.dz/md/index.php?lvl=notice_display&id=9979 Exemplaires
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