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| Titre : |
Molecular Modeling and Theoretical Study of New AChE and BuChE’s Inhibitors Implicated in Alzheimer Disease Treatment. |
| Type de document : |
texte imprimé |
| Auteurs : |
Nini Ismahene, Auteur ; A Krid, Directeur de thèse |
| Editeur : |
CONSTANTINE [ALGERIE] : Université Frères Mentouri Constantine |
| Année de publication : |
2019 |
| Importance : |
55 f. |
| Format : |
30 cm. |
| Note générale : |
Une copie electronique PDF disponible au BUC. |
| Langues : |
Anglais (eng) |
| Catégories : |
Sciences Exactes:Chimie
|
| Tags : |
AChE BuChE |
| Index. décimale : |
540 Chimie |
| Résumé : |
Drug design, is the inventive process of finding new medications based on the knowledge of a
biological target and Using its structure. As theoretical chemists, we were interested on ProteinLigand interactions between synthesized Ligands and Cholinesterases enzymes: Acetylcholinesterase
and Butyrylcholinesterase in the Alzheimer desease treatment via in silico Molecular Docking using
Autodock Vina program. The molecules treated in this work are Galantamine as reference, ligand
01 and ligand 02, tow molecules synthesised at organic chemistry laboratory at Frères Mentouri
Univercity Constantine 1, showing antiAlzheimer activity. To better understand and broaden our
knowledge concerning the mechanism of the incorporation of thoes molecules in cholinesterases
active sites, molecular dynamic simulations are our challenge to take all biological parameters in
consideration and to quantify energies in real scale. |
| Diplome : |
Master 2 |
| Permalink : |
https://bu.umc.edu.dz/master/index.php?lvl=notice_display&id=11240 |
Molecular Modeling and Theoretical Study of New AChE and BuChE’s Inhibitors Implicated in Alzheimer Disease Treatment. [texte imprimé] / Nini Ismahene, Auteur ; A Krid, Directeur de thèse . - CONSTANTINE [ALGERIE] : Université Frères Mentouri Constantine, 2019 . - 55 f. ; 30 cm. Une copie electronique PDF disponible au BUC. Langues : Anglais ( eng)
| Catégories : |
Sciences Exactes:Chimie
|
| Tags : |
AChE BuChE |
| Index. décimale : |
540 Chimie |
| Résumé : |
Drug design, is the inventive process of finding new medications based on the knowledge of a
biological target and Using its structure. As theoretical chemists, we were interested on ProteinLigand interactions between synthesized Ligands and Cholinesterases enzymes: Acetylcholinesterase
and Butyrylcholinesterase in the Alzheimer desease treatment via in silico Molecular Docking using
Autodock Vina program. The molecules treated in this work are Galantamine as reference, ligand
01 and ligand 02, tow molecules synthesised at organic chemistry laboratory at Frères Mentouri
Univercity Constantine 1, showing antiAlzheimer activity. To better understand and broaden our
knowledge concerning the mechanism of the incorporation of thoes molecules in cholinesterases
active sites, molecular dynamic simulations are our challenge to take all biological parameters in
consideration and to quantify energies in real scale. |
| Diplome : |
Master 2 |
| Permalink : |
https://bu.umc.edu.dz/master/index.php?lvl=notice_display&id=11240 |
|
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| MSCHI190015 | MSCHI190015 | Document électronique | Bibliothèque principale | Mémoires | Disponible |
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