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Auteur Soumia Teniou |
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Affiner la recherche Interroger des sources externesConception in silico de nouveaux inhibiteurs de la topoisomérase I de cellules cancéreuses. / Soumia Teniou
Titre : Conception in silico de nouveaux inhibiteurs de la topoisomérase I de cellules cancéreuses. Type de document : texte imprimé Auteurs : Soumia Teniou, Auteur ; Abdellatif Bensegueni, Directeur de thèse Editeur : Constantine : Université Mentouri Constantine Année de publication : 2012 Importance : 95 f. Format : 31 cm. Note générale : 2 copies imprimées disponibles Langues : Français (fre) Catégories : Français - Anglais
BiologieTags : Biochimie:Technologie des Explorations Biochimiques L'ADN Topoisomérase I Flavonoides Modélisation moléculaire Docking moléculaire Surflex Affinité Myricétine DNA topoisomérase I Flavonoids Molecular modeling Molecular Docking Affinity Myricetin الفلافونويدات النمذجة الجزيئية الجاذبية Index. décimale : 570 Sciences de la vie. Biologie Résumé :
Human DNA Topoisomérase I (topo I) is the target of several drugs commonly used in cancer chemotherapy. These drugs induce topo-DNA complexes that eventually trigger cell death. Several flavonoides have been shown as inhibitors of topo I, having an anticancer activity. Using the methods of molecular modeling in particularl the docking by the Surflex program, we theoretically evaluated the affinity of four flavonoids: myricetin, fisetin, quercetin and apigenin, presented in recent studies as inhibitors of topo I. Myricetin with the lowest IC50 (11.1 ± 2.0 µM) gave the best affinity (7.01 M-1). For the development in silico of novel molecules most powerful myricetin, we have made several substitutions. Replacing the hydroxyl group carried by the carbone C3´ of the myricetin by an alcoholic group CH2OH significantly improves the affinity increases from 7.01 M-1 to 8.79 M-1. The application of the rule of Lipinski informs in a positive way about the ADME properties of this new molecule that is as an inhibitor potentially more active than myricetin.Note de contenu : Annexes. Diplôme : Magistère En ligne : ../theses/biologie/TEN6172.pdf Format de la ressource électronique : Permalink : index.php?lvl=notice_display&id=6108 Conception in silico de nouveaux inhibiteurs de la topoisomérase I de cellules cancéreuses. [texte imprimé] / Soumia Teniou, Auteur ; Abdellatif Bensegueni, Directeur de thèse . - Constantine : Université Mentouri Constantine, 2012 . - 95 f. ; 31 cm.
2 copies imprimées disponibles
Langues : Français (fre)
Catégories : Français - Anglais
BiologieTags : Biochimie:Technologie des Explorations Biochimiques L'ADN Topoisomérase I Flavonoides Modélisation moléculaire Docking moléculaire Surflex Affinité Myricétine DNA topoisomérase I Flavonoids Molecular modeling Molecular Docking Affinity Myricetin الفلافونويدات النمذجة الجزيئية الجاذبية Index. décimale : 570 Sciences de la vie. Biologie Résumé :
Human DNA Topoisomérase I (topo I) is the target of several drugs commonly used in cancer chemotherapy. These drugs induce topo-DNA complexes that eventually trigger cell death. Several flavonoides have been shown as inhibitors of topo I, having an anticancer activity. Using the methods of molecular modeling in particularl the docking by the Surflex program, we theoretically evaluated the affinity of four flavonoids: myricetin, fisetin, quercetin and apigenin, presented in recent studies as inhibitors of topo I. Myricetin with the lowest IC50 (11.1 ± 2.0 µM) gave the best affinity (7.01 M-1). For the development in silico of novel molecules most powerful myricetin, we have made several substitutions. Replacing the hydroxyl group carried by the carbone C3´ of the myricetin by an alcoholic group CH2OH significantly improves the affinity increases from 7.01 M-1 to 8.79 M-1. The application of the rule of Lipinski informs in a positive way about the ADME properties of this new molecule that is as an inhibitor potentially more active than myricetin.Note de contenu : Annexes. Diplôme : Magistère En ligne : ../theses/biologie/TEN6172.pdf Format de la ressource électronique : Permalink : index.php?lvl=notice_display&id=6108 Exemplaires (1)
Code-barres Cote Support Localisation Section Disponibilité TEN/6172 TEN/6172 Thèse Bibliothèque principale Thèses Disponible
