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Auteur S Zerizer |
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Affiner la recherche Interroger des sources externesBiological activities of some medicinal plants on rheumatoid arthritis induced by hyperhomocysteinemia and formalin and on tumoral process / Boutheyna Aribi
Titre : Biological activities of some medicinal plants on rheumatoid arthritis induced by hyperhomocysteinemia and formalin and on tumoral process Type de document : texte imprimé Auteurs : Boutheyna Aribi, Auteur ; S Zerizer, Directeur de thèse Editeur : جامعة الإخوة منتوري قسنطينة Année de publication : 2016 Importance : 166 f. Format : 30 cm. Note générale : 2 copies imprimes disponibles Langues : Français (fre) Catégories : Français - Anglais
BiologieTags : Biologie animal Immuno-oncology Inflammation, arthrite rhumatoïde, cancer, hyperhomocystéinémie, activité
immunomodulatrice, Argania spinosa, Citrullus colocynthis, Boswellia serrata, huile olive
vierge, protéines de signalisation ERK1 /2 et NOTCH1.
Inflammation, rheumatoid arthritis, hyperhomocysteinemia, cancer, analgesic, anti-inflammatory, antiarthritic,
antiproliferative, immunomodulatory activity, Argania spinosa, Citrullus colocynthis, Boswellia serrata.
الالتهاب-الالتهاب المفاصل-ارتفاع تركيز الهوموسستيين البلازمي-السرطان-تحفيز النشاط المناعي-مضاد للألم-مضاد للإلتهاب - مضاد للسرطان-الأرغان-الحنظل-اللبانIndex. décimale : 570 Sciences de la vie. Biologie Résumé : Inflammation is an immune response that underlies a wide variety of physiological and pathological processes;
there is growing evidence suggesting that inflammation plays a key role in the pathogenesis of rheumatoid
arthritis, cardiovascular diseases and cancer. In addition, some chronic inflammatory diseases are recently found
to be associated with an increased level of homocysteine (hyperhomocysteinemia). In fact, a link seems to
connect homocysteine (Hcy) and the immuno-inflammatory activation, when inflammatory activation may
contribute to Hcy increase, Hcy, in its turn, may act as a pro-inflammatory molecule cooperating to the injury.
Natural products from medicinal plants play a crucial role in drug discovery; the investigation of medicinal
plants products has resulted in wide number of compounds with promising biological activities.
In the present study we evaluated in vivo the effect of three Algerian medicinal plants namely Argania spinosa,
Citrullus colocynthis, and Boswellia serrata harvested in Tindouf andTiguentourine respectively on the toxicity,
immunostimulatory activity and pain. Another work was about a comparative screening of the
immunomodulatory activity of the three oils which were compared with virgin olive oil.
The toxicity assessment was performed using up and down test in Albinos rats , the immunomodulatory activity
was assessed in the reticulo-endothelial system using carbon clearance assay, the analgesic effect was studied by
acetic acid induced writhing test in Mus musculus mice. The results obtained showed that the extracts of
medicinal plants did not present any toxic effect with the administration of the dose 2000mg/kg; also increased
significantly the phagocytic activity in dose dependent manner and have analgesic effect by reducing
significantly the writhing in mice induced by acetic acid. Also we have obtained that the phagocytic activity was
increased very highly significantly in the groups of rats treated with Boswellia serrata (200mg/kg) and olive oil
(100mg/kg) P≤0,001.
Another study was carried on the anti-inflammatory activity of the three plants extracts which was assessed
using an acute model of inflammation which is xylene ear oedema and other was carried with only Argania
spinosa seeds on arthritis which was assessed in two chronic models of inflammation consisting of formalin
induced arthritis and formalin induced arthritis associated with L- methionine induced hyperhomocysteinemia.
The results obtained demonstrated that there was significant inhibition of ear oedema caused by the three
extracts treatment. Our research also revealed that administration of L- methionine at dose 400mg/kg caused
aggravation of inflammation presented by very high significantly increase of C-reactive proteins (CRP) P≤0,001
and high significantly increase of homocysteine (Hcy) P ≤0,01, in addition , necrosis, degeneration and
inflammatory cells accumulation were observed in the articular cartilage, but the treatment by crude extract of
Argania spinosa seeds at doses of 100 and 200 mg/kg attenuate this effect reducing the paw thickness in both
models of chronic arthritis and this also was confirmed by normal histological sections.
Moreover, in the present thesis, we conducted a study in vitro to evaluate the anti-proliferative effect of the three
oils on the T-cell acute lymphoblastic leukemia cell lines and on signaling proteins (NOTCH 1 and ERK1/2).The
results revealed that treatment with the different oils at the dose of 100μg/ml inhibited the growth of tumor cells,
but the Argania spinosa oil only reduced the expression levels of signaling proteins ERK1/2 and NOTCH1.Diplôme : Doctorat En ligne : ../theses/biologie/ARI6827.pdf Format de la ressource électronique : Permalink : index.php?lvl=notice_display&id=10119 Biological activities of some medicinal plants on rheumatoid arthritis induced by hyperhomocysteinemia and formalin and on tumoral process [texte imprimé] / Boutheyna Aribi, Auteur ; S Zerizer, Directeur de thèse . - جامعة الإخوة منتوري قسنطينة, 2016 . - 166 f. ; 30 cm.
2 copies imprimes disponibles
Langues : Français (fre)
Catégories : Français - Anglais
BiologieTags : Biologie animal Immuno-oncology Inflammation, arthrite rhumatoïde, cancer, hyperhomocystéinémie, activité
immunomodulatrice, Argania spinosa, Citrullus colocynthis, Boswellia serrata, huile olive
vierge, protéines de signalisation ERK1 /2 et NOTCH1.
Inflammation, rheumatoid arthritis, hyperhomocysteinemia, cancer, analgesic, anti-inflammatory, antiarthritic,
antiproliferative, immunomodulatory activity, Argania spinosa, Citrullus colocynthis, Boswellia serrata.
الالتهاب-الالتهاب المفاصل-ارتفاع تركيز الهوموسستيين البلازمي-السرطان-تحفيز النشاط المناعي-مضاد للألم-مضاد للإلتهاب - مضاد للسرطان-الأرغان-الحنظل-اللبانIndex. décimale : 570 Sciences de la vie. Biologie Résumé : Inflammation is an immune response that underlies a wide variety of physiological and pathological processes;
there is growing evidence suggesting that inflammation plays a key role in the pathogenesis of rheumatoid
arthritis, cardiovascular diseases and cancer. In addition, some chronic inflammatory diseases are recently found
to be associated with an increased level of homocysteine (hyperhomocysteinemia). In fact, a link seems to
connect homocysteine (Hcy) and the immuno-inflammatory activation, when inflammatory activation may
contribute to Hcy increase, Hcy, in its turn, may act as a pro-inflammatory molecule cooperating to the injury.
Natural products from medicinal plants play a crucial role in drug discovery; the investigation of medicinal
plants products has resulted in wide number of compounds with promising biological activities.
In the present study we evaluated in vivo the effect of three Algerian medicinal plants namely Argania spinosa,
Citrullus colocynthis, and Boswellia serrata harvested in Tindouf andTiguentourine respectively on the toxicity,
immunostimulatory activity and pain. Another work was about a comparative screening of the
immunomodulatory activity of the three oils which were compared with virgin olive oil.
The toxicity assessment was performed using up and down test in Albinos rats , the immunomodulatory activity
was assessed in the reticulo-endothelial system using carbon clearance assay, the analgesic effect was studied by
acetic acid induced writhing test in Mus musculus mice. The results obtained showed that the extracts of
medicinal plants did not present any toxic effect with the administration of the dose 2000mg/kg; also increased
significantly the phagocytic activity in dose dependent manner and have analgesic effect by reducing
significantly the writhing in mice induced by acetic acid. Also we have obtained that the phagocytic activity was
increased very highly significantly in the groups of rats treated with Boswellia serrata (200mg/kg) and olive oil
(100mg/kg) P≤0,001.
Another study was carried on the anti-inflammatory activity of the three plants extracts which was assessed
using an acute model of inflammation which is xylene ear oedema and other was carried with only Argania
spinosa seeds on arthritis which was assessed in two chronic models of inflammation consisting of formalin
induced arthritis and formalin induced arthritis associated with L- methionine induced hyperhomocysteinemia.
The results obtained demonstrated that there was significant inhibition of ear oedema caused by the three
extracts treatment. Our research also revealed that administration of L- methionine at dose 400mg/kg caused
aggravation of inflammation presented by very high significantly increase of C-reactive proteins (CRP) P≤0,001
and high significantly increase of homocysteine (Hcy) P ≤0,01, in addition , necrosis, degeneration and
inflammatory cells accumulation were observed in the articular cartilage, but the treatment by crude extract of
Argania spinosa seeds at doses of 100 and 200 mg/kg attenuate this effect reducing the paw thickness in both
models of chronic arthritis and this also was confirmed by normal histological sections.
Moreover, in the present thesis, we conducted a study in vitro to evaluate the anti-proliferative effect of the three
oils on the T-cell acute lymphoblastic leukemia cell lines and on signaling proteins (NOTCH 1 and ERK1/2).The
results revealed that treatment with the different oils at the dose of 100μg/ml inhibited the growth of tumor cells,
but the Argania spinosa oil only reduced the expression levels of signaling proteins ERK1/2 and NOTCH1.Diplôme : Doctorat En ligne : ../theses/biologie/ARI6827.pdf Format de la ressource électronique : Permalink : index.php?lvl=notice_display&id=10119 Exemplaires (1)
Code-barres Cote Support Localisation Section Disponibilité ARI/6827 ARI/6827 Thèse Bibliothèque principale Thèses Disponible
Titre : "Effect of Algerian olive oil on cardiovascular diseases and lipids status in hyperhomocysteinemia treated mice" Type de document : texte imprimé Auteurs : Fatima Zahra Sakhri, Auteur ; S Zerizer, Directeur de thèse Editeur : constantine [Algérie] : Université Constantine 1 Année de publication : 2014 Importance : 89 f. Format : 30 cm. Note générale : 2 copies imprimées disponibles
Langues : Anglais (eng) Catégories : Français - Anglais
BiologieTags : "Cholestérol total, Huile d’olive, HDL-c, Homocystéine, Glutathion réduit,
HDL-c, Triglycérides."
"HDL-c, Homocysteine, Glutathione reduced, LDL-c, Olive oil, Total cholesterol,
Triglyceride."
الهوموسستيين،الكولسترول الكلي،LDL،HDL-c ، الجليسريدات الثلاثية، الجلوثاثيون المختزل،زيت الزيتونIndex. décimale : 570 Sciences de la vie. Biologie Résumé : "L'huile d'olive est l’une des huiles végétales les plus anciens et le seul qui peut être
consommé dans sa forme brute, sans traitement préalable. Les avantages bien connus d'huile
d'olive pour la santé sont liées à sa composition en acides gras et en biomolécules mineur, tels
que les vitamines et les antioxydants naturels.
L'homocystéine (Hcy) est un acide aminé soufré synthétisée dans le corps par la conversion
de la méthionine. Il existe un équilibre dans le métabolisme de l'Hcy dans les conditions
physiologiques. En cas d’excès, l’hyperhomocystéinémie (HHcy), considéré comme un
facteur de risque indépendant des maladies cardio-vasculaires.
Dans cette étude, nous avons dosé l’Hcy plasmatique, les paramètres lipidiques (cholestérol
total, LDL, HDL, triglycérides) et les enzymes antioxydants (glutathion réduit) chez des
souris auxquelles nous avons administré (400mg/kg) de L-méthionine pendant 21 jours. Après
administration orale de la dose élevée de L-méthionine, la dégradation de cette dernière
produit un excès d’Hcy dans le plasma sanguin, qui est à son tour exerce une action
angiotoxique sur l’aorte iliaque et abdominal et une action toxique sur le coeur et le foie. Ceci
est montré à la perte et la dégénérescence de l'endothélium, la fenestration et la formation de
cellules spumeuses dans les médias de l'aorte abdominale et iliaque, également l'altération du
muscle cardiaque et la nécrose du foie. Cependant, l’histologie aortique des souris traitées par
la L-méthionine avec huile d’olive (7ml/60kg) montre un endothélium intact et des cellules
musculaires avec des noyaux fusiformes. Néanmoins, on a observé quelques noyaux ovales et
quelques cellules spumeuses.
Ainsi, le traitement par l’huile d’olive diminue le taux plasmatique d’Hcy, cholestérol total,
triglycéride et LDL-c cependant les niveaux des HDL-c et le glutathion réduit augmentent.
Donc, l’huile d’olive utilisé dans cette étude exerce un effet antioxydant.
Les résultats obtenus dans cette étude montrent que l’huile d’olive Algérienne peut être
considérer comme une source naturelle pour prévenir et traiter les maladies cardiovasculaires.
Les mots"
Diplôme : Magistère En ligne : ../theses/biologie/SAK6597.pdf Format de la ressource électronique : Permalink : index.php?lvl=notice_display&id=9710 "Effect of Algerian olive oil on cardiovascular diseases and lipids status in hyperhomocysteinemia treated mice" [texte imprimé] / Fatima Zahra Sakhri, Auteur ; S Zerizer, Directeur de thèse . - constantine [Algérie] : Université Constantine 1, 2014 . - 89 f. ; 30 cm.
2 copies imprimées disponibles
Langues : Anglais (eng)
Catégories : Français - Anglais
BiologieTags : "Cholestérol total, Huile d’olive, HDL-c, Homocystéine, Glutathion réduit,
HDL-c, Triglycérides."
"HDL-c, Homocysteine, Glutathione reduced, LDL-c, Olive oil, Total cholesterol,
Triglyceride."
الهوموسستيين،الكولسترول الكلي،LDL،HDL-c ، الجليسريدات الثلاثية، الجلوثاثيون المختزل،زيت الزيتونIndex. décimale : 570 Sciences de la vie. Biologie Résumé : "L'huile d'olive est l’une des huiles végétales les plus anciens et le seul qui peut être
consommé dans sa forme brute, sans traitement préalable. Les avantages bien connus d'huile
d'olive pour la santé sont liées à sa composition en acides gras et en biomolécules mineur, tels
que les vitamines et les antioxydants naturels.
L'homocystéine (Hcy) est un acide aminé soufré synthétisée dans le corps par la conversion
de la méthionine. Il existe un équilibre dans le métabolisme de l'Hcy dans les conditions
physiologiques. En cas d’excès, l’hyperhomocystéinémie (HHcy), considéré comme un
facteur de risque indépendant des maladies cardio-vasculaires.
Dans cette étude, nous avons dosé l’Hcy plasmatique, les paramètres lipidiques (cholestérol
total, LDL, HDL, triglycérides) et les enzymes antioxydants (glutathion réduit) chez des
souris auxquelles nous avons administré (400mg/kg) de L-méthionine pendant 21 jours. Après
administration orale de la dose élevée de L-méthionine, la dégradation de cette dernière
produit un excès d’Hcy dans le plasma sanguin, qui est à son tour exerce une action
angiotoxique sur l’aorte iliaque et abdominal et une action toxique sur le coeur et le foie. Ceci
est montré à la perte et la dégénérescence de l'endothélium, la fenestration et la formation de
cellules spumeuses dans les médias de l'aorte abdominale et iliaque, également l'altération du
muscle cardiaque et la nécrose du foie. Cependant, l’histologie aortique des souris traitées par
la L-méthionine avec huile d’olive (7ml/60kg) montre un endothélium intact et des cellules
musculaires avec des noyaux fusiformes. Néanmoins, on a observé quelques noyaux ovales et
quelques cellules spumeuses.
Ainsi, le traitement par l’huile d’olive diminue le taux plasmatique d’Hcy, cholestérol total,
triglycéride et LDL-c cependant les niveaux des HDL-c et le glutathion réduit augmentent.
Donc, l’huile d’olive utilisé dans cette étude exerce un effet antioxydant.
Les résultats obtenus dans cette étude montrent que l’huile d’olive Algérienne peut être
considérer comme une source naturelle pour prévenir et traiter les maladies cardiovasculaires.
Les mots"
Diplôme : Magistère En ligne : ../theses/biologie/SAK6597.pdf Format de la ressource électronique : Permalink : index.php?lvl=notice_display&id=9710 Exemplaires (1)
Code-barres Cote Support Localisation Section Disponibilité SAK/6597 SAK/6597 Thèse Bibliothèque principale Thèses Disponible
Titre : Effect of bioactive molecules extracted from medicinal plants on inflammation induced by hyperhomocysteinemia and tumoral process Type de document : texte imprimé Auteurs : Assia Benmebarek, Auteur ; S Zerizer, Directeur de thèse Editeur : جامعة الإخوة منتوري قسنطينة Année de publication : 2014 Importance : 231 f. Note générale : 2 copies imprimées disponibles
Langues : Anglais (eng) Catégories : Français - Anglais
BiologieTags : Hyperhomocysteinemia atherogenesis inflammation carcinogenesis Stachys mialhesi Stachys ocymastrum immunomodulatory activity Hyperhomocysteinémie athérogénèse carcinogénèse activité immunomodulatrice زیادة الھوموسستیین البلازمي تصلب الشرایین الالتھاب السرطان التنبیھ المناعي Index. décimale : 570 Sciences de la vie. Biologie Résumé : Hyperhomocysteinemia is an important risk factor in cardiovascular diseases and may also be implicated in cancer biology. Elevated plasma homocysteine (Hcy) levels may mediate long-term oxidative damage at the vascular interface and there appear to be a mechanism by which they may also be carcinogenic. In addition, immunostimulatory therapy is one solution to enhance the immunity, however, the immunopharmacologic activities of herbal extracts may be antagonistic, they can be immunosupressive or immunostimulating. In the present study, we evaluated the in vivo effect of S. mialhesi extract on the inflammation induced by hyperhomocysteinemia and damages induced to the aorta, heart, liver, thymus and spleen. Another study was carried on the immunomodulatory potential of S. mialhesi
and S. ocymastrum on the phagocytic activity which was evaluated using the Carbon Clearance Assay. The results obtained showed that plasma hs-CRP concentrations were elevated significantly after the administration of L-methionine in high doses to mice (200mg/kg). Also, the loss and degeneration of endothelium, fenestration, foam cells formation, and a change in the appearance of smooth muscle cells nuclei from a fusiform nuclei aspect to a rounded one, were observed in the media of the aorta as well as the alteration of the cardiac muscle, liver necrosis, lymphocytes membrane destruction in the thymus, and a hypertrophy of the spleen white pulp. Our research also revealed that at different doses, S. mialhesi extract increased the reticuloendothelial system (RES)
phagocytic activity in a dose dependant manner, in contrast to S. ocymastrum who exhibited a biphasic dose response effect. Hcy initiated inflammation and mediated early atherogenesis lesions through increased oxidant stress, and the treatment with S. mialhesi extract at a dose of (50mg/kg) prevented the alterations. Also, S. mialhesi extract exhibited a dose-dependent immunostimulatory effect on the RES and S. ocymastrum extract appeared immunostimulatory at low concentrations and immunosuppressive at high concentrations. Moreover, in the present thesis, we performed a review study which demonstrated that Hcy may mediate carcinogenesis namely through folate deficiency, oxidative stress, aberrant DNA methylation and the production of homocysteine thiolactone.
Diplôme : Doctorat En ligne : ../theses/biologie/BEN6973.pdf Format de la ressource électronique : Permalink : index.php?lvl=notice_display&id=10371 Effect of bioactive molecules extracted from medicinal plants on inflammation induced by hyperhomocysteinemia and tumoral process [texte imprimé] / Assia Benmebarek, Auteur ; S Zerizer, Directeur de thèse . - جامعة الإخوة منتوري قسنطينة, 2014 . - 231 f.
2 copies imprimées disponibles
Langues : Anglais (eng)
Catégories : Français - Anglais
BiologieTags : Hyperhomocysteinemia atherogenesis inflammation carcinogenesis Stachys mialhesi Stachys ocymastrum immunomodulatory activity Hyperhomocysteinémie athérogénèse carcinogénèse activité immunomodulatrice زیادة الھوموسستیین البلازمي تصلب الشرایین الالتھاب السرطان التنبیھ المناعي Index. décimale : 570 Sciences de la vie. Biologie Résumé : Hyperhomocysteinemia is an important risk factor in cardiovascular diseases and may also be implicated in cancer biology. Elevated plasma homocysteine (Hcy) levels may mediate long-term oxidative damage at the vascular interface and there appear to be a mechanism by which they may also be carcinogenic. In addition, immunostimulatory therapy is one solution to enhance the immunity, however, the immunopharmacologic activities of herbal extracts may be antagonistic, they can be immunosupressive or immunostimulating. In the present study, we evaluated the in vivo effect of S. mialhesi extract on the inflammation induced by hyperhomocysteinemia and damages induced to the aorta, heart, liver, thymus and spleen. Another study was carried on the immunomodulatory potential of S. mialhesi
and S. ocymastrum on the phagocytic activity which was evaluated using the Carbon Clearance Assay. The results obtained showed that plasma hs-CRP concentrations were elevated significantly after the administration of L-methionine in high doses to mice (200mg/kg). Also, the loss and degeneration of endothelium, fenestration, foam cells formation, and a change in the appearance of smooth muscle cells nuclei from a fusiform nuclei aspect to a rounded one, were observed in the media of the aorta as well as the alteration of the cardiac muscle, liver necrosis, lymphocytes membrane destruction in the thymus, and a hypertrophy of the spleen white pulp. Our research also revealed that at different doses, S. mialhesi extract increased the reticuloendothelial system (RES)
phagocytic activity in a dose dependant manner, in contrast to S. ocymastrum who exhibited a biphasic dose response effect. Hcy initiated inflammation and mediated early atherogenesis lesions through increased oxidant stress, and the treatment with S. mialhesi extract at a dose of (50mg/kg) prevented the alterations. Also, S. mialhesi extract exhibited a dose-dependent immunostimulatory effect on the RES and S. ocymastrum extract appeared immunostimulatory at low concentrations and immunosuppressive at high concentrations. Moreover, in the present thesis, we performed a review study which demonstrated that Hcy may mediate carcinogenesis namely through folate deficiency, oxidative stress, aberrant DNA methylation and the production of homocysteine thiolactone.
Diplôme : Doctorat En ligne : ../theses/biologie/BEN6973.pdf Format de la ressource électronique : Permalink : index.php?lvl=notice_display&id=10371 Exemplaires (1)
Code-barres Cote Support Localisation Section Disponibilité BEN/6973 BEN/6973 Thèse Bibliothèque principale Thèses Disponible 
Titre : Effet comparatif de l’extrait butanolique de la plante Stachys mialhesi avec les vitamines B9 et B12 sur quelques paramètres biochimiques et la structure de l’aorte chez des souris induites par une hyperhomocystéinémie Type de document : texte imprimé Auteurs : Samira Boudebouz, Auteur ; S Zerizer, Directeur de thèse Editeur : constantine [Algérie] : Université Constantine 1 Année de publication : 2014 Importance : 104 f. Format : 30 cm. Note générale : 2 copies imprimées disponibles Langues : Français (fre) Catégories : Français - Anglais
BiologieTags : Homocystéine Stachys mialhesi Vitamines B9 et B12 Cholestérol total LDL HDL Triglycérides Aorte Homocysteine Vitamins B9 and B12, Total cholesterol Triglycerides Aorta الهوسستیین فیتامین ب 9 و ب 12 الكولسترول الكلي الجلیسریدات الثلاثیة الأورطي Index. décimale : 570 Sciences de la vie. Biologie Résumé : Homocysteine (Hcy) is a sulfur amino acid, synthesized from the metabolism of Lmethionine.
There is a balance in the metabolism of Hcy at physiological conditions.
At high level, the hyperhomocysteinemia (HHcy), considered as an independent risk factor in atherosclerosis, which can cause cellular and molecular alterations.
In the present study, we have measured thiol amino acid (homocysteine), lipidic statut (total cholesterol, LDL, HDL, triglycerides), and activity of transaminases (GOT, GPT) in mice administered with (400mg/kg) of L-methionine during 21 days. Following oral administration of L-methionine in high dose, its degradation product Hcy which is markedly
elevated in plasma and exerts an angiotoxic action directed to the iliac aorta and the other organs (liver, heart and kidneys). This is showed degradation and desquamation of endothelial cells also formation of foam cells in the media part with oval nuclei in mediocytes.
However, the aortic intima of the groups of mice that had been fed with L-methionine plus S.
mialhesi extract (500mg/kg) and also with vitamins B9 and B12 (0,7mg/kg and 0,75μg/kg), respectively showed intact endothelium and spindle-shaped mediocytes nuclei. Nevertheless, oval-shaped mediocytes nuclei and a few foam cells were observed. In the histological sections of the cardiac muscle, liver and kidneys no lysis was observed.
The vitamins B9 and B12 serve as cofactors in the metabolism of L-methionine. So, the vitamins therapy and the extract of S. mialhesi in mice have reduced Hcy, total cholesterol, triglycerides and LDL however, the concentration of HDL was increased.
The extract of medicinal plant S. mialhesi used in this study has antioxidant effect as the vitamins B9 and B12 in mice.
Our results obtained in this study showed that S. mialhesi can be considered as natural source in the prevention against cardiovascular disease.Diplôme : Magistère En ligne : ../theses/biologie/BOU6451.pdf Format de la ressource électronique : Permalink : index.php?lvl=notice_display&id=9486 Effet comparatif de l’extrait butanolique de la plante Stachys mialhesi avec les vitamines B9 et B12 sur quelques paramètres biochimiques et la structure de l’aorte chez des souris induites par une hyperhomocystéinémie [texte imprimé] / Samira Boudebouz, Auteur ; S Zerizer, Directeur de thèse . - constantine [Algérie] : Université Constantine 1, 2014 . - 104 f. ; 30 cm.
2 copies imprimées disponibles
Langues : Français (fre)
Catégories : Français - Anglais
BiologieTags : Homocystéine Stachys mialhesi Vitamines B9 et B12 Cholestérol total LDL HDL Triglycérides Aorte Homocysteine Vitamins B9 and B12, Total cholesterol Triglycerides Aorta الهوسستیین فیتامین ب 9 و ب 12 الكولسترول الكلي الجلیسریدات الثلاثیة الأورطي Index. décimale : 570 Sciences de la vie. Biologie Résumé : Homocysteine (Hcy) is a sulfur amino acid, synthesized from the metabolism of Lmethionine.
There is a balance in the metabolism of Hcy at physiological conditions.
At high level, the hyperhomocysteinemia (HHcy), considered as an independent risk factor in atherosclerosis, which can cause cellular and molecular alterations.
In the present study, we have measured thiol amino acid (homocysteine), lipidic statut (total cholesterol, LDL, HDL, triglycerides), and activity of transaminases (GOT, GPT) in mice administered with (400mg/kg) of L-methionine during 21 days. Following oral administration of L-methionine in high dose, its degradation product Hcy which is markedly
elevated in plasma and exerts an angiotoxic action directed to the iliac aorta and the other organs (liver, heart and kidneys). This is showed degradation and desquamation of endothelial cells also formation of foam cells in the media part with oval nuclei in mediocytes.
However, the aortic intima of the groups of mice that had been fed with L-methionine plus S.
mialhesi extract (500mg/kg) and also with vitamins B9 and B12 (0,7mg/kg and 0,75μg/kg), respectively showed intact endothelium and spindle-shaped mediocytes nuclei. Nevertheless, oval-shaped mediocytes nuclei and a few foam cells were observed. In the histological sections of the cardiac muscle, liver and kidneys no lysis was observed.
The vitamins B9 and B12 serve as cofactors in the metabolism of L-methionine. So, the vitamins therapy and the extract of S. mialhesi in mice have reduced Hcy, total cholesterol, triglycerides and LDL however, the concentration of HDL was increased.
The extract of medicinal plant S. mialhesi used in this study has antioxidant effect as the vitamins B9 and B12 in mice.
Our results obtained in this study showed that S. mialhesi can be considered as natural source in the prevention against cardiovascular disease.Diplôme : Magistère En ligne : ../theses/biologie/BOU6451.pdf Format de la ressource électronique : Permalink : index.php?lvl=notice_display&id=9486 Exemplaires (1)
Code-barres Cote Support Localisation Section Disponibilité BOU/6451 BOU/6451 Thèse Bibliothèque principale Thèses Disponible Documents numériques
texte intégraleAdobe Acrobat PDF
