| Titre : |
Synthèse, caractérisation et évaluation biologique De nouveaux dérivés hétérocycliques : 1,8-naphthyridines, gem-bisphosphonates et 4h-pyranes. |
| Type de document : |
texte imprimé |
| Auteurs : |
Mohamed Abdennour Redouane, Auteur ; N. Khiri-Meribout, Directeur de thèse ; M. Lecouvey, Directeur de thèse |
| Mention d'édition : |
03/03/2020 |
| Editeur : |
جامعة الإخوة منتوري قسنطينة |
| Année de publication : |
2020 |
| Importance : |
204 f. |
| Format : |
30 cm. |
| Note générale : |
Doctorat 3éme CYCLE LMD.
1 copies imprimées disponibles
|
| Langues : |
Français (fre) |
| Catégories : |
Français - Anglais
Chimie
|
| Tags : |
Chimie: Chimie Organique [1,8]-naphthyridines pyrrolidines gem-bisphosphonates 4H-pyranes liquide ionique cycloaddition 1,3-dipolaire Click Chemistry réaction multicomposants inhibiteur d'AChE anti-Alzheimer anti-oxydant inhibiteur de FPPS voie mévalonate Zolédronate anti-cancer ionic liquid 1,3-dipolaire cycloaddition multi component reaction AChE inhibitor anti-oxidant FPPS inhibitor mevalonate pathway Zoledronate anti cancer [-]1,8النفثريدينات البيروليدين ثنائية الفسفونات المتجاورة -4ىيدرو بيران السائل الأيوني اضافة
حلقية ثنائية القطب- 1,3التف اعلات متعددة المركبات مثبطات استيل كولين إستراز مضادات الأكسدة مثبطات FPPS
مسار الميف الونات زوليدرونات مضاد للسرطان |
| Index. décimale : |
540 Chimie et sciences connexes |
| Résumé : |
In this manuscript, subdivided into three chapters, we are interested in the development of simple and effective new approaches for the synthesis of new functional and structural diversified heterocyclic and poly-heterocyclic systems, which represent potential biological activities. In the first chapter, we proceeded to the synthesis of the new [1,8] -naphthyridines derivatives and their tetracyclic analogs by the development of an efficient multi-step synthesis strategy. AChE and BuChE inhibition potency of synthesized products was evaluated in vitro as well as their antioxidant power. Analysis of obtained results as well as an additional study carried out by Molecular Doking confirmed the effectiveness of these molecules, specially compound 4, as multi-target agents for the treatment of AD. In the second chapter, we focused on the synthesis of new Zoledronate analogs, with a variously substituted triazole motif, via click chemistry reactions. These new gembisphosphonate derivatives was synthesized for the purpose of designing compounds with high FPPS inhibiting potency, as well as good passive penetration through the cancer cell’s membrane. The last chapter was devoted to an exclusive study comparing the catalytic efficiency of a series of different synthesized pyridinium, phosphonium or imidazolium based ionic liquids, in the synthesis of a varied range of 4H-pyran derivatives by one pot Biginelli-like multi component reaction. |
| Diplôme : |
Doctorat |
| En ligne : |
../theses/chimie/RED7711.pdf |
| Format de la ressource électronique : |
pdf |
| Permalink : |
index.php?lvl=notice_display&id=11545 |
Synthèse, caractérisation et évaluation biologique De nouveaux dérivés hétérocycliques : 1,8-naphthyridines, gem-bisphosphonates et 4h-pyranes. [texte imprimé] / Mohamed Abdennour Redouane, Auteur ; N. Khiri-Meribout, Directeur de thèse ; M. Lecouvey, Directeur de thèse . - 03/03/2020 . - جامعة الإخوة منتوري قسنطينة, 2020 . - 204 f. ; 30 cm. Doctorat 3éme CYCLE LMD.
1 copies imprimées disponibles
Langues : Français ( fre)
| Catégories : |
Français - Anglais
Chimie
|
| Tags : |
Chimie: Chimie Organique [1,8]-naphthyridines pyrrolidines gem-bisphosphonates 4H-pyranes liquide ionique cycloaddition 1,3-dipolaire Click Chemistry réaction multicomposants inhibiteur d'AChE anti-Alzheimer anti-oxydant inhibiteur de FPPS voie mévalonate Zolédronate anti-cancer ionic liquid 1,3-dipolaire cycloaddition multi component reaction AChE inhibitor anti-oxidant FPPS inhibitor mevalonate pathway Zoledronate anti cancer [-]1,8النفثريدينات البيروليدين ثنائية الفسفونات المتجاورة -4ىيدرو بيران السائل الأيوني اضافة
حلقية ثنائية القطب- 1,3التف اعلات متعددة المركبات مثبطات استيل كولين إستراز مضادات الأكسدة مثبطات FPPS
مسار الميف الونات زوليدرونات مضاد للسرطان |
| Index. décimale : |
540 Chimie et sciences connexes |
| Résumé : |
In this manuscript, subdivided into three chapters, we are interested in the development of simple and effective new approaches for the synthesis of new functional and structural diversified heterocyclic and poly-heterocyclic systems, which represent potential biological activities. In the first chapter, we proceeded to the synthesis of the new [1,8] -naphthyridines derivatives and their tetracyclic analogs by the development of an efficient multi-step synthesis strategy. AChE and BuChE inhibition potency of synthesized products was evaluated in vitro as well as their antioxidant power. Analysis of obtained results as well as an additional study carried out by Molecular Doking confirmed the effectiveness of these molecules, specially compound 4, as multi-target agents for the treatment of AD. In the second chapter, we focused on the synthesis of new Zoledronate analogs, with a variously substituted triazole motif, via click chemistry reactions. These new gembisphosphonate derivatives was synthesized for the purpose of designing compounds with high FPPS inhibiting potency, as well as good passive penetration through the cancer cell’s membrane. The last chapter was devoted to an exclusive study comparing the catalytic efficiency of a series of different synthesized pyridinium, phosphonium or imidazolium based ionic liquids, in the synthesis of a varied range of 4H-pyran derivatives by one pot Biginelli-like multi component reaction. |
| Diplôme : |
Doctorat |
| En ligne : |
../theses/chimie/RED7711.pdf |
| Format de la ressource électronique : |
pdf |
| Permalink : |
index.php?lvl=notice_display&id=11545 |
|
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