| Titre : |
Reductive removal of trityl group from tetrazoles via indium : Zinc and Arene catalyzed lithiation |
| Type de document : |
texte imprimé |
| Auteurs : |
Kenza Bouchelouche, Auteur ; Cherif Behloul, Directeur de thèse |
| Editeur : |
جامعة الإخوة منتوري قسنطينة |
| Année de publication : |
2015 |
| Importance : |
202 f. |
| Format : |
30 cm. |
| Note générale : |
2 copies imprimes disponibles |
| Langues : |
Anglais (eng) |
| Catégories : |
Français - Anglais
Chimie
|
| Tags : |
chimie organique Tétrazoles protéction aréne lithiation cleavage zinc indium trityl Tetrazoles protection arene تيترازول ليثيوم حلقة ارينية حماية ازاحة زنك انديوم تريتيل |
| Index. décimale : |
540 Chimie et sciences connexes |
| Résumé : |
This manuscript describes the reductive removal of trityl groups from N-protected
tetrazoles, using indium, zinc and arene-catalysed lithiation processes.
Chapters 1 and 2 report the development of two efficient processes one for transforming a
wide variety of nitriles into the corresponding tetrazoles in high yield, using a simple and sofe
protocole, and other to protect tetrazoles wich is our starting materials.
Chapter 3 shows the deprotection of the trityl (triphenylmethyl) group, from tritylated
tetrazoles using lithium powder and a catalytic amount of naphtalene to give corresponding free
tetrazoles without decomposition of the tetrazole ring.
Chapter 4 describes the reductive cleavage of the same group from the same protected Ntetrazoles using indium as a source of free electron transfer which can show you a good method
even in the presence of the air moister.
Chapter 5 In the latter case, deals with the deblocking of tetrazoles, protected with trityl
group, respectively. Using in this case zinc as a dissolving metal in Methanol/THF, in the
opposite of lithium; this methodology led to the removal of this group from different tetrazoles
even in the presence of the proton source.
|
| Diplôme : |
Doctorat |
| En ligne : |
../theses/chimie/BOU6831.pdf |
| Format de la ressource électronique : |
pdf |
| Permalink : |
https://bu.umc.edu.dz/md/index.php?lvl=notice_display&id=10123 |
Reductive removal of trityl group from tetrazoles via indium : Zinc and Arene catalyzed lithiation [texte imprimé] / Kenza Bouchelouche, Auteur ; Cherif Behloul, Directeur de thèse . - جامعة الإخوة منتوري قسنطينة, 2015 . - 202 f. ; 30 cm. 2 copies imprimes disponibles Langues : Anglais ( eng)
| Catégories : |
Français - Anglais
Chimie
|
| Tags : |
chimie organique Tétrazoles protéction aréne lithiation cleavage zinc indium trityl Tetrazoles protection arene تيترازول ليثيوم حلقة ارينية حماية ازاحة زنك انديوم تريتيل |
| Index. décimale : |
540 Chimie et sciences connexes |
| Résumé : |
This manuscript describes the reductive removal of trityl groups from N-protected
tetrazoles, using indium, zinc and arene-catalysed lithiation processes.
Chapters 1 and 2 report the development of two efficient processes one for transforming a
wide variety of nitriles into the corresponding tetrazoles in high yield, using a simple and sofe
protocole, and other to protect tetrazoles wich is our starting materials.
Chapter 3 shows the deprotection of the trityl (triphenylmethyl) group, from tritylated
tetrazoles using lithium powder and a catalytic amount of naphtalene to give corresponding free
tetrazoles without decomposition of the tetrazole ring.
Chapter 4 describes the reductive cleavage of the same group from the same protected Ntetrazoles using indium as a source of free electron transfer which can show you a good method
even in the presence of the air moister.
Chapter 5 In the latter case, deals with the deblocking of tetrazoles, protected with trityl
group, respectively. Using in this case zinc as a dissolving metal in Methanol/THF, in the
opposite of lithium; this methodology led to the removal of this group from different tetrazoles
even in the presence of the proton source.
|
| Diplôme : |
Doctorat |
| En ligne : |
../theses/chimie/BOU6831.pdf |
| Format de la ressource électronique : |
pdf |
| Permalink : |
https://bu.umc.edu.dz/md/index.php?lvl=notice_display&id=10123 |
|
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