| Titre : |
Nouvelles voies de Synthèse des 1,4-dihydropyridines, polyhydroquinoléines et 1,4-benzoxazines |
| Type de document : |
texte imprimé |
| Auteurs : |
Louisa Chouguiat, Auteur ; Abdelmadjid Debache, Directeur de thèse |
| Editeur : |
جامعة الإخوة منتوري قسنطينة |
| Année de publication : |
2015 |
| Importance : |
201 f. |
| Format : |
30 cm. |
| Note générale : |
2 copies imprimées disponibles
|
| Langues : |
Français (fre) |
| Catégories : |
Français - Anglais
Chimie
|
| Tags : |
1,4-dihydropyridine polyhydroquinoléine Hantzsch t-BuOK tétrahydropyridines Bi(OTf)3 4-hydroxy-1,4-benzoxazine amines secondaire amination réductrice Petasis polyhydroquinoline tetrahydropyridines secondary amines reductive amination ديهيدروبيريدين بوليهيدروكينولين هانتش رباعي بيوتوكسيد البوتاسيوم تتراهيدروبيريدين تريفلات
البيسموث - 4هيدروكسي- -4,1بنزوكزازين الأمينات الثانوية تفاعل إرجاع أميني, بيتاسيس |
| Index. décimale : |
540 Chimie et sciences connexes |
| Résumé : |
The work undertaken through this thesis is part of the development of new synthetic methods leading to biologically interesting molecules, whose main objective was to carry out multicomponent reactions resulting in original molecules.
This thesis is divided into three main chapters: the first and the second were the
subject of the study of new synthetic routes to 1,4-dihydropyridine via Hantzsch reaction, and the synthesis of highly functionalized tetrahydropyridines respectively and using two new catalysts for these syntheses. However, the third chapter contains two parts: in the first part we realized the synthesis of a range of secondary amines which have served as the starting material for the second part, which deals with the preparation of a series of new derivatives 4-hydroxy-1,4-benzoxazine synthesized via the reaction Petasis.
In the first chapter, we have described the use of a novel catalyst in the multicomponent Hantzsch reaction. The t-BuOK which is a basic catalyst was used with a catalytic amount of 10 mol% and led to a series of 1,4-dihydropyridine and
polyhydroquinolines with good to excellent yields.
Like in the second chapter, we studied the synthesis of tetrahydropyridine but using a Lewis acid catalyst. It is a derivative of triflates: Bi (OTf) 3, which showed good catalytic activity envres this synthesis and leads to the production of desired molecules in good yields.
Finally, in the first part of the last chapter we have synthesized a series of secondary amines via reductive amination rection. However, in the second part of this chapter we have prepared a series of 2-hydroxy-1,4-benzoxazine in a Petasis type reaction, where the reaction is a cyclocondensation between the amino alcohol previously prepared in the first Part, boronic acid, and glyoxal. This reaction has allowed us to get nine new products with good to excellent yields, which were the subject of a paper. |
| Diplôme : |
Doctorat en sciences |
| En ligne : |
../theses/chimie/CHO6890.pdf |
| Format de la ressource électronique : |
pdf |
| Permalink : |
index.php?lvl=notice_display&id=10219 |
Nouvelles voies de Synthèse des 1,4-dihydropyridines, polyhydroquinoléines et 1,4-benzoxazines [texte imprimé] / Louisa Chouguiat, Auteur ; Abdelmadjid Debache, Directeur de thèse . - جامعة الإخوة منتوري قسنطينة, 2015 . - 201 f. ; 30 cm. 2 copies imprimées disponibles
Langues : Français ( fre)
| Catégories : |
Français - Anglais
Chimie
|
| Tags : |
1,4-dihydropyridine polyhydroquinoléine Hantzsch t-BuOK tétrahydropyridines Bi(OTf)3 4-hydroxy-1,4-benzoxazine amines secondaire amination réductrice Petasis polyhydroquinoline tetrahydropyridines secondary amines reductive amination ديهيدروبيريدين بوليهيدروكينولين هانتش رباعي بيوتوكسيد البوتاسيوم تتراهيدروبيريدين تريفلات
البيسموث - 4هيدروكسي- -4,1بنزوكزازين الأمينات الثانوية تفاعل إرجاع أميني, بيتاسيس |
| Index. décimale : |
540 Chimie et sciences connexes |
| Résumé : |
The work undertaken through this thesis is part of the development of new synthetic methods leading to biologically interesting molecules, whose main objective was to carry out multicomponent reactions resulting in original molecules.
This thesis is divided into three main chapters: the first and the second were the
subject of the study of new synthetic routes to 1,4-dihydropyridine via Hantzsch reaction, and the synthesis of highly functionalized tetrahydropyridines respectively and using two new catalysts for these syntheses. However, the third chapter contains two parts: in the first part we realized the synthesis of a range of secondary amines which have served as the starting material for the second part, which deals with the preparation of a series of new derivatives 4-hydroxy-1,4-benzoxazine synthesized via the reaction Petasis.
In the first chapter, we have described the use of a novel catalyst in the multicomponent Hantzsch reaction. The t-BuOK which is a basic catalyst was used with a catalytic amount of 10 mol% and led to a series of 1,4-dihydropyridine and
polyhydroquinolines with good to excellent yields.
Like in the second chapter, we studied the synthesis of tetrahydropyridine but using a Lewis acid catalyst. It is a derivative of triflates: Bi (OTf) 3, which showed good catalytic activity envres this synthesis and leads to the production of desired molecules in good yields.
Finally, in the first part of the last chapter we have synthesized a series of secondary amines via reductive amination rection. However, in the second part of this chapter we have prepared a series of 2-hydroxy-1,4-benzoxazine in a Petasis type reaction, where the reaction is a cyclocondensation between the amino alcohol previously prepared in the first Part, boronic acid, and glyoxal. This reaction has allowed us to get nine new products with good to excellent yields, which were the subject of a paper. |
| Diplôme : |
Doctorat en sciences |
| En ligne : |
../theses/chimie/CHO6890.pdf |
| Format de la ressource électronique : |
pdf |
| Permalink : |
index.php?lvl=notice_display&id=10219 |
|
Nouvelles voies de Synthèse des 1,4-dihydropyridines, polyhydroquinoléines et 1,4-benzoxazines
