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Auteur Abdelmadjid Debache |
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Affiner la recherche Interroger des sources externesNouvelles procédures « vertes » dans la synthèse des dérivés de la 3,4-dihydropyrimidin-2(1H)-one, de la 1,4-dihydropyridine et du tétrahydrobenzo[b]pyrane / Imane Sehout
Titre : Nouvelles procédures « vertes » dans la synthèse des dérivés de la 3,4-dihydropyrimidin-2(1H)-one, de la 1,4-dihydropyridine et du tétrahydrobenzo[b]pyrane Type de document : texte imprimé Auteurs : Imane Sehout, Auteur ; Abdelmadjid Debache, Directeur de thèse Editeur : constantine [Algérie] : Université Constantine 1 Année de publication : 2014 Importance : 207 f. Format : 30 cm. Note générale : 2 copies imprimées disponibles
Langues : Français (fre) Catégories : Français - Anglais
ChimieTags : synthèse organique chimie verte acide ascorbique acide acétylsalicylique réactions à composants multiples la réaction de Biginelli Hantzsch et la synthèse des benzopyranes green chemistry ascorbic acid acetylsalicylic acid multicomponent reactions the reaction of Biginelli Hantzsch and synthesis of benzopyran ??????? ??? ?????????? ??? ?????? ??????????? ????????? ???????? ???????? ????? ???????? ? ?????? ??????????? Index. décimale : 540 Chimie et sciences connexes Résumé : In this manuscript, we explained the purpose of our study, and the results obtained. We are interested in developing new protocols that fall within the field of green chemistry (sustainable chemistry) , offering two new Brϕnsted acids of natural origin catalysts ( ascorbic acid and acetylsalicylic acid); the reactions on which we did our study are multi-component reactions : reaction Biginelli , Hantzsch and synthesis of benzopyran which are divided into
three chapters.
The three reactions are carried out in a dry environment , which was a plus for our research, we could obtain very good results , that am for returns or for necessary for the progress of the reactions , we have also enriched the library of molecules, the production of new molecules with very good yields in record time.
Diplôme : Doctorat En ligne : ../theses/chimie/SEH6706.pdf Format de la ressource électronique : Permalink : https://bu.umc.edu.dz/md/index.php?lvl=notice_display&id=9917 Nouvelles procédures « vertes » dans la synthèse des dérivés de la 3,4-dihydropyrimidin-2(1H)-one, de la 1,4-dihydropyridine et du tétrahydrobenzo[b]pyrane [texte imprimé] / Imane Sehout, Auteur ; Abdelmadjid Debache, Directeur de thèse . - constantine (Route ain el bey, Algérie) : Université Constantine 1, 2014 . - 207 f. ; 30 cm.
2 copies imprimées disponibles
Langues : Français (fre)
Catégories : Français - Anglais
ChimieTags : synthèse organique chimie verte acide ascorbique acide acétylsalicylique réactions à composants multiples la réaction de Biginelli Hantzsch et la synthèse des benzopyranes green chemistry ascorbic acid acetylsalicylic acid multicomponent reactions the reaction of Biginelli Hantzsch and synthesis of benzopyran ??????? ??? ?????????? ??? ?????? ??????????? ????????? ???????? ???????? ????? ???????? ? ?????? ??????????? Index. décimale : 540 Chimie et sciences connexes Résumé : In this manuscript, we explained the purpose of our study, and the results obtained. We are interested in developing new protocols that fall within the field of green chemistry (sustainable chemistry) , offering two new Brϕnsted acids of natural origin catalysts ( ascorbic acid and acetylsalicylic acid); the reactions on which we did our study are multi-component reactions : reaction Biginelli , Hantzsch and synthesis of benzopyran which are divided into
three chapters.
The three reactions are carried out in a dry environment , which was a plus for our research, we could obtain very good results , that am for returns or for necessary for the progress of the reactions , we have also enriched the library of molecules, the production of new molecules with very good yields in record time.
Diplôme : Doctorat En ligne : ../theses/chimie/SEH6706.pdf Format de la ressource électronique : Permalink : https://bu.umc.edu.dz/md/index.php?lvl=notice_display&id=9917 Exemplaires (1)
Code-barres Cote Support Localisation Section Disponibilité SEH/6706 SEH/6706 Thèse Bibliothèque principale Thèses Disponible
Titre : Nouvelles voies d'accès a des molécules d'intér¼t biologique : acides allonorcoronamiques et 2-hydroxymorpholines Type de document : texte imprimé Auteurs : Abdelmadjid Debache ; Université Mentouri, Editeur scientifique ; B. Carboni, Directeur de thèse Année de publication : 2002 Importance : 110 f. Note générale : 01 Disponible dans la salle de recherche
02 Disponibles au magasin de la bibliothèque centraleLangues : Français (fre) Catégories : Français - Anglais
ChimieTags : Synthèse asymétrique Alpha-aminoacides Acides norcoronamiques Acides allonorcoronamiques Hyfroxymorpholines Index. décimale : 540 Chimie et sciences connexes Permalink : https://bu.umc.edu.dz/md/index.php?lvl=notice_display&id=4070 Nouvelles voies d'accès a des molécules d'intér¼t biologique : acides allonorcoronamiques et 2-hydroxymorpholines [texte imprimé] / Abdelmadjid Debache ; Université Mentouri, Editeur scientifique ; B. Carboni, Directeur de thèse . - 2002 . - 110 f.
01 Disponible dans la salle de recherche
02 Disponibles au magasin de la bibliothèque centrale
Langues : Français (fre)
Catégories : Français - Anglais
ChimieTags : Synthèse asymétrique Alpha-aminoacides Acides norcoronamiques Acides allonorcoronamiques Hyfroxymorpholines Index. décimale : 540 Chimie et sciences connexes Permalink : https://bu.umc.edu.dz/md/index.php?lvl=notice_display&id=4070 Exemplaires (1)
Code-barres Cote Support Localisation Section Disponibilité DEB/3667 DEB/3667 Thèse Bibliothèque principale Thèses Disponible
Titre : Nouvelles voies de Synthèse des 1,4-dihydropyranopyrazoles, tétrahydrobenzo[b]pyranes et β-acétamidoacétones. Type de document : texte imprimé Auteurs : Adil Ziadi Chibane, Auteur ; Abdelmadjid Debache, Directeur de thèse Editeur : جامعة الإخوة منتوري قسنطينة Année de publication : 2018 Importance : 176 f. Format : 30 cm. Note générale : 2 copies imprimées disponibles
Langues : Français (fre) Catégories : Français - Anglais
ChimieTags : dihydropyrano [2,3- c]pyrazoles tétrahydrobenzo[b]pyranes ?-acétamidocétones réactions
multicomposants acide phénylboronique acide de Lewis acétylacétonate d’aluminium anti
acétylcholinestérase anti butyrylcholinestérase multicomponent reactions phenylboronic acid Lewis acid aluminum acetylacetonate anti
acetylcholinesterase anti-butyrylcholinesterase -4 ,1?????????????[-3?2?] ??????? ???????????????[?]????? ???????????? ????? ??????? ?????? ???????? ???
????? ??????? ??? ????? ??????? ???????? ????????? ?? ???????? ????? ??????? ?????????? ????? ???????.Index. décimale : 540 Chimie et sciences connexes Résumé : The work undertaken through this thesis is part of the development of new procedures for the synthesis of molecules of biological interest, through multi-component reactions. The results obtained are presented in three main chapters: -In the first chapter we studied the catalytic effect of aluminum acetylacetonate on a fourcomponent reaction to access to 1,4-dihydropyrano [2,3-c] pyrazoles derivatives and wen proposed the optimal conditions for obtaining them with good yields. -The second chapter was devoted to the catalytic power of the same catalyst on the threecomponent synthesis of tetrahydrobenzo [b] pyrans, which have also been obtained, in general, with good yields. -As for the third chapter, it was devoted to the development of a new pathway to β- acetamidoketones, another class of molecules with interesting biological and medicinal properties, using phenylboronic acid, a Lewis acid catalyst, which has the advantage of being nontoxic, inexpensive and environmentally friendly. The yields obtained are good to excellent. In addition, the inhibitory activities of acetylcholinesterase and butyrylcholinesterase of certain molecules have been examined and proved to be of interest. All the synthesized products were identified by the usual spectrometric analyzes (IR, 1H NMR and 13C NMR).
Diplôme : Doctorat Permalink : https://bu.umc.edu.dz/md/index.php?lvl=notice_display&id=11003 Nouvelles voies de Synthèse des 1,4-dihydropyranopyrazoles, tétrahydrobenzo[b]pyranes et β-acétamidoacétones. [texte imprimé] / Adil Ziadi Chibane, Auteur ; Abdelmadjid Debache, Directeur de thèse . - [S.l.] : جامعة الإخوة منتوري قسنطينة, 2018 . - 176 f. ; 30 cm.
2 copies imprimées disponibles
Langues : Français (fre)
Catégories : Français - Anglais
ChimieTags : dihydropyrano [2,3- c]pyrazoles tétrahydrobenzo[b]pyranes ?-acétamidocétones réactions
multicomposants acide phénylboronique acide de Lewis acétylacétonate d’aluminium anti
acétylcholinestérase anti butyrylcholinestérase multicomponent reactions phenylboronic acid Lewis acid aluminum acetylacetonate anti
acetylcholinesterase anti-butyrylcholinesterase -4 ,1?????????????[-3?2?] ??????? ???????????????[?]????? ???????????? ????? ??????? ?????? ???????? ???
????? ??????? ??? ????? ??????? ???????? ????????? ?? ???????? ????? ??????? ?????????? ????? ???????.Index. décimale : 540 Chimie et sciences connexes Résumé : The work undertaken through this thesis is part of the development of new procedures for the synthesis of molecules of biological interest, through multi-component reactions. The results obtained are presented in three main chapters: -In the first chapter we studied the catalytic effect of aluminum acetylacetonate on a fourcomponent reaction to access to 1,4-dihydropyrano [2,3-c] pyrazoles derivatives and wen proposed the optimal conditions for obtaining them with good yields. -The second chapter was devoted to the catalytic power of the same catalyst on the threecomponent synthesis of tetrahydrobenzo [b] pyrans, which have also been obtained, in general, with good yields. -As for the third chapter, it was devoted to the development of a new pathway to β- acetamidoketones, another class of molecules with interesting biological and medicinal properties, using phenylboronic acid, a Lewis acid catalyst, which has the advantage of being nontoxic, inexpensive and environmentally friendly. The yields obtained are good to excellent. In addition, the inhibitory activities of acetylcholinesterase and butyrylcholinesterase of certain molecules have been examined and proved to be of interest. All the synthesized products were identified by the usual spectrometric analyzes (IR, 1H NMR and 13C NMR).
Diplôme : Doctorat Permalink : https://bu.umc.edu.dz/md/index.php?lvl=notice_display&id=11003 Exemplaires (1)
Code-barres Cote Support Localisation Section Disponibilité ZIA/7354 ZIA/7354 Thèse Bibliothèque principale Thèses Disponible
Titre : Nouvelles voies de Synthèse des 1,4-dihydropyridines, polyhydroquinoléines et 1,4-benzoxazines Type de document : texte imprimé Auteurs : Louisa Chouguiat, Auteur ; Abdelmadjid Debache, Directeur de thèse Editeur : جامعة الإخوة منتوري قسنطينة Année de publication : 2015 Importance : 201 f. Format : 30 cm. Note générale : 2 copies imprimées disponibles
Langues : Français (fre) Catégories : Français - Anglais
ChimieTags : 1,4-dihydropyridine polyhydroquinoléine Hantzsch t-BuOK tétrahydropyridines Bi(OTf)3 4-hydroxy-1,4-benzoxazine amines secondaire amination réductrice Petasis polyhydroquinoline tetrahydropyridines secondary amines reductive amination ?????????????? ???????????????? ????? ????? ????????? ?????????? ???????
???????? - 4????????- -4,1?????????? ???????? ???????? ????? ????? ?????, ???????Index. décimale : 540 Chimie et sciences connexes Résumé :
The work undertaken through this thesis is part of the development of new synthetic methods leading to biologically interesting molecules, whose main objective was to carry out multicomponent reactions resulting in original molecules.
This thesis is divided into three main chapters: the first and the second were the
subject of the study of new synthetic routes to 1,4-dihydropyridine via Hantzsch reaction, and the synthesis of highly functionalized tetrahydropyridines respectively and using two new catalysts for these syntheses. However, the third chapter contains two parts: in the first part we realized the synthesis of a range of secondary amines which have served as the starting material for the second part, which deals with the preparation of a series of new derivatives 4-hydroxy-1,4-benzoxazine synthesized via the reaction Petasis.
In the first chapter, we have described the use of a novel catalyst in the multicomponent Hantzsch reaction. The t-BuOK which is a basic catalyst was used with a catalytic amount of 10 mol% and led to a series of 1,4-dihydropyridine and
polyhydroquinolines with good to excellent yields.
Like in the second chapter, we studied the synthesis of tetrahydropyridine but using a Lewis acid catalyst. It is a derivative of triflates: Bi (OTf) 3, which showed good catalytic activity envres this synthesis and leads to the production of desired molecules in good yields.
Finally, in the first part of the last chapter we have synthesized a series of secondary amines via reductive amination rection. However, in the second part of this chapter we have prepared a series of 2-hydroxy-1,4-benzoxazine in a Petasis type reaction, where the reaction is a cyclocondensation between the amino alcohol previously prepared in the first Part, boronic acid, and glyoxal. This reaction has allowed us to get nine new products with good to excellent yields, which were the subject of a paper.Diplôme : Doctorat en sciences En ligne : ../theses/chimie/CHO6890.pdf Format de la ressource électronique : Permalink : https://bu.umc.edu.dz/md/index.php?lvl=notice_display&id=10219 Nouvelles voies de Synthèse des 1,4-dihydropyridines, polyhydroquinoléines et 1,4-benzoxazines [texte imprimé] / Louisa Chouguiat, Auteur ; Abdelmadjid Debache, Directeur de thèse . - [S.l.] : جامعة الإخوة منتوري قسنطينة, 2015 . - 201 f. ; 30 cm.
2 copies imprimées disponibles
Langues : Français (fre)
Catégories : Français - Anglais
ChimieTags : 1,4-dihydropyridine polyhydroquinoléine Hantzsch t-BuOK tétrahydropyridines Bi(OTf)3 4-hydroxy-1,4-benzoxazine amines secondaire amination réductrice Petasis polyhydroquinoline tetrahydropyridines secondary amines reductive amination ?????????????? ???????????????? ????? ????? ????????? ?????????? ???????
???????? - 4????????- -4,1?????????? ???????? ???????? ????? ????? ?????, ???????Index. décimale : 540 Chimie et sciences connexes Résumé :
The work undertaken through this thesis is part of the development of new synthetic methods leading to biologically interesting molecules, whose main objective was to carry out multicomponent reactions resulting in original molecules.
This thesis is divided into three main chapters: the first and the second were the
subject of the study of new synthetic routes to 1,4-dihydropyridine via Hantzsch reaction, and the synthesis of highly functionalized tetrahydropyridines respectively and using two new catalysts for these syntheses. However, the third chapter contains two parts: in the first part we realized the synthesis of a range of secondary amines which have served as the starting material for the second part, which deals with the preparation of a series of new derivatives 4-hydroxy-1,4-benzoxazine synthesized via the reaction Petasis.
In the first chapter, we have described the use of a novel catalyst in the multicomponent Hantzsch reaction. The t-BuOK which is a basic catalyst was used with a catalytic amount of 10 mol% and led to a series of 1,4-dihydropyridine and
polyhydroquinolines with good to excellent yields.
Like in the second chapter, we studied the synthesis of tetrahydropyridine but using a Lewis acid catalyst. It is a derivative of triflates: Bi (OTf) 3, which showed good catalytic activity envres this synthesis and leads to the production of desired molecules in good yields.
Finally, in the first part of the last chapter we have synthesized a series of secondary amines via reductive amination rection. However, in the second part of this chapter we have prepared a series of 2-hydroxy-1,4-benzoxazine in a Petasis type reaction, where the reaction is a cyclocondensation between the amino alcohol previously prepared in the first Part, boronic acid, and glyoxal. This reaction has allowed us to get nine new products with good to excellent yields, which were the subject of a paper.Diplôme : Doctorat en sciences En ligne : ../theses/chimie/CHO6890.pdf Format de la ressource électronique : Permalink : https://bu.umc.edu.dz/md/index.php?lvl=notice_display&id=10219 Exemplaires (1)
Code-barres Cote Support Localisation Section Disponibilité CHO/6890 CHO/6890 Thèse Bibliothèque principale Thèses Disponible
Titre : Synthèse de composés polyhétérocycliques par une réaction de couplage pallado-catalysée et de composés polycycliques à système rigide via la réaction d'addition-cyclisation Type de document : texte imprimé Auteurs : Besma Saoudi ép Djema, Auteur ; Abdelmadjid Debache, Directeur de thèse Editeur : جامعة الإخوة منتوري قسنطينة Année de publication : 2016 Importance : 138 f. Format : 30 cm. Note générale : 2 copies imprimes disponibles Langues : Français (fre) Catégories : Français - Anglais
ChimieTags : Heteroarylation reaction Heteroarenes addition- cyclisation Benzaldehyde Quinoxaline Réaction d’arylation Hétéro-arènes benzaldéhyde ????? ??????????? ????????? ????? ???? ????? ?????????? Index. décimale : 540 Chimie et sciences connexes Résumé : We prepared, in the first part of our work, the original heterocyclic derivatives by palladiumcatalyzed direct heteroarylation reaction of heteroarenes by chloride derivatives heteroarylsulfonyl.
The use of the catalytic system PdCl2 (CH3CN)2/Li2CO3 in middle 1,4-dioxane, developed in the
laboratory of Professor H. Doucet, proved to be the most suitable for the preparation, in one phase, of
poly–heterocycliques compounds.
Thus, we first synthesized a series of original heterocyclic derivatives (14 compounds) by a
coupling reaction involving the chloride thiophen-3-sulfonyl carrier of various groups (halogen, alkyl
or ester) in position α of the sulfur atom as the arylating agent, and hetero aryl groups such as Nmethyl-1H-pyrrole, furan and substituted benzofuran and benzothiophene.
Then, we have extended the reaction to the use of heterocyclic rings having as the heteroatom
nitrogen (methyl N-methyl-1H-pyrrol-2-carboxylate and pyridine) bearing a chlorosulfonyl group in
C-5 pyrrole and meta position of pyridine as arylating agents. We used as substrates N-methyl-1Hpyrrole and 2-butylfurane. Analysis of the overall results suggest that the presence of n-butyl group at
C-2 furan (donor group) '' deactivate '' C-H bonds in the heterocyclic ring.
In a second approach, we addressed the coupling of 4-(3-methyl-1H-pyrrazol-1-yl)benzen-1-
chlorosulfonyl, with two hetero five-membered, N-methyl-1H-pyrrole and 2-methylthiophene, under
the same conditions. The arylation reaction is successful and leads to the expected coupling products.
Finally, we have completed our investigations on the reaction pallado-catalyzed arylation by a
conventional coupling between the 2-(5-bromothiophen-2-yl)-1-methyl-1H-pyrrole with 2-ethyl
(isopropyl)-4-methylthiazole. To do this we used PdCl(C3H5)(dppb) as catalyst (2 mol%) in the excess
presence of KOAc (3 equiv.) in refluxing DMA: tricyclic compounds are obtained.
In the second part, a series of heterocyclic compounds poly-rigid system (fused), derivatives of
2,3-disubstituted-thieno[2,3-b]quinoxaline was prepared (13 compounds) by a reaction of additioncyclisation acid-catalysed of benzaldehyde derivatives in the 3-methylquinoxalin-2-thione. The results
of this study show that a substrate / aldehyde / acid 1: 2.2: 2 is the most appropriate, and sulfuric acid
is the most effective.
Yields are good in the majority of the feedback we have achieved. All the formulated products
were identified by conventional spectroscopic methods (1H-NMR, 13C-NMR), and for most further
analysis such as elementary analysis and another MS mass spectrometry were performed.Diplôme : Doctorat En ligne : ../theses/chimie/SAO6851.pdf Format de la ressource électronique : Permalink : https://bu.umc.edu.dz/md/index.php?lvl=notice_display&id=10148 Synthèse de composés polyhétérocycliques par une réaction de couplage pallado-catalysée et de composés polycycliques à système rigide via la réaction d'addition-cyclisation [texte imprimé] / Besma Saoudi ép Djema, Auteur ; Abdelmadjid Debache, Directeur de thèse . - [S.l.] : جامعة الإخوة منتوري قسنطينة, 2016 . - 138 f. ; 30 cm.
2 copies imprimes disponibles
Langues : Français (fre)
Catégories : Français - Anglais
ChimieTags : Heteroarylation reaction Heteroarenes addition- cyclisation Benzaldehyde Quinoxaline Réaction d’arylation Hétéro-arènes benzaldéhyde ????? ??????????? ????????? ????? ???? ????? ?????????? Index. décimale : 540 Chimie et sciences connexes Résumé : We prepared, in the first part of our work, the original heterocyclic derivatives by palladiumcatalyzed direct heteroarylation reaction of heteroarenes by chloride derivatives heteroarylsulfonyl.
The use of the catalytic system PdCl2 (CH3CN)2/Li2CO3 in middle 1,4-dioxane, developed in the
laboratory of Professor H. Doucet, proved to be the most suitable for the preparation, in one phase, of
poly–heterocycliques compounds.
Thus, we first synthesized a series of original heterocyclic derivatives (14 compounds) by a
coupling reaction involving the chloride thiophen-3-sulfonyl carrier of various groups (halogen, alkyl
or ester) in position α of the sulfur atom as the arylating agent, and hetero aryl groups such as Nmethyl-1H-pyrrole, furan and substituted benzofuran and benzothiophene.
Then, we have extended the reaction to the use of heterocyclic rings having as the heteroatom
nitrogen (methyl N-methyl-1H-pyrrol-2-carboxylate and pyridine) bearing a chlorosulfonyl group in
C-5 pyrrole and meta position of pyridine as arylating agents. We used as substrates N-methyl-1Hpyrrole and 2-butylfurane. Analysis of the overall results suggest that the presence of n-butyl group at
C-2 furan (donor group) '' deactivate '' C-H bonds in the heterocyclic ring.
In a second approach, we addressed the coupling of 4-(3-methyl-1H-pyrrazol-1-yl)benzen-1-
chlorosulfonyl, with two hetero five-membered, N-methyl-1H-pyrrole and 2-methylthiophene, under
the same conditions. The arylation reaction is successful and leads to the expected coupling products.
Finally, we have completed our investigations on the reaction pallado-catalyzed arylation by a
conventional coupling between the 2-(5-bromothiophen-2-yl)-1-methyl-1H-pyrrole with 2-ethyl
(isopropyl)-4-methylthiazole. To do this we used PdCl(C3H5)(dppb) as catalyst (2 mol%) in the excess
presence of KOAc (3 equiv.) in refluxing DMA: tricyclic compounds are obtained.
In the second part, a series of heterocyclic compounds poly-rigid system (fused), derivatives of
2,3-disubstituted-thieno[2,3-b]quinoxaline was prepared (13 compounds) by a reaction of additioncyclisation acid-catalysed of benzaldehyde derivatives in the 3-methylquinoxalin-2-thione. The results
of this study show that a substrate / aldehyde / acid 1: 2.2: 2 is the most appropriate, and sulfuric acid
is the most effective.
Yields are good in the majority of the feedback we have achieved. All the formulated products
were identified by conventional spectroscopic methods (1H-NMR, 13C-NMR), and for most further
analysis such as elementary analysis and another MS mass spectrometry were performed.Diplôme : Doctorat En ligne : ../theses/chimie/SAO6851.pdf Format de la ressource électronique : Permalink : https://bu.umc.edu.dz/md/index.php?lvl=notice_display&id=10148 Exemplaires (1)
Code-barres Cote Support Localisation Section Disponibilité SAO/6851 SAO/6851 Thèse Bibliothèque principale Thèses Disponible PermalinkPermalink
