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Partager le résultat de cette recherche Interroger des sources externesAccès rapide à des hétérocycles polyfonctionnalisés biologiquement actifs via des réactions multicomposants / Sara Mahdjoub
Titre : Accès rapide à des hétérocycles polyfonctionnalisés biologiquement actifs via des réactions multicomposants : Synthèse des 1,4-benzoxazines, α-aminoacides, 4Hchromenylphosphonates et pyrazolylphosphonates Type de document : texte imprimé Auteurs : Sara Mahdjoub, Auteur ; Raouf Boulcina, Directeur de thèse Editeur : جامعة الإخوة منتوري قسنطينة Année de publication : 2017 Importance : 198 f. Format : 30 cm. Note générale : 2 copies imprimées disponibles
Langues : Français (fre) Catégories : Français - Anglais
ChimieTags : réactions à composants multiples Petasis 2-hydroxy-1,4-benzoxazine PPTS ?-arylglycines organophosphorés nanocatalyse (2-amino-3-cyano-4H-chromén-4-
yl)phosphonates micro-ondes pyrazolylphosphonates multicomponent reactions organophosphorus compounds nanocatalysis microwave ????????? ???????? ???????? ??????? 2-????????-1?4-???????????? ??????-????????? ????????
????????? ??????? ???????? ???? ?????? ?????? ????????? ?? )2-?????- 3-?????-4?-??????-4-??(,
?????????? ????????? ?????? PPT"Index. décimale : 540 Chimie et sciences connexes Résumé : In this manuscript we interested in the development of reactions with multicomponent producing novel molecules through studying the efficiency of new catalysts.
This thesis consists of two main parts:
The first part has been devoted to the study of the Petasis reaction of and its applications to the synthesis of novel structures which could exhibit interesting biological properties. The first application of the Petasis reaction was the preparation of the novel 2- hydroxy-1,4-benzoxazine derivatives, developing a novel method of synthesis by using an ionic complex which was PPTS as a catalyst.
For the second application of the Petasis reaction, a series of novel α-arylglycine derivatives was prepared.
In the second part of this work, two new rapid methods have been developed for the synthesis of organophosphorus derivatives via multicomponent reactions. The first developed method was the nanocatalyzed synthesis which has been used for the preparation of (2-amino- 3-cyano-4H-chromen-4-yl) phosphonates derivatives.
The second method was microwave-assisted synthesis which has been employed for the preparation of novel pyrazolylphosphonate derivatives. These molecules which are bearing pyrazole skeletons could possess wide variety of pharmacological properties.Diplôme : Doctorat En ligne : ../theses/chimie/MAH7141.pdf Format de la ressource électronique : Permalink : https://bu.umc.edu.dz/md/index.php?lvl=notice_display&id=10461 Accès rapide à des hétérocycles polyfonctionnalisés biologiquement actifs via des réactions multicomposants : Synthèse des 1,4-benzoxazines, α-aminoacides, 4Hchromenylphosphonates et pyrazolylphosphonates [texte imprimé] / Sara Mahdjoub, Auteur ; Raouf Boulcina, Directeur de thèse . - [S.l.] : جامعة الإخوة منتوري قسنطينة, 2017 . - 198 f. ; 30 cm.
2 copies imprimées disponibles
Langues : Français (fre)
Catégories : Français - Anglais
ChimieTags : réactions à composants multiples Petasis 2-hydroxy-1,4-benzoxazine PPTS ?-arylglycines organophosphorés nanocatalyse (2-amino-3-cyano-4H-chromén-4-
yl)phosphonates micro-ondes pyrazolylphosphonates multicomponent reactions organophosphorus compounds nanocatalysis microwave ????????? ???????? ???????? ??????? 2-????????-1?4-???????????? ??????-????????? ????????
????????? ??????? ???????? ???? ?????? ?????? ????????? ?? )2-?????- 3-?????-4?-??????-4-??(,
?????????? ????????? ?????? PPT"Index. décimale : 540 Chimie et sciences connexes Résumé : In this manuscript we interested in the development of reactions with multicomponent producing novel molecules through studying the efficiency of new catalysts.
This thesis consists of two main parts:
The first part has been devoted to the study of the Petasis reaction of and its applications to the synthesis of novel structures which could exhibit interesting biological properties. The first application of the Petasis reaction was the preparation of the novel 2- hydroxy-1,4-benzoxazine derivatives, developing a novel method of synthesis by using an ionic complex which was PPTS as a catalyst.
For the second application of the Petasis reaction, a series of novel α-arylglycine derivatives was prepared.
In the second part of this work, two new rapid methods have been developed for the synthesis of organophosphorus derivatives via multicomponent reactions. The first developed method was the nanocatalyzed synthesis which has been used for the preparation of (2-amino- 3-cyano-4H-chromen-4-yl) phosphonates derivatives.
The second method was microwave-assisted synthesis which has been employed for the preparation of novel pyrazolylphosphonate derivatives. These molecules which are bearing pyrazole skeletons could possess wide variety of pharmacological properties.Diplôme : Doctorat En ligne : ../theses/chimie/MAH7141.pdf Format de la ressource électronique : Permalink : https://bu.umc.edu.dz/md/index.php?lvl=notice_display&id=10461 Exemplaires (1)
Code-barres Cote Support Localisation Section Disponibilité MAH/7141 MAH/7141 Thèse Bibliothèque principale Thèses Disponible
Titre : Élaboration de nouvelles voies catalytiques dans la synthese de molécules hétérocycliques Type de document : texte imprimé Auteurs : Faiza Boukezzoula, Auteur ; Taoues Boumoud, Directeur de thèse Editeur : جامعة الإخوة منتوري قسنطينة Année de publication : 2016 Importance : 196 f. Format : 30 cm. Note générale : 2 copies imprimées disponibles
Langues : Français (fre) Catégories : Français - Anglais
ChimieTags : hétérocycles synthèse convergente réactions à composants multiples catalyse
organique molécules chirales et achirales synthèse asymétrique liquides ioniques pyrazolopyranopyrimidines pyranopyrazoles spirooxindoles heterocyclic compounds convergent strategy MCRs Organocatalysis asymmetrical and symmetrical molecules asymmetric synthesis ionic liquids ???????? ??????? ????? ??????? ????????? ????????? ???????? ?????????? ???????? ??????? ???????? ????????? ?????????? ??????? ???????? ??????????????????????? ????????????? ?????? ???????Index. décimale : 540 Chimie et sciences connexes Résumé : The subject that we developed "Elaboration of novel catalytic methods for the synthesis of
heterocyclic molecules " summarizes:
- Through a bibliographical study which puts forward the heterocyclic compounds, the advantage of the reactions making their synthesis possible, in occurrence MCRs and the privilege of organic catalysis.
- Through a study of the catalytic properties of two molecules asymmetrical (DMAP and DABCO) and two symmetrical (L-Proline and Cinchonine) with respect to the synthesis of
pyrazolpyrnopyrimidindiones/ones and pyranopyrazoles, via multicomponent reactions
- Through a study of catalytic properties of two ionic liquids [MePPh3][Br] and [OPPh3][Br] in the synthesis of the spirooxindoles and the pyranopyrazoles. The results with [OPPh3][Br] are not as good as those obtained with [MePPh3][Br], which certainly due to its cumbersome properties.
- This study reinforced the idea of the organic catalysis in MCRs giving the
pyrazolopyranopyrimidindiones/ones the pyranopyrazoles and the spirooxindoles
heterocyclic compoundsDiplôme : Doctorat En ligne : ../theses/chimie/BOU6898.pdf Format de la ressource électronique : Permalink : https://bu.umc.edu.dz/md/index.php?lvl=notice_display&id=10228 Élaboration de nouvelles voies catalytiques dans la synthese de molécules hétérocycliques [texte imprimé] / Faiza Boukezzoula, Auteur ; Taoues Boumoud, Directeur de thèse . - [S.l.] : جامعة الإخوة منتوري قسنطينة, 2016 . - 196 f. ; 30 cm.
2 copies imprimées disponibles
Langues : Français (fre)
Catégories : Français - Anglais
ChimieTags : hétérocycles synthèse convergente réactions à composants multiples catalyse
organique molécules chirales et achirales synthèse asymétrique liquides ioniques pyrazolopyranopyrimidines pyranopyrazoles spirooxindoles heterocyclic compounds convergent strategy MCRs Organocatalysis asymmetrical and symmetrical molecules asymmetric synthesis ionic liquids ???????? ??????? ????? ??????? ????????? ????????? ???????? ?????????? ???????? ??????? ???????? ????????? ?????????? ??????? ???????? ??????????????????????? ????????????? ?????? ???????Index. décimale : 540 Chimie et sciences connexes Résumé : The subject that we developed "Elaboration of novel catalytic methods for the synthesis of
heterocyclic molecules " summarizes:
- Through a bibliographical study which puts forward the heterocyclic compounds, the advantage of the reactions making their synthesis possible, in occurrence MCRs and the privilege of organic catalysis.
- Through a study of the catalytic properties of two molecules asymmetrical (DMAP and DABCO) and two symmetrical (L-Proline and Cinchonine) with respect to the synthesis of
pyrazolpyrnopyrimidindiones/ones and pyranopyrazoles, via multicomponent reactions
- Through a study of catalytic properties of two ionic liquids [MePPh3][Br] and [OPPh3][Br] in the synthesis of the spirooxindoles and the pyranopyrazoles. The results with [OPPh3][Br] are not as good as those obtained with [MePPh3][Br], which certainly due to its cumbersome properties.
- This study reinforced the idea of the organic catalysis in MCRs giving the
pyrazolopyranopyrimidindiones/ones the pyranopyrazoles and the spirooxindoles
heterocyclic compoundsDiplôme : Doctorat En ligne : ../theses/chimie/BOU6898.pdf Format de la ressource électronique : Permalink : https://bu.umc.edu.dz/md/index.php?lvl=notice_display&id=10228 Exemplaires (1)
Code-barres Cote Support Localisation Section Disponibilité BOU/6898 BOU/6898 Thèse Bibliothèque principale Thèses Disponible
Titre : Nouvelles procédures « vertes » dans la synthèse des dérivés de la 3,4-dihydropyrimidin-2(1H)-one, de la 1,4-dihydropyridine et du tétrahydrobenzo[b]pyrane Type de document : texte imprimé Auteurs : Imane Sehout, Auteur ; Abdelmadjid Debache, Directeur de thèse Editeur : constantine [Algérie] : Université Constantine 1 Année de publication : 2014 Importance : 207 f. Format : 30 cm. Note générale : 2 copies imprimées disponibles
Langues : Français (fre) Catégories : Français - Anglais
ChimieTags : synthèse organique chimie verte acide ascorbique acide acétylsalicylique réactions à composants multiples la réaction de Biginelli Hantzsch et la synthèse des benzopyranes green chemistry ascorbic acid acetylsalicylic acid multicomponent reactions the reaction of Biginelli Hantzsch and synthesis of benzopyran ??????? ??? ?????????? ??? ?????? ??????????? ????????? ???????? ???????? ????? ???????? ? ?????? ??????????? Index. décimale : 540 Chimie et sciences connexes Résumé : In this manuscript, we explained the purpose of our study, and the results obtained. We are interested in developing new protocols that fall within the field of green chemistry (sustainable chemistry) , offering two new Brϕnsted acids of natural origin catalysts ( ascorbic acid and acetylsalicylic acid); the reactions on which we did our study are multi-component reactions : reaction Biginelli , Hantzsch and synthesis of benzopyran which are divided into
three chapters.
The three reactions are carried out in a dry environment , which was a plus for our research, we could obtain very good results , that am for returns or for necessary for the progress of the reactions , we have also enriched the library of molecules, the production of new molecules with very good yields in record time.
Diplôme : Doctorat En ligne : ../theses/chimie/SEH6706.pdf Format de la ressource électronique : Permalink : https://bu.umc.edu.dz/md/index.php?lvl=notice_display&id=9917 Nouvelles procédures « vertes » dans la synthèse des dérivés de la 3,4-dihydropyrimidin-2(1H)-one, de la 1,4-dihydropyridine et du tétrahydrobenzo[b]pyrane [texte imprimé] / Imane Sehout, Auteur ; Abdelmadjid Debache, Directeur de thèse . - constantine (Route ain el bey, Algérie) : Université Constantine 1, 2014 . - 207 f. ; 30 cm.
2 copies imprimées disponibles
Langues : Français (fre)
Catégories : Français - Anglais
ChimieTags : synthèse organique chimie verte acide ascorbique acide acétylsalicylique réactions à composants multiples la réaction de Biginelli Hantzsch et la synthèse des benzopyranes green chemistry ascorbic acid acetylsalicylic acid multicomponent reactions the reaction of Biginelli Hantzsch and synthesis of benzopyran ??????? ??? ?????????? ??? ?????? ??????????? ????????? ???????? ???????? ????? ???????? ? ?????? ??????????? Index. décimale : 540 Chimie et sciences connexes Résumé : In this manuscript, we explained the purpose of our study, and the results obtained. We are interested in developing new protocols that fall within the field of green chemistry (sustainable chemistry) , offering two new Brϕnsted acids of natural origin catalysts ( ascorbic acid and acetylsalicylic acid); the reactions on which we did our study are multi-component reactions : reaction Biginelli , Hantzsch and synthesis of benzopyran which are divided into
three chapters.
The three reactions are carried out in a dry environment , which was a plus for our research, we could obtain very good results , that am for returns or for necessary for the progress of the reactions , we have also enriched the library of molecules, the production of new molecules with very good yields in record time.
Diplôme : Doctorat En ligne : ../theses/chimie/SEH6706.pdf Format de la ressource électronique : Permalink : https://bu.umc.edu.dz/md/index.php?lvl=notice_display&id=9917 Exemplaires (1)
Code-barres Cote Support Localisation Section Disponibilité SEH/6706 SEH/6706 Thèse Bibliothèque principale Thèses Disponible
