| Titre : |
Nouvelles voies de Synthèse des 1,4-dihydropyranopyrazoles, tétrahydrobenzo[b]pyranes et β-acétamidoacétones. |
| Type de document : |
texte imprimé |
| Auteurs : |
Adil Ziadi Chibane, Auteur ; Abdelmadjid Debache, Directeur de thèse |
| Editeur : |
جامعة الإخوة منتوري قسنطينة |
| Année de publication : |
2018 |
| Importance : |
176 f. |
| Format : |
30 cm. |
| Note générale : |
2 copies imprimées disponibles
|
| Langues : |
Français (fre) |
| Tags : |
dihydropyrano [2,3- c]pyrazoles tétrahydrobenzo[b]pyranes ?-acétamidocétones réactions
multicomposants acide phénylboronique acide de Lewis acétylacétonate d’aluminium anti
acétylcholinestérase anti butyrylcholinestérase multicomponent reactions phenylboronic acid Lewis acid aluminum acetylacetonate anti
acetylcholinesterase anti-butyrylcholinesterase -4 ,1?????????????[-3?2?] ??????? ???????????????[?]????? ???????????? ????? ??????? ?????? ???????? ???
????? ??????? ??? ????? ??????? ???????? ????????? ?? ???????? ????? ??????? ?????????? ????? ???????. |
| Index. décimale : |
540 Chimie et sciences connexes |
| Résumé : |
The work undertaken through this thesis is part of the development of new procedures for the synthesis of molecules of biological interest, through multi-component reactions. The results obtained are presented in three main chapters: -In the first chapter we studied the catalytic effect of aluminum acetylacetonate on a fourcomponent reaction to access to 1,4-dihydropyrano [2,3-c] pyrazoles derivatives and wen proposed the optimal conditions for obtaining them with good yields. -The second chapter was devoted to the catalytic power of the same catalyst on the threecomponent synthesis of tetrahydrobenzo [b] pyrans, which have also been obtained, in general, with good yields. -As for the third chapter, it was devoted to the development of a new pathway to β- acetamidoketones, another class of molecules with interesting biological and medicinal properties, using phenylboronic acid, a Lewis acid catalyst, which has the advantage of being nontoxic, inexpensive and environmentally friendly. The yields obtained are good to excellent. In addition, the inhibitory activities of acetylcholinesterase and butyrylcholinesterase of certain molecules have been examined and proved to be of interest. All the synthesized products were identified by the usual spectrometric analyzes (IR, 1H NMR and 13C NMR).
|
| Diplôme : |
Doctorat |
| Permalink : |
https://bu.umc.edu.dz/md/index.php?lvl=notice_display&id=11003 |
Nouvelles voies de Synthèse des 1,4-dihydropyranopyrazoles, tétrahydrobenzo[b]pyranes et β-acétamidoacétones. [texte imprimé] / Adil Ziadi Chibane, Auteur ; Abdelmadjid Debache, Directeur de thèse . - [S.l.] : جامعة الإخوة منتوري قسنطينة, 2018 . - 176 f. ; 30 cm. 2 copies imprimées disponibles
Langues : Français ( fre)
| Tags : |
dihydropyrano [2,3- c]pyrazoles tétrahydrobenzo[b]pyranes ?-acétamidocétones réactions
multicomposants acide phénylboronique acide de Lewis acétylacétonate d’aluminium anti
acétylcholinestérase anti butyrylcholinestérase multicomponent reactions phenylboronic acid Lewis acid aluminum acetylacetonate anti
acetylcholinesterase anti-butyrylcholinesterase -4 ,1?????????????[-3?2?] ??????? ???????????????[?]????? ???????????? ????? ??????? ?????? ???????? ???
????? ??????? ??? ????? ??????? ???????? ????????? ?? ???????? ????? ??????? ?????????? ????? ???????. |
| Index. décimale : |
540 Chimie et sciences connexes |
| Résumé : |
The work undertaken through this thesis is part of the development of new procedures for the synthesis of molecules of biological interest, through multi-component reactions. The results obtained are presented in three main chapters: -In the first chapter we studied the catalytic effect of aluminum acetylacetonate on a fourcomponent reaction to access to 1,4-dihydropyrano [2,3-c] pyrazoles derivatives and wen proposed the optimal conditions for obtaining them with good yields. -The second chapter was devoted to the catalytic power of the same catalyst on the threecomponent synthesis of tetrahydrobenzo [b] pyrans, which have also been obtained, in general, with good yields. -As for the third chapter, it was devoted to the development of a new pathway to β- acetamidoketones, another class of molecules with interesting biological and medicinal properties, using phenylboronic acid, a Lewis acid catalyst, which has the advantage of being nontoxic, inexpensive and environmentally friendly. The yields obtained are good to excellent. In addition, the inhibitory activities of acetylcholinesterase and butyrylcholinesterase of certain molecules have been examined and proved to be of interest. All the synthesized products were identified by the usual spectrometric analyzes (IR, 1H NMR and 13C NMR).
|
| Diplôme : |
Doctorat |
| Permalink : |
https://bu.umc.edu.dz/md/index.php?lvl=notice_display&id=11003 |
|
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