| Titre : |
الدراسة الفیتوكیمیائیة و الفعالیة البیولوجیة للنوعین النباتیین Retama monosperma(L.) Boiss. (Fabaceae) Blackstonia grandiflora(Viv.) Maire. (Gantianaceae) |
| Type de document : |
texte imprimé |
| Auteurs : |
فاطمة الزھراء بالفاضل, Auteur ; كمال مجروبي, Directeur de thèse |
| Editeur : |
جامعة الإخوة منتوري قسنطينة |
| Année de publication : |
2017 |
| Importance : |
239 ورقة. |
| Format : |
30 سم. |
| Note générale : |
2نسخ موجودة مكتبة المركزية
|
| Langues : |
Arabe (ara) |
| Catégories : |
Arabe
الكيمياء و العلوم ذات العلاقة
|
| Tags : |
الفلافونیدات الزانثونات غلیكوزیدات سیكو-ازیدویدز النشاطیة المضاد للبكتیریا Flavonoids Xanthones Secoiridoids glycosides Anti bacterial antiglycation activity Gentianaceae Fabaceae Blackstonia grandiflora (Viv.) Maire Retama monosperma (L.) Activité anti bactérienne antiglycation |
| Index. décimale : |
540 الكيمياء و العلوم ذات العلاقة |
| Résumé : |
In this work, we focused on phytochemical and biological study of two plant species:
Retama monosperma (L.) (fabaceae) and Blackstonia grandiflora (Viv.) Maire
(Gentianaceae).
A phytochemical study of Blackstonia grandiflora aerial parts extracts lead to isolation
of new oxygenated xanthone named 1,8-dihydroxy-2,3,4- trimethoxyxanthone, as well as to
four known compounds namely methylswertianin; decussatin; halenaquinone and
gentiopicroside.
A detailed chemical investigation of the secondary metabolites from the extracts of
fruits of Retama monosperma lead to isolation of four known compounds namely
isorhamnetin; kaempferol; quercetin and genistein-8-C-glucoside. All compound structures
were determined by CPG-MS, 1 D and 2-D NMR techniques.
The compounds isolated from EtOAc extract of R. monosperma exhibited a great ability
to inhibit the formation of fluorescent AGEs in BSA/Ribose system, whereas the aerial parts
extracts from B. grandiflora showed a weak inhibitory ability against pentosidine-like AGE
formation. Those extracts displayed a moderate inhibitory potency against vesperlysine-like
AGE formation compared with the standard antiglycation agent aminoguanidine.
The study of anti bacterial activity of aerial parts extracts of B. grandiflora carried out
against two gram-negative bacteria (Escherichia coli ATCC 25922; Pseudomonas aeruginosa
ATCC 27853) and two gram-positive bacteria (Staphylococcus aureus ATCC 29213;
Bacillus sp.) using diffusion method. The results indicated a good inhibition of EtOAc extract
of bacterial growth especially gram-negative bacteria. Furthermore, CH2Cl2 extract showed a
significant inhibitory effect against gram-positive bacteria.
|
| Diplôme : |
Doctorat en sciences |
| En ligne : |
../theses/chimie/ABAL4194.pdf |
| Format de la ressource électronique : |
pdf |
| Permalink : |
index.php?lvl=notice_display&id=10680 |
الدراسة الفیتوكیمیائیة و الفعالیة البیولوجیة للنوعین النباتیین Retama monosperma(L.) Boiss. (Fabaceae) Blackstonia grandiflora(Viv.) Maire. (Gantianaceae) [texte imprimé] / فاطمة الزھراء بالفاضل, Auteur ; كمال مجروبي, Directeur de thèse . - جامعة الإخوة منتوري قسنطينة, 2017 . - 239 ورقة. ; 30 سم. 2نسخ موجودة مكتبة المركزية
Langues : Arabe ( ara)
| Catégories : |
Arabe
الكيمياء و العلوم ذات العلاقة
|
| Tags : |
الفلافونیدات الزانثونات غلیكوزیدات سیكو-ازیدویدز النشاطیة المضاد للبكتیریا Flavonoids Xanthones Secoiridoids glycosides Anti bacterial antiglycation activity Gentianaceae Fabaceae Blackstonia grandiflora (Viv.) Maire Retama monosperma (L.) Activité anti bactérienne antiglycation |
| Index. décimale : |
540 الكيمياء و العلوم ذات العلاقة |
| Résumé : |
In this work, we focused on phytochemical and biological study of two plant species:
Retama monosperma (L.) (fabaceae) and Blackstonia grandiflora (Viv.) Maire
(Gentianaceae).
A phytochemical study of Blackstonia grandiflora aerial parts extracts lead to isolation
of new oxygenated xanthone named 1,8-dihydroxy-2,3,4- trimethoxyxanthone, as well as to
four known compounds namely methylswertianin; decussatin; halenaquinone and
gentiopicroside.
A detailed chemical investigation of the secondary metabolites from the extracts of
fruits of Retama monosperma lead to isolation of four known compounds namely
isorhamnetin; kaempferol; quercetin and genistein-8-C-glucoside. All compound structures
were determined by CPG-MS, 1 D and 2-D NMR techniques.
The compounds isolated from EtOAc extract of R. monosperma exhibited a great ability
to inhibit the formation of fluorescent AGEs in BSA/Ribose system, whereas the aerial parts
extracts from B. grandiflora showed a weak inhibitory ability against pentosidine-like AGE
formation. Those extracts displayed a moderate inhibitory potency against vesperlysine-like
AGE formation compared with the standard antiglycation agent aminoguanidine.
The study of anti bacterial activity of aerial parts extracts of B. grandiflora carried out
against two gram-negative bacteria (Escherichia coli ATCC 25922; Pseudomonas aeruginosa
ATCC 27853) and two gram-positive bacteria (Staphylococcus aureus ATCC 29213;
Bacillus sp.) using diffusion method. The results indicated a good inhibition of EtOAc extract
of bacterial growth especially gram-negative bacteria. Furthermore, CH2Cl2 extract showed a
significant inhibitory effect against gram-positive bacteria.
|
| Diplôme : |
Doctorat en sciences |
| En ligne : |
../theses/chimie/ABAL4194.pdf |
| Format de la ressource électronique : |
pdf |
| Permalink : |
index.php?lvl=notice_display&id=10680 |
|
الدراسة الفیتوكیمیائیة و الفعالیة البیولوجیة للنوعین النباتیین Retama monosperma(L.) Boiss. (Fabaceae) Blackstonia grandiflora(Viv.) Maire. (Gantianaceae)
