Résultat de la recherche
15 recherche sur le tag
'Fabaceae' 
Affiner la recherche Générer le flux rss de la recherche
Partager le résultat de cette recherche Interroger des sources externesEtude phytochimique et biologique de Bituminaria bituminosa(L.)C.H.Stirton (Fabaceae) et Centaaurea dimorphaViv. (Asteraceae) / Salima Azzouzi ep Ouchtati
Titre : Etude phytochimique et biologique de Bituminaria bituminosa(L.)C.H.Stirton (Fabaceae) et Centaaurea dimorphaViv. (Asteraceae) Type de document : texte imprimé Auteurs : Salima Azzouzi ep Ouchtati, Auteur ; Kamel Medjroubi, Directeur de thèse Editeur : جامعة الإخوة منتوري قسنطينة Année de publication : 2016 Importance : 135 f. Format : 30 cm. Note générale : 2 copies imprimées disponibles
Langues : Français (fre) Catégories : Français - Anglais
ChimieTags : Fabaceae Asteracea Bituminaria bituminosa Centaurea dimorpha antioxydante activité antibactérienne antioxidant antibacterial activity العائلة الباقولیة العائلة المركبة مضادة للاكسدة فعالیة مضادة للبكتیریا Index. décimale : 540 Chimie et sciences connexes Résumé : Our research includes the stady of the phytochemical and biological aspects of the two presented species Bituminaria bituminosa(L.) C.H.Stirton. which belongs to Fabaceae family and Centaurea dimorpha Viv. which belongs to Asteraceae family.
Several chromatographic methods were used in our work. Thes methods allowed us to isolate four products from B.bituminosa plant (only three have been identified), and five products from C.dimorpha plant (only four have been identified).
The identification of structures has been realised by combining the different spectrometric and spectroscopic methods (SMES, UV, RMN-1D,2D).
Butanolic extract of B.bituminosa species showed a weak antioxidant capacity. The various extracts of the two studied plants have shown a good antibacterial activity.Diplôme : Doctorat en sciences En ligne : ../theses/chimie/AZZ6871.pdf Format de la ressource électronique : Permalink : index.php?lvl=notice_display&id=10185 Etude phytochimique et biologique de Bituminaria bituminosa(L.)C.H.Stirton (Fabaceae) et Centaaurea dimorphaViv. (Asteraceae) [texte imprimé] / Salima Azzouzi ep Ouchtati, Auteur ; Kamel Medjroubi, Directeur de thèse . - جامعة الإخوة منتوري قسنطينة, 2016 . - 135 f. ; 30 cm.
2 copies imprimées disponibles
Langues : Français (fre)
Catégories : Français - Anglais
ChimieTags : Fabaceae Asteracea Bituminaria bituminosa Centaurea dimorpha antioxydante activité antibactérienne antioxidant antibacterial activity العائلة الباقولیة العائلة المركبة مضادة للاكسدة فعالیة مضادة للبكتیریا Index. décimale : 540 Chimie et sciences connexes Résumé : Our research includes the stady of the phytochemical and biological aspects of the two presented species Bituminaria bituminosa(L.) C.H.Stirton. which belongs to Fabaceae family and Centaurea dimorpha Viv. which belongs to Asteraceae family.
Several chromatographic methods were used in our work. Thes methods allowed us to isolate four products from B.bituminosa plant (only three have been identified), and five products from C.dimorpha plant (only four have been identified).
The identification of structures has been realised by combining the different spectrometric and spectroscopic methods (SMES, UV, RMN-1D,2D).
Butanolic extract of B.bituminosa species showed a weak antioxidant capacity. The various extracts of the two studied plants have shown a good antibacterial activity.Diplôme : Doctorat en sciences En ligne : ../theses/chimie/AZZ6871.pdf Format de la ressource électronique : Permalink : index.php?lvl=notice_display&id=10185 Exemplaires (1)
Code-barres Cote Support Localisation Section Disponibilité AZZ/6871 AZZ/6871 Thèse Bibliothèque principale Thèses Disponible
Titre : L’étude phytochimique et biologique des métabolismes secondaire de deux espèces de la famille des Fabaceae : Ononis angustissima Lam. Var et Lotus corniculatus L. Type de document : texte imprimé Auteurs : Abderrahmane Mezrag, Auteur ; Mohamed Bouheroum, Directeur de thèse Editeur : جامعة الإخوة منتوري قسنطينة Année de publication : 2019 Importance : 274 f. Format : 30 cm. Note générale : 1 copies imprimées disponibles
Langues : Français (fre) Catégories : Français - Anglais
ChimieTags : Chimie organique : phytochimie Fabaceae Ononis angustissima Lam. Var Lotus corniculatus L activité
antioxydante RMN 1D and 2D Flavonoïdes agents antioxydants application thérapeutique antioxidant activity NMR 1D and 2D Flavonoïds class antioxidants therapeutic applications نشاط مضاد للأكسدة فعالية بيولوجية فلافونويداتIndex. décimale : 540 Chimie et sciences connexes Résumé :
Our phytochemical and biological work concerns the aerial parts of two endemic Saharan species belonging to the Fabaceae family: Ononis angustissima Lam. Var and Lotus corniculatus L. Several chromatographic methods were used in our experimental work which allowed us to isolate nineteen products from the butanolic extract of Ononis angustissima Lam. Var. from which two are new, and eight products from Lotus corniculatus L. The structures were established by different spectral methods: nuclear magnetic resonance with different applications (NMR 1H, NMR 13C, DEPT, COSY, HMQC and HMBC), the mass spectrometry, UV, as well as comparison with literature data. The antiproliferative activity tests of the n-butanol extract and the compounds isolated from L. corniculatus were carried out on three cell lines: J774.A1 (murine macrophages monocytes), WEHI-164 (murine fibrosarcoma) and HEK-293 (human epithelial renal cells) have shown that the n-butanol extract and the pharbitoside A compound are the most active against the three cell lines. The two extracts and most of the isolated compounds of Ononis angustissima Lam. Var have excellent activity, so these molecules are considered first class antioxidants compared to reference molecules. They can therefore be used for therapeutic applications. Finally, the quantitative estimate of total polyphenols has shown that these extracts have a high content of polyphenols.Note de contenu :
Annexes.Diplôme : Doctorat en sciences En ligne : ../theses/chimie/MEZ7553.pdf Format de la ressource électronique : Permalink : index.php?lvl=notice_display&id=11391 L’étude phytochimique et biologique des métabolismes secondaire de deux espèces de la famille des Fabaceae : Ononis angustissima Lam. Var et Lotus corniculatus L. [texte imprimé] / Abderrahmane Mezrag, Auteur ; Mohamed Bouheroum, Directeur de thèse . - جامعة الإخوة منتوري قسنطينة, 2019 . - 274 f. ; 30 cm.
1 copies imprimées disponibles
Langues : Français (fre)
Catégories : Français - Anglais
ChimieTags : Chimie organique : phytochimie Fabaceae Ononis angustissima Lam. Var Lotus corniculatus L activité
antioxydante RMN 1D and 2D Flavonoïdes agents antioxydants application thérapeutique antioxidant activity NMR 1D and 2D Flavonoïds class antioxidants therapeutic applications نشاط مضاد للأكسدة فعالية بيولوجية فلافونويداتIndex. décimale : 540 Chimie et sciences connexes Résumé :
Our phytochemical and biological work concerns the aerial parts of two endemic Saharan species belonging to the Fabaceae family: Ononis angustissima Lam. Var and Lotus corniculatus L. Several chromatographic methods were used in our experimental work which allowed us to isolate nineteen products from the butanolic extract of Ononis angustissima Lam. Var. from which two are new, and eight products from Lotus corniculatus L. The structures were established by different spectral methods: nuclear magnetic resonance with different applications (NMR 1H, NMR 13C, DEPT, COSY, HMQC and HMBC), the mass spectrometry, UV, as well as comparison with literature data. The antiproliferative activity tests of the n-butanol extract and the compounds isolated from L. corniculatus were carried out on three cell lines: J774.A1 (murine macrophages monocytes), WEHI-164 (murine fibrosarcoma) and HEK-293 (human epithelial renal cells) have shown that the n-butanol extract and the pharbitoside A compound are the most active against the three cell lines. The two extracts and most of the isolated compounds of Ononis angustissima Lam. Var have excellent activity, so these molecules are considered first class antioxidants compared to reference molecules. They can therefore be used for therapeutic applications. Finally, the quantitative estimate of total polyphenols has shown that these extracts have a high content of polyphenols.Note de contenu :
Annexes.Diplôme : Doctorat en sciences En ligne : ../theses/chimie/MEZ7553.pdf Format de la ressource électronique : Permalink : index.php?lvl=notice_display&id=11391 Exemplaires (1)
Code-barres Cote Support Localisation Section Disponibilité MEZ/7553 MEZ/7553 Thèse Bibliothèque principale Thèses Disponible
Titre : Etude phytochimique et évaluation biologique d’une plante endémique du genre Genista (Fabaceae) : Genista numidica Spach. Type de document : texte imprimé Auteurs : Feryal Benayache, Auteur ; Samir Benayache, Directeur de thèse Editeur : جامعة الإخوة منتوري قسنطينة Année de publication : 2019 Importance : 194 f. Format : 30 cm. Note générale : 2 copies imprimées disponibles
Langues : Français (fre) Catégories : Français - Anglais
ChimieTags : Chimie organique : phytochimie Fabacées Genista numidica lignanes triterpènes activité antioxydante activité cytotoxique RMN 1D et 2D Fabaceae lignans Triterpenoid antioxidant activity Cytotoxic activity NMR 1D and 2D تربينات النشاط المضاد الاكسدة النشاط السام للخلايا الرنين النووي المغناطيسي Index. décimale : 540 Chimie et sciences connexes Résumé : The present work concerns the phytochemical and biological study of an endemic species belonging to the Fabaceae family: Genista numidica Spach which has been collected from the region of Constantine. Our work on the extraction of the aerial parts of G. numidica followed by the chromatographic separation permitted the isolation of 14 secondary metabolites from the chloroformic and ethyl acetate extracts. The structures of 13 were identified and fully described, including a new triterpene. The molecular structures of isolated compounds were established mainly by the use of NMR 1D and 2D (1H, 13C, TOCSY-1D, COSY, HSQC and HMBC), high resolution mass spectrometry (HRESI-MS) and by comparison with the literature Data. The antioxidant activity of CHCl3, EtOAc and n-BuOH extracts of G.numidica has been investigated by DPPH test, the results showed that the ethyl acetate extract has a good scavenging effect in vitro against the DPPH radical (IC50 = 40.43 ±3.09 µg / ml). The antiproliferative activity of isolates ( lignans and saponins) was investigated on Jurkat, HeLa and MCF-7 cell lines. The most active component, the triterpene, 3-O- β-D-glucopyranosyl-olean-12-en-3β,27,28,29-tetraol, showed activity in all cell lines, an IC50 value of 37 ± 2.3 µM (Jurkat), 35 ± 1.7 µM (HeLa) and 50 ± 3.6 µM (MCF-7) respectively. The mechanism underlying its antiproliferative effect was investigated in HeLa cells. The results showed that this compound affect the cell cycle progression by inducing a robust G2/M bloc in HeLa cells. Note de contenu : Annexe. Diplôme : Doctorat en sciences En ligne : ../theses/chimie/BEN7494.pdf Format de la ressource électronique : Permalink : index.php?lvl=notice_display&id=11326 Etude phytochimique et évaluation biologique d’une plante endémique du genre Genista (Fabaceae) : Genista numidica Spach. [texte imprimé] / Feryal Benayache, Auteur ; Samir Benayache, Directeur de thèse . - جامعة الإخوة منتوري قسنطينة, 2019 . - 194 f. ; 30 cm.
2 copies imprimées disponibles
Langues : Français (fre)
Catégories : Français - Anglais
ChimieTags : Chimie organique : phytochimie Fabacées Genista numidica lignanes triterpènes activité antioxydante activité cytotoxique RMN 1D et 2D Fabaceae lignans Triterpenoid antioxidant activity Cytotoxic activity NMR 1D and 2D تربينات النشاط المضاد الاكسدة النشاط السام للخلايا الرنين النووي المغناطيسي Index. décimale : 540 Chimie et sciences connexes Résumé : The present work concerns the phytochemical and biological study of an endemic species belonging to the Fabaceae family: Genista numidica Spach which has been collected from the region of Constantine. Our work on the extraction of the aerial parts of G. numidica followed by the chromatographic separation permitted the isolation of 14 secondary metabolites from the chloroformic and ethyl acetate extracts. The structures of 13 were identified and fully described, including a new triterpene. The molecular structures of isolated compounds were established mainly by the use of NMR 1D and 2D (1H, 13C, TOCSY-1D, COSY, HSQC and HMBC), high resolution mass spectrometry (HRESI-MS) and by comparison with the literature Data. The antioxidant activity of CHCl3, EtOAc and n-BuOH extracts of G.numidica has been investigated by DPPH test, the results showed that the ethyl acetate extract has a good scavenging effect in vitro against the DPPH radical (IC50 = 40.43 ±3.09 µg / ml). The antiproliferative activity of isolates ( lignans and saponins) was investigated on Jurkat, HeLa and MCF-7 cell lines. The most active component, the triterpene, 3-O- β-D-glucopyranosyl-olean-12-en-3β,27,28,29-tetraol, showed activity in all cell lines, an IC50 value of 37 ± 2.3 µM (Jurkat), 35 ± 1.7 µM (HeLa) and 50 ± 3.6 µM (MCF-7) respectively. The mechanism underlying its antiproliferative effect was investigated in HeLa cells. The results showed that this compound affect the cell cycle progression by inducing a robust G2/M bloc in HeLa cells. Note de contenu : Annexe. Diplôme : Doctorat en sciences En ligne : ../theses/chimie/BEN7494.pdf Format de la ressource électronique : Permalink : index.php?lvl=notice_display&id=11326 Exemplaires (1)
Code-barres Cote Support Localisation Section Disponibilité BEN/7494 BEN/7494 Thèse Bibliothèque principale Thèses Disponible
Titre : Etude phytochimique et pharmacologique de Crataegus oxyacantha L. (Rosaceae) et Cytisus triflorus L’Her. (Fabaceae). Type de document : texte imprimé Auteurs : Wassila Benabderrahmane, Auteur ; Ouahiba Benaissa, Directeur de thèse Editeur : جامعة الإخوة منتوري قسنطينة Année de publication : 2019 Importance : 234 f. Format : 30 cm. Note générale : 2 copies imprimées disponibles
Langues : Français (fre) Catégories : Français - Anglais
ChimieTags : Chimie organique: phytochimie Rosaceae Fabaceae Crataegus oxyacantha Cytisus triflorus Flavonoïdes composés phénoliques Activité antioxydante Activité antimicrobienne RMN 1D et 2D HPLC-DAD Flavonoids Phenolic compounds Antioxidant activity Antimicrobial activity 1D and 2D NMR HPLCDAD فلافونويدات مركبات فينولية النشاط المضاد للأكسدة النشاط المصاد للميكروبات Index. décimale : 540 Chimie et sciences connexes Résumé :
The work presented in this thesis contributes to the valorization of both Algerian medicinal plants (Crataegus oxyacantha L. (Rosaceae) and Cytisus triflorus L'Her. (Fabaceae) by characterizing them by a phytochemical study, an evaluation of the antioxidant and antimicrobial activities, and a structural identification of certain phenolic compounds. Thus, in order to obtain an extract enriched in metabolites of interest, flavonoids, we opted for two extraction methods, a liquid solid extraction using different solvents of increasing polarity (CHCl3, EtOAc and n-Butanol) and a second extraction using the Matrix solid phase dispersion (MSPD) method, using different solvents of increasing polarity (100% H2O, 1:1 H2O / EtOH and 100% EtOH).
This study allowed the isolation 21 compounds and structural elucidation of 16 compounds.
Of these 16 compounds, 3 acids and 7 flavonoids: (3 flavonols including 1 glucosyl, 1 glucosyl flavanone, 1 Flavanol and 2 flavones) were isolated from C. oxyacantha L. From the EtOAc extract the aerial parts (Flowers + Leaves) of the species Cytisus triflorus L'Her., 6 secondary metabolites were identified (flavonoids). Among these compounds, 3 flavones: (Chrysin, Prunetin) and 3 glucosyl flavonoids (2 Chrysine and Isoquercitrin). Of these isolated compounds, 3 new in the species. These major active ingredients possess various biological activities and play an important and acknowledged role in maintaining good health. The structures of the isolated compounds were established by HPLC-DAD chromatogram analysis, UV-vis spectra and high resolution electrospray mass spectra (HRESI-MS), by extensive use and interpretation of NMR experiments spectra : 1D NMR (1H, 13C and DEPT) and 2D NMR (COSY, HSQC and HMBC) and by comparison with the literature data. The in vitro evaluation antioxidant activity of the various extracts and of three isolated products of C. oxyacantha, and the AcOEt extract and three products isolated from C. triflorus was performed by the radical scavenging method (DPPH *). The extracts of two plants have interesting antioxidant activities, dependent on the content of total polyphenols and flavonoids. The various extracts studied were also revealed a high antibacterial activity towards S. aureus. Similarly, a tendency shown indicating that the richest extracts of flavonoids and polyphenols exhibit the higher antibacterial activities.Note de contenu :
Annexe.Diplôme : Doctorat en sciences En ligne : ../theses/chimie/BEN7472.pdf Format de la ressource électronique : Permalink : index.php?lvl=notice_display&id=11304 Etude phytochimique et pharmacologique de Crataegus oxyacantha L. (Rosaceae) et Cytisus triflorus L’Her. (Fabaceae). [texte imprimé] / Wassila Benabderrahmane, Auteur ; Ouahiba Benaissa, Directeur de thèse . - جامعة الإخوة منتوري قسنطينة, 2019 . - 234 f. ; 30 cm.
2 copies imprimées disponibles
Langues : Français (fre)
Catégories : Français - Anglais
ChimieTags : Chimie organique: phytochimie Rosaceae Fabaceae Crataegus oxyacantha Cytisus triflorus Flavonoïdes composés phénoliques Activité antioxydante Activité antimicrobienne RMN 1D et 2D HPLC-DAD Flavonoids Phenolic compounds Antioxidant activity Antimicrobial activity 1D and 2D NMR HPLCDAD فلافونويدات مركبات فينولية النشاط المضاد للأكسدة النشاط المصاد للميكروبات Index. décimale : 540 Chimie et sciences connexes Résumé :
The work presented in this thesis contributes to the valorization of both Algerian medicinal plants (Crataegus oxyacantha L. (Rosaceae) and Cytisus triflorus L'Her. (Fabaceae) by characterizing them by a phytochemical study, an evaluation of the antioxidant and antimicrobial activities, and a structural identification of certain phenolic compounds. Thus, in order to obtain an extract enriched in metabolites of interest, flavonoids, we opted for two extraction methods, a liquid solid extraction using different solvents of increasing polarity (CHCl3, EtOAc and n-Butanol) and a second extraction using the Matrix solid phase dispersion (MSPD) method, using different solvents of increasing polarity (100% H2O, 1:1 H2O / EtOH and 100% EtOH).
This study allowed the isolation 21 compounds and structural elucidation of 16 compounds.
Of these 16 compounds, 3 acids and 7 flavonoids: (3 flavonols including 1 glucosyl, 1 glucosyl flavanone, 1 Flavanol and 2 flavones) were isolated from C. oxyacantha L. From the EtOAc extract the aerial parts (Flowers + Leaves) of the species Cytisus triflorus L'Her., 6 secondary metabolites were identified (flavonoids). Among these compounds, 3 flavones: (Chrysin, Prunetin) and 3 glucosyl flavonoids (2 Chrysine and Isoquercitrin). Of these isolated compounds, 3 new in the species. These major active ingredients possess various biological activities and play an important and acknowledged role in maintaining good health. The structures of the isolated compounds were established by HPLC-DAD chromatogram analysis, UV-vis spectra and high resolution electrospray mass spectra (HRESI-MS), by extensive use and interpretation of NMR experiments spectra : 1D NMR (1H, 13C and DEPT) and 2D NMR (COSY, HSQC and HMBC) and by comparison with the literature data. The in vitro evaluation antioxidant activity of the various extracts and of three isolated products of C. oxyacantha, and the AcOEt extract and three products isolated from C. triflorus was performed by the radical scavenging method (DPPH *). The extracts of two plants have interesting antioxidant activities, dependent on the content of total polyphenols and flavonoids. The various extracts studied were also revealed a high antibacterial activity towards S. aureus. Similarly, a tendency shown indicating that the richest extracts of flavonoids and polyphenols exhibit the higher antibacterial activities.Note de contenu :
Annexe.Diplôme : Doctorat en sciences En ligne : ../theses/chimie/BEN7472.pdf Format de la ressource électronique : Permalink : index.php?lvl=notice_display&id=11304 Exemplaires (1)
Code-barres Cote Support Localisation Section Disponibilité BEN/7472 BEN/7472 Thèse Bibliothèque principale Thèses Disponible
Titre : Etude phytochimique et pharmacologique de plantes médicinales Algériennes Genista ulicina Spach (Fabaceae) et Chrysanthemum macrocarpum (Sch. Bip.) Coss. & Kralik ex Batt (Asteraceae) Type de document : texte imprimé Auteurs : Naima Boutaghane, Auteur ; Zahia Kabouche, Directeur de thèse ; Laurence Voutquenne, Directeur de thèse Editeur : constantine [Algérie] : Université Constantine 1 Année de publication : 2013 Importance : 270 f. Format : 30 cm. Note générale : 2 copies imprimées disponibles Langues : Français (fre) Catégories : Français - Anglais
ChimieTags : Fabaceae Asteraceae Genista ulicina Chrysanthemum macrocarpum cyclitols Saponines flavonoïdes Huile essentielle activités biologiques RMN 1D et 2D Spectrométrie de masse Saponins flavonoids essential oil biological activities NMR 1D and 2D mass spectroscopy الصابونين الفلافونيدات الزيوت الطيارة مطيافية الرنين النووي المغناطيسي أحادية و ثنائية البعد مطيافية الكتلة Index. décimale : 540 Chimie et sciences connexes Résumé :
This report is concerning the phytochemical study of two Algerian plants belonging to the Fabaceae family (Genista ulicina Spach) and Asteraceae family (Chrysanthemum macrocarpum Coss. & Kralik ex Batt). This study led to the isolation and identification of 36 compounds from which 10 compounds are new.
The structures of isolated compounds were established particularly by the use of NMR highfield
1D and 2D technics (1H, 13C J-modulated, COSY H-H, HSQC J-modulated, HMBC and NOESY), high resolution mass spectrometry (ESI-MS and HR-ESI-MS), measurement of rotatory power and comparison with literature data.
GC and GC / MS analyses of the essential oil of C. macrocarpum showed that it was mainly represented by: T-cadinol (19.6%), spathulenol (12.5%), caryophyllene oxide (6.5%), and α- cadinol (5.6%).
The chloroform fraction of C. macrocarpum showed a weak antibacterial activity against: E.
coli, S. aureus, P.aeruginosa, E. faecalis and K. pneumoniae.
The same chloroform fraction was evaluated for its antiproliferative activity against human cancer HT-29 cells and human PC3 cells. The results indicate that the chloroform fraction inhibited cell proliferation of both HT-29 and PC-3 cells,The chloroform fraction showed an excellent analegesic, anti-inflammatory and antiulcerogenic activities.
The butanolic fraction of G. ulicina and isolated compounds were investigated for their antibacterial and antiproliferative growth inhibition, but no significant activities were observed.Diplôme : Doctorat en sciences En ligne : ../theses/chimie/BOU6343.pdf Format de la ressource électronique : Permalink : index.php?lvl=notice_display&id=6313 Etude phytochimique et pharmacologique de plantes médicinales Algériennes Genista ulicina Spach (Fabaceae) et Chrysanthemum macrocarpum (Sch. Bip.) Coss. & Kralik ex Batt (Asteraceae) [texte imprimé] / Naima Boutaghane, Auteur ; Zahia Kabouche, Directeur de thèse ; Laurence Voutquenne, Directeur de thèse . - constantine [Algérie] : Université Constantine 1, 2013 . - 270 f. ; 30 cm.
2 copies imprimées disponibles
Langues : Français (fre)
Catégories : Français - Anglais
ChimieTags : Fabaceae Asteraceae Genista ulicina Chrysanthemum macrocarpum cyclitols Saponines flavonoïdes Huile essentielle activités biologiques RMN 1D et 2D Spectrométrie de masse Saponins flavonoids essential oil biological activities NMR 1D and 2D mass spectroscopy الصابونين الفلافونيدات الزيوت الطيارة مطيافية الرنين النووي المغناطيسي أحادية و ثنائية البعد مطيافية الكتلة Index. décimale : 540 Chimie et sciences connexes Résumé :
This report is concerning the phytochemical study of two Algerian plants belonging to the Fabaceae family (Genista ulicina Spach) and Asteraceae family (Chrysanthemum macrocarpum Coss. & Kralik ex Batt). This study led to the isolation and identification of 36 compounds from which 10 compounds are new.
The structures of isolated compounds were established particularly by the use of NMR highfield
1D and 2D technics (1H, 13C J-modulated, COSY H-H, HSQC J-modulated, HMBC and NOESY), high resolution mass spectrometry (ESI-MS and HR-ESI-MS), measurement of rotatory power and comparison with literature data.
GC and GC / MS analyses of the essential oil of C. macrocarpum showed that it was mainly represented by: T-cadinol (19.6%), spathulenol (12.5%), caryophyllene oxide (6.5%), and α- cadinol (5.6%).
The chloroform fraction of C. macrocarpum showed a weak antibacterial activity against: E.
coli, S. aureus, P.aeruginosa, E. faecalis and K. pneumoniae.
The same chloroform fraction was evaluated for its antiproliferative activity against human cancer HT-29 cells and human PC3 cells. The results indicate that the chloroform fraction inhibited cell proliferation of both HT-29 and PC-3 cells,The chloroform fraction showed an excellent analegesic, anti-inflammatory and antiulcerogenic activities.
The butanolic fraction of G. ulicina and isolated compounds were investigated for their antibacterial and antiproliferative growth inhibition, but no significant activities were observed.Diplôme : Doctorat en sciences En ligne : ../theses/chimie/BOU6343.pdf Format de la ressource électronique : Permalink : index.php?lvl=notice_display&id=6313 Exemplaires (1)
Code-barres Cote Support Localisation Section Disponibilité BOU/6343 BOU/6343 Thèse Bibliothèque principale Thèses Disponible
Permalink
Permalink
Permalink
Permalink
Permalink
Permalink
Permalink
Permalink
Permalink
Permalink
