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Partager le résultat de cette recherche Interroger des sources externesEvaluation de l'activité antioxydante et antimicrobienne de l'homogénat du gastéropode / Rima Hammoud
Titre : Evaluation de l'activité antioxydante et antimicrobienne de l'homogénat du gastéropode : Helix aspersa Type de document : texte imprimé Auteurs : Rima Hammoud, Auteur ; D. Naimi, Directeur de thèse Editeur : constantine [Algérie] : Université Constantine 1 Année de publication : 2013 Importance : 87 f. Format : 30 cm. Note générale : 2 copies imprimées disponibles Langues : Français (fre) Tags : L-Méthionine hyperhomocystéinémie Helix aspersa extraits organiques bruts activité
antioxydante activité antimicrobienne L-Methionine hyerhomocysteinemia crude organic extracts antioxidant activity antimicrobial activity ?????????? ??????? ????? ?????? ?????? ??????? ???????? ????? ??????????????? L
?????? ?????? ???????? ????? ????????.Index. décimale : 570 Sciences de la vie. Biologie Résumé : In this study, we took an interest in the evaluation of the antioxidant and antimicrobial effects of Helix aspersa snail homogenate. In order to reach our goals, three principal stages were undertaken:
* Submission of rats at a high L-Methionine diet (400mg/kg of the weight of the rat/day) in order to induce an oxidative stress.
* Treatment of rats by Helix aspersa snail homogenate (100mg/kg of the weight of the rat/day) associated with a high dose of the L-Methionine.
* Evaluation of the antimicrobial activity of Helix aspersa snail crude organic extracts against three bacterial strains (Escherichia coli ATCC 25922, Klebsiella pneumoniae ATCC 700603,Pseudomonas aeruginosa 13), twoo fungal strains (Aspergillus fumigatus CIP 1082.74,Trichophytum rubrum CIP 2043.92) and one strain of yeast (Candida albicans UMIP 88465) by the use of paper disk assay method.
The results of MDA and total protein mixtures showed that:
* On one hand, an increase of hepatic MD (p≤0,001) and plasmatic total protein levels (p≤0,0001) on rats that receiving a high dose of the L-Methionine, explaining thus theproceedings of lipid peroxidation phenomenons and the cellular proteins oxidation.
* On the other hand, a decrease of the levels of plasmatic (p≤0,0001) and hepatic MDA (p≤0,001), and plasmatic total proteins (p≤0,0001) following treatment of hyperhomocysteinemic rats with the snails homogenate. This allowed us to conclude that the Helix aspersa snail homogenate has antioxidant properties.
The microbiological test revealed an antibacterial activity of snails crude organic extracts prepared with distilled water.
Escherichia coli ATCC 25922 was revealed as the most sensitive of the three test-bacteria.
No anti fungal activity was determined.
The preliminary characterization of antibacterial molecules of Helix aspersa snail crude organic extracts allowed us to conclude that they can probably have protein linked and/or free nature.Diplôme : Magistère En ligne : ../theses/biologie/HAM6355.pdf Format de la ressource électronique : Permalink : https://bu.umc.edu.dz/md/index.php?lvl=notice_display&id=6321 Evaluation de l'activité antioxydante et antimicrobienne de l'homogénat du gastéropode : Helix aspersa [texte imprimé] / Rima Hammoud, Auteur ; D. Naimi, Directeur de thèse . - constantine (Route ain el bey, Algérie) : Université Constantine 1, 2013 . - 87 f. ; 30 cm.
2 copies imprimées disponibles
Langues : Français (fre)
Tags : L-Méthionine hyperhomocystéinémie Helix aspersa extraits organiques bruts activité
antioxydante activité antimicrobienne L-Methionine hyerhomocysteinemia crude organic extracts antioxidant activity antimicrobial activity ?????????? ??????? ????? ?????? ?????? ??????? ???????? ????? ??????????????? L
?????? ?????? ???????? ????? ????????.Index. décimale : 570 Sciences de la vie. Biologie Résumé : In this study, we took an interest in the evaluation of the antioxidant and antimicrobial effects of Helix aspersa snail homogenate. In order to reach our goals, three principal stages were undertaken:
* Submission of rats at a high L-Methionine diet (400mg/kg of the weight of the rat/day) in order to induce an oxidative stress.
* Treatment of rats by Helix aspersa snail homogenate (100mg/kg of the weight of the rat/day) associated with a high dose of the L-Methionine.
* Evaluation of the antimicrobial activity of Helix aspersa snail crude organic extracts against three bacterial strains (Escherichia coli ATCC 25922, Klebsiella pneumoniae ATCC 700603,Pseudomonas aeruginosa 13), twoo fungal strains (Aspergillus fumigatus CIP 1082.74,Trichophytum rubrum CIP 2043.92) and one strain of yeast (Candida albicans UMIP 88465) by the use of paper disk assay method.
The results of MDA and total protein mixtures showed that:
* On one hand, an increase of hepatic MD (p≤0,001) and plasmatic total protein levels (p≤0,0001) on rats that receiving a high dose of the L-Methionine, explaining thus theproceedings of lipid peroxidation phenomenons and the cellular proteins oxidation.
* On the other hand, a decrease of the levels of plasmatic (p≤0,0001) and hepatic MDA (p≤0,001), and plasmatic total proteins (p≤0,0001) following treatment of hyperhomocysteinemic rats with the snails homogenate. This allowed us to conclude that the Helix aspersa snail homogenate has antioxidant properties.
The microbiological test revealed an antibacterial activity of snails crude organic extracts prepared with distilled water.
Escherichia coli ATCC 25922 was revealed as the most sensitive of the three test-bacteria.
No anti fungal activity was determined.
The preliminary characterization of antibacterial molecules of Helix aspersa snail crude organic extracts allowed us to conclude that they can probably have protein linked and/or free nature.Diplôme : Magistère En ligne : ../theses/biologie/HAM6355.pdf Format de la ressource électronique : Permalink : https://bu.umc.edu.dz/md/index.php?lvl=notice_display&id=6321 Exemplaires
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Titre : Préparation, caractérisation et application des complexes à base d’hétérocycles azotés. : Dérivés d'imidazole et de Benzimidazole Type de document : texte imprimé Auteurs : Mehdi Bouchouit, Auteur ; Sofiane Bouacida, Directeur de thèse Editeur : جامعة الإخوة منتوري قسنطينة Année de publication : 2017 Importance : 180 f. Format : 30 cm. Note générale : 2 copies imprimées disponibles
Langues : Français (fre) Tags : Complexes de coordination Benzimidazole Imidazole Inhibiteur de corrosion Etude
électrochimique Activité antimicrobienne Structure électronique Complexes Corrosion inhibitors Electrochemical technique Antimicrobial activity Electronic structure ???? ?????? ???????? ??????????? ?????? ?????? ?????? ?????????????? ?????? ?????????? ?????? ???????????Index. décimale : 540 Chimie et sciences connexes Résumé : The aim of this work was the preparation and characterization of new heterocyclic nitrogen donor ligands derived from imidazole and benzimidazole and their coordination compounds 3dn in order to evaluate their corrosion inhibition efficiency and their antimicrobial activity.
The ligands ((1 H-benzo[d]imidazol-2-yl)methyl)sulfane (bbms), 2-((1Hbenzo[d]imidazol-2-ylthio))-1H- benzo[d]imidazole (btmb), 1-benzyl-2-methyl-1H-imidazole (bmi), 2-((benzo[d]thiazol-2-ylthio)methyl)-1H-benzo[d]imidazole (btmbt) react with cobalt(II)chloride, zinc(II)chloride and mercury(II)chloride to give various complexes. The
structures of the ligands and the corresponding complexes were determined by IR, UV-vis, 1H
NMR, 13C NMR, elemental analysis and X-ray diffraction.
The structural characterization revealed the tetrahedral environment of the complexes
and the stability of the crystalline structure by hydrogen bonds and π-π interactions.
Theoretical calculations for some complexes were carried out in order to understand the
geometry and the electronic structure of some compounds.
The anticorrosive properties of some prepared compounds on steel in (0.5M) H2SO4
medium were studied. In other hand, their antimicrobial properties were tested against four
microbial strains: Pseudomonas syringae, Staphylococcus aureus, Klebsiella pneumonia et
Pichia caribbica.
Diplôme : Doctorat En ligne : ../theses/chimie/BOU7134.pdf Format de la ressource électronique : Permalink : https://bu.umc.edu.dz/md/index.php?lvl=notice_display&id=10468 Préparation, caractérisation et application des complexes à base d’hétérocycles azotés. : Dérivés d'imidazole et de Benzimidazole [texte imprimé] / Mehdi Bouchouit, Auteur ; Sofiane Bouacida, Directeur de thèse . - [S.l.] : جامعة الإخوة منتوري قسنطينة, 2017 . - 180 f. ; 30 cm.
2 copies imprimées disponibles
Langues : Français (fre)
Tags : Complexes de coordination Benzimidazole Imidazole Inhibiteur de corrosion Etude
électrochimique Activité antimicrobienne Structure électronique Complexes Corrosion inhibitors Electrochemical technique Antimicrobial activity Electronic structure ???? ?????? ???????? ??????????? ?????? ?????? ?????? ?????????????? ?????? ?????????? ?????? ???????????Index. décimale : 540 Chimie et sciences connexes Résumé : The aim of this work was the preparation and characterization of new heterocyclic nitrogen donor ligands derived from imidazole and benzimidazole and their coordination compounds 3dn in order to evaluate their corrosion inhibition efficiency and their antimicrobial activity.
The ligands ((1 H-benzo[d]imidazol-2-yl)methyl)sulfane (bbms), 2-((1Hbenzo[d]imidazol-2-ylthio))-1H- benzo[d]imidazole (btmb), 1-benzyl-2-methyl-1H-imidazole (bmi), 2-((benzo[d]thiazol-2-ylthio)methyl)-1H-benzo[d]imidazole (btmbt) react with cobalt(II)chloride, zinc(II)chloride and mercury(II)chloride to give various complexes. The
structures of the ligands and the corresponding complexes were determined by IR, UV-vis, 1H
NMR, 13C NMR, elemental analysis and X-ray diffraction.
The structural characterization revealed the tetrahedral environment of the complexes
and the stability of the crystalline structure by hydrogen bonds and π-π interactions.
Theoretical calculations for some complexes were carried out in order to understand the
geometry and the electronic structure of some compounds.
The anticorrosive properties of some prepared compounds on steel in (0.5M) H2SO4
medium were studied. In other hand, their antimicrobial properties were tested against four
microbial strains: Pseudomonas syringae, Staphylococcus aureus, Klebsiella pneumonia et
Pichia caribbica.
Diplôme : Doctorat En ligne : ../theses/chimie/BOU7134.pdf Format de la ressource électronique : Permalink : https://bu.umc.edu.dz/md/index.php?lvl=notice_display&id=10468 Exemplaires
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Titre : Préparation de nouveaux matériaux à base de (benz)imidazole et bio-activité : synthèse de complexes à base de (benz)imidazole, étude structurale et théorique et préparation d’analogues structuraux de la Tacrine à base de benzimidazole. Type de document : texte imprimé Auteurs : Anfel Benhassine ép Lifa, Auteur ; Ali Belfaitah, Directeur de thèse Editeur : جامعة الإخوة منتوري قسنطينة Année de publication : 2018 Importance : 186 f. Format : 30 cm. Note générale : 2 copies imprimées disponibles
Langues : Français (fre) Tags : Imidazole Benzimidazole Complexassion Métaux de transition divalents DFT orbitales frontières Tacrine réaction de Friedländer poly-hétérocycles DPPH ABTS activité antimicrobienne Divalent transition metals calculations Frontier orbitals Friedländer's reaction poly-heterocyclic compounds antimicrobial activity ????????? ??????????? ???????? ??????? ?????????? ?????? ??????? ?????? ?????? ??????? ???????? ????????????????? ?????? ?????? ?????????? Index. décimale : 540 Chimie et sciences connexes Résumé : The first part, which is subdivided into two chapters, concerns the synthesis, characterization (IR and UV-Vis, X-ray diffraction, and other elemental analysis) and biological evaluation of divalent transition metal complexes (M = Co , Cu, Cd, Zn, Ni) based on (1-methyl- 1Hbenzo[d]imidazol-2-yl) methanol (L1/Hmbm) (complexes 1-4) and (1-methyl-1H- imidazol-2-yl) methanol (L2/Hmim) (complexes 5-11). In both series of coordination compounds, the ligand (L1 or L2) gives rise to a variety of metal-ligand coordination modes(monodentate or bidentadate) exhibiting tetrahedral or octahedral geometry.The in vitro measurement of the antioxidant activity of the L1 and L2 ligands and their respective metal complexes against the free radical scavenger DPPH at low concentration (100 &g / mL), showed a moderate to significant antioxidant activities, compared to the standard (Asc). The complexes (5-11) and the ligand L2 were submitted to an in vitro evaluation of their antimicrobial activity against five pathogenic strains: animal bacteria:
Gram (+) (S. aureus) and Gram (-) (K pneumonia), a Gram (+) phytopathogenic bacterium (P.
syringae), a yeast (P. caribbica) and a fungus (Trichodermsp), using the disk diffusion method
(agar).The analysis of the results revealed a significant difference in the inhibition profile of the selected strains. The complex 5 and to a lesser extent the complex 6, gave the best results displaying significant inhibitory activities on mostly all pathogenic strains (broad spectrum). In the second part dedicated to the synthesis of structural analogs of Tacrine, a whole series of new poly-heterocyclic compounds (10-14) was prepared from the corresponding 4H-pyrans (5- 9) by an addition-hetero-cyclization reaction of cyclohexanone under the Friedl‰ndler's standard conditions reaction. The in vitro antioxidant tests (DPPH and ABTS) of
benzimidazopyranotacrines, showed that the five compounds have an antioxidant activities, and
the 5-Amino-2-methyl-4-(1-methyl-1H-benzo[d]imidazol-2-yl)-6,7,8,9-tetrahydro-4H-pyrano
[2,3-b]uinolin-3-yl) ethanone (compound 12) is the most efficient, exhibiting a comparable
inhibitory power of free radicals to that of reference compounds (controls). The structure of all the complexes (1-11) was determined by X-ray diffraction, IR, UV and other elemental analysis. For complexes 1-4, theoretical studies using DFT and TD-DFT calculations have been performed and confirmed the experimental results. Benzimidazopyranotacrines (10-14) as structural Tacrine's analogues and their intermediates 4Hpyrans (5-9), were identified by the usual spectroscopic methods (IR, 1H NMR and13C).Diplôme : Doctorat En ligne : ../theses/chimie/LIF7359.pdf Format de la ressource électronique : Permalink : https://bu.umc.edu.dz/md/index.php?lvl=notice_display&id=11008 Préparation de nouveaux matériaux à base de (benz)imidazole et bio-activité : synthèse de complexes à base de (benz)imidazole, étude structurale et théorique et préparation d’analogues structuraux de la Tacrine à base de benzimidazole. [texte imprimé] / Anfel Benhassine ép Lifa, Auteur ; Ali Belfaitah, Directeur de thèse . - [S.l.] : جامعة الإخوة منتوري قسنطينة, 2018 . - 186 f. ; 30 cm.
2 copies imprimées disponibles
Langues : Français (fre)
Tags : Imidazole Benzimidazole Complexassion Métaux de transition divalents DFT orbitales frontières Tacrine réaction de Friedländer poly-hétérocycles DPPH ABTS activité antimicrobienne Divalent transition metals calculations Frontier orbitals Friedländer's reaction poly-heterocyclic compounds antimicrobial activity ????????? ??????????? ???????? ??????? ?????????? ?????? ??????? ?????? ?????? ??????? ???????? ????????????????? ?????? ?????? ?????????? Index. décimale : 540 Chimie et sciences connexes Résumé : The first part, which is subdivided into two chapters, concerns the synthesis, characterization (IR and UV-Vis, X-ray diffraction, and other elemental analysis) and biological evaluation of divalent transition metal complexes (M = Co , Cu, Cd, Zn, Ni) based on (1-methyl- 1Hbenzo[d]imidazol-2-yl) methanol (L1/Hmbm) (complexes 1-4) and (1-methyl-1H- imidazol-2-yl) methanol (L2/Hmim) (complexes 5-11). In both series of coordination compounds, the ligand (L1 or L2) gives rise to a variety of metal-ligand coordination modes(monodentate or bidentadate) exhibiting tetrahedral or octahedral geometry.The in vitro measurement of the antioxidant activity of the L1 and L2 ligands and their respective metal complexes against the free radical scavenger DPPH at low concentration (100 &g / mL), showed a moderate to significant antioxidant activities, compared to the standard (Asc). The complexes (5-11) and the ligand L2 were submitted to an in vitro evaluation of their antimicrobial activity against five pathogenic strains: animal bacteria:
Gram (+) (S. aureus) and Gram (-) (K pneumonia), a Gram (+) phytopathogenic bacterium (P.
syringae), a yeast (P. caribbica) and a fungus (Trichodermsp), using the disk diffusion method
(agar).The analysis of the results revealed a significant difference in the inhibition profile of the selected strains. The complex 5 and to a lesser extent the complex 6, gave the best results displaying significant inhibitory activities on mostly all pathogenic strains (broad spectrum). In the second part dedicated to the synthesis of structural analogs of Tacrine, a whole series of new poly-heterocyclic compounds (10-14) was prepared from the corresponding 4H-pyrans (5- 9) by an addition-hetero-cyclization reaction of cyclohexanone under the Friedl‰ndler's standard conditions reaction. The in vitro antioxidant tests (DPPH and ABTS) of
benzimidazopyranotacrines, showed that the five compounds have an antioxidant activities, and
the 5-Amino-2-methyl-4-(1-methyl-1H-benzo[d]imidazol-2-yl)-6,7,8,9-tetrahydro-4H-pyrano
[2,3-b]uinolin-3-yl) ethanone (compound 12) is the most efficient, exhibiting a comparable
inhibitory power of free radicals to that of reference compounds (controls). The structure of all the complexes (1-11) was determined by X-ray diffraction, IR, UV and other elemental analysis. For complexes 1-4, theoretical studies using DFT and TD-DFT calculations have been performed and confirmed the experimental results. Benzimidazopyranotacrines (10-14) as structural Tacrine's analogues and their intermediates 4Hpyrans (5-9), were identified by the usual spectroscopic methods (IR, 1H NMR and13C).Diplôme : Doctorat En ligne : ../theses/chimie/LIF7359.pdf Format de la ressource électronique : Permalink : https://bu.umc.edu.dz/md/index.php?lvl=notice_display&id=11008 Exemplaires
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Titre : Etude des activités antioxydante et antibactérienne des polyphénols d’Allium triquetrum L. en vue de leur application sur la sardine commune Type de document : texte imprimé Auteurs : Hayat Himed èp Idir, Auteur ; Lila Boulekbache, Directeur de thèse Editeur : constantine [Algérie] : Université Constantine 1 Année de publication : 2014 Importance : 95 f. Format : 30 cm. Note générale : 2 copies imprimées disponibles
Langues : Français (fre) Tags : Allium triquetrum L. activité antioxydante activité antimicrobienne polyphénols Sardina pichardus antioxidant activity antimicrobial activity polyphenols ????? ?????? ??????? ????? ?????? ????????? ????????? ?????? ??????? ?????? Index. décimale : 640 Industrie Alimentaire Résumé :
phenolic compounds to study their antioxidant and antibacterial effects. The best phenolic
extract was tested to prevent sardine deterioration.
The extraction of polyphénols from leaves and bulbs was carried out by a conventional method (maceration) and the innovative one (microwave), using three solvent systems (acetone, ethanol, methanol) at 70%. We found that samples irradiated for three minutes gave the best yields.
For comparative purposes, total phenolics, flavonoïds and tannins are quantified from the different extracts. It found that leaves content is higher than that of bulbs. Extraction assisted by microwave, using acetone and ethanol, was best procedure of extraction of these bioactive compounds.
The antioxidant activity of selected extracts (FA, FA3, FE, FE3, BA, BE3) was evaluated by the means of three methods: FRAP method, DPPH essay and the β-carotene bleaching method. Results displayed that leaves extracts exercise notable antioxydant effect than the bulbs ones. The extract FA3 appears the best but less powerful than BHA which is used as standard.
A correlation between these extracts content’s of flavonoïds and antioxidant was highly significant (R2 > 0.95; p < 0.05) and even more significant than that obtained with total phenols and tannins.
Antibacterial potential of these extracts (FA, FA3, FE, FE3, BA, BE3) was tested by the Agar-well diffusion method against Bacillus subtilis ATCC6633, Staphylococcus aureus ATCC43300, Escherichia coli ATCC25922 and Pseudomonas aeruginosa ATCC27853. A moderate antibacterial activity of acetone extracts of leaves against Escherichia coli and Staphylococcus aureus was noted with a load of 1000 μg/disk.
The extract FA3 has been tested for its efficacy upon sardine with a concentration of 10, 25 and 50 mg/ml during 10 days of conservation at 6°C, using the TBARS method. The results showed that this extract reduce significantly the oxidation of sardine’s lipids.Diplôme : Magistère En ligne : ../theses/agronomie/HIM6626.pdf Format de la ressource électronique : Permalink : https://bu.umc.edu.dz/md/index.php?lvl=notice_display&id=9750 Etude des activités antioxydante et antibactérienne des polyphénols d’Allium triquetrum L. en vue de leur application sur la sardine commune [texte imprimé] / Hayat Himed èp Idir, Auteur ; Lila Boulekbache, Directeur de thèse . - constantine (Route ain el bey, Algérie) : Université Constantine 1, 2014 . - 95 f. ; 30 cm.
2 copies imprimées disponibles
Langues : Français (fre)
Tags : Allium triquetrum L. activité antioxydante activité antimicrobienne polyphénols Sardina pichardus antioxidant activity antimicrobial activity polyphenols ????? ?????? ??????? ????? ?????? ????????? ????????? ?????? ??????? ?????? Index. décimale : 640 Industrie Alimentaire Résumé :
phenolic compounds to study their antioxidant and antibacterial effects. The best phenolic
extract was tested to prevent sardine deterioration.
The extraction of polyphénols from leaves and bulbs was carried out by a conventional method (maceration) and the innovative one (microwave), using three solvent systems (acetone, ethanol, methanol) at 70%. We found that samples irradiated for three minutes gave the best yields.
For comparative purposes, total phenolics, flavonoïds and tannins are quantified from the different extracts. It found that leaves content is higher than that of bulbs. Extraction assisted by microwave, using acetone and ethanol, was best procedure of extraction of these bioactive compounds.
The antioxidant activity of selected extracts (FA, FA3, FE, FE3, BA, BE3) was evaluated by the means of three methods: FRAP method, DPPH essay and the β-carotene bleaching method. Results displayed that leaves extracts exercise notable antioxydant effect than the bulbs ones. The extract FA3 appears the best but less powerful than BHA which is used as standard.
A correlation between these extracts content’s of flavonoïds and antioxidant was highly significant (R2 > 0.95; p < 0.05) and even more significant than that obtained with total phenols and tannins.
Antibacterial potential of these extracts (FA, FA3, FE, FE3, BA, BE3) was tested by the Agar-well diffusion method against Bacillus subtilis ATCC6633, Staphylococcus aureus ATCC43300, Escherichia coli ATCC25922 and Pseudomonas aeruginosa ATCC27853. A moderate antibacterial activity of acetone extracts of leaves against Escherichia coli and Staphylococcus aureus was noted with a load of 1000 μg/disk.
The extract FA3 has been tested for its efficacy upon sardine with a concentration of 10, 25 and 50 mg/ml during 10 days of conservation at 6°C, using the TBARS method. The results showed that this extract reduce significantly the oxidation of sardine’s lipids.Diplôme : Magistère En ligne : ../theses/agronomie/HIM6626.pdf Format de la ressource électronique : Permalink : https://bu.umc.edu.dz/md/index.php?lvl=notice_display&id=9750 Exemplaires
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Titre : Étude phytochimique et biologique de trois espèces Algériennes : Calendula stellata Cav. (Asteraceae), Scabiosa stellata L. (Caprifoliaceae) et Salvia barrelieri Etl. (Lamiaceae). Type de document : texte imprimé Auteurs : Meryem Lehbili, Auteur ; Ahmed Kabouche, Directeur de thèse ; Abdulmagid Alabdul Magid, Directeur de thèse Editeur : جامعة الإخوة منتوري قسنطينة Année de publication : 2018 Importance : 375 f. Format : 30 cm. Note générale : 2 copies imprimées disponibles
Langues : Français (fre) Tags : Calendula stellata Scabiosa stellata Salvia barrelieri saponosides iridoïdes triterpenoïdes flavonoïdes activité antioxydante activité antimicrobienne cytotoxicité saponosids iridoids triterpenes flavonoids antioxidant activity antimicrobial activity cytotoxicity ???????? ?????????? ????? ??????? ????? ????????? ???? ????? Index. décimale : 540 Chimie et sciences connexes Résumé : The phytochemical study of three species: Calendula stellata, Scabiosa stellata and Salvia barrelieri led to the isolation of 55 compounds, from which 16 were new, by the use of different chromatographic methods of separation and purification on solid or liquid support.
The isolated compounds were distributed through 27 saponosids, 7 triterpenes, 11 flavonoids, 7 iridoids and 2 chlorogenic acid derivatives. Two mono-iridoids and two flavonoids showed an important antiradical activity (IC50:7-16 µM). Fourteen compounds exhibited a good antibacterial activity (MIC: 15- 125 µg/mL). The new compounds showed a low to moderate cytotoxic activity against all tested cell lines, except for the monodesmoside, obtained from Scabiosa stellata (Scabiostellatoside F) which exhibited a good antiproliferative effect against HT1080 (IC50 = 12 µM).
Diplôme : Doctorat En ligne : ../theses/chimie/LEH7306.pdf Format de la ressource électronique : Permalink : https://bu.umc.edu.dz/md/index.php?lvl=notice_display&id=10921 Étude phytochimique et biologique de trois espèces Algériennes : Calendula stellata Cav. (Asteraceae), Scabiosa stellata L. (Caprifoliaceae) et Salvia barrelieri Etl. (Lamiaceae). [texte imprimé] / Meryem Lehbili, Auteur ; Ahmed Kabouche, Directeur de thèse ; Abdulmagid Alabdul Magid, Directeur de thèse . - [S.l.] : جامعة الإخوة منتوري قسنطينة, 2018 . - 375 f. ; 30 cm.
2 copies imprimées disponibles
Langues : Français (fre)
Tags : Calendula stellata Scabiosa stellata Salvia barrelieri saponosides iridoïdes triterpenoïdes flavonoïdes activité antioxydante activité antimicrobienne cytotoxicité saponosids iridoids triterpenes flavonoids antioxidant activity antimicrobial activity cytotoxicity ???????? ?????????? ????? ??????? ????? ????????? ???? ????? Index. décimale : 540 Chimie et sciences connexes Résumé : The phytochemical study of three species: Calendula stellata, Scabiosa stellata and Salvia barrelieri led to the isolation of 55 compounds, from which 16 were new, by the use of different chromatographic methods of separation and purification on solid or liquid support.
The isolated compounds were distributed through 27 saponosids, 7 triterpenes, 11 flavonoids, 7 iridoids and 2 chlorogenic acid derivatives. Two mono-iridoids and two flavonoids showed an important antiradical activity (IC50:7-16 µM). Fourteen compounds exhibited a good antibacterial activity (MIC: 15- 125 µg/mL). The new compounds showed a low to moderate cytotoxic activity against all tested cell lines, except for the monodesmoside, obtained from Scabiosa stellata (Scabiostellatoside F) which exhibited a good antiproliferative effect against HT1080 (IC50 = 12 µM).
Diplôme : Doctorat En ligne : ../theses/chimie/LEH7306.pdf Format de la ressource électronique : Permalink : https://bu.umc.edu.dz/md/index.php?lvl=notice_display&id=10921 Exemplaires
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