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Partager le résultat de cette recherche Interroger des sources externesSynthèse de Chalcones adamantylées, de dérivés Thiazolylpyrazolines et évaluation de leurs activités antimicrobienne et anticancéreuse. / Aouatef Tabbi-Benmerkhi
Titre : Synthèse de Chalcones adamantylées, de dérivés Thiazolylpyrazolines et évaluation de leurs activités antimicrobienne et anticancéreuse. Type de document : texte imprimé Auteurs : Aouatef Tabbi-Benmerkhi, Auteur ; Dahmane Tebbani, Directeur de thèse Editeur : جامعة الإخوة منتوري قسنطينة Année de publication : 2017 Importance : 192 f. Format : 30 cm. Note générale : 2 copies imprimées disponibles
Langues : Français (fre) Catégories : Français - Anglais
ChimieTags : Chalcones adamantylées Thiazolylpyrazolines activité antimicrobienne activité
anti cancéreuse MiaPaca2 A549 NIH/3T3 RMN adamantylated Chalcones Thiazolylpyrazoline antimirobial activity anticancer
activity NMR الشالكونات الادمونتلية تيازوليل بيرازولين مضادات الميكروبات النشاط المضاد للسرطانIndex. décimale : 540 Chimie et sciences connexes Résumé : In the first part, a new variety of adamantyl chalcones was efficiently prepared by ClaisenSchmidt reaction of 4-adamantyl acetophenone with a series of aromatic aldehydes in good
yields. Their structures were confirmed by spectroscopic data, and the relative configuration
of compound 3d was confirmed by X-ray crystallography. All synthesized chalcones were
tested against a panel of Gram-positive and Gram-negative bacteria and pathogenic fungus.
They displayed a strong antibacterial activity against Enterococcus faecali 29212,
Pseudomonas aeruginosa ATCC27853, Escherichia coli, as well as an interesting antifungal
activity against Candida glabrata ATCC 90030. The effect of these compounds was also
tested in vitro as antitumor on Miapaca2 cells. The compounds also showed anticancer
activity against human pancreas cancer cell MiaPaca2.
In the second part, several thiazolyl-pyrazoline derivatives were synthesized by reacting
substituted 3, 5-diaryl-1-thiocarbamoyl-2-pyrazolines with phenacylbromides. The structures
of the synthesized compounds were confirmed by IR, 1H NMR, 13C NMR, and MS spectral
data. Their antimicrobial, anticancer activities and cytotoxicity were investigated. A
significant level of antimicrobial activity and anticancer activity against A549 human lung
carcinoma cell line and low cytotoxicity were observed.Diplôme : Doctorat En ligne : ../theses/chimie/TAB7068.pdf Format de la ressource électronique : Permalink : index.php?lvl=notice_display&id=10533 Synthèse de Chalcones adamantylées, de dérivés Thiazolylpyrazolines et évaluation de leurs activités antimicrobienne et anticancéreuse. [texte imprimé] / Aouatef Tabbi-Benmerkhi, Auteur ; Dahmane Tebbani, Directeur de thèse . - جامعة الإخوة منتوري قسنطينة, 2017 . - 192 f. ; 30 cm.
2 copies imprimées disponibles
Langues : Français (fre)
Catégories : Français - Anglais
ChimieTags : Chalcones adamantylées Thiazolylpyrazolines activité antimicrobienne activité
anti cancéreuse MiaPaca2 A549 NIH/3T3 RMN adamantylated Chalcones Thiazolylpyrazoline antimirobial activity anticancer
activity NMR الشالكونات الادمونتلية تيازوليل بيرازولين مضادات الميكروبات النشاط المضاد للسرطانIndex. décimale : 540 Chimie et sciences connexes Résumé : In the first part, a new variety of adamantyl chalcones was efficiently prepared by ClaisenSchmidt reaction of 4-adamantyl acetophenone with a series of aromatic aldehydes in good
yields. Their structures were confirmed by spectroscopic data, and the relative configuration
of compound 3d was confirmed by X-ray crystallography. All synthesized chalcones were
tested against a panel of Gram-positive and Gram-negative bacteria and pathogenic fungus.
They displayed a strong antibacterial activity against Enterococcus faecali 29212,
Pseudomonas aeruginosa ATCC27853, Escherichia coli, as well as an interesting antifungal
activity against Candida glabrata ATCC 90030. The effect of these compounds was also
tested in vitro as antitumor on Miapaca2 cells. The compounds also showed anticancer
activity against human pancreas cancer cell MiaPaca2.
In the second part, several thiazolyl-pyrazoline derivatives were synthesized by reacting
substituted 3, 5-diaryl-1-thiocarbamoyl-2-pyrazolines with phenacylbromides. The structures
of the synthesized compounds were confirmed by IR, 1H NMR, 13C NMR, and MS spectral
data. Their antimicrobial, anticancer activities and cytotoxicity were investigated. A
significant level of antimicrobial activity and anticancer activity against A549 human lung
carcinoma cell line and low cytotoxicity were observed.Diplôme : Doctorat En ligne : ../theses/chimie/TAB7068.pdf Format de la ressource électronique : Permalink : index.php?lvl=notice_display&id=10533 Exemplaires (1)
Code-barres Cote Support Localisation Section Disponibilité TAB/7068 TAB/7068 Thèse Bibliothèque principale Thèses Disponible
Titre : Recherche de substances à activités antimicrobiennes (antibactériennes et anticandidoses) produites par des souches levuriennes isolées des sols sahariens Type de document : texte imprimé Auteurs : Sarah Lammi, Auteur ; Zahia Meraihi, Directeur de thèse Editeur : Constantine : Université Mentouri Constantine Année de publication : 2011 Importance : 75 f. Format : 31 cm Note générale : Magister
2 copies imprimées disponiblesLangues : Français (fre) Catégories : Français - Anglais
BiologieTags : Levures killer Toxines killer Activité antimicrobienne Sol Bactéries pathogénes Candida albicans. Biologie Index. décimale : 570 Sciences de la vie. Biologie En ligne : ../theses/biologie/LAM5887.pdf Format de la ressource électronique : Permalink : index.php?lvl=notice_display&id=5691 Recherche de substances à activités antimicrobiennes (antibactériennes et anticandidoses) produites par des souches levuriennes isolées des sols sahariens [texte imprimé] / Sarah Lammi, Auteur ; Zahia Meraihi, Directeur de thèse . - Constantine : Université Mentouri Constantine, 2011 . - 75 f. ; 31 cm.
Magister
2 copies imprimées disponibles
Langues : Français (fre)
Catégories : Français - Anglais
BiologieTags : Levures killer Toxines killer Activité antimicrobienne Sol Bactéries pathogénes Candida albicans. Biologie Index. décimale : 570 Sciences de la vie. Biologie En ligne : ../theses/biologie/LAM5887.pdf Format de la ressource électronique : Permalink : index.php?lvl=notice_display&id=5691 Exemplaires (1)
Code-barres Cote Support Localisation Section Disponibilité LAM/5887 LAM/5887 Thèse Bibliothèque principale Thèses Disponible
Titre : Etude de la micropropagation de Mentha x rotundifolia (L.)Huds et Mentha pulegium L. : Production des huiles essentielles et évaluation des activités biologiques. Type de document : texte imprimé Auteurs : Amira Benahmed ép Meskaldji, Auteur ; Abdelmalik Belkhiri, Directeur de thèse Editeur : جامعة الإخوة منتوري قسنطينة Année de publication : 2019 Importance : 141 f. Format : 30 cm. Note générale : 1 copies imprimées disponibles Langues : Français (fre) Catégories : Français - Anglais
BiologieTags : biologie et écologie végétale: Biotechnologie végétale Mentha pulegium Mentha rotundifolia micropropagation huile essentielle activité antioxydante activité antimicrobienne M. pulegium M. rotundifolia essential oil antioxidant
activity antimicrobial activity الإكثار الدقيق الزيت العطري النشاط المضاد للأكسدة النشاط المًضاد للميكروباتIndex. décimale : 570 Sciences de la vie. Biologie Résumé :
Micropropagation of two local species M. rotundifolia and M. pulegium has been carried with two main objectives: firstly, to set up optimal conditions for culture and regeneration of the two species, then evaluate temperature and photoperiod stress conditions on the EO composition and the antioxidant and antimicrobial activities. Explant of the two species was settled on culture with MS medium, acclimated under temperature and photoperiod stress conditions. Mother plants and vitro plants EO were obtained by hydrodistillation and analyzed by GC-MS. Antioxydant and antimicrobial activities of EO were carried out with standards methods (DPPH, ABTS, and CUPRAC) and (diffusion), respectively. Cultures inductions were achieved with MS medium supplemented with 1 mg/l BAP + 1 mg/l GA3. Explants multiplications of M. rotundifolia and M. pulegium were successfully done on MS medium supplemented with 0,5 mg/l BAP +0,5 mg/l GA3 and 0,5 mg/l BAP +1 mg/l GA3, respectively. In vitro rooted plants of the two mints species were well acclimated with a total survival rate greater than 96%. Regarding EO production, photoperiod and light stress assays have shown a significant increase in EO content and selective biosynthesis orientations in relation with phyto-constituents with high value (l-menthone, oxyde de piperitenone) or with side effects (hépatotoxic pulegone).This study has shown that abiotic parameters (light and photoperiod) positively affect vitro plants EO antioxidant activities, while no obvious effect was observed for antimicrobial activities. Finally, the results of this study led to the establishment of an effective in vitro micropropagation protocol from Mentha axillary buds, with the possibility to increase yield and / or to direct the chemical profile of EO for future commercial use.Note de contenu :
Annexes.Diplôme : Doctorat en sciences En ligne : ../theses/biologie/BEN7456.pdf Format de la ressource électronique : Permalink : index.php?lvl=notice_display&id=11287 Etude de la micropropagation de Mentha x rotundifolia (L.)Huds et Mentha pulegium L. : Production des huiles essentielles et évaluation des activités biologiques. [texte imprimé] / Amira Benahmed ép Meskaldji, Auteur ; Abdelmalik Belkhiri, Directeur de thèse . - جامعة الإخوة منتوري قسنطينة, 2019 . - 141 f. ; 30 cm.
1 copies imprimées disponibles
Langues : Français (fre)
Catégories : Français - Anglais
BiologieTags : biologie et écologie végétale: Biotechnologie végétale Mentha pulegium Mentha rotundifolia micropropagation huile essentielle activité antioxydante activité antimicrobienne M. pulegium M. rotundifolia essential oil antioxidant
activity antimicrobial activity الإكثار الدقيق الزيت العطري النشاط المضاد للأكسدة النشاط المًضاد للميكروباتIndex. décimale : 570 Sciences de la vie. Biologie Résumé :
Micropropagation of two local species M. rotundifolia and M. pulegium has been carried with two main objectives: firstly, to set up optimal conditions for culture and regeneration of the two species, then evaluate temperature and photoperiod stress conditions on the EO composition and the antioxidant and antimicrobial activities. Explant of the two species was settled on culture with MS medium, acclimated under temperature and photoperiod stress conditions. Mother plants and vitro plants EO were obtained by hydrodistillation and analyzed by GC-MS. Antioxydant and antimicrobial activities of EO were carried out with standards methods (DPPH, ABTS, and CUPRAC) and (diffusion), respectively. Cultures inductions were achieved with MS medium supplemented with 1 mg/l BAP + 1 mg/l GA3. Explants multiplications of M. rotundifolia and M. pulegium were successfully done on MS medium supplemented with 0,5 mg/l BAP +0,5 mg/l GA3 and 0,5 mg/l BAP +1 mg/l GA3, respectively. In vitro rooted plants of the two mints species were well acclimated with a total survival rate greater than 96%. Regarding EO production, photoperiod and light stress assays have shown a significant increase in EO content and selective biosynthesis orientations in relation with phyto-constituents with high value (l-menthone, oxyde de piperitenone) or with side effects (hépatotoxic pulegone).This study has shown that abiotic parameters (light and photoperiod) positively affect vitro plants EO antioxidant activities, while no obvious effect was observed for antimicrobial activities. Finally, the results of this study led to the establishment of an effective in vitro micropropagation protocol from Mentha axillary buds, with the possibility to increase yield and / or to direct the chemical profile of EO for future commercial use.Note de contenu :
Annexes.Diplôme : Doctorat en sciences En ligne : ../theses/biologie/BEN7456.pdf Format de la ressource électronique : Permalink : index.php?lvl=notice_display&id=11287 Exemplaires (1)
Code-barres Cote Support Localisation Section Disponibilité BEN/7456 BEN/7456 Thèse Bibliothèque principale Thèses Disponible
Titre : Isolement et détermination structurale de métabolites secondaires d’espèces des genres Santolina et Centaurea (Asteraceae) - Activités biologiques. Type de document : texte imprimé Auteurs : Fatiha Labed, Auteur ; Fadila Benayache, Directeur de thèse Mention d'édition : déc-19 Année de publication : 2019 Importance : 300 f. Note générale : 1 copies imprimées disponibles
Langues : Français (fre) Catégories : Français - Anglais
ChimieTags : Chimie organique : phytochimie Santolina chamaecyparissus Centaurea pungens Asteraceae Métabolites secondaires Activité antioxydante Dosage des phénols et flavonoïdes totaux Activité antimicrobienne Antimicrobial activity Secondary metabolites Antioxidant activity Determination of phenol content بنغوريات Centaurea الثانوية نشاط مضادات الأكسدة تقدير الفينولات والفلافونيدات الكلية نشاط مضادات الميكروبات Index. décimale : 540 Chimie et sciences connexes Résumé : This work is part of the research program established by our research unit which consists in the phytochemical investigation of Algerian medicinal plants belonging to families known for their richness in secondary metabolites with potential biological activities. In this context, two species were selected: Santolina chamaecyparissus and Centaurea pungens, given their belonging to the family Asteraceae whose richness in bioactive compounds is well established. Known mainly for their essential oils, the aerial parts of S. chamaecyparissus (leaves + flowers) were macerated in 70% ethanol. After filtration, concentration and dilution with distilled water, the obtained hydroalcoholic extract is subjected to successive extractions by solvents of increasing polarity (CHCl3, AcOEt and n-BuOH) to give the three corresponding derivative extracts. Our experiments concerned the CHCl3 and n-BuOH extracts and focused on the determination of the total phenols of the two extracts and then the evaluation of their antioxidant activity by the DPPH radical reduction and TEAC tests. The results showed that the n-BuOH extract is richer in phenolic compounds and is better antioxidant than the CHCl3 extract in the DPPH radical scavenging assay with vitamin C as positive control. In the TEAC test, the results were in agreement with those of the DPPH radical test, in fact the n-BuOH extract showed a significant and similar activity to that of quercetin 3-O-glucoside used as positive control.
Following these encouraging results, both extracts were subjected to chromatographic techniques
and 15 compounds were isolated. The structures of 14 of these compounds were determined.
These are 5 flavone aglycones including 4 methoxylated; 3 glycosylated flavones, 2 of which were new for Santolina genus; 2 megastigmane glucosides new for Asteraceae family; 2 phenylpropanoids new for the genus Santolina and 2 cyanogenic compounds also new for the genus Santolina. The phytochemical investigation of Centaurea pungens (Flowers) conducted by similar methods as reported for S. chamaecyparissus, allowed the isolation of 9 pure products: 3 sesquiterpene lactones, 2 of which were described for the first time in the literature, 2 methoxylated flavones, 3 glucosylated flavones and a derivative of quinic acid. In order to validate the use of C. pungens in traditional medicine, the antimicrobial activity of the 9 isolated compounds was assessed against Gram-positive strains: Bacillus cereus, Staphylococcus aureus and Listeria innocua, and Gramnegative strains: Pseudomonas aeruginosa and Pseudomonas fragi.Note de contenu : Annexes. Diplôme : Doctorat en sciences En ligne : ../theses/chimie/LAB7860.pdf Format de la ressource électronique : Permalink : index.php?lvl=notice_display&id=11849 Isolement et détermination structurale de métabolites secondaires d’espèces des genres Santolina et Centaurea (Asteraceae) - Activités biologiques. [texte imprimé] / Fatiha Labed, Auteur ; Fadila Benayache, Directeur de thèse . - déc-19 . - 2019 . - 300 f.
1 copies imprimées disponibles
Langues : Français (fre)
Catégories : Français - Anglais
ChimieTags : Chimie organique : phytochimie Santolina chamaecyparissus Centaurea pungens Asteraceae Métabolites secondaires Activité antioxydante Dosage des phénols et flavonoïdes totaux Activité antimicrobienne Antimicrobial activity Secondary metabolites Antioxidant activity Determination of phenol content بنغوريات Centaurea الثانوية نشاط مضادات الأكسدة تقدير الفينولات والفلافونيدات الكلية نشاط مضادات الميكروبات Index. décimale : 540 Chimie et sciences connexes Résumé : This work is part of the research program established by our research unit which consists in the phytochemical investigation of Algerian medicinal plants belonging to families known for their richness in secondary metabolites with potential biological activities. In this context, two species were selected: Santolina chamaecyparissus and Centaurea pungens, given their belonging to the family Asteraceae whose richness in bioactive compounds is well established. Known mainly for their essential oils, the aerial parts of S. chamaecyparissus (leaves + flowers) were macerated in 70% ethanol. After filtration, concentration and dilution with distilled water, the obtained hydroalcoholic extract is subjected to successive extractions by solvents of increasing polarity (CHCl3, AcOEt and n-BuOH) to give the three corresponding derivative extracts. Our experiments concerned the CHCl3 and n-BuOH extracts and focused on the determination of the total phenols of the two extracts and then the evaluation of their antioxidant activity by the DPPH radical reduction and TEAC tests. The results showed that the n-BuOH extract is richer in phenolic compounds and is better antioxidant than the CHCl3 extract in the DPPH radical scavenging assay with vitamin C as positive control. In the TEAC test, the results were in agreement with those of the DPPH radical test, in fact the n-BuOH extract showed a significant and similar activity to that of quercetin 3-O-glucoside used as positive control.
Following these encouraging results, both extracts were subjected to chromatographic techniques
and 15 compounds were isolated. The structures of 14 of these compounds were determined.
These are 5 flavone aglycones including 4 methoxylated; 3 glycosylated flavones, 2 of which were new for Santolina genus; 2 megastigmane glucosides new for Asteraceae family; 2 phenylpropanoids new for the genus Santolina and 2 cyanogenic compounds also new for the genus Santolina. The phytochemical investigation of Centaurea pungens (Flowers) conducted by similar methods as reported for S. chamaecyparissus, allowed the isolation of 9 pure products: 3 sesquiterpene lactones, 2 of which were described for the first time in the literature, 2 methoxylated flavones, 3 glucosylated flavones and a derivative of quinic acid. In order to validate the use of C. pungens in traditional medicine, the antimicrobial activity of the 9 isolated compounds was assessed against Gram-positive strains: Bacillus cereus, Staphylococcus aureus and Listeria innocua, and Gramnegative strains: Pseudomonas aeruginosa and Pseudomonas fragi.Note de contenu : Annexes. Diplôme : Doctorat en sciences En ligne : ../theses/chimie/LAB7860.pdf Format de la ressource électronique : Permalink : index.php?lvl=notice_display&id=11849 Exemplaires (1)
Code-barres Cote Support Localisation Section Disponibilité LAB/7860 LAB/7860 Thèse Bibliothèque principale Thèses Disponible
Titre : Préparation de nouveaux matériaux à base de (benz)imidazole et bio-activité : synthèse de complexes à base de (benz)imidazole, étude structurale et théorique et préparation d’analogues structuraux de la Tacrine à base de benzimidazole. Type de document : texte imprimé Auteurs : Anfel Benhassine ép Lifa, Auteur ; Ali Belfaitah, Directeur de thèse Editeur : جامعة الإخوة منتوري قسنطينة Année de publication : 2018 Importance : 186 f. Format : 30 cm. Note générale : 2 copies imprimées disponibles
Langues : Français (fre) Catégories : Français - Anglais
ChimieTags : Imidazole Benzimidazole Complexassion Métaux de transition divalents DFT orbitales frontières Tacrine réaction de Friedländer poly-hétérocycles DPPH ABTS activité antimicrobienne Divalent transition metals calculations Frontier orbitals Friedländer's reaction poly-heterocyclic compounds antimicrobial activity إيميدازول بنزيميدازول المعقدات المعادن الانتقالية ثنائية التكافؤ النشاط المضاد للأكسدة التاكرين البنزوبرانوتاكرين النشاط المضاد للميكروبات Index. décimale : 540 Chimie et sciences connexes Résumé : The first part, which is subdivided into two chapters, concerns the synthesis, characterization (IR and UV-Vis, X-ray diffraction, and other elemental analysis) and biological evaluation of divalent transition metal complexes (M = Co , Cu, Cd, Zn, Ni) based on (1-methyl- 1Hbenzo[d]imidazol-2-yl) methanol (L1/Hmbm) (complexes 1-4) and (1-methyl-1H- imidazol-2-yl) methanol (L2/Hmim) (complexes 5-11). In both series of coordination compounds, the ligand (L1 or L2) gives rise to a variety of metal-ligand coordination modes(monodentate or bidentadate) exhibiting tetrahedral or octahedral geometry.The in vitro measurement of the antioxidant activity of the L1 and L2 ligands and their respective metal complexes against the free radical scavenger DPPH at low concentration (100 &g / mL), showed a moderate to significant antioxidant activities, compared to the standard (Asc). The complexes (5-11) and the ligand L2 were submitted to an in vitro evaluation of their antimicrobial activity against five pathogenic strains: animal bacteria:
Gram (+) (S. aureus) and Gram (-) (K pneumonia), a Gram (+) phytopathogenic bacterium (P.
syringae), a yeast (P. caribbica) and a fungus (Trichodermsp), using the disk diffusion method
(agar).The analysis of the results revealed a significant difference in the inhibition profile of the selected strains. The complex 5 and to a lesser extent the complex 6, gave the best results displaying significant inhibitory activities on mostly all pathogenic strains (broad spectrum). In the second part dedicated to the synthesis of structural analogs of Tacrine, a whole series of new poly-heterocyclic compounds (10-14) was prepared from the corresponding 4H-pyrans (5- 9) by an addition-hetero-cyclization reaction of cyclohexanone under the Friedl‰ndler's standard conditions reaction. The in vitro antioxidant tests (DPPH and ABTS) of
benzimidazopyranotacrines, showed that the five compounds have an antioxidant activities, and
the 5-Amino-2-methyl-4-(1-methyl-1H-benzo[d]imidazol-2-yl)-6,7,8,9-tetrahydro-4H-pyrano
[2,3-b]uinolin-3-yl) ethanone (compound 12) is the most efficient, exhibiting a comparable
inhibitory power of free radicals to that of reference compounds (controls). The structure of all the complexes (1-11) was determined by X-ray diffraction, IR, UV and other elemental analysis. For complexes 1-4, theoretical studies using DFT and TD-DFT calculations have been performed and confirmed the experimental results. Benzimidazopyranotacrines (10-14) as structural Tacrine's analogues and their intermediates 4Hpyrans (5-9), were identified by the usual spectroscopic methods (IR, 1H NMR and13C).Diplôme : Doctorat En ligne : ../theses/chimie/LIF7359.pdf Format de la ressource électronique : Permalink : index.php?lvl=notice_display&id=11008 Préparation de nouveaux matériaux à base de (benz)imidazole et bio-activité : synthèse de complexes à base de (benz)imidazole, étude structurale et théorique et préparation d’analogues structuraux de la Tacrine à base de benzimidazole. [texte imprimé] / Anfel Benhassine ép Lifa, Auteur ; Ali Belfaitah, Directeur de thèse . - جامعة الإخوة منتوري قسنطينة, 2018 . - 186 f. ; 30 cm.
2 copies imprimées disponibles
Langues : Français (fre)
Catégories : Français - Anglais
ChimieTags : Imidazole Benzimidazole Complexassion Métaux de transition divalents DFT orbitales frontières Tacrine réaction de Friedländer poly-hétérocycles DPPH ABTS activité antimicrobienne Divalent transition metals calculations Frontier orbitals Friedländer's reaction poly-heterocyclic compounds antimicrobial activity إيميدازول بنزيميدازول المعقدات المعادن الانتقالية ثنائية التكافؤ النشاط المضاد للأكسدة التاكرين البنزوبرانوتاكرين النشاط المضاد للميكروبات Index. décimale : 540 Chimie et sciences connexes Résumé : The first part, which is subdivided into two chapters, concerns the synthesis, characterization (IR and UV-Vis, X-ray diffraction, and other elemental analysis) and biological evaluation of divalent transition metal complexes (M = Co , Cu, Cd, Zn, Ni) based on (1-methyl- 1Hbenzo[d]imidazol-2-yl) methanol (L1/Hmbm) (complexes 1-4) and (1-methyl-1H- imidazol-2-yl) methanol (L2/Hmim) (complexes 5-11). In both series of coordination compounds, the ligand (L1 or L2) gives rise to a variety of metal-ligand coordination modes(monodentate or bidentadate) exhibiting tetrahedral or octahedral geometry.The in vitro measurement of the antioxidant activity of the L1 and L2 ligands and their respective metal complexes against the free radical scavenger DPPH at low concentration (100 &g / mL), showed a moderate to significant antioxidant activities, compared to the standard (Asc). The complexes (5-11) and the ligand L2 were submitted to an in vitro evaluation of their antimicrobial activity against five pathogenic strains: animal bacteria:
Gram (+) (S. aureus) and Gram (-) (K pneumonia), a Gram (+) phytopathogenic bacterium (P.
syringae), a yeast (P. caribbica) and a fungus (Trichodermsp), using the disk diffusion method
(agar).The analysis of the results revealed a significant difference in the inhibition profile of the selected strains. The complex 5 and to a lesser extent the complex 6, gave the best results displaying significant inhibitory activities on mostly all pathogenic strains (broad spectrum). In the second part dedicated to the synthesis of structural analogs of Tacrine, a whole series of new poly-heterocyclic compounds (10-14) was prepared from the corresponding 4H-pyrans (5- 9) by an addition-hetero-cyclization reaction of cyclohexanone under the Friedl‰ndler's standard conditions reaction. The in vitro antioxidant tests (DPPH and ABTS) of
benzimidazopyranotacrines, showed that the five compounds have an antioxidant activities, and
the 5-Amino-2-methyl-4-(1-methyl-1H-benzo[d]imidazol-2-yl)-6,7,8,9-tetrahydro-4H-pyrano
[2,3-b]uinolin-3-yl) ethanone (compound 12) is the most efficient, exhibiting a comparable
inhibitory power of free radicals to that of reference compounds (controls). The structure of all the complexes (1-11) was determined by X-ray diffraction, IR, UV and other elemental analysis. For complexes 1-4, theoretical studies using DFT and TD-DFT calculations have been performed and confirmed the experimental results. Benzimidazopyranotacrines (10-14) as structural Tacrine's analogues and their intermediates 4Hpyrans (5-9), were identified by the usual spectroscopic methods (IR, 1H NMR and13C).Diplôme : Doctorat En ligne : ../theses/chimie/LIF7359.pdf Format de la ressource électronique : Permalink : index.php?lvl=notice_display&id=11008 Exemplaires (1)
Code-barres Cote Support Localisation Section Disponibilité LIF/7359 LIF/7359 Thèse Bibliothèque principale Thèses Disponible
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