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Partager le résultat de cette recherche Interroger des sources externesSynthèse de Chalcones adamantylées, de dérivés Thiazolylpyrazolines et évaluation de leurs activités antimicrobienne et anticancéreuse. / Aouatef Tabbi-Benmerkhi
Titre : Synthèse de Chalcones adamantylées, de dérivés Thiazolylpyrazolines et évaluation de leurs activités antimicrobienne et anticancéreuse. Type de document : texte imprimé Auteurs : Aouatef Tabbi-Benmerkhi, Auteur ; Dahmane Tebbani, Directeur de thèse Editeur : جامعة الإخوة منتوري قسنطينة Année de publication : 2017 Importance : 192 f. Format : 30 cm. Note générale : 2 copies imprimées disponibles
Langues : Français (fre) Catégories : Français - Anglais
ChimieTags : Chalcones adamantylées Thiazolylpyrazolines activité antimicrobienne activité
anti cancéreuse MiaPaca2 A549 NIH/3T3 RMN adamantylated Chalcones Thiazolylpyrazoline antimirobial activity anticancer
activity NMR ?????????? ??????????? ???????? ????????? ?????? ?????????? ?????? ?????? ???????Index. décimale : 540 Chimie et sciences connexes Résumé : In the first part, a new variety of adamantyl chalcones was efficiently prepared by ClaisenSchmidt reaction of 4-adamantyl acetophenone with a series of aromatic aldehydes in good
yields. Their structures were confirmed by spectroscopic data, and the relative configuration
of compound 3d was confirmed by X-ray crystallography. All synthesized chalcones were
tested against a panel of Gram-positive and Gram-negative bacteria and pathogenic fungus.
They displayed a strong antibacterial activity against Enterococcus faecali 29212,
Pseudomonas aeruginosa ATCC27853, Escherichia coli, as well as an interesting antifungal
activity against Candida glabrata ATCC 90030. The effect of these compounds was also
tested in vitro as antitumor on Miapaca2 cells. The compounds also showed anticancer
activity against human pancreas cancer cell MiaPaca2.
In the second part, several thiazolyl-pyrazoline derivatives were synthesized by reacting
substituted 3, 5-diaryl-1-thiocarbamoyl-2-pyrazolines with phenacylbromides. The structures
of the synthesized compounds were confirmed by IR, 1H NMR, 13C NMR, and MS spectral
data. Their antimicrobial, anticancer activities and cytotoxicity were investigated. A
significant level of antimicrobial activity and anticancer activity against A549 human lung
carcinoma cell line and low cytotoxicity were observed.Diplôme : Doctorat En ligne : ../theses/chimie/TAB7068.pdf Format de la ressource électronique : Permalink : https://bu.umc.edu.dz/md/index.php?lvl=notice_display&id=10533 Synthèse de Chalcones adamantylées, de dérivés Thiazolylpyrazolines et évaluation de leurs activités antimicrobienne et anticancéreuse. [texte imprimé] / Aouatef Tabbi-Benmerkhi, Auteur ; Dahmane Tebbani, Directeur de thèse . - [S.l.] : جامعة الإخوة منتوري قسنطينة, 2017 . - 192 f. ; 30 cm.
2 copies imprimées disponibles
Langues : Français (fre)
Catégories : Français - Anglais
ChimieTags : Chalcones adamantylées Thiazolylpyrazolines activité antimicrobienne activité
anti cancéreuse MiaPaca2 A549 NIH/3T3 RMN adamantylated Chalcones Thiazolylpyrazoline antimirobial activity anticancer
activity NMR ?????????? ??????????? ???????? ????????? ?????? ?????????? ?????? ?????? ???????Index. décimale : 540 Chimie et sciences connexes Résumé : In the first part, a new variety of adamantyl chalcones was efficiently prepared by ClaisenSchmidt reaction of 4-adamantyl acetophenone with a series of aromatic aldehydes in good
yields. Their structures were confirmed by spectroscopic data, and the relative configuration
of compound 3d was confirmed by X-ray crystallography. All synthesized chalcones were
tested against a panel of Gram-positive and Gram-negative bacteria and pathogenic fungus.
They displayed a strong antibacterial activity against Enterococcus faecali 29212,
Pseudomonas aeruginosa ATCC27853, Escherichia coli, as well as an interesting antifungal
activity against Candida glabrata ATCC 90030. The effect of these compounds was also
tested in vitro as antitumor on Miapaca2 cells. The compounds also showed anticancer
activity against human pancreas cancer cell MiaPaca2.
In the second part, several thiazolyl-pyrazoline derivatives were synthesized by reacting
substituted 3, 5-diaryl-1-thiocarbamoyl-2-pyrazolines with phenacylbromides. The structures
of the synthesized compounds were confirmed by IR, 1H NMR, 13C NMR, and MS spectral
data. Their antimicrobial, anticancer activities and cytotoxicity were investigated. A
significant level of antimicrobial activity and anticancer activity against A549 human lung
carcinoma cell line and low cytotoxicity were observed.Diplôme : Doctorat En ligne : ../theses/chimie/TAB7068.pdf Format de la ressource électronique : Permalink : https://bu.umc.edu.dz/md/index.php?lvl=notice_display&id=10533 Exemplaires (1)
Code-barres Cote Support Localisation Section Disponibilité TAB/7068 TAB/7068 Thèse Bibliothèque principale Thèses Disponible
Titre : Recherche de substances à activités antimicrobiennes (antibactériennes et anticandidoses) produites par des souches levuriennes isolées des sols sahariens Type de document : texte imprimé Auteurs : Sarah Lammi, Auteur ; Zahia Meraihi, Directeur de thèse Editeur : Constantine : Université Mentouri Constantine Année de publication : 2011 Importance : 75 f. Format : 31 cm Note générale : Magister
2 copies imprimées disponiblesLangues : Français (fre) Catégories : Français - Anglais
BiologieTags : Levures killer Toxines killer Activité antimicrobienne Sol Bactéries pathogénes Candida albicans. Biologie Index. décimale : 570 Sciences de la vie. Biologie En ligne : ../theses/biologie/LAM5887.pdf Format de la ressource électronique : Permalink : https://bu.umc.edu.dz/md/index.php?lvl=notice_display&id=5691 Recherche de substances à activités antimicrobiennes (antibactériennes et anticandidoses) produites par des souches levuriennes isolées des sols sahariens [texte imprimé] / Sarah Lammi, Auteur ; Zahia Meraihi, Directeur de thèse . - Constantine : Université Mentouri Constantine, 2011 . - 75 f. ; 31 cm.
Magister
2 copies imprimées disponibles
Langues : Français (fre)
Catégories : Français - Anglais
BiologieTags : Levures killer Toxines killer Activité antimicrobienne Sol Bactéries pathogénes Candida albicans. Biologie Index. décimale : 570 Sciences de la vie. Biologie En ligne : ../theses/biologie/LAM5887.pdf Format de la ressource électronique : Permalink : https://bu.umc.edu.dz/md/index.php?lvl=notice_display&id=5691 Exemplaires (1)
Code-barres Cote Support Localisation Section Disponibilité LAM/5887 LAM/5887 Thèse Bibliothèque principale Thèses Disponible
Titre : Préparation de nouveaux matériaux à base de (benz)imidazole et bio-activité : synthèse de complexes à base de (benz)imidazole, étude structurale et théorique et préparation d’analogues structuraux de la Tacrine à base de benzimidazole. Type de document : texte imprimé Auteurs : Anfel Benhassine ép Lifa, Auteur ; Ali Belfaitah, Directeur de thèse Editeur : جامعة الإخوة منتوري قسنطينة Année de publication : 2018 Importance : 186 f. Format : 30 cm. Note générale : 2 copies imprimées disponibles
Langues : Français (fre) Catégories : Français - Anglais
ChimieTags : Imidazole Benzimidazole Complexassion Métaux de transition divalents DFT orbitales frontières Tacrine réaction de Friedländer poly-hétérocycles DPPH ABTS activité antimicrobienne Divalent transition metals calculations Frontier orbitals Friedländer's reaction poly-heterocyclic compounds antimicrobial activity ????????? ??????????? ???????? ??????? ?????????? ?????? ??????? ?????? ?????? ??????? ???????? ????????????????? ?????? ?????? ?????????? Index. décimale : 540 Chimie et sciences connexes Résumé : The first part, which is subdivided into two chapters, concerns the synthesis, characterization (IR and UV-Vis, X-ray diffraction, and other elemental analysis) and biological evaluation of divalent transition metal complexes (M = Co , Cu, Cd, Zn, Ni) based on (1-methyl- 1Hbenzo[d]imidazol-2-yl) methanol (L1/Hmbm) (complexes 1-4) and (1-methyl-1H- imidazol-2-yl) methanol (L2/Hmim) (complexes 5-11). In both series of coordination compounds, the ligand (L1 or L2) gives rise to a variety of metal-ligand coordination modes(monodentate or bidentadate) exhibiting tetrahedral or octahedral geometry.The in vitro measurement of the antioxidant activity of the L1 and L2 ligands and their respective metal complexes against the free radical scavenger DPPH at low concentration (100 &g / mL), showed a moderate to significant antioxidant activities, compared to the standard (Asc). The complexes (5-11) and the ligand L2 were submitted to an in vitro evaluation of their antimicrobial activity against five pathogenic strains: animal bacteria:
Gram (+) (S. aureus) and Gram (-) (K pneumonia), a Gram (+) phytopathogenic bacterium (P.
syringae), a yeast (P. caribbica) and a fungus (Trichodermsp), using the disk diffusion method
(agar).The analysis of the results revealed a significant difference in the inhibition profile of the selected strains. The complex 5 and to a lesser extent the complex 6, gave the best results displaying significant inhibitory activities on mostly all pathogenic strains (broad spectrum). In the second part dedicated to the synthesis of structural analogs of Tacrine, a whole series of new poly-heterocyclic compounds (10-14) was prepared from the corresponding 4H-pyrans (5- 9) by an addition-hetero-cyclization reaction of cyclohexanone under the Friedl‰ndler's standard conditions reaction. The in vitro antioxidant tests (DPPH and ABTS) of
benzimidazopyranotacrines, showed that the five compounds have an antioxidant activities, and
the 5-Amino-2-methyl-4-(1-methyl-1H-benzo[d]imidazol-2-yl)-6,7,8,9-tetrahydro-4H-pyrano
[2,3-b]uinolin-3-yl) ethanone (compound 12) is the most efficient, exhibiting a comparable
inhibitory power of free radicals to that of reference compounds (controls). The structure of all the complexes (1-11) was determined by X-ray diffraction, IR, UV and other elemental analysis. For complexes 1-4, theoretical studies using DFT and TD-DFT calculations have been performed and confirmed the experimental results. Benzimidazopyranotacrines (10-14) as structural Tacrine's analogues and their intermediates 4Hpyrans (5-9), were identified by the usual spectroscopic methods (IR, 1H NMR and13C).Diplôme : Doctorat En ligne : ../theses/chimie/LIF7359.pdf Format de la ressource électronique : Permalink : https://bu.umc.edu.dz/md/index.php?lvl=notice_display&id=11008 Préparation de nouveaux matériaux à base de (benz)imidazole et bio-activité : synthèse de complexes à base de (benz)imidazole, étude structurale et théorique et préparation d’analogues structuraux de la Tacrine à base de benzimidazole. [texte imprimé] / Anfel Benhassine ép Lifa, Auteur ; Ali Belfaitah, Directeur de thèse . - [S.l.] : جامعة الإخوة منتوري قسنطينة, 2018 . - 186 f. ; 30 cm.
2 copies imprimées disponibles
Langues : Français (fre)
Catégories : Français - Anglais
ChimieTags : Imidazole Benzimidazole Complexassion Métaux de transition divalents DFT orbitales frontières Tacrine réaction de Friedländer poly-hétérocycles DPPH ABTS activité antimicrobienne Divalent transition metals calculations Frontier orbitals Friedländer's reaction poly-heterocyclic compounds antimicrobial activity ????????? ??????????? ???????? ??????? ?????????? ?????? ??????? ?????? ?????? ??????? ???????? ????????????????? ?????? ?????? ?????????? Index. décimale : 540 Chimie et sciences connexes Résumé : The first part, which is subdivided into two chapters, concerns the synthesis, characterization (IR and UV-Vis, X-ray diffraction, and other elemental analysis) and biological evaluation of divalent transition metal complexes (M = Co , Cu, Cd, Zn, Ni) based on (1-methyl- 1Hbenzo[d]imidazol-2-yl) methanol (L1/Hmbm) (complexes 1-4) and (1-methyl-1H- imidazol-2-yl) methanol (L2/Hmim) (complexes 5-11). In both series of coordination compounds, the ligand (L1 or L2) gives rise to a variety of metal-ligand coordination modes(monodentate or bidentadate) exhibiting tetrahedral or octahedral geometry.The in vitro measurement of the antioxidant activity of the L1 and L2 ligands and their respective metal complexes against the free radical scavenger DPPH at low concentration (100 &g / mL), showed a moderate to significant antioxidant activities, compared to the standard (Asc). The complexes (5-11) and the ligand L2 were submitted to an in vitro evaluation of their antimicrobial activity against five pathogenic strains: animal bacteria:
Gram (+) (S. aureus) and Gram (-) (K pneumonia), a Gram (+) phytopathogenic bacterium (P.
syringae), a yeast (P. caribbica) and a fungus (Trichodermsp), using the disk diffusion method
(agar).The analysis of the results revealed a significant difference in the inhibition profile of the selected strains. The complex 5 and to a lesser extent the complex 6, gave the best results displaying significant inhibitory activities on mostly all pathogenic strains (broad spectrum). In the second part dedicated to the synthesis of structural analogs of Tacrine, a whole series of new poly-heterocyclic compounds (10-14) was prepared from the corresponding 4H-pyrans (5- 9) by an addition-hetero-cyclization reaction of cyclohexanone under the Friedl‰ndler's standard conditions reaction. The in vitro antioxidant tests (DPPH and ABTS) of
benzimidazopyranotacrines, showed that the five compounds have an antioxidant activities, and
the 5-Amino-2-methyl-4-(1-methyl-1H-benzo[d]imidazol-2-yl)-6,7,8,9-tetrahydro-4H-pyrano
[2,3-b]uinolin-3-yl) ethanone (compound 12) is the most efficient, exhibiting a comparable
inhibitory power of free radicals to that of reference compounds (controls). The structure of all the complexes (1-11) was determined by X-ray diffraction, IR, UV and other elemental analysis. For complexes 1-4, theoretical studies using DFT and TD-DFT calculations have been performed and confirmed the experimental results. Benzimidazopyranotacrines (10-14) as structural Tacrine's analogues and their intermediates 4Hpyrans (5-9), were identified by the usual spectroscopic methods (IR, 1H NMR and13C).Diplôme : Doctorat En ligne : ../theses/chimie/LIF7359.pdf Format de la ressource électronique : Permalink : https://bu.umc.edu.dz/md/index.php?lvl=notice_display&id=11008 Exemplaires (1)
Code-barres Cote Support Localisation Section Disponibilité LIF/7359 LIF/7359 Thèse Bibliothèque principale Thèses Disponible
Titre : Etude des activités antioxydante et antibactérienne des polyphénols d’Allium triquetrum L. en vue de leur application sur la sardine commune Type de document : texte imprimé Auteurs : Hayat Himed èp Idir, Auteur ; Lila Boulekbache, Directeur de thèse Editeur : constantine [Algérie] : Université Constantine 1 Année de publication : 2014 Importance : 95 f. Format : 30 cm. Note générale : 2 copies imprimées disponibles
Langues : Français (fre) Catégories : Français - Anglais
Nutrition, Alimentation et Technologies Agro-AlimentairesTags : Allium triquetrum L. activité antioxydante activité antimicrobienne polyphénols Sardina pichardus antioxidant activity antimicrobial activity polyphenols ????? ?????? ??????? ????? ?????? ????????? ????????? ?????? ??????? ?????? Index. décimale : 640 Industrie Alimentaire Résumé :
phenolic compounds to study their antioxidant and antibacterial effects. The best phenolic
extract was tested to prevent sardine deterioration.
The extraction of polyphénols from leaves and bulbs was carried out by a conventional method (maceration) and the innovative one (microwave), using three solvent systems (acetone, ethanol, methanol) at 70%. We found that samples irradiated for three minutes gave the best yields.
For comparative purposes, total phenolics, flavonoïds and tannins are quantified from the different extracts. It found that leaves content is higher than that of bulbs. Extraction assisted by microwave, using acetone and ethanol, was best procedure of extraction of these bioactive compounds.
The antioxidant activity of selected extracts (FA, FA3, FE, FE3, BA, BE3) was evaluated by the means of three methods: FRAP method, DPPH essay and the β-carotene bleaching method. Results displayed that leaves extracts exercise notable antioxydant effect than the bulbs ones. The extract FA3 appears the best but less powerful than BHA which is used as standard.
A correlation between these extracts content’s of flavonoïds and antioxidant was highly significant (R2 > 0.95; p < 0.05) and even more significant than that obtained with total phenols and tannins.
Antibacterial potential of these extracts (FA, FA3, FE, FE3, BA, BE3) was tested by the Agar-well diffusion method against Bacillus subtilis ATCC6633, Staphylococcus aureus ATCC43300, Escherichia coli ATCC25922 and Pseudomonas aeruginosa ATCC27853. A moderate antibacterial activity of acetone extracts of leaves against Escherichia coli and Staphylococcus aureus was noted with a load of 1000 μg/disk.
The extract FA3 has been tested for its efficacy upon sardine with a concentration of 10, 25 and 50 mg/ml during 10 days of conservation at 6°C, using the TBARS method. The results showed that this extract reduce significantly the oxidation of sardine’s lipids.Diplôme : Magistère En ligne : ../theses/agronomie/HIM6626.pdf Format de la ressource électronique : Permalink : https://bu.umc.edu.dz/md/index.php?lvl=notice_display&id=9750 Etude des activités antioxydante et antibactérienne des polyphénols d’Allium triquetrum L. en vue de leur application sur la sardine commune [texte imprimé] / Hayat Himed èp Idir, Auteur ; Lila Boulekbache, Directeur de thèse . - constantine (Route ain el bey, Algérie) : Université Constantine 1, 2014 . - 95 f. ; 30 cm.
2 copies imprimées disponibles
Langues : Français (fre)
Catégories : Français - Anglais
Nutrition, Alimentation et Technologies Agro-AlimentairesTags : Allium triquetrum L. activité antioxydante activité antimicrobienne polyphénols Sardina pichardus antioxidant activity antimicrobial activity polyphenols ????? ?????? ??????? ????? ?????? ????????? ????????? ?????? ??????? ?????? Index. décimale : 640 Industrie Alimentaire Résumé :
phenolic compounds to study their antioxidant and antibacterial effects. The best phenolic
extract was tested to prevent sardine deterioration.
The extraction of polyphénols from leaves and bulbs was carried out by a conventional method (maceration) and the innovative one (microwave), using three solvent systems (acetone, ethanol, methanol) at 70%. We found that samples irradiated for three minutes gave the best yields.
For comparative purposes, total phenolics, flavonoïds and tannins are quantified from the different extracts. It found that leaves content is higher than that of bulbs. Extraction assisted by microwave, using acetone and ethanol, was best procedure of extraction of these bioactive compounds.
The antioxidant activity of selected extracts (FA, FA3, FE, FE3, BA, BE3) was evaluated by the means of three methods: FRAP method, DPPH essay and the β-carotene bleaching method. Results displayed that leaves extracts exercise notable antioxydant effect than the bulbs ones. The extract FA3 appears the best but less powerful than BHA which is used as standard.
A correlation between these extracts content’s of flavonoïds and antioxidant was highly significant (R2 > 0.95; p < 0.05) and even more significant than that obtained with total phenols and tannins.
Antibacterial potential of these extracts (FA, FA3, FE, FE3, BA, BE3) was tested by the Agar-well diffusion method against Bacillus subtilis ATCC6633, Staphylococcus aureus ATCC43300, Escherichia coli ATCC25922 and Pseudomonas aeruginosa ATCC27853. A moderate antibacterial activity of acetone extracts of leaves against Escherichia coli and Staphylococcus aureus was noted with a load of 1000 μg/disk.
The extract FA3 has been tested for its efficacy upon sardine with a concentration of 10, 25 and 50 mg/ml during 10 days of conservation at 6°C, using the TBARS method. The results showed that this extract reduce significantly the oxidation of sardine’s lipids.Diplôme : Magistère En ligne : ../theses/agronomie/HIM6626.pdf Format de la ressource électronique : Permalink : https://bu.umc.edu.dz/md/index.php?lvl=notice_display&id=9750 Exemplaires (1)
Code-barres Cote Support Localisation Section Disponibilité HIM/6626 HIM/6626 Thèse Bibliothèque principale Thèses Disponible
Titre : Etude phytochimique et activité antimicrobienne de l'espèce Ranunculus arvensis L. Type de document : texte imprimé Auteurs : Ahèam Hachelaf ; Université Mentouri, Editeur scientifique ; Salah Rhouati, Directeur de thèse Année de publication : 2006 Importance : 126 f. Note générale : 01 Disponible à la salle de recherche 02 Disponibles au magazin de la B.U.C. Langues : Français (fre) Catégories : Français - Anglais
ChimieTags : Flavonoides Activité antimicrobienne Etude phytochimique Alcaloides Ranunculus arvensis Coumarine Index. décimale : 540 Chimie et sciences connexes Permalink : https://bu.umc.edu.dz/md/index.php?lvl=notice_display&id=3833 Etude phytochimique et activité antimicrobienne de l'espèce Ranunculus arvensis L. [texte imprimé] / Ahèam Hachelaf ; Université Mentouri, Editeur scientifique ; Salah Rhouati, Directeur de thèse . - 2006 . - 126 f.
01 Disponible à la salle de recherche 02 Disponibles au magazin de la B.U.C.
Langues : Français (fre)
Catégories : Français - Anglais
ChimieTags : Flavonoides Activité antimicrobienne Etude phytochimique Alcaloides Ranunculus arvensis Coumarine Index. décimale : 540 Chimie et sciences connexes Permalink : https://bu.umc.edu.dz/md/index.php?lvl=notice_display&id=3833 Exemplaires (1)
Code-barres Cote Support Localisation Section Disponibilité HAC/4411 HAC/4411 Thèse Bibliothèque principale Thèses Disponible Permalink
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