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Partager le résultat de cette recherche Interroger des sources externesPréparation de nouveaux matériaux à base de (benz)imidazole et bio-activité / Anfel Benhassine ép Lifa
Titre : Préparation de nouveaux matériaux à base de (benz)imidazole et bio-activité : synthèse de complexes à base de (benz)imidazole, étude structurale et théorique et préparation d’analogues structuraux de la Tacrine à base de benzimidazole. Type de document : texte imprimé Auteurs : Anfel Benhassine ép Lifa, Auteur ; Ali Belfaitah, Directeur de thèse Editeur : جامعة الإخوة منتوري قسنطينة Année de publication : 2018 Importance : 186 f. Format : 30 cm. Note générale : 2 copies imprimées disponibles
Langues : Français (fre) Catégories : Français - Anglais
ChimieTags : Imidazole Benzimidazole Complexassion Métaux de transition divalents DFT orbitales frontières Tacrine réaction de Friedländer poly-hétérocycles DPPH ABTS activité antimicrobienne Divalent transition metals calculations Frontier orbitals Friedländer's reaction poly-heterocyclic compounds antimicrobial activity إيميدازول بنزيميدازول المعقدات المعادن الانتقالية ثنائية التكافؤ النشاط المضاد للأكسدة التاكرين البنزوبرانوتاكرين النشاط المضاد للميكروبات Index. décimale : 540 Chimie et sciences connexes Résumé : The first part, which is subdivided into two chapters, concerns the synthesis, characterization (IR and UV-Vis, X-ray diffraction, and other elemental analysis) and biological evaluation of divalent transition metal complexes (M = Co , Cu, Cd, Zn, Ni) based on (1-methyl- 1Hbenzo[d]imidazol-2-yl) methanol (L1/Hmbm) (complexes 1-4) and (1-methyl-1H- imidazol-2-yl) methanol (L2/Hmim) (complexes 5-11). In both series of coordination compounds, the ligand (L1 or L2) gives rise to a variety of metal-ligand coordination modes(monodentate or bidentadate) exhibiting tetrahedral or octahedral geometry.The in vitro measurement of the antioxidant activity of the L1 and L2 ligands and their respective metal complexes against the free radical scavenger DPPH at low concentration (100 &g / mL), showed a moderate to significant antioxidant activities, compared to the standard (Asc). The complexes (5-11) and the ligand L2 were submitted to an in vitro evaluation of their antimicrobial activity against five pathogenic strains: animal bacteria:
Gram (+) (S. aureus) and Gram (-) (K pneumonia), a Gram (+) phytopathogenic bacterium (P.
syringae), a yeast (P. caribbica) and a fungus (Trichodermsp), using the disk diffusion method
(agar).The analysis of the results revealed a significant difference in the inhibition profile of the selected strains. The complex 5 and to a lesser extent the complex 6, gave the best results displaying significant inhibitory activities on mostly all pathogenic strains (broad spectrum). In the second part dedicated to the synthesis of structural analogs of Tacrine, a whole series of new poly-heterocyclic compounds (10-14) was prepared from the corresponding 4H-pyrans (5- 9) by an addition-hetero-cyclization reaction of cyclohexanone under the Friedl‰ndler's standard conditions reaction. The in vitro antioxidant tests (DPPH and ABTS) of
benzimidazopyranotacrines, showed that the five compounds have an antioxidant activities, and
the 5-Amino-2-methyl-4-(1-methyl-1H-benzo[d]imidazol-2-yl)-6,7,8,9-tetrahydro-4H-pyrano
[2,3-b]uinolin-3-yl) ethanone (compound 12) is the most efficient, exhibiting a comparable
inhibitory power of free radicals to that of reference compounds (controls). The structure of all the complexes (1-11) was determined by X-ray diffraction, IR, UV and other elemental analysis. For complexes 1-4, theoretical studies using DFT and TD-DFT calculations have been performed and confirmed the experimental results. Benzimidazopyranotacrines (10-14) as structural Tacrine's analogues and their intermediates 4Hpyrans (5-9), were identified by the usual spectroscopic methods (IR, 1H NMR and13C).Diplôme : Doctorat En ligne : ../theses/chimie/LIF7359.pdf Format de la ressource électronique : Permalink : https://bu.umc.edu.dz/md/index.php?lvl=notice_display&id=11008 Préparation de nouveaux matériaux à base de (benz)imidazole et bio-activité : synthèse de complexes à base de (benz)imidazole, étude structurale et théorique et préparation d’analogues structuraux de la Tacrine à base de benzimidazole. [texte imprimé] / Anfel Benhassine ép Lifa, Auteur ; Ali Belfaitah, Directeur de thèse . - جامعة الإخوة منتوري قسنطينة, 2018 . - 186 f. ; 30 cm.
2 copies imprimées disponibles
Langues : Français (fre)
Catégories : Français - Anglais
ChimieTags : Imidazole Benzimidazole Complexassion Métaux de transition divalents DFT orbitales frontières Tacrine réaction de Friedländer poly-hétérocycles DPPH ABTS activité antimicrobienne Divalent transition metals calculations Frontier orbitals Friedländer's reaction poly-heterocyclic compounds antimicrobial activity إيميدازول بنزيميدازول المعقدات المعادن الانتقالية ثنائية التكافؤ النشاط المضاد للأكسدة التاكرين البنزوبرانوتاكرين النشاط المضاد للميكروبات Index. décimale : 540 Chimie et sciences connexes Résumé : The first part, which is subdivided into two chapters, concerns the synthesis, characterization (IR and UV-Vis, X-ray diffraction, and other elemental analysis) and biological evaluation of divalent transition metal complexes (M = Co , Cu, Cd, Zn, Ni) based on (1-methyl- 1Hbenzo[d]imidazol-2-yl) methanol (L1/Hmbm) (complexes 1-4) and (1-methyl-1H- imidazol-2-yl) methanol (L2/Hmim) (complexes 5-11). In both series of coordination compounds, the ligand (L1 or L2) gives rise to a variety of metal-ligand coordination modes(monodentate or bidentadate) exhibiting tetrahedral or octahedral geometry.The in vitro measurement of the antioxidant activity of the L1 and L2 ligands and their respective metal complexes against the free radical scavenger DPPH at low concentration (100 &g / mL), showed a moderate to significant antioxidant activities, compared to the standard (Asc). The complexes (5-11) and the ligand L2 were submitted to an in vitro evaluation of their antimicrobial activity against five pathogenic strains: animal bacteria:
Gram (+) (S. aureus) and Gram (-) (K pneumonia), a Gram (+) phytopathogenic bacterium (P.
syringae), a yeast (P. caribbica) and a fungus (Trichodermsp), using the disk diffusion method
(agar).The analysis of the results revealed a significant difference in the inhibition profile of the selected strains. The complex 5 and to a lesser extent the complex 6, gave the best results displaying significant inhibitory activities on mostly all pathogenic strains (broad spectrum). In the second part dedicated to the synthesis of structural analogs of Tacrine, a whole series of new poly-heterocyclic compounds (10-14) was prepared from the corresponding 4H-pyrans (5- 9) by an addition-hetero-cyclization reaction of cyclohexanone under the Friedl‰ndler's standard conditions reaction. The in vitro antioxidant tests (DPPH and ABTS) of
benzimidazopyranotacrines, showed that the five compounds have an antioxidant activities, and
the 5-Amino-2-methyl-4-(1-methyl-1H-benzo[d]imidazol-2-yl)-6,7,8,9-tetrahydro-4H-pyrano
[2,3-b]uinolin-3-yl) ethanone (compound 12) is the most efficient, exhibiting a comparable
inhibitory power of free radicals to that of reference compounds (controls). The structure of all the complexes (1-11) was determined by X-ray diffraction, IR, UV and other elemental analysis. For complexes 1-4, theoretical studies using DFT and TD-DFT calculations have been performed and confirmed the experimental results. Benzimidazopyranotacrines (10-14) as structural Tacrine's analogues and their intermediates 4Hpyrans (5-9), were identified by the usual spectroscopic methods (IR, 1H NMR and13C).Diplôme : Doctorat En ligne : ../theses/chimie/LIF7359.pdf Format de la ressource électronique : Permalink : https://bu.umc.edu.dz/md/index.php?lvl=notice_display&id=11008 Exemplaires (1)
Code-barres Cote Support Localisation Section Disponibilité LIF/7359 LIF/7359 Thèse Bibliothèque principale Thèses Disponible
Titre : Synthèse et caractérisation d’imines et benzoquinoléines, active biologiquement. Type de document : texte imprimé Auteurs : Nadir Ghichi, Auteur ; Ali Benboudiaf, Directeur de thèse Editeur : جامعة الإخوة منتوري قسنطينة Année de publication : 2018 Importance : 197 f. Format : 30 cm. Note générale : 1 copies imprimées disponibles
Langues : Français (fre) Catégories : Français - Anglais
ChimieTags : Bases de Schiff RMN DRX monocristal antioxydante DPPH CUPRAC ABTS Shiff bases NMR XRD single crystal antioxidant " قواعد شيف XRDالبلور الحادي مضادات الكسدة Index. décimale : 540 Chimie et sciences connexes Résumé : The principal objective of this thesis is based on the synthesis of two amide-based quinoléine dérivatives, and seven original organic compounds of imine derivatives [Shiff’s base] of bidentate NO type, tridentate NOO and NNO, tetradentate NNOO. These organic compounds were identified by the proton and carbon 13 NMR mthod. The synthesized compounds were prepared according to known methods. The imine derivative structures were determined from the diffraction data measured on single crystal. The results of study of biological activity [antioxidant activity] are as follows :
- The imine derivatives [compound 1, 4 and 7] and the organic compound Q4 showed the best activity with the CUPRAC test. -Compound Q3 showed low trapping activity with the ABTS test. -The organic compounds Q3 and Q4 , and the imine derivative 4 showed a low antiradical activity with the standard DPPH test.Diplôme : Doctorat en sciences En ligne : ../theses/chimie/GHI7358.pdf Format de la ressource électronique : Permalink : https://bu.umc.edu.dz/md/index.php?lvl=notice_display&id=11007 Synthèse et caractérisation d’imines et benzoquinoléines, active biologiquement. [texte imprimé] / Nadir Ghichi, Auteur ; Ali Benboudiaf, Directeur de thèse . - جامعة الإخوة منتوري قسنطينة, 2018 . - 197 f. ; 30 cm.
1 copies imprimées disponibles
Langues : Français (fre)
Catégories : Français - Anglais
ChimieTags : Bases de Schiff RMN DRX monocristal antioxydante DPPH CUPRAC ABTS Shiff bases NMR XRD single crystal antioxidant " قواعد شيف XRDالبلور الحادي مضادات الكسدة Index. décimale : 540 Chimie et sciences connexes Résumé : The principal objective of this thesis is based on the synthesis of two amide-based quinoléine dérivatives, and seven original organic compounds of imine derivatives [Shiff’s base] of bidentate NO type, tridentate NOO and NNO, tetradentate NNOO. These organic compounds were identified by the proton and carbon 13 NMR mthod. The synthesized compounds were prepared according to known methods. The imine derivative structures were determined from the diffraction data measured on single crystal. The results of study of biological activity [antioxidant activity] are as follows :
- The imine derivatives [compound 1, 4 and 7] and the organic compound Q4 showed the best activity with the CUPRAC test. -Compound Q3 showed low trapping activity with the ABTS test. -The organic compounds Q3 and Q4 , and the imine derivative 4 showed a low antiradical activity with the standard DPPH test.Diplôme : Doctorat en sciences En ligne : ../theses/chimie/GHI7358.pdf Format de la ressource électronique : Permalink : https://bu.umc.edu.dz/md/index.php?lvl=notice_display&id=11007 Exemplaires (1)
Code-barres Cote Support Localisation Section Disponibilité GHI/7358 GHI/7358 Thèse Bibliothèque principale Thèses Disponible
Titre : Recherche et détermination structurale de métabolites secondaires de deux plantes Algériennes de la famille des lamiaceae Type de document : texte imprimé Auteurs : Sabrina Mohamadi, Auteur ; Samir Benayache, Directeur de thèse Editeur : جامعة الإخوة منتوري قسنطينة Année de publication : 2016 Importance : 334 f. Format : 30 cm. Note générale : 2 copies imprimées disponibles
Langues : Français (fre) Catégories : Français - Anglais
ChimieTags : UV-visible SM-MR RMN,1H 13C cosy noesy HSQC HMBC ABTS ORAC DPPH طرق التحليل الطيفي مطيافية الأشعة فوق البنفسجية مطيافية الكتلة عالية الدقة مطيافية الرنين المغناطيسي Index. décimale : 540 Chimie et sciences connexes Résumé : This work deals with the structural determination and biological evaluation of natural substances isolated from two species of the Lamiaceae family (Salvia aegyptiaca and Saccocalyx satureioides). These family and the genus Salvia are known for their rich antioxidant compounds including polyphenols and flavonoids.
The phytochemical study of the aerial parts of these species allowed after extraction, separation and purification the isolation and identification of nineteen compounds from Saccocalyx satureioides and fourteen compounds from Salvia aegyptiaca .These compounds were identified by the combination of spectroscopic methods including : UV-visible absorption spectroscopy, high resolution HR-MS mass spectrometry, 1H and 13C-NMR and two-dimensional experiments (COSY, NOESY, HSQC, and HMBC) The isolated compounds were :
A flavonol : Quercetin (14).
Fifteen flavones : 7-methyl- sudachitin (8), Sideritiflavone (17), Luteolin (25),
Apigenin (27), Salvigenin(28), 4',7-dimethylapigenin (29), 5-hydroxy 3', 4', 6,7-
tetraméthoxyflavone(30), IsoIscutellarein-7-O-allosyl (1→2) glucoside (11),Isoscutellarein-7-O-[ β-D-allopyranosyl-(1→2)]-6’’-O-acetyl- β-D-glucopyranoside
(12), Isoscutellarein-7-O-[6”’-O-acetyl- β-D-allopyranosyl-(1→2)]- β-Dglucopyranoside (13) , Isoscutellarein -7-O-[6‴-O -acetyl-β-D-allopyranosyl (1→2) ]-
6″-O-acetyl-β-D-glucopyranoside. (15), Apigenin- 7-O-(6’’-trans-p-coumaroyl- β -Dglucopyranoside (16), Luteolin 7-O glucoside (21), Apigenine 7-O glucoside (22),
Diosmin (23).
Sixteen phenolic compounds : Piceol(1), Vanillin (2), Ferulic aldehyde (3), 3,3’-bis (3,4-
dihydro-4-hydroxy-6,8-dimethoxy-2H-1-benzopyran) (4), 3,3’-bis (3,4-dihydro-4-
hydroxy-6-methoxy-2H-1-benzopyran) (5), Dimethylcaffeic acid (6), Balanophonin (7),
Caffeic acid (9), p-coumaric acid (10), 4-methoxyphenol, Salicylic acid, Caffeic acide
(18), Vanillic acid (19), Syringic acid (20), Rosmarinic acid (24), Methyl rosmarinate
(26).
A furocoumarin : 6`,7`-dihydroxybergamottin(31)The study of the chemical composition of essential oil of Salvia aegyptiaca species growing in
Algeria was characterized by a high level of sesquiterpene fraction and a moderate level of
monoterpene components. β-caryophyllene (10.2%), Selina-4,11-diene (9.7%), bornyl acetate
(8.5%), β-gurjunene (7.6%), germacrene D (7.0 %) and β-caryophyllene oxide (6.2%) were the
major components of this essential oil.
This work led to the publications of two articles subject entitled “ On-line screening and
identification of antioxidant phenolic compounds of Saccocalyx satureioides Coss. et Dur.” and
“ Chemical composition of the Essential oil of Salvia aegyptiaca” . A third paper is in
preparation and will be devoted to the phytochemical and biological study of Salvia aegyptiaca.
Diplôme : Doctorat En ligne : ../theses/chimie/MOH6938.pdf Format de la ressource électronique : Permalink : https://bu.umc.edu.dz/md/index.php?lvl=notice_display&id=10289 Recherche et détermination structurale de métabolites secondaires de deux plantes Algériennes de la famille des lamiaceae [texte imprimé] / Sabrina Mohamadi, Auteur ; Samir Benayache, Directeur de thèse . - جامعة الإخوة منتوري قسنطينة, 2016 . - 334 f. ; 30 cm.
2 copies imprimées disponibles
Langues : Français (fre)
Catégories : Français - Anglais
ChimieTags : UV-visible SM-MR RMN,1H 13C cosy noesy HSQC HMBC ABTS ORAC DPPH طرق التحليل الطيفي مطيافية الأشعة فوق البنفسجية مطيافية الكتلة عالية الدقة مطيافية الرنين المغناطيسي Index. décimale : 540 Chimie et sciences connexes Résumé : This work deals with the structural determination and biological evaluation of natural substances isolated from two species of the Lamiaceae family (Salvia aegyptiaca and Saccocalyx satureioides). These family and the genus Salvia are known for their rich antioxidant compounds including polyphenols and flavonoids.
The phytochemical study of the aerial parts of these species allowed after extraction, separation and purification the isolation and identification of nineteen compounds from Saccocalyx satureioides and fourteen compounds from Salvia aegyptiaca .These compounds were identified by the combination of spectroscopic methods including : UV-visible absorption spectroscopy, high resolution HR-MS mass spectrometry, 1H and 13C-NMR and two-dimensional experiments (COSY, NOESY, HSQC, and HMBC) The isolated compounds were :
A flavonol : Quercetin (14).
Fifteen flavones : 7-methyl- sudachitin (8), Sideritiflavone (17), Luteolin (25),
Apigenin (27), Salvigenin(28), 4',7-dimethylapigenin (29), 5-hydroxy 3', 4', 6,7-
tetraméthoxyflavone(30), IsoIscutellarein-7-O-allosyl (1→2) glucoside (11),Isoscutellarein-7-O-[ β-D-allopyranosyl-(1→2)]-6’’-O-acetyl- β-D-glucopyranoside
(12), Isoscutellarein-7-O-[6”’-O-acetyl- β-D-allopyranosyl-(1→2)]- β-Dglucopyranoside (13) , Isoscutellarein -7-O-[6‴-O -acetyl-β-D-allopyranosyl (1→2) ]-
6″-O-acetyl-β-D-glucopyranoside. (15), Apigenin- 7-O-(6’’-trans-p-coumaroyl- β -Dglucopyranoside (16), Luteolin 7-O glucoside (21), Apigenine 7-O glucoside (22),
Diosmin (23).
Sixteen phenolic compounds : Piceol(1), Vanillin (2), Ferulic aldehyde (3), 3,3’-bis (3,4-
dihydro-4-hydroxy-6,8-dimethoxy-2H-1-benzopyran) (4), 3,3’-bis (3,4-dihydro-4-
hydroxy-6-methoxy-2H-1-benzopyran) (5), Dimethylcaffeic acid (6), Balanophonin (7),
Caffeic acid (9), p-coumaric acid (10), 4-methoxyphenol, Salicylic acid, Caffeic acide
(18), Vanillic acid (19), Syringic acid (20), Rosmarinic acid (24), Methyl rosmarinate
(26).
A furocoumarin : 6`,7`-dihydroxybergamottin(31)The study of the chemical composition of essential oil of Salvia aegyptiaca species growing in
Algeria was characterized by a high level of sesquiterpene fraction and a moderate level of
monoterpene components. β-caryophyllene (10.2%), Selina-4,11-diene (9.7%), bornyl acetate
(8.5%), β-gurjunene (7.6%), germacrene D (7.0 %) and β-caryophyllene oxide (6.2%) were the
major components of this essential oil.
This work led to the publications of two articles subject entitled “ On-line screening and
identification of antioxidant phenolic compounds of Saccocalyx satureioides Coss. et Dur.” and
“ Chemical composition of the Essential oil of Salvia aegyptiaca” . A third paper is in
preparation and will be devoted to the phytochemical and biological study of Salvia aegyptiaca.
Diplôme : Doctorat En ligne : ../theses/chimie/MOH6938.pdf Format de la ressource électronique : Permalink : https://bu.umc.edu.dz/md/index.php?lvl=notice_display&id=10289 Exemplaires (1)
Code-barres Cote Support Localisation Section Disponibilité MOH/6938 MOH/6938 Thèse Bibliothèque principale Thèses Disponible
