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Partager le résultat de cette recherche Interroger des sources externesPropriétés antioxydantes et activité inhibitrice de la Xanthine oxydase des extraits de la plante médicinale Ajuga iva (L.) Schreber. / Moufida Adjadj
Titre : Propriétés antioxydantes et activité inhibitrice de la Xanthine oxydase des extraits de la plante médicinale Ajuga iva (L.) Schreber. Type de document : texte imprimé Auteurs : Moufida Adjadj, Auteur ; Abderrahmane Baghiani, Directeur de thèse Editeur : جامعة الإخوة منتوري قسنطينة Année de publication : 2009 Importance : 96 f. Format : 30 cm. Note générale : 01 Disponible à la salle de recherche 02 Disponibles au magazin de la B.U.C. 01 CD Langues : Français (fre) Tags : Flavonoides Stress oxydatif Antioxydants Plantes médicinales Ajuga iva Effet scavenger DPPH Péroxydationlipidique Béta-caroèe/acide linoléique Index. décimale : 570 Sciences de la vie. Biologie Résumé : This study was conducted to search for XO inhibitors from Ajuga iva shoot extracts
(AISE) traditionally used in folk medicine in Algeria. XO was purified from fresh bovine
milk with yields of ? ? ? ? ? mg / L, protein / flavine ratio of 5.15 and a single major band, on
SDS-PAGE, of approximately 150 KDa, indicating a high purity of the purified enzyme. The
specific activity of the purified enzyme was of 2055.05 nmol / min / mg protein. The analysis
of methanol (CrE), chloroform (ChE) and ethyl acetate (EaE) extracts, showed that the EaE
has significant amount of polyphenols (35.83 ± 0.69 mg EGA / g dry extract), followed by
ChE and CrE (30.58 ± 0.2 and 17.38 ± 0.29 mg EGA / g dry extract, respectively). The ChE
has the highest flavonoids content (9.64 ± 0.33 mg EQ / g dry extract), followed by EaE and
CrE with 7.72 ± 0.19 et 4.92 ± 0.30 mg EQ / g dry extract, respectively. The ChE showed the
highest inhibitory properties on the XO activity (IC50 = 0.134 ± 0.00032 mg / ml) and on the
cytochrome c reduction (IC50 = 0.23 ± 0.0017 mg / ml), followed by EaE with IC50 of XO
inhibitory activity and an IC50 of the inhibition of cyt c reduction of 0.185 ± 0.0019 and 1.046
± 0.0055 mg /ml, respectively. Finally, CrE had the lowest inhibitory effect on XO activity
and on cyt c reduction with 0.367 ± 0.0041 and 3.34 ± 0.018 mg / ml, respectively. The
antioxidant potential was confirmed with the non enzymatic methods, DPPH assay and β-
carotene / linoleic acid bleaching assay. The highest DPPH radical scavenging activity was
observed with EaE (IC50 = 228.01 ± 2.26 µg / ml), followed by CrE and ChE with IC50 of
415.06 ± 0.59 and 466.33 ± 3.20 µg / ml, respectively. The β-carotene / linoleic acid
bleaching assay revealed that AISE have a very important antioxidant activity. Results
showed that ChE has the highest antioxidant activity (95.64 ± 0.15 %), followed by CrE and
EaE with 87.97 ± 0.10 % and 72.30 ± 0.35 %, respectively. These results suggest that these
natural products could be used to treat lot of diseases, where inhibition of XO, free radical
scavenging activity and / or inhibition of lipid peroxidation are necessary.Diplôme : Magistère En ligne : ../theses/biologie/ADJ5396.pdf Format de la ressource électronique : Permalink : https://bu.umc.edu.dz/md/index.php?lvl=notice_display&id=1800 Propriétés antioxydantes et activité inhibitrice de la Xanthine oxydase des extraits de la plante médicinale Ajuga iva (L.) Schreber. [texte imprimé] / Moufida Adjadj, Auteur ; Abderrahmane Baghiani, Directeur de thèse . - [S.l.] : جامعة الإخوة منتوري قسنطينة, 2009 . - 96 f. ; 30 cm.
01 Disponible à la salle de recherche 02 Disponibles au magazin de la B.U.C. 01 CD
Langues : Français (fre)
Tags : Flavonoides Stress oxydatif Antioxydants Plantes médicinales Ajuga iva Effet scavenger DPPH Péroxydationlipidique Béta-caroèe/acide linoléique Index. décimale : 570 Sciences de la vie. Biologie Résumé : This study was conducted to search for XO inhibitors from Ajuga iva shoot extracts
(AISE) traditionally used in folk medicine in Algeria. XO was purified from fresh bovine
milk with yields of ? ? ? ? ? mg / L, protein / flavine ratio of 5.15 and a single major band, on
SDS-PAGE, of approximately 150 KDa, indicating a high purity of the purified enzyme. The
specific activity of the purified enzyme was of 2055.05 nmol / min / mg protein. The analysis
of methanol (CrE), chloroform (ChE) and ethyl acetate (EaE) extracts, showed that the EaE
has significant amount of polyphenols (35.83 ± 0.69 mg EGA / g dry extract), followed by
ChE and CrE (30.58 ± 0.2 and 17.38 ± 0.29 mg EGA / g dry extract, respectively). The ChE
has the highest flavonoids content (9.64 ± 0.33 mg EQ / g dry extract), followed by EaE and
CrE with 7.72 ± 0.19 et 4.92 ± 0.30 mg EQ / g dry extract, respectively. The ChE showed the
highest inhibitory properties on the XO activity (IC50 = 0.134 ± 0.00032 mg / ml) and on the
cytochrome c reduction (IC50 = 0.23 ± 0.0017 mg / ml), followed by EaE with IC50 of XO
inhibitory activity and an IC50 of the inhibition of cyt c reduction of 0.185 ± 0.0019 and 1.046
± 0.0055 mg /ml, respectively. Finally, CrE had the lowest inhibitory effect on XO activity
and on cyt c reduction with 0.367 ± 0.0041 and 3.34 ± 0.018 mg / ml, respectively. The
antioxidant potential was confirmed with the non enzymatic methods, DPPH assay and β-
carotene / linoleic acid bleaching assay. The highest DPPH radical scavenging activity was
observed with EaE (IC50 = 228.01 ± 2.26 µg / ml), followed by CrE and ChE with IC50 of
415.06 ± 0.59 and 466.33 ± 3.20 µg / ml, respectively. The β-carotene / linoleic acid
bleaching assay revealed that AISE have a very important antioxidant activity. Results
showed that ChE has the highest antioxidant activity (95.64 ± 0.15 %), followed by CrE and
EaE with 87.97 ± 0.10 % and 72.30 ± 0.35 %, respectively. These results suggest that these
natural products could be used to treat lot of diseases, where inhibition of XO, free radical
scavenging activity and / or inhibition of lipid peroxidation are necessary.Diplôme : Magistère En ligne : ../theses/biologie/ADJ5396.pdf Format de la ressource électronique : Permalink : https://bu.umc.edu.dz/md/index.php?lvl=notice_display&id=1800 Exemplaires
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Titre : Synthèse et caractérisation d’imines et benzoquinoléines, active biologiquement. Type de document : texte imprimé Auteurs : Nadir Ghichi, Auteur ; Ali Benboudiaf, Directeur de thèse Editeur : جامعة الإخوة منتوري قسنطينة Année de publication : 2018 Importance : 197 f. Format : 30 cm. Note générale : 1 copies imprimées disponibles
Langues : Français (fre) Tags : Bases de Schiff RMN DRX monocristal antioxydante DPPH CUPRAC ABTS Shiff bases NMR XRD single crystal antioxidant " ????? ??? XRD?????? ?????? ?????? ?????? Index. décimale : 540 Chimie et sciences connexes Résumé : The principal objective of this thesis is based on the synthesis of two amide-based quinoléine dérivatives, and seven original organic compounds of imine derivatives [Shiff’s base] of bidentate NO type, tridentate NOO and NNO, tetradentate NNOO. These organic compounds were identified by the proton and carbon 13 NMR mthod. The synthesized compounds were prepared according to known methods. The imine derivative structures were determined from the diffraction data measured on single crystal. The results of study of biological activity [antioxidant activity] are as follows :
- The imine derivatives [compound 1, 4 and 7] and the organic compound Q4 showed the best activity with the CUPRAC test. -Compound Q3 showed low trapping activity with the ABTS test. -The organic compounds Q3 and Q4 , and the imine derivative 4 showed a low antiradical activity with the standard DPPH test.Diplôme : Doctorat en sciences En ligne : ../theses/chimie/GHI7358.pdf Format de la ressource électronique : Permalink : https://bu.umc.edu.dz/md/index.php?lvl=notice_display&id=11007 Synthèse et caractérisation d’imines et benzoquinoléines, active biologiquement. [texte imprimé] / Nadir Ghichi, Auteur ; Ali Benboudiaf, Directeur de thèse . - [S.l.] : جامعة الإخوة منتوري قسنطينة, 2018 . - 197 f. ; 30 cm.
1 copies imprimées disponibles
Langues : Français (fre)
Tags : Bases de Schiff RMN DRX monocristal antioxydante DPPH CUPRAC ABTS Shiff bases NMR XRD single crystal antioxidant " ????? ??? XRD?????? ?????? ?????? ?????? Index. décimale : 540 Chimie et sciences connexes Résumé : The principal objective of this thesis is based on the synthesis of two amide-based quinoléine dérivatives, and seven original organic compounds of imine derivatives [Shiff’s base] of bidentate NO type, tridentate NOO and NNO, tetradentate NNOO. These organic compounds were identified by the proton and carbon 13 NMR mthod. The synthesized compounds were prepared according to known methods. The imine derivative structures were determined from the diffraction data measured on single crystal. The results of study of biological activity [antioxidant activity] are as follows :
- The imine derivatives [compound 1, 4 and 7] and the organic compound Q4 showed the best activity with the CUPRAC test. -Compound Q3 showed low trapping activity with the ABTS test. -The organic compounds Q3 and Q4 , and the imine derivative 4 showed a low antiradical activity with the standard DPPH test.Diplôme : Doctorat en sciences En ligne : ../theses/chimie/GHI7358.pdf Format de la ressource électronique : Permalink : https://bu.umc.edu.dz/md/index.php?lvl=notice_display&id=11007 Exemplaires
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Titre : Préparation de nouveaux matériaux à base de (benz)imidazole et bio-activité : synthèse de complexes à base de (benz)imidazole, étude structurale et théorique et préparation d’analogues structuraux de la Tacrine à base de benzimidazole. Type de document : texte imprimé Auteurs : Anfel Benhassine ép Lifa, Auteur ; Ali Belfaitah, Directeur de thèse Editeur : جامعة الإخوة منتوري قسنطينة Année de publication : 2018 Importance : 186 f. Format : 30 cm. Note générale : 2 copies imprimées disponibles
Langues : Français (fre) Tags : Imidazole Benzimidazole Complexassion Métaux de transition divalents DFT orbitales frontières Tacrine réaction de Friedländer poly-hétérocycles DPPH ABTS activité antimicrobienne Divalent transition metals calculations Frontier orbitals Friedländer's reaction poly-heterocyclic compounds antimicrobial activity ????????? ??????????? ???????? ??????? ?????????? ?????? ??????? ?????? ?????? ??????? ???????? ????????????????? ?????? ?????? ?????????? Index. décimale : 540 Chimie et sciences connexes Résumé : The first part, which is subdivided into two chapters, concerns the synthesis, characterization (IR and UV-Vis, X-ray diffraction, and other elemental analysis) and biological evaluation of divalent transition metal complexes (M = Co , Cu, Cd, Zn, Ni) based on (1-methyl- 1Hbenzo[d]imidazol-2-yl) methanol (L1/Hmbm) (complexes 1-4) and (1-methyl-1H- imidazol-2-yl) methanol (L2/Hmim) (complexes 5-11). In both series of coordination compounds, the ligand (L1 or L2) gives rise to a variety of metal-ligand coordination modes(monodentate or bidentadate) exhibiting tetrahedral or octahedral geometry.The in vitro measurement of the antioxidant activity of the L1 and L2 ligands and their respective metal complexes against the free radical scavenger DPPH at low concentration (100 &g / mL), showed a moderate to significant antioxidant activities, compared to the standard (Asc). The complexes (5-11) and the ligand L2 were submitted to an in vitro evaluation of their antimicrobial activity against five pathogenic strains: animal bacteria:
Gram (+) (S. aureus) and Gram (-) (K pneumonia), a Gram (+) phytopathogenic bacterium (P.
syringae), a yeast (P. caribbica) and a fungus (Trichodermsp), using the disk diffusion method
(agar).The analysis of the results revealed a significant difference in the inhibition profile of the selected strains. The complex 5 and to a lesser extent the complex 6, gave the best results displaying significant inhibitory activities on mostly all pathogenic strains (broad spectrum). In the second part dedicated to the synthesis of structural analogs of Tacrine, a whole series of new poly-heterocyclic compounds (10-14) was prepared from the corresponding 4H-pyrans (5- 9) by an addition-hetero-cyclization reaction of cyclohexanone under the Friedl‰ndler's standard conditions reaction. The in vitro antioxidant tests (DPPH and ABTS) of
benzimidazopyranotacrines, showed that the five compounds have an antioxidant activities, and
the 5-Amino-2-methyl-4-(1-methyl-1H-benzo[d]imidazol-2-yl)-6,7,8,9-tetrahydro-4H-pyrano
[2,3-b]uinolin-3-yl) ethanone (compound 12) is the most efficient, exhibiting a comparable
inhibitory power of free radicals to that of reference compounds (controls). The structure of all the complexes (1-11) was determined by X-ray diffraction, IR, UV and other elemental analysis. For complexes 1-4, theoretical studies using DFT and TD-DFT calculations have been performed and confirmed the experimental results. Benzimidazopyranotacrines (10-14) as structural Tacrine's analogues and their intermediates 4Hpyrans (5-9), were identified by the usual spectroscopic methods (IR, 1H NMR and13C).Diplôme : Doctorat En ligne : ../theses/chimie/LIF7359.pdf Format de la ressource électronique : Permalink : https://bu.umc.edu.dz/md/index.php?lvl=notice_display&id=11008 Préparation de nouveaux matériaux à base de (benz)imidazole et bio-activité : synthèse de complexes à base de (benz)imidazole, étude structurale et théorique et préparation d’analogues structuraux de la Tacrine à base de benzimidazole. [texte imprimé] / Anfel Benhassine ép Lifa, Auteur ; Ali Belfaitah, Directeur de thèse . - [S.l.] : جامعة الإخوة منتوري قسنطينة, 2018 . - 186 f. ; 30 cm.
2 copies imprimées disponibles
Langues : Français (fre)
Tags : Imidazole Benzimidazole Complexassion Métaux de transition divalents DFT orbitales frontières Tacrine réaction de Friedländer poly-hétérocycles DPPH ABTS activité antimicrobienne Divalent transition metals calculations Frontier orbitals Friedländer's reaction poly-heterocyclic compounds antimicrobial activity ????????? ??????????? ???????? ??????? ?????????? ?????? ??????? ?????? ?????? ??????? ???????? ????????????????? ?????? ?????? ?????????? Index. décimale : 540 Chimie et sciences connexes Résumé : The first part, which is subdivided into two chapters, concerns the synthesis, characterization (IR and UV-Vis, X-ray diffraction, and other elemental analysis) and biological evaluation of divalent transition metal complexes (M = Co , Cu, Cd, Zn, Ni) based on (1-methyl- 1Hbenzo[d]imidazol-2-yl) methanol (L1/Hmbm) (complexes 1-4) and (1-methyl-1H- imidazol-2-yl) methanol (L2/Hmim) (complexes 5-11). In both series of coordination compounds, the ligand (L1 or L2) gives rise to a variety of metal-ligand coordination modes(monodentate or bidentadate) exhibiting tetrahedral or octahedral geometry.The in vitro measurement of the antioxidant activity of the L1 and L2 ligands and their respective metal complexes against the free radical scavenger DPPH at low concentration (100 &g / mL), showed a moderate to significant antioxidant activities, compared to the standard (Asc). The complexes (5-11) and the ligand L2 were submitted to an in vitro evaluation of their antimicrobial activity against five pathogenic strains: animal bacteria:
Gram (+) (S. aureus) and Gram (-) (K pneumonia), a Gram (+) phytopathogenic bacterium (P.
syringae), a yeast (P. caribbica) and a fungus (Trichodermsp), using the disk diffusion method
(agar).The analysis of the results revealed a significant difference in the inhibition profile of the selected strains. The complex 5 and to a lesser extent the complex 6, gave the best results displaying significant inhibitory activities on mostly all pathogenic strains (broad spectrum). In the second part dedicated to the synthesis of structural analogs of Tacrine, a whole series of new poly-heterocyclic compounds (10-14) was prepared from the corresponding 4H-pyrans (5- 9) by an addition-hetero-cyclization reaction of cyclohexanone under the Friedl‰ndler's standard conditions reaction. The in vitro antioxidant tests (DPPH and ABTS) of
benzimidazopyranotacrines, showed that the five compounds have an antioxidant activities, and
the 5-Amino-2-methyl-4-(1-methyl-1H-benzo[d]imidazol-2-yl)-6,7,8,9-tetrahydro-4H-pyrano
[2,3-b]uinolin-3-yl) ethanone (compound 12) is the most efficient, exhibiting a comparable
inhibitory power of free radicals to that of reference compounds (controls). The structure of all the complexes (1-11) was determined by X-ray diffraction, IR, UV and other elemental analysis. For complexes 1-4, theoretical studies using DFT and TD-DFT calculations have been performed and confirmed the experimental results. Benzimidazopyranotacrines (10-14) as structural Tacrine's analogues and their intermediates 4Hpyrans (5-9), were identified by the usual spectroscopic methods (IR, 1H NMR and13C).Diplôme : Doctorat En ligne : ../theses/chimie/LIF7359.pdf Format de la ressource électronique : Permalink : https://bu.umc.edu.dz/md/index.php?lvl=notice_display&id=11008 Exemplaires
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Titre : Rhantherium والمستخلص البوتانولي لنباتي C ،E دور فیتامین في الوقایة من التسمم Chrysanthemum fontanesii و suaveolens لدى الفئران الحوامل Sodium Valproate المحرض بدواء : دراسةIn vitro و In vivo Type de document : texte imprimé Auteurs : أمال عمراني, Auteur ; جميلة زعمة, Directeur de thèse Editeur : قسنطينة [الجزائر] : جامعة منتوري قسنطينة Année de publication : 2013 Importance : 140 ورقة. Format : 30 سم. Note générale : 2نسخ موجودة في المكتبة المركزية Langues : Arabe (ara) Tags : Valproic acid embryotoxicity Oxidative stress, Lipid peroxidation, Plant extract, Flavonoids,
Vitamin E Vitamin C Chrysanthemum fontanesii Rhantherium suaveolens Antioxidant activity Phenolic
compounds DPPH Membrane stabilizing activity Antibacterial activity Anticancer activity.Index. décimale : 570 بيولوجيا Diplôme : Doctorat en sciences En ligne : ../theses/biologie/AAME3933.pdf Format de la ressource électronique : Permalink : https://bu.umc.edu.dz/md/index.php?lvl=notice_display&id=9390 Rhantherium والمستخلص البوتانولي لنباتي C ،E دور فیتامین في الوقایة من التسمم Chrysanthemum fontanesii و suaveolens لدى الفئران الحوامل Sodium Valproate المحرض بدواء : دراسةIn vitro و In vivo [texte imprimé] / أمال عمراني, Auteur ; جميلة زعمة, Directeur de thèse . - قسنطينة (الجزائر) : جامعة منتوري قسنطينة, 2013 . - 140 ورقة. ; 30 سم.
2نسخ موجودة في المكتبة المركزية
Langues : Arabe (ara)
Tags : Valproic acid embryotoxicity Oxidative stress, Lipid peroxidation, Plant extract, Flavonoids,
Vitamin E Vitamin C Chrysanthemum fontanesii Rhantherium suaveolens Antioxidant activity Phenolic
compounds DPPH Membrane stabilizing activity Antibacterial activity Anticancer activity.Index. décimale : 570 بيولوجيا Diplôme : Doctorat en sciences En ligne : ../theses/biologie/AAME3933.pdf Format de la ressource électronique : Permalink : https://bu.umc.edu.dz/md/index.php?lvl=notice_display&id=9390 Exemplaires
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Titre : Recherche et détermination structurale de métabolites secondaires de deux plantes Algériennes de la famille des lamiaceae Type de document : texte imprimé Auteurs : Sabrina Mohamadi, Auteur ; Samir Benayache, Directeur de thèse Editeur : جامعة الإخوة منتوري قسنطينة Année de publication : 2016 Importance : 334 f. Format : 30 cm. Note générale : 2 copies imprimées disponibles
Langues : Français (fre) Tags : UV-visible SM-MR RMN,1H 13C cosy noesy HSQC HMBC ABTS ORAC DPPH ??? ??????? ?????? ??????? ?????? ??? ????????? ??????? ?????? ????? ????? ??????? ?????? ?????????? Index. décimale : 540 Chimie et sciences connexes Résumé : This work deals with the structural determination and biological evaluation of natural substances isolated from two species of the Lamiaceae family (Salvia aegyptiaca and Saccocalyx satureioides). These family and the genus Salvia are known for their rich antioxidant compounds including polyphenols and flavonoids.
The phytochemical study of the aerial parts of these species allowed after extraction, separation and purification the isolation and identification of nineteen compounds from Saccocalyx satureioides and fourteen compounds from Salvia aegyptiaca .These compounds were identified by the combination of spectroscopic methods including : UV-visible absorption spectroscopy, high resolution HR-MS mass spectrometry, 1H and 13C-NMR and two-dimensional experiments (COSY, NOESY, HSQC, and HMBC) The isolated compounds were :
A flavonol : Quercetin (14).
Fifteen flavones : 7-methyl- sudachitin (8), Sideritiflavone (17), Luteolin (25),
Apigenin (27), Salvigenin(28), 4',7-dimethylapigenin (29), 5-hydroxy 3', 4', 6,7-
tetraméthoxyflavone(30), IsoIscutellarein-7-O-allosyl (1→2) glucoside (11),Isoscutellarein-7-O-[ β-D-allopyranosyl-(1→2)]-6’’-O-acetyl- β-D-glucopyranoside
(12), Isoscutellarein-7-O-[6”’-O-acetyl- β-D-allopyranosyl-(1→2)]- β-Dglucopyranoside (13) , Isoscutellarein -7-O-[6‴-O -acetyl-β-D-allopyranosyl (1→2) ]-
6″-O-acetyl-β-D-glucopyranoside. (15), Apigenin- 7-O-(6’’-trans-p-coumaroyl- β -Dglucopyranoside (16), Luteolin 7-O glucoside (21), Apigenine 7-O glucoside (22),
Diosmin (23).
Sixteen phenolic compounds : Piceol(1), Vanillin (2), Ferulic aldehyde (3), 3,3’-bis (3,4-
dihydro-4-hydroxy-6,8-dimethoxy-2H-1-benzopyran) (4), 3,3’-bis (3,4-dihydro-4-
hydroxy-6-methoxy-2H-1-benzopyran) (5), Dimethylcaffeic acid (6), Balanophonin (7),
Caffeic acid (9), p-coumaric acid (10), 4-methoxyphenol, Salicylic acid, Caffeic acide
(18), Vanillic acid (19), Syringic acid (20), Rosmarinic acid (24), Methyl rosmarinate
(26).
A furocoumarin : 6`,7`-dihydroxybergamottin(31)The study of the chemical composition of essential oil of Salvia aegyptiaca species growing in
Algeria was characterized by a high level of sesquiterpene fraction and a moderate level of
monoterpene components. β-caryophyllene (10.2%), Selina-4,11-diene (9.7%), bornyl acetate
(8.5%), β-gurjunene (7.6%), germacrene D (7.0 %) and β-caryophyllene oxide (6.2%) were the
major components of this essential oil.
This work led to the publications of two articles subject entitled “ On-line screening and
identification of antioxidant phenolic compounds of Saccocalyx satureioides Coss. et Dur.” and
“ Chemical composition of the Essential oil of Salvia aegyptiaca” . A third paper is in
preparation and will be devoted to the phytochemical and biological study of Salvia aegyptiaca.
Diplôme : Doctorat En ligne : ../theses/chimie/MOH6938.pdf Format de la ressource électronique : Permalink : https://bu.umc.edu.dz/md/index.php?lvl=notice_display&id=10289 Recherche et détermination structurale de métabolites secondaires de deux plantes Algériennes de la famille des lamiaceae [texte imprimé] / Sabrina Mohamadi, Auteur ; Samir Benayache, Directeur de thèse . - [S.l.] : جامعة الإخوة منتوري قسنطينة, 2016 . - 334 f. ; 30 cm.
2 copies imprimées disponibles
Langues : Français (fre)
Tags : UV-visible SM-MR RMN,1H 13C cosy noesy HSQC HMBC ABTS ORAC DPPH ??? ??????? ?????? ??????? ?????? ??? ????????? ??????? ?????? ????? ????? ??????? ?????? ?????????? Index. décimale : 540 Chimie et sciences connexes Résumé : This work deals with the structural determination and biological evaluation of natural substances isolated from two species of the Lamiaceae family (Salvia aegyptiaca and Saccocalyx satureioides). These family and the genus Salvia are known for their rich antioxidant compounds including polyphenols and flavonoids.
The phytochemical study of the aerial parts of these species allowed after extraction, separation and purification the isolation and identification of nineteen compounds from Saccocalyx satureioides and fourteen compounds from Salvia aegyptiaca .These compounds were identified by the combination of spectroscopic methods including : UV-visible absorption spectroscopy, high resolution HR-MS mass spectrometry, 1H and 13C-NMR and two-dimensional experiments (COSY, NOESY, HSQC, and HMBC) The isolated compounds were :
A flavonol : Quercetin (14).
Fifteen flavones : 7-methyl- sudachitin (8), Sideritiflavone (17), Luteolin (25),
Apigenin (27), Salvigenin(28), 4',7-dimethylapigenin (29), 5-hydroxy 3', 4', 6,7-
tetraméthoxyflavone(30), IsoIscutellarein-7-O-allosyl (1→2) glucoside (11),Isoscutellarein-7-O-[ β-D-allopyranosyl-(1→2)]-6’’-O-acetyl- β-D-glucopyranoside
(12), Isoscutellarein-7-O-[6”’-O-acetyl- β-D-allopyranosyl-(1→2)]- β-Dglucopyranoside (13) , Isoscutellarein -7-O-[6‴-O -acetyl-β-D-allopyranosyl (1→2) ]-
6″-O-acetyl-β-D-glucopyranoside. (15), Apigenin- 7-O-(6’’-trans-p-coumaroyl- β -Dglucopyranoside (16), Luteolin 7-O glucoside (21), Apigenine 7-O glucoside (22),
Diosmin (23).
Sixteen phenolic compounds : Piceol(1), Vanillin (2), Ferulic aldehyde (3), 3,3’-bis (3,4-
dihydro-4-hydroxy-6,8-dimethoxy-2H-1-benzopyran) (4), 3,3’-bis (3,4-dihydro-4-
hydroxy-6-methoxy-2H-1-benzopyran) (5), Dimethylcaffeic acid (6), Balanophonin (7),
Caffeic acid (9), p-coumaric acid (10), 4-methoxyphenol, Salicylic acid, Caffeic acide
(18), Vanillic acid (19), Syringic acid (20), Rosmarinic acid (24), Methyl rosmarinate
(26).
A furocoumarin : 6`,7`-dihydroxybergamottin(31)The study of the chemical composition of essential oil of Salvia aegyptiaca species growing in
Algeria was characterized by a high level of sesquiterpene fraction and a moderate level of
monoterpene components. β-caryophyllene (10.2%), Selina-4,11-diene (9.7%), bornyl acetate
(8.5%), β-gurjunene (7.6%), germacrene D (7.0 %) and β-caryophyllene oxide (6.2%) were the
major components of this essential oil.
This work led to the publications of two articles subject entitled “ On-line screening and
identification of antioxidant phenolic compounds of Saccocalyx satureioides Coss. et Dur.” and
“ Chemical composition of the Essential oil of Salvia aegyptiaca” . A third paper is in
preparation and will be devoted to the phytochemical and biological study of Salvia aegyptiaca.
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