Détail de l'auteur
Auteur Abdelmalik Belkhiri |
Documents disponibles écrits par cet auteur
Affiner la recherche Interroger des sources externesCaractérisation botanique et chimique et évaluation pharmaco-toxicologique d'une préparation topique à base d'huile de Pistacia lentiscus L. (Anacardiaceae) / Ahmed Boukeloua
Titre : Caractérisation botanique et chimique et évaluation pharmaco-toxicologique d'une préparation topique à base d'huile de Pistacia lentiscus L. (Anacardiaceae) Type de document : texte imprimé Auteurs : Ahmed Boukeloua, Auteur ; Université Mentouri, Editeur scientifique ; Abdelmalik Belkhiri, Directeur de thèse Année de publication : 2009 Importance : 79 f. Note générale : 01 Disponible à la salle de recherche 02 Disponibles au magazin de la B.U.C. 01 CD Langues : Français (fre) Catégories : Français - Anglais
BiologieTags : CCM Pistacia lentiscus Anacardiaceae Indices physico-chimiques Etude toxicologique physico-chimiques indexes toxicological studies thin layer chromatography essay phytosterols Index. décimale : 570 Sciences de la vie. Biologie Résumé : Pistacia lentiscus L. (Anacacrdiaceae), known locally as « ed’drew”, is a shrubby tree with a
fruit containing a fixed oil, used in traditional medicine, specially at Eastern part of North
Africa (Algeria, Tunisia), for its wound healing effect and as remedy against respiratory
allergy ailments.
This study deals with evaluation of physico-chemical indexes, a comparative thin layer
chromatography of Pistacia lentiscus oil, unsaponifiable fraction and lipophilic hexane extract
of P. lentiscus fruits, as well as, a topical and oral toxicological study of oil in animal
(mousse, rabbit).
Values of physico-chemical P. lentiscus oil parameters are comparable to those published
elsewhere [i.e. density index : 0,918 to 0,920, refraction index : 1,468 to 1,469 ; acid
index:5,891 à 6,203 (mg KOH / g) ; saponification index(mg KOH / g) : 197,75 à 200,45].
Chromarography revealed phytosterols presence in all samples examined. Cutaneous and oral
toxicities evaluations of P. lentiscus oil in animal (mousse, rabbit) concluded to the absence
of short time toxicities at used concentrations.Diplôme : Magistère En ligne : ../theses/biologie/BOU5424.pdf Permalink : https://bu.umc.edu.dz/md/index.php?lvl=notice_display&id=1804 Caractérisation botanique et chimique et évaluation pharmaco-toxicologique d'une préparation topique à base d'huile de Pistacia lentiscus L. (Anacardiaceae) [texte imprimé] / Ahmed Boukeloua, Auteur ; Université Mentouri, Editeur scientifique ; Abdelmalik Belkhiri, Directeur de thèse . - 2009 . - 79 f.
01 Disponible à la salle de recherche 02 Disponibles au magazin de la B.U.C. 01 CD
Langues : Français (fre)
Catégories : Français - Anglais
BiologieTags : CCM Pistacia lentiscus Anacardiaceae Indices physico-chimiques Etude toxicologique physico-chimiques indexes toxicological studies thin layer chromatography essay phytosterols Index. décimale : 570 Sciences de la vie. Biologie Résumé : Pistacia lentiscus L. (Anacacrdiaceae), known locally as « ed’drew”, is a shrubby tree with a
fruit containing a fixed oil, used in traditional medicine, specially at Eastern part of North
Africa (Algeria, Tunisia), for its wound healing effect and as remedy against respiratory
allergy ailments.
This study deals with evaluation of physico-chemical indexes, a comparative thin layer
chromatography of Pistacia lentiscus oil, unsaponifiable fraction and lipophilic hexane extract
of P. lentiscus fruits, as well as, a topical and oral toxicological study of oil in animal
(mousse, rabbit).
Values of physico-chemical P. lentiscus oil parameters are comparable to those published
elsewhere [i.e. density index : 0,918 to 0,920, refraction index : 1,468 to 1,469 ; acid
index:5,891 à 6,203 (mg KOH / g) ; saponification index(mg KOH / g) : 197,75 à 200,45].
Chromarography revealed phytosterols presence in all samples examined. Cutaneous and oral
toxicities evaluations of P. lentiscus oil in animal (mousse, rabbit) concluded to the absence
of short time toxicities at used concentrations.Diplôme : Magistère En ligne : ../theses/biologie/BOU5424.pdf Permalink : https://bu.umc.edu.dz/md/index.php?lvl=notice_display&id=1804 Exemplaires (1)
Code-barres Cote Support Localisation Section Disponibilité BOU/5424 BOU/5424 Thèse Bibliothèque principale Thèses Disponible
Titre : Caractérisation chimique des principes à effet antidermatophyte des racines d'anacyclus L. Type de document : texte imprimé Auteurs : Souad Hamimed ; Abdelmalik Belkhiri, Directeur de thèse ; Université Mentouri, Editeur scientifique Année de publication : 2009 Importance : 138 f. Note générale : 01 Disponible à la salle de recherche 02 Disponibles au magazin de la B.U.C. 01 CD Langues : Français (fre) Catégories : Français - Anglais
ChimieTags : Anacyclus pyrethrum Racines Asteraceae Criblage phytochimique Bioactivités antifongiques Triterpènes pentacycliques et coumarines roots phytochemical screening bio guided isolation antifungal pentacyclic triterpenes and coumarins m?????? ????????( ???? Asteraceae????? ???? ???????? ????? ???????? ?? ???????? ????????????????? ??? ????? ??????? ? ?????????? ? Index. décimale : 540 Chimie et sciences connexes Résumé : A preliminary biological evaluation of Anacyclus pyrethrum roots (Asteraceae) for antifungal effect
localized a potent activity in the dichloromethane (DCM) extract. Bio guided fractionation of DCM active
extract able us to track down a major activity in enriched fractions of triterpenes and alkamides. From the
triterpene fraction, four compounds were isolated, from which two were formally identified as pentacyclic
triterpenes. From the crude alcoholic extract of the roots, also investigated in this work, four products
were isolated, one of which is a pyranocoumarin, and the other three compounds were identified as a
phenylpropane derivatives. The nature of these phenylpropane, probably of lignan type, is under
investigation.
From the chemical point of view, the results obtained in this work provide a better understanding of
secondary metabolism in the roots of A. pyrethrum. The metabolic profile of the roots is characterized by
the presence of pentacyclic triterpenes, phenylpropane derivatives, coumarins and alkamides. Besides the
already reported alkamides, the other types of secondary metabolites are reported for the first time in this
species.
From the biological point of view, the results obtained by bioguided fractionation allowed to track a
significant antifungal activity in the moderately polar fractions, mainly containing triterpenes and
alkamides compounds.Diplôme : Magistère En ligne : ../theses/chimie/HAM5430.pdf Permalink : https://bu.umc.edu.dz/md/index.php?lvl=notice_display&id=3795 Caractérisation chimique des principes à effet antidermatophyte des racines d'anacyclus L. [texte imprimé] / Souad Hamimed ; Abdelmalik Belkhiri, Directeur de thèse ; Université Mentouri, Editeur scientifique . - 2009 . - 138 f.
01 Disponible à la salle de recherche 02 Disponibles au magazin de la B.U.C. 01 CD
Langues : Français (fre)
Catégories : Français - Anglais
ChimieTags : Anacyclus pyrethrum Racines Asteraceae Criblage phytochimique Bioactivités antifongiques Triterpènes pentacycliques et coumarines roots phytochemical screening bio guided isolation antifungal pentacyclic triterpenes and coumarins m?????? ????????( ???? Asteraceae????? ???? ???????? ????? ???????? ?? ???????? ????????????????? ??? ????? ??????? ? ?????????? ? Index. décimale : 540 Chimie et sciences connexes Résumé : A preliminary biological evaluation of Anacyclus pyrethrum roots (Asteraceae) for antifungal effect
localized a potent activity in the dichloromethane (DCM) extract. Bio guided fractionation of DCM active
extract able us to track down a major activity in enriched fractions of triterpenes and alkamides. From the
triterpene fraction, four compounds were isolated, from which two were formally identified as pentacyclic
triterpenes. From the crude alcoholic extract of the roots, also investigated in this work, four products
were isolated, one of which is a pyranocoumarin, and the other three compounds were identified as a
phenylpropane derivatives. The nature of these phenylpropane, probably of lignan type, is under
investigation.
From the chemical point of view, the results obtained in this work provide a better understanding of
secondary metabolism in the roots of A. pyrethrum. The metabolic profile of the roots is characterized by
the presence of pentacyclic triterpenes, phenylpropane derivatives, coumarins and alkamides. Besides the
already reported alkamides, the other types of secondary metabolites are reported for the first time in this
species.
From the biological point of view, the results obtained by bioguided fractionation allowed to track a
significant antifungal activity in the moderately polar fractions, mainly containing triterpenes and
alkamides compounds.Diplôme : Magistère En ligne : ../theses/chimie/HAM5430.pdf Permalink : https://bu.umc.edu.dz/md/index.php?lvl=notice_display&id=3795 Exemplaires (1)
Code-barres Cote Support Localisation Section Disponibilité HAM/5430 HAM/5430 Thèse Bibliothèque principale Thèses Disponible
Titre : Caractérisation chimique des principes molluscicides des feuilles de Nerium oleander L. Type de document : texte imprimé Auteurs : Warda Trifa (Ep. Boudraa), Auteur ; Abdelmalik Belkhiri, Directeur de thèse Editeur : Constantine : Université Mentouri Constantine Année de publication : 2009 Importance : 112 f. Format : 31 cm Note générale : Magister
2 copies imprimées disponiblesLangues : Français (fre) Catégories : Français - Anglais
ChimieTags : Nerium oleander Apocynaceae feuilles cardénolide molluscicide. Chimie Index. décimale : 540 Chimie et sciences connexes Diplôme : Magistère En ligne : ../theses/chimie/TRI5429.pdf Format de la ressource électronique : Permalink : https://bu.umc.edu.dz/md/index.php?lvl=notice_display&id=5789 Caractérisation chimique des principes molluscicides des feuilles de Nerium oleander L. [texte imprimé] / Warda Trifa (Ep. Boudraa), Auteur ; Abdelmalik Belkhiri, Directeur de thèse . - Constantine : Université Mentouri Constantine, 2009 . - 112 f. ; 31 cm.
Magister
2 copies imprimées disponibles
Langues : Français (fre)
Catégories : Français - Anglais
ChimieTags : Nerium oleander Apocynaceae feuilles cardénolide molluscicide. Chimie Index. décimale : 540 Chimie et sciences connexes Diplôme : Magistère En ligne : ../theses/chimie/TRI5429.pdf Format de la ressource électronique : Permalink : https://bu.umc.edu.dz/md/index.php?lvl=notice_display&id=5789 Exemplaires (1)
Code-barres Cote Support Localisation Section Disponibilité TRI/5429 TRI/5429 Thèse Bibliothèque principale Thèses Disponible
Titre : Caractérisation chimique des principes molluscicides des feuilles de Nerium oleander L. Type de document : texte imprimé Auteurs : Warda Boudraa (Née Trifa) ; Abdelmalik Belkhiri, Directeur de thèse ; Université Mentouri, Editeur scientifique Année de publication : 2009 Importance : 109 f. Note générale : 01 Disponible à la salle de recherche 02 Disponibles au magazin de la B.U.C. 01 CD Langues : Français (fre) Catégories : Français - Anglais
ChimieTags : Nerium oleander Apocynaceae Feuilles Cardiénolide mollscicide leaves molluscicidal cardenolide ?????? ????? Apocynaceae????????? ?? ???????? Index. décimale : 540 Chimie et sciences connexes Résumé : Molluscicidal screening of N. oleander leaf gradient extracts (20µg/ml) localized
strong activities in both diethyl ether (EE) and ethyl acetate (AE) crude extracts.
Ethyl acetate extract fractioning leads to three cardenolides glycosides. One of
which, hereafter named as W4, contains a digitoxigenine aglycone with disaccharides
attached to carbone 3. A potent molluscicidal activity is revealed after exposing snails
for 24 hours to cardenolide W4. Lethal concentrations DL50 et DL90 were found to be,
respectively equal to 3,35 ± 1,19 et 19,13 ± 10,67. Molluscicidal activity of
cardenolide W4, towards snails of Bulinus truncatus species, vector in growth cycle of
urogenital Bilharzia parasites, is reported by this study for the first time. In the expand
of time used (24 hours), the study showed also an inverse relationship between
exposing time and lethal concentration of cardenolide W4. This indicates that lethal
concentration may be minimized with expanding time of snails exposing to the tested
cardenolide W4.Diplôme : Magistère En ligne : ../theses/chimie/BOU5429.pdf Permalink : https://bu.umc.edu.dz/md/index.php?lvl=notice_display&id=3802 Caractérisation chimique des principes molluscicides des feuilles de Nerium oleander L. [texte imprimé] / Warda Boudraa (Née Trifa) ; Abdelmalik Belkhiri, Directeur de thèse ; Université Mentouri, Editeur scientifique . - 2009 . - 109 f.
01 Disponible à la salle de recherche 02 Disponibles au magazin de la B.U.C. 01 CD
Langues : Français (fre)
Catégories : Français - Anglais
ChimieTags : Nerium oleander Apocynaceae Feuilles Cardiénolide mollscicide leaves molluscicidal cardenolide ?????? ????? Apocynaceae????????? ?? ???????? Index. décimale : 540 Chimie et sciences connexes Résumé : Molluscicidal screening of N. oleander leaf gradient extracts (20µg/ml) localized
strong activities in both diethyl ether (EE) and ethyl acetate (AE) crude extracts.
Ethyl acetate extract fractioning leads to three cardenolides glycosides. One of
which, hereafter named as W4, contains a digitoxigenine aglycone with disaccharides
attached to carbone 3. A potent molluscicidal activity is revealed after exposing snails
for 24 hours to cardenolide W4. Lethal concentrations DL50 et DL90 were found to be,
respectively equal to 3,35 ± 1,19 et 19,13 ± 10,67. Molluscicidal activity of
cardenolide W4, towards snails of Bulinus truncatus species, vector in growth cycle of
urogenital Bilharzia parasites, is reported by this study for the first time. In the expand
of time used (24 hours), the study showed also an inverse relationship between
exposing time and lethal concentration of cardenolide W4. This indicates that lethal
concentration may be minimized with expanding time of snails exposing to the tested
cardenolide W4.Diplôme : Magistère En ligne : ../theses/chimie/BOU5429.pdf Permalink : https://bu.umc.edu.dz/md/index.php?lvl=notice_display&id=3802 Exemplaires (1)
Code-barres Cote Support Localisation Section Disponibilité BOU/5429 BOU/5429 Thèse Bibliothèque principale Thèses Disponible
Titre : Caractérisation phytochimique et évaluation des activités biologiques de Cleome arabica. Type de document : texte imprimé Auteurs : Aicha Madi, Auteur ; Abdelmalik Belkhiri, Directeur de thèse Editeur : جامعة الإخوة منتوري قسنطينة Année de publication : 2018 Importance : 146 f. Format : 30 cm. Note générale : 2 copies imprimées disponibles. Langues : Français (fre) Catégories : Français - Anglais
BiologieTags : Cleome arabica ssp arabica HPLC/DAD/MS phénols totaux flavonoïdes bioactivité toxicité total phenols flavonoids bioactivity toxicity assays ????????? ???????????? ?????? ????????? ????? ?????? Index. décimale : 570 Sciences de la vie. Biologie Résumé : Cleome arabica ssp arabica, a threatened desert plant, has been subjected to the phytochemical and pharmacological screening.
Hydroalcoholic extracts from different parts (leaves, seeds and roots) of C. arabica have been tested for their antioxidant, analgesic and wound healing activities, as well as their toxic potential.
Quantitative evaluation of the total phenols, flavonoids and anthocyanidins contents of the different extracts were made and completed with chromatographic HPLC/DAD/SM analysis. The obtained results revealed that leaves extract was characterized by a highly content in phenolic compounds, compared to other extracts.
Hydroalcoholic extract of the three parts of plant were marked by the presence of flavonoids, specially of flavonols type (quercetin, keampferol, and isorhamnetin).
Phenolic acids content is marked by the presence in the seeds extract of ferulic acid, para-hydroxybenzoic acid, and para-coumaric acid, and in the roots extract of tricaffeoylquinic, gallic, ferulic, and vanillic acids.
Evaluation of antioxidant effect made by the three in vitro tests (DPPH, FRAP and Phosphomolybdenum) showed a highly antioxidant activity of the leaves extract compared to those of seeds and roots. A direct correlation was found between phenol total and flavonoids contents and antioxidant activity.
The effectives doses obtained by three pain tests, namely tail flick, hot plate and acetic acid test were 291,84mg/Kg, 848,53mg/Kg and 683,52mg/Kg respectively. Analgesic activity of the aerial part of C. arabica was found to be dose- dependent. The Hydroalcoholic extract displayed on excision and thermal healing activities
wounds. The wound healing effect of C.arabica was significantly more important than that of a commercial ointment used as a positive control (Cicatryl®).
Toxicity assays (acute toxicity, and hemolytic effect) have showed that Hydroalcoholic extract of aerial part of C. arabica is safe at the maximal described doses.
Diplôme : Doctorat en sciences En ligne : ../theses/biologie/MAD7196.pdf Format de la ressource électronique : Permalink : https://bu.umc.edu.dz/md/index.php?lvl=notice_display&id=10767 Caractérisation phytochimique et évaluation des activités biologiques de Cleome arabica. [texte imprimé] / Aicha Madi, Auteur ; Abdelmalik Belkhiri, Directeur de thèse . - [S.l.] : جامعة الإخوة منتوري قسنطينة, 2018 . - 146 f. ; 30 cm.
2 copies imprimées disponibles.
Langues : Français (fre)
Catégories : Français - Anglais
BiologieTags : Cleome arabica ssp arabica HPLC/DAD/MS phénols totaux flavonoïdes bioactivité toxicité total phenols flavonoids bioactivity toxicity assays ????????? ???????????? ?????? ????????? ????? ?????? Index. décimale : 570 Sciences de la vie. Biologie Résumé : Cleome arabica ssp arabica, a threatened desert plant, has been subjected to the phytochemical and pharmacological screening.
Hydroalcoholic extracts from different parts (leaves, seeds and roots) of C. arabica have been tested for their antioxidant, analgesic and wound healing activities, as well as their toxic potential.
Quantitative evaluation of the total phenols, flavonoids and anthocyanidins contents of the different extracts were made and completed with chromatographic HPLC/DAD/SM analysis. The obtained results revealed that leaves extract was characterized by a highly content in phenolic compounds, compared to other extracts.
Hydroalcoholic extract of the three parts of plant were marked by the presence of flavonoids, specially of flavonols type (quercetin, keampferol, and isorhamnetin).
Phenolic acids content is marked by the presence in the seeds extract of ferulic acid, para-hydroxybenzoic acid, and para-coumaric acid, and in the roots extract of tricaffeoylquinic, gallic, ferulic, and vanillic acids.
Evaluation of antioxidant effect made by the three in vitro tests (DPPH, FRAP and Phosphomolybdenum) showed a highly antioxidant activity of the leaves extract compared to those of seeds and roots. A direct correlation was found between phenol total and flavonoids contents and antioxidant activity.
The effectives doses obtained by three pain tests, namely tail flick, hot plate and acetic acid test were 291,84mg/Kg, 848,53mg/Kg and 683,52mg/Kg respectively. Analgesic activity of the aerial part of C. arabica was found to be dose- dependent. The Hydroalcoholic extract displayed on excision and thermal healing activities
wounds. The wound healing effect of C.arabica was significantly more important than that of a commercial ointment used as a positive control (Cicatryl®).
Toxicity assays (acute toxicity, and hemolytic effect) have showed that Hydroalcoholic extract of aerial part of C. arabica is safe at the maximal described doses.
Diplôme : Doctorat en sciences En ligne : ../theses/biologie/MAD7196.pdf Format de la ressource électronique : Permalink : https://bu.umc.edu.dz/md/index.php?lvl=notice_display&id=10767 Exemplaires (1)
Code-barres Cote Support Localisation Section Disponibilité MAD/7196 MAD/7196 Thèse Bibliothèque principale Thèses Disponible
PermalinkPermalink
