| Titre : |
Caractérisation chimique des principes à effet antidermatophyte des racines d'anacyclus L. |
| Type de document : |
texte imprimé |
| Auteurs : |
Souad Hamimed ; Abdelmalik Belkhiri, Directeur de thèse ; Université Mentouri, Editeur scientifique |
| Année de publication : |
2009 |
| Importance : |
138 f. |
| Note générale : |
01 Disponible à la salle de recherche 02 Disponibles au magazin de la B.U.C. 01 CD |
| Langues : |
Français (fre) |
| Catégories : |
Français - Anglais
Chimie
|
| Tags : |
Anacyclus pyrethrum Racines Asteraceae Criblage phytochimique Bioactivités antifongiques Triterpènes pentacycliques et coumarines roots phytochemical screening bio guided isolation antifungal pentacyclic triterpenes and coumarins m?????? ????????( ???? Asteraceae????? ???? ???????? ????? ???????? ?? ???????? ????????????????? ??? ????? ??????? ? ?????????? ? |
| Index. décimale : |
540 Chimie et sciences connexes |
| Résumé : |
A preliminary biological evaluation of Anacyclus pyrethrum roots (Asteraceae) for antifungal effect
localized a potent activity in the dichloromethane (DCM) extract. Bio guided fractionation of DCM active
extract able us to track down a major activity in enriched fractions of triterpenes and alkamides. From the
triterpene fraction, four compounds were isolated, from which two were formally identified as pentacyclic
triterpenes. From the crude alcoholic extract of the roots, also investigated in this work, four products
were isolated, one of which is a pyranocoumarin, and the other three compounds were identified as a
phenylpropane derivatives. The nature of these phenylpropane, probably of lignan type, is under
investigation.
From the chemical point of view, the results obtained in this work provide a better understanding of
secondary metabolism in the roots of A. pyrethrum. The metabolic profile of the roots is characterized by
the presence of pentacyclic triterpenes, phenylpropane derivatives, coumarins and alkamides. Besides the
already reported alkamides, the other types of secondary metabolites are reported for the first time in this
species.
From the biological point of view, the results obtained by bioguided fractionation allowed to track a
significant antifungal activity in the moderately polar fractions, mainly containing triterpenes and
alkamides compounds. |
| Diplôme : |
Magistère |
| En ligne : |
../theses/chimie/HAM5430.pdf |
| Permalink : |
https://bu.umc.edu.dz/md/index.php?lvl=notice_display&id=3795 |
Caractérisation chimique des principes à effet antidermatophyte des racines d'anacyclus L. [texte imprimé] / Souad Hamimed ; Abdelmalik Belkhiri, Directeur de thèse ; Université Mentouri, Editeur scientifique . - 2009 . - 138 f. 01 Disponible à la salle de recherche 02 Disponibles au magazin de la B.U.C. 01 CD Langues : Français ( fre)
| Catégories : |
Français - Anglais
Chimie
|
| Tags : |
Anacyclus pyrethrum Racines Asteraceae Criblage phytochimique Bioactivités antifongiques Triterpènes pentacycliques et coumarines roots phytochemical screening bio guided isolation antifungal pentacyclic triterpenes and coumarins m?????? ????????( ???? Asteraceae????? ???? ???????? ????? ???????? ?? ???????? ????????????????? ??? ????? ??????? ? ?????????? ? |
| Index. décimale : |
540 Chimie et sciences connexes |
| Résumé : |
A preliminary biological evaluation of Anacyclus pyrethrum roots (Asteraceae) for antifungal effect
localized a potent activity in the dichloromethane (DCM) extract. Bio guided fractionation of DCM active
extract able us to track down a major activity in enriched fractions of triterpenes and alkamides. From the
triterpene fraction, four compounds were isolated, from which two were formally identified as pentacyclic
triterpenes. From the crude alcoholic extract of the roots, also investigated in this work, four products
were isolated, one of which is a pyranocoumarin, and the other three compounds were identified as a
phenylpropane derivatives. The nature of these phenylpropane, probably of lignan type, is under
investigation.
From the chemical point of view, the results obtained in this work provide a better understanding of
secondary metabolism in the roots of A. pyrethrum. The metabolic profile of the roots is characterized by
the presence of pentacyclic triterpenes, phenylpropane derivatives, coumarins and alkamides. Besides the
already reported alkamides, the other types of secondary metabolites are reported for the first time in this
species.
From the biological point of view, the results obtained by bioguided fractionation allowed to track a
significant antifungal activity in the moderately polar fractions, mainly containing triterpenes and
alkamides compounds. |
| Diplôme : |
Magistère |
| En ligne : |
../theses/chimie/HAM5430.pdf |
| Permalink : |
https://bu.umc.edu.dz/md/index.php?lvl=notice_display&id=3795 |
|
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