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Partager le résultat de cette recherche Interroger des sources externesEtude chimique et biologique des espèces Calligonum azel et Calligonum comosum (Polygonaceae) et une espèce du genre Thymus (Lamiaceae). / Soumia Belaabed Khalfaoui
Titre : Etude chimique et biologique des espèces Calligonum azel et Calligonum comosum (Polygonaceae) et une espèce du genre Thymus (Lamiaceae). Type de document : texte imprimé Auteurs : Soumia Belaabed Khalfaoui, Auteur ; Nour-eddine Beghidja, Directeur de thèse Editeur : جامعة الإخوة منتوري قسنطينة Année de publication : 2018 Importance : 250 f. Format : 30 cm. Note générale : 2 copies imprimées disponibles
Langues : Français (fre) Catégories : Français - Anglais
ChimieTags : Calligonum azel Calligonum comosum Thymus ciliatus Polygonaceae Lamiaceae RMN 1D et 2D CLHP HRESIMS activités biologiques huile essentielle NMR 1D and 2D HPLC Biological activities essential oil ??????? ?????? ??????????1D ?2D ????????????? HPLC ??????? ?????? ???????? ?????????? ?????? ???????? Index. décimale : 540 Chimie et sciences connexes Résumé : The phytochemical and biological study concerns the aerial parts of two endemic Saharian species belonging to the polygonaceae family: Calligonum azel and Calligonum comosum and a third one belonging to the Lamiaceae family.
The object of our work focused on the valorization of the Algerian flora. For this, firstly; we carried out a phytochemical study on Calligonum azel and Calligonum comosum which concerned mainly the biologically active compounds then we tested the antioxidant, antibacterial, antifungal and anti-inflammatory properties of all the organic extracts and some isolated compounds. Secondly; we studied the chemical composition and biological activities of Thymus ciliatus essential oil.
The study of aerial parts of C. azel and C. comosum, in order to know the active compounds responsible for their biological activity, leading to purification, chromatographic identification (CC, TLC and HPLC), and characterization using the different spectroscopic methods (1D and 2D NMR, MS and UV) of twenty one pure compounds (21) in which eighteen (18) compounds were identified.
The investigation of the biological activities of the extracts of Calligonum azel and Calligonum comosum showed that the best antioxidant activity was exhibited by the Chloroform and ethyl acetate extracts of C. azel and the Chloroform extract of C. comosum. The chloroform extracts of both species showed the best antibacterial activity. Chloroform extract from C. comosum has better antifungal activity against Candida albicans ATCC 2019 and Candida parapsilosis ATCC 22019.
From the isolated compounds, three have an antioxidant and anti-inflammatory activity. These compounds were: protocatachuic ethyl ester acid, -diamino (4-hydroxy benzene) butanoic acid and tamgernanetin.
The qualitative and quantitative analysis of essential oil of T. ciliatus allows the identification of 25 compounds representing 87.18 % of the total essential oil mainly. The GC and GC-MS analysis showed that this essential oils was mainly rich of thymol (54.26%), carvacrol methyl ether (1,373 %), o-cymene (5.72 %) carvacrol (1.373%)-cymen-7-ol (17.58 %), however it was the first time that -cymen-7-ol (17.58 %) was found as main component in the essential oils of T. ciliatus.
The evaluation of the antibacterial activity was assessed by disc diffusion method against bacterial strains. The essential oil exhibited a good antibacterial activity against Escherichia coli ATCC 25922, Staphylococcus aureus ATCC 43300 and Staphylocossus aureus.
All of our works confirms the medicinal properties of the Saharian species, and contributes to their scientific descriptions.Diplôme : Doctorat En ligne : ../theses/chimie/BEL7311.pdf Format de la ressource électronique : Permalink : https://bu.umc.edu.dz/md/index.php?lvl=notice_display&id=10926 Etude chimique et biologique des espèces Calligonum azel et Calligonum comosum (Polygonaceae) et une espèce du genre Thymus (Lamiaceae). [texte imprimé] / Soumia Belaabed Khalfaoui, Auteur ; Nour-eddine Beghidja, Directeur de thèse . - [S.l.] : جامعة الإخوة منتوري قسنطينة, 2018 . - 250 f. ; 30 cm.
2 copies imprimées disponibles
Langues : Français (fre)
Catégories : Français - Anglais
ChimieTags : Calligonum azel Calligonum comosum Thymus ciliatus Polygonaceae Lamiaceae RMN 1D et 2D CLHP HRESIMS activités biologiques huile essentielle NMR 1D and 2D HPLC Biological activities essential oil ??????? ?????? ??????????1D ?2D ????????????? HPLC ??????? ?????? ???????? ?????????? ?????? ???????? Index. décimale : 540 Chimie et sciences connexes Résumé : The phytochemical and biological study concerns the aerial parts of two endemic Saharian species belonging to the polygonaceae family: Calligonum azel and Calligonum comosum and a third one belonging to the Lamiaceae family.
The object of our work focused on the valorization of the Algerian flora. For this, firstly; we carried out a phytochemical study on Calligonum azel and Calligonum comosum which concerned mainly the biologically active compounds then we tested the antioxidant, antibacterial, antifungal and anti-inflammatory properties of all the organic extracts and some isolated compounds. Secondly; we studied the chemical composition and biological activities of Thymus ciliatus essential oil.
The study of aerial parts of C. azel and C. comosum, in order to know the active compounds responsible for their biological activity, leading to purification, chromatographic identification (CC, TLC and HPLC), and characterization using the different spectroscopic methods (1D and 2D NMR, MS and UV) of twenty one pure compounds (21) in which eighteen (18) compounds were identified.
The investigation of the biological activities of the extracts of Calligonum azel and Calligonum comosum showed that the best antioxidant activity was exhibited by the Chloroform and ethyl acetate extracts of C. azel and the Chloroform extract of C. comosum. The chloroform extracts of both species showed the best antibacterial activity. Chloroform extract from C. comosum has better antifungal activity against Candida albicans ATCC 2019 and Candida parapsilosis ATCC 22019.
From the isolated compounds, three have an antioxidant and anti-inflammatory activity. These compounds were: protocatachuic ethyl ester acid, -diamino (4-hydroxy benzene) butanoic acid and tamgernanetin.
The qualitative and quantitative analysis of essential oil of T. ciliatus allows the identification of 25 compounds representing 87.18 % of the total essential oil mainly. The GC and GC-MS analysis showed that this essential oils was mainly rich of thymol (54.26%), carvacrol methyl ether (1,373 %), o-cymene (5.72 %) carvacrol (1.373%)-cymen-7-ol (17.58 %), however it was the first time that -cymen-7-ol (17.58 %) was found as main component in the essential oils of T. ciliatus.
The evaluation of the antibacterial activity was assessed by disc diffusion method against bacterial strains. The essential oil exhibited a good antibacterial activity against Escherichia coli ATCC 25922, Staphylococcus aureus ATCC 43300 and Staphylocossus aureus.
All of our works confirms the medicinal properties of the Saharian species, and contributes to their scientific descriptions.Diplôme : Doctorat En ligne : ../theses/chimie/BEL7311.pdf Format de la ressource électronique : Permalink : https://bu.umc.edu.dz/md/index.php?lvl=notice_display&id=10926 Exemplaires (1)
Code-barres Cote Support Localisation Section Disponibilité BEL/7311 BEL/7311 Thèse Bibliothèque principale Thèses Disponible
Titre : Etude phytochimique et biologique de deux plantes médicinales Algériennes. Type de document : texte imprimé Auteurs : Houria Bechlem ép Boucenna, Auteur ; Mohamed Bouheroum, Directeur de thèse Editeur : جامعة الإخوة منتوري قسنطينة Année de publication : 2018 Importance : 226 f. Format : 30 cm. Note générale : 2 copies imprimées disponibles Langues : Français (fre) Catégories : Français - Anglais
ChimieTags : Caryophyllaceae Lamiaceae Gymnocarpos decander Mentha pulegium saponines flavonoïdes acides phénoliques RMN 1D et 2D activités antiprolifératives saponins flavonoids phenolic acids NMR 1D and 2D antiproliferative activity ??????? ?????? ???????? ????? ????????? ????? ?????????????? ????? Mentha pulegium????????? ??????? ??????? ??????? Index. décimale : 540 Chimie et sciences connexes Résumé : The present work deals with the phytochemical study and the evaluation of the biological activity of two plants belonging to the Algerian flora Gymnocarpos decander (Caryophyllaceae) and Mentha pulegium (Lamiaceae).
The Extraction process has been done on the aerial parts of the two species previously mentioned using organic solvents with different methods followed by chromatographic separations (CC, TLC and HPLC), the outcomes of the said extraction gave 19 products of which 5 are new (2 saponins and 3 flavonol glycosides) which have been isolated from nbutanol phase of the hydroalcoholic extract of Gymnocarpos decander, and three known
compounds isolated from the ethyl acetate extract. The remaining 11 products isolated from Mentha pulegium are known flavonoids and phenolic acids.
Structural elucidation of the isolated compounds was performed by high resolution mass spectra (HRESI-MS), 1D NMR (1H, 13C) and 2D NMR (COSY, HSQC, HMBC) and comparing them with data from the literature.
The antiproliferative activity research tests of the five new products isolated from the n-butanol extract of G. decander showed that both saponins are active against Hela cell line and the results have been very promising and hence incite to effect the vivo studies to confirm its pharmacological properties.
Quantitative estimation for total polyphenols of the hydroalcoholic extract (aerial parts) of M. pulegium has shown clearly that this extract has a high content of polyphenols.
Evaluation of the biological activity carried out on this extract showed that this species had a good scavenging effect against the DPPH radical.
On the chemotaxonomic level, the results show a rich and varied composition of secondary metabolites which is matching the plants of the same family characteristics. In fact, for the Caryophyllaceae family, saponins are considered as chemotaxonomic markers. As for the Lamiaceae family, its reputation for flavonoid accumulation is well known.
Diplôme : Doctorat En ligne : ../theses/chimie/BEC7211.pdf Format de la ressource électronique : Permalink : https://bu.umc.edu.dz/md/index.php?lvl=notice_display&id=10780 Etude phytochimique et biologique de deux plantes médicinales Algériennes. [texte imprimé] / Houria Bechlem ép Boucenna, Auteur ; Mohamed Bouheroum, Directeur de thèse . - [S.l.] : جامعة الإخوة منتوري قسنطينة, 2018 . - 226 f. ; 30 cm.
2 copies imprimées disponibles
Langues : Français (fre)
Catégories : Français - Anglais
ChimieTags : Caryophyllaceae Lamiaceae Gymnocarpos decander Mentha pulegium saponines flavonoïdes acides phénoliques RMN 1D et 2D activités antiprolifératives saponins flavonoids phenolic acids NMR 1D and 2D antiproliferative activity ??????? ?????? ???????? ????? ????????? ????? ?????????????? ????? Mentha pulegium????????? ??????? ??????? ??????? Index. décimale : 540 Chimie et sciences connexes Résumé : The present work deals with the phytochemical study and the evaluation of the biological activity of two plants belonging to the Algerian flora Gymnocarpos decander (Caryophyllaceae) and Mentha pulegium (Lamiaceae).
The Extraction process has been done on the aerial parts of the two species previously mentioned using organic solvents with different methods followed by chromatographic separations (CC, TLC and HPLC), the outcomes of the said extraction gave 19 products of which 5 are new (2 saponins and 3 flavonol glycosides) which have been isolated from nbutanol phase of the hydroalcoholic extract of Gymnocarpos decander, and three known
compounds isolated from the ethyl acetate extract. The remaining 11 products isolated from Mentha pulegium are known flavonoids and phenolic acids.
Structural elucidation of the isolated compounds was performed by high resolution mass spectra (HRESI-MS), 1D NMR (1H, 13C) and 2D NMR (COSY, HSQC, HMBC) and comparing them with data from the literature.
The antiproliferative activity research tests of the five new products isolated from the n-butanol extract of G. decander showed that both saponins are active against Hela cell line and the results have been very promising and hence incite to effect the vivo studies to confirm its pharmacological properties.
Quantitative estimation for total polyphenols of the hydroalcoholic extract (aerial parts) of M. pulegium has shown clearly that this extract has a high content of polyphenols.
Evaluation of the biological activity carried out on this extract showed that this species had a good scavenging effect against the DPPH radical.
On the chemotaxonomic level, the results show a rich and varied composition of secondary metabolites which is matching the plants of the same family characteristics. In fact, for the Caryophyllaceae family, saponins are considered as chemotaxonomic markers. As for the Lamiaceae family, its reputation for flavonoid accumulation is well known.
Diplôme : Doctorat En ligne : ../theses/chimie/BEC7211.pdf Format de la ressource électronique : Permalink : https://bu.umc.edu.dz/md/index.php?lvl=notice_display&id=10780 Exemplaires (1)
Code-barres Cote Support Localisation Section Disponibilité BEC/7211 BEC/7211 Thèse Bibliothèque principale Thèses Disponible
Titre : Etude phytochimique et évaluation des activités biologiques des espèces : Mentha aquatica, Stachys guyoniana et Thymus dreatensis (LAMIACEAE) Type de document : texte imprimé Auteurs : Maria Ferhat, Auteur ; Zahia Kabouche, Directeur de thèse Editeur : جامعة الإخوة منتوري قسنطينة Année de publication : 2016 Importance : 114 f. Format : 30 cm. Note générale : 2 copies imprimées disponibles
Langues : Français (fre) Catégories : Français - Anglais
ChimieTags : Lamiaceae Mentha aquatica Stachys guyoniana Thymus dreatensis Triterpènes Huile essentielle Activités biologiques RMN 1D et 2D Triterpenoids Essential oil biological activities NMR 1D and 2D " Lamiaceae aquatica Mentha dreatensis Thymys guyonina Stachys
????? ?????? ?????? ?????????? ??????? ?????? ???????? ???? ?????"Index. décimale : 540 Chimie et sciences connexes Résumé : This present work concerns the phytochemical and biological study of three Algerian plants belonging to the Lamiaceae family : Mentha aquatica L., Stachys guyoniana de Noé and Thymus dreatensis Batt. Chromatographic separations and purifications of extracts from the aerial parts and roots of Mentha aquatica led to the isolation and identification of 1 6 compounds, including one new triterpene and 5 triterpene acids which are new for the genus.
The structures of isolated compounds were particularly established by the use of NMR 1D and 2D (1H, 13C, COSY H-H, HMQC and HMBC), high resolution mass spectrometry (ESI-MS and HR-ESI-MS) and by comparison with literature data.
GC and GC/MS analyses of T. dreatensis essential oil showed that it was mainly represented by thymol (28.1%) followed by γ-terpinene (18.7%), thymyl methyl ether (10.9%) and linalool (5.0%). This oil showed a good antioxidant activity by the bleaching of β-carotene.
5 methods were used to evaluate the antioxidant activity of Mentha aquatica and Stachys guyoniana. The latter showed a good activity with 4 methods: β-carotene, DPPH, ABTS and metal chelating whereas Mentha aquatica exhibited a moderate activity with CUPRAC and ABTS tests. Compared with the other tested extracts, the n-butanol extract of
Stachys guyoniana showed the highest anticholinesterase activity.
The two plants showed an antibacterial potential against some bacterial strains, by the use of agar diffusion method and MIC's determination.
Diplôme : Doctorat en sciences En ligne : ../theses/chimie/FER6964.pdf Format de la ressource électronique : Permalink : https://bu.umc.edu.dz/md/index.php?lvl=notice_display&id=10362 Etude phytochimique et évaluation des activités biologiques des espèces : Mentha aquatica, Stachys guyoniana et Thymus dreatensis (LAMIACEAE) [texte imprimé] / Maria Ferhat, Auteur ; Zahia Kabouche, Directeur de thèse . - [S.l.] : جامعة الإخوة منتوري قسنطينة, 2016 . - 114 f. ; 30 cm.
2 copies imprimées disponibles
Langues : Français (fre)
Catégories : Français - Anglais
ChimieTags : Lamiaceae Mentha aquatica Stachys guyoniana Thymus dreatensis Triterpènes Huile essentielle Activités biologiques RMN 1D et 2D Triterpenoids Essential oil biological activities NMR 1D and 2D " Lamiaceae aquatica Mentha dreatensis Thymys guyonina Stachys
????? ?????? ?????? ?????????? ??????? ?????? ???????? ???? ?????"Index. décimale : 540 Chimie et sciences connexes Résumé : This present work concerns the phytochemical and biological study of three Algerian plants belonging to the Lamiaceae family : Mentha aquatica L., Stachys guyoniana de Noé and Thymus dreatensis Batt. Chromatographic separations and purifications of extracts from the aerial parts and roots of Mentha aquatica led to the isolation and identification of 1 6 compounds, including one new triterpene and 5 triterpene acids which are new for the genus.
The structures of isolated compounds were particularly established by the use of NMR 1D and 2D (1H, 13C, COSY H-H, HMQC and HMBC), high resolution mass spectrometry (ESI-MS and HR-ESI-MS) and by comparison with literature data.
GC and GC/MS analyses of T. dreatensis essential oil showed that it was mainly represented by thymol (28.1%) followed by γ-terpinene (18.7%), thymyl methyl ether (10.9%) and linalool (5.0%). This oil showed a good antioxidant activity by the bleaching of β-carotene.
5 methods were used to evaluate the antioxidant activity of Mentha aquatica and Stachys guyoniana. The latter showed a good activity with 4 methods: β-carotene, DPPH, ABTS and metal chelating whereas Mentha aquatica exhibited a moderate activity with CUPRAC and ABTS tests. Compared with the other tested extracts, the n-butanol extract of
Stachys guyoniana showed the highest anticholinesterase activity.
The two plants showed an antibacterial potential against some bacterial strains, by the use of agar diffusion method and MIC's determination.
Diplôme : Doctorat en sciences En ligne : ../theses/chimie/FER6964.pdf Format de la ressource électronique : Permalink : https://bu.umc.edu.dz/md/index.php?lvl=notice_display&id=10362 Exemplaires (1)
Code-barres Cote Support Localisation Section Disponibilité FER/6964 FER/6964 Thèse Bibliothèque principale Thèses Disponible
Titre : Etude phytochimique et pharmacologique de plantes médicinales Algériennes Genista ulicina Spach (Fabaceae) et Chrysanthemum macrocarpum (Sch. Bip.) Coss. & Kralik ex Batt (Asteraceae) Type de document : texte imprimé Auteurs : Naima Boutaghane, Auteur ; Zahia Kabouche, Directeur de thèse ; Laurence Voutquenne, Directeur de thèse Editeur : constantine [Algérie] : Université Constantine 1 Année de publication : 2013 Importance : 270 f. Format : 30 cm. Note générale : 2 copies imprimées disponibles Langues : Français (fre) Catégories : Français - Anglais
ChimieTags : Fabaceae Asteraceae Genista ulicina Chrysanthemum macrocarpum cyclitols Saponines flavonoïdes Huile essentielle activités biologiques RMN 1D et 2D Spectrométrie de masse Saponins flavonoids essential oil biological activities NMR 1D and 2D mass spectroscopy ????????? ???????????? ?????? ??????? ??????? ?????? ?????? ?????????? ?????? ? ?????? ????? ??????? ?????? Index. décimale : 540 Chimie et sciences connexes Résumé :
This report is concerning the phytochemical study of two Algerian plants belonging to the Fabaceae family (Genista ulicina Spach) and Asteraceae family (Chrysanthemum macrocarpum Coss. & Kralik ex Batt). This study led to the isolation and identification of 36 compounds from which 10 compounds are new.
The structures of isolated compounds were established particularly by the use of NMR highfield
1D and 2D technics (1H, 13C J-modulated, COSY H-H, HSQC J-modulated, HMBC and NOESY), high resolution mass spectrometry (ESI-MS and HR-ESI-MS), measurement of rotatory power and comparison with literature data.
GC and GC / MS analyses of the essential oil of C. macrocarpum showed that it was mainly represented by: T-cadinol (19.6%), spathulenol (12.5%), caryophyllene oxide (6.5%), and α- cadinol (5.6%).
The chloroform fraction of C. macrocarpum showed a weak antibacterial activity against: E.
coli, S. aureus, P.aeruginosa, E. faecalis and K. pneumoniae.
The same chloroform fraction was evaluated for its antiproliferative activity against human cancer HT-29 cells and human PC3 cells. The results indicate that the chloroform fraction inhibited cell proliferation of both HT-29 and PC-3 cells,The chloroform fraction showed an excellent analegesic, anti-inflammatory and antiulcerogenic activities.
The butanolic fraction of G. ulicina and isolated compounds were investigated for their antibacterial and antiproliferative growth inhibition, but no significant activities were observed.Diplôme : Doctorat en sciences En ligne : ../theses/chimie/BOU6343.pdf Format de la ressource électronique : Permalink : https://bu.umc.edu.dz/md/index.php?lvl=notice_display&id=6313 Etude phytochimique et pharmacologique de plantes médicinales Algériennes Genista ulicina Spach (Fabaceae) et Chrysanthemum macrocarpum (Sch. Bip.) Coss. & Kralik ex Batt (Asteraceae) [texte imprimé] / Naima Boutaghane, Auteur ; Zahia Kabouche, Directeur de thèse ; Laurence Voutquenne, Directeur de thèse . - constantine (Route ain el bey, Algérie) : Université Constantine 1, 2013 . - 270 f. ; 30 cm.
2 copies imprimées disponibles
Langues : Français (fre)
Catégories : Français - Anglais
ChimieTags : Fabaceae Asteraceae Genista ulicina Chrysanthemum macrocarpum cyclitols Saponines flavonoïdes Huile essentielle activités biologiques RMN 1D et 2D Spectrométrie de masse Saponins flavonoids essential oil biological activities NMR 1D and 2D mass spectroscopy ????????? ???????????? ?????? ??????? ??????? ?????? ?????? ?????????? ?????? ? ?????? ????? ??????? ?????? Index. décimale : 540 Chimie et sciences connexes Résumé :
This report is concerning the phytochemical study of two Algerian plants belonging to the Fabaceae family (Genista ulicina Spach) and Asteraceae family (Chrysanthemum macrocarpum Coss. & Kralik ex Batt). This study led to the isolation and identification of 36 compounds from which 10 compounds are new.
The structures of isolated compounds were established particularly by the use of NMR highfield
1D and 2D technics (1H, 13C J-modulated, COSY H-H, HSQC J-modulated, HMBC and NOESY), high resolution mass spectrometry (ESI-MS and HR-ESI-MS), measurement of rotatory power and comparison with literature data.
GC and GC / MS analyses of the essential oil of C. macrocarpum showed that it was mainly represented by: T-cadinol (19.6%), spathulenol (12.5%), caryophyllene oxide (6.5%), and α- cadinol (5.6%).
The chloroform fraction of C. macrocarpum showed a weak antibacterial activity against: E.
coli, S. aureus, P.aeruginosa, E. faecalis and K. pneumoniae.
The same chloroform fraction was evaluated for its antiproliferative activity against human cancer HT-29 cells and human PC3 cells. The results indicate that the chloroform fraction inhibited cell proliferation of both HT-29 and PC-3 cells,The chloroform fraction showed an excellent analegesic, anti-inflammatory and antiulcerogenic activities.
The butanolic fraction of G. ulicina and isolated compounds were investigated for their antibacterial and antiproliferative growth inhibition, but no significant activities were observed.Diplôme : Doctorat en sciences En ligne : ../theses/chimie/BOU6343.pdf Format de la ressource électronique : Permalink : https://bu.umc.edu.dz/md/index.php?lvl=notice_display&id=6313 Exemplaires (1)
Code-barres Cote Support Localisation Section Disponibilité BOU/6343 BOU/6343 Thèse Bibliothèque principale Thèses Disponible
Titre : isolement et caractérisation de saponosides extraits de deux plantes médicinales cyclamen africanum, zygophyllum cornutum et évaluation de leur activité anti-inflammatoire Type de document : texte imprimé Auteurs : Soumeya Betina-Bencharif, Auteur ; Zahia Kabouche, Directeur de thèse Editeur : constantine [Algérie] : Université Constantine 1 Année de publication : 2014 Autre Editeur : Universite de Bourgogne Importance : 204 f. Format : 30 cm. Note générale : 2 copies imprimées disponibles
Langues : Français (fre) Catégories : Français - Anglais
BiologieTags : Biotechnologie végétale Cyclamen africanum Zygophyllum cornutum Activité anti inflammatoire Saponines triterpéniques RMN 1D et 2D spectrométrie de masse protéines réponse inflammatoire (PRI) anti-inflammatoires (AINS) médiateurs pro-inflammatoire (COX-2, PGE2, TNF -? ,iNOS) anti inflammatory activity saponins triterpene 1D and 2D NMR mass spectrometry protein inflammatory response (PRI) anti-inflammatory drugs (NSAIDs) pro-inflammatory mediators (COX-2, PGE2, TNF -?,iNOS) ?????? ?????? ?????????? ? ???? ??????? ?????? Zygophyllum cornutum ???? ???? ???????? ????????? ???????? ?????? . Index. décimale : 570 Sciences de la vie. Biologie Résumé : The appearance of several diseases, such as cancer, diabetes, high blood pressure and spread of infections mutagenic virus type can be linked to the quality and lifestyle that we lead today. Indeed, several studies on the factors triggering these so-called ""morbid"" long-or short-term illnesses are related to stress and quality of food consumed, whether of plant and animal origin. These diseases are becoming a common occurrence, they affect different
races and all classes of society. According ethnobotanical research, naturally occurring substances, allowed civilizations to survive deadly diseases. For example, we thus find references to periods of malarial fever in China and one of the symptoms of this disease in the ""Huangdi Neijiang"" The Canon of Medicine dating from around the first century BC, more than 2000 years, which relates to the use of herbal medicines to relieve fevers (Desgrouas et
al., 2014).
Around 186 BC appears, in some parts of China, the use in herbal tea, Qing hao su, later known as artemisinin in the West and extracted from a medicinal plant used as antipyretic called ""Qing hao"" Artemisia annua or annual wormwood. Artemisinin blocks an enzyme which enables the parasite to pump calcium and prevents it from developing. As of today the Artemisinin-based combination therapy in French Combination therapy of artemisinin
and ACT acronym, is a therapy and tertiary prevention in cases of uncomplicated malaria.
From this perspective our study adds to a long series of studies on medicinal plants and natural substances extracted. It aims to reveal new biomolecules, highlighting their biological activities through techniques of biotechnology on the one hand. Moreover, these investigations will develop natural resources that are characterized by endemic.
To do this, our choice is focused on two endemic medicinal plants in Algeria Cyclamen africanum Boiss. & Reuter and Zygophyllum cornutum Coss. After an ethnobotanical research on traditional medicine in Northern Africa, which showed the effectiveness of these plants in minimal inflammatory problems among Aboriginal, we undertook biochemical
pharmacological investigations.
The latter allowed us to isolate, five compounds from the methanol extract of the roots of the species Cyclamen africanum Boiss. Reuter & two new oleanane triterpene saponins type,Afrocyclamin A and B (1, 2) and three triterpenoid saponins known lysikokianoside of (3), deglucocyclamin I (4) and its derivative dicrotalique acid (5) September and known from the methanol extract saponins from the whole plant of Zygophyllum cornutum Coss. these
saponins are ursane type, type triterpenes are reported in this species for the first time and can be considered a chemotherapy marker Taxonomic (chemotype) of Zygophyllum kind.
The structures were elucidated on the basis of the analysis of NMR spectra of the experience-1D and 2D-NMR (COSY, TOCSY, NOESY, HSQC and HMBC) and mass spectrometry method negative ion FAB source. The biological activities of saponosidiques FR.1 and Fr.2 fractions were tested on lines of male and female rats of the Winstar rats to evaluate the anti-inflammatory activity. The saponosidique fraction FR.1 Cyclamen africanum the 5 mg dose, showed a significant effect on inflammation caused by carrageenan, reducing edema and immune response, which resulted in the concentration of protein the inflammatory response (PRI) through their action on the pro-inflammatory mediators (COX-2, PGE2, TNF - α, iNOS). The fraction of Fr.2 saponosidique Zygophyllum dose 20 mg did not show a
significant effect on inflammation in generalDiplôme : Doctorat en sciences En ligne : ../theses/biologie/BET6701.pdf Format de la ressource électronique : Permalink : https://bu.umc.edu.dz/md/index.php?lvl=notice_display&id=9922 isolement et caractérisation de saponosides extraits de deux plantes médicinales cyclamen africanum, zygophyllum cornutum et évaluation de leur activité anti-inflammatoire [texte imprimé] / Soumeya Betina-Bencharif, Auteur ; Zahia Kabouche, Directeur de thèse . - constantine (Route ain el bey, Algérie) : Université Constantine 1 : France : Universite de Bourgogne, 2014 . - 204 f. ; 30 cm.
2 copies imprimées disponibles
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BiologieTags : Biotechnologie végétale Cyclamen africanum Zygophyllum cornutum Activité anti inflammatoire Saponines triterpéniques RMN 1D et 2D spectrométrie de masse protéines réponse inflammatoire (PRI) anti-inflammatoires (AINS) médiateurs pro-inflammatoire (COX-2, PGE2, TNF -? ,iNOS) anti inflammatory activity saponins triterpene 1D and 2D NMR mass spectrometry protein inflammatory response (PRI) anti-inflammatory drugs (NSAIDs) pro-inflammatory mediators (COX-2, PGE2, TNF -?,iNOS) ?????? ?????? ?????????? ? ???? ??????? ?????? Zygophyllum cornutum ???? ???? ???????? ????????? ???????? ?????? . Index. décimale : 570 Sciences de la vie. Biologie Résumé : The appearance of several diseases, such as cancer, diabetes, high blood pressure and spread of infections mutagenic virus type can be linked to the quality and lifestyle that we lead today. Indeed, several studies on the factors triggering these so-called ""morbid"" long-or short-term illnesses are related to stress and quality of food consumed, whether of plant and animal origin. These diseases are becoming a common occurrence, they affect different
races and all classes of society. According ethnobotanical research, naturally occurring substances, allowed civilizations to survive deadly diseases. For example, we thus find references to periods of malarial fever in China and one of the symptoms of this disease in the ""Huangdi Neijiang"" The Canon of Medicine dating from around the first century BC, more than 2000 years, which relates to the use of herbal medicines to relieve fevers (Desgrouas et
al., 2014).
Around 186 BC appears, in some parts of China, the use in herbal tea, Qing hao su, later known as artemisinin in the West and extracted from a medicinal plant used as antipyretic called ""Qing hao"" Artemisia annua or annual wormwood. Artemisinin blocks an enzyme which enables the parasite to pump calcium and prevents it from developing. As of today the Artemisinin-based combination therapy in French Combination therapy of artemisinin
and ACT acronym, is a therapy and tertiary prevention in cases of uncomplicated malaria.
From this perspective our study adds to a long series of studies on medicinal plants and natural substances extracted. It aims to reveal new biomolecules, highlighting their biological activities through techniques of biotechnology on the one hand. Moreover, these investigations will develop natural resources that are characterized by endemic.
To do this, our choice is focused on two endemic medicinal plants in Algeria Cyclamen africanum Boiss. & Reuter and Zygophyllum cornutum Coss. After an ethnobotanical research on traditional medicine in Northern Africa, which showed the effectiveness of these plants in minimal inflammatory problems among Aboriginal, we undertook biochemical
pharmacological investigations.
The latter allowed us to isolate, five compounds from the methanol extract of the roots of the species Cyclamen africanum Boiss. Reuter & two new oleanane triterpene saponins type,Afrocyclamin A and B (1, 2) and three triterpenoid saponins known lysikokianoside of (3), deglucocyclamin I (4) and its derivative dicrotalique acid (5) September and known from the methanol extract saponins from the whole plant of Zygophyllum cornutum Coss. these
saponins are ursane type, type triterpenes are reported in this species for the first time and can be considered a chemotherapy marker Taxonomic (chemotype) of Zygophyllum kind.
The structures were elucidated on the basis of the analysis of NMR spectra of the experience-1D and 2D-NMR (COSY, TOCSY, NOESY, HSQC and HMBC) and mass spectrometry method negative ion FAB source. The biological activities of saponosidiques FR.1 and Fr.2 fractions were tested on lines of male and female rats of the Winstar rats to evaluate the anti-inflammatory activity. The saponosidique fraction FR.1 Cyclamen africanum the 5 mg dose, showed a significant effect on inflammation caused by carrageenan, reducing edema and immune response, which resulted in the concentration of protein the inflammatory response (PRI) through their action on the pro-inflammatory mediators (COX-2, PGE2, TNF - α, iNOS). The fraction of Fr.2 saponosidique Zygophyllum dose 20 mg did not show a
significant effect on inflammation in generalDiplôme : Doctorat en sciences En ligne : ../theses/biologie/BET6701.pdf Format de la ressource électronique : Permalink : https://bu.umc.edu.dz/md/index.php?lvl=notice_display&id=9922 Exemplaires (1)
Code-barres Cote Support Localisation Section Disponibilité BET/6701 BET/6701 Thèse Bibliothèque principale Thèses Disponible
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