Résultat de la recherche
6 résultat(s) recherche sur le tag 'Biological activities' 
Affiner la recherche Générer le flux rss de la recherche
Partager le résultat de cette recherche Interroger des sources externes
Titre : Etude phytochimique et évaluation des activités biologiques des espèces : Mentha aquatica, Stachys guyoniana et Thymus dreatensis (LAMIACEAE) Type de document : texte imprimé Auteurs : Maria Ferhat, Auteur ; Zahia Kabouche, Directeur de thèse Editeur : جامعة الإخوة منتوري قسنطينة Année de publication : 2016 Importance : 114 f. Format : 30 cm. Note générale : 2 copies imprimées disponibles
Langues : Français (fre) Catégories : Français - Anglais
ChimieTags : Lamiaceae Mentha aquatica Stachys guyoniana Thymus dreatensis Triterpènes Huile essentielle Activités biologiques RMN 1D et 2D Triterpenoids Essential oil biological activities NMR 1D and 2D " Lamiaceae aquatica Mentha dreatensis Thymys guyonina Stachys
????? ?????? ?????? ?????????? ??????? ?????? ???????? ???? ?????"Index. décimale : 540 Chimie et sciences connexes Résumé : This present work concerns the phytochemical and biological study of three Algerian plants belonging to the Lamiaceae family : Mentha aquatica L., Stachys guyoniana de Noé and Thymus dreatensis Batt. Chromatographic separations and purifications of extracts from the aerial parts and roots of Mentha aquatica led to the isolation and identification of 1 6 compounds, including one new triterpene and 5 triterpene acids which are new for the genus.
The structures of isolated compounds were particularly established by the use of NMR 1D and 2D (1H, 13C, COSY H-H, HMQC and HMBC), high resolution mass spectrometry (ESI-MS and HR-ESI-MS) and by comparison with literature data.
GC and GC/MS analyses of T. dreatensis essential oil showed that it was mainly represented by thymol (28.1%) followed by γ-terpinene (18.7%), thymyl methyl ether (10.9%) and linalool (5.0%). This oil showed a good antioxidant activity by the bleaching of β-carotene.
5 methods were used to evaluate the antioxidant activity of Mentha aquatica and Stachys guyoniana. The latter showed a good activity with 4 methods: β-carotene, DPPH, ABTS and metal chelating whereas Mentha aquatica exhibited a moderate activity with CUPRAC and ABTS tests. Compared with the other tested extracts, the n-butanol extract of
Stachys guyoniana showed the highest anticholinesterase activity.
The two plants showed an antibacterial potential against some bacterial strains, by the use of agar diffusion method and MIC's determination.
Diplôme : Doctorat en sciences En ligne : ../theses/chimie/FER6964.pdf Format de la ressource électronique : Permalink : https://bu.umc.edu.dz/md/index.php?lvl=notice_display&id=10362 Etude phytochimique et évaluation des activités biologiques des espèces : Mentha aquatica, Stachys guyoniana et Thymus dreatensis (LAMIACEAE) [texte imprimé] / Maria Ferhat, Auteur ; Zahia Kabouche, Directeur de thèse . - [S.l.] : جامعة الإخوة منتوري قسنطينة, 2016 . - 114 f. ; 30 cm.
2 copies imprimées disponibles
Langues : Français (fre)
Catégories : Français - Anglais
ChimieTags : Lamiaceae Mentha aquatica Stachys guyoniana Thymus dreatensis Triterpènes Huile essentielle Activités biologiques RMN 1D et 2D Triterpenoids Essential oil biological activities NMR 1D and 2D " Lamiaceae aquatica Mentha dreatensis Thymys guyonina Stachys
????? ?????? ?????? ?????????? ??????? ?????? ???????? ???? ?????"Index. décimale : 540 Chimie et sciences connexes Résumé : This present work concerns the phytochemical and biological study of three Algerian plants belonging to the Lamiaceae family : Mentha aquatica L., Stachys guyoniana de Noé and Thymus dreatensis Batt. Chromatographic separations and purifications of extracts from the aerial parts and roots of Mentha aquatica led to the isolation and identification of 1 6 compounds, including one new triterpene and 5 triterpene acids which are new for the genus.
The structures of isolated compounds were particularly established by the use of NMR 1D and 2D (1H, 13C, COSY H-H, HMQC and HMBC), high resolution mass spectrometry (ESI-MS and HR-ESI-MS) and by comparison with literature data.
GC and GC/MS analyses of T. dreatensis essential oil showed that it was mainly represented by thymol (28.1%) followed by γ-terpinene (18.7%), thymyl methyl ether (10.9%) and linalool (5.0%). This oil showed a good antioxidant activity by the bleaching of β-carotene.
5 methods were used to evaluate the antioxidant activity of Mentha aquatica and Stachys guyoniana. The latter showed a good activity with 4 methods: β-carotene, DPPH, ABTS and metal chelating whereas Mentha aquatica exhibited a moderate activity with CUPRAC and ABTS tests. Compared with the other tested extracts, the n-butanol extract of
Stachys guyoniana showed the highest anticholinesterase activity.
The two plants showed an antibacterial potential against some bacterial strains, by the use of agar diffusion method and MIC's determination.
Diplôme : Doctorat en sciences En ligne : ../theses/chimie/FER6964.pdf Format de la ressource électronique : Permalink : https://bu.umc.edu.dz/md/index.php?lvl=notice_display&id=10362 Exemplaires (1)
Code-barres Cote Support Localisation Section Disponibilité FER/6964 FER/6964 Thèse Bibliothèque principale Thèses Disponible Etude phytochimique et évaluation des activités biologiques d'Abies numidica de Lannoy et de Cedrus atlantica (Endl) Manetti (Pinaceae) / Maya Belhadj-Mostefa
Titre : Etude phytochimique et évaluation des activités biologiques d'Abies numidica de Lannoy et de Cedrus atlantica (Endl) Manetti (Pinaceae) Type de document : texte imprimé Auteurs : Maya Belhadj-Mostefa, Auteur ; Zahia Kabouche, Directeur de thèse Editeur : جامعة الإخوة منتوري قسنطينة Année de publication : 2017 Importance : 278 f. Format : 30 cm. Note générale : 2 copies imprimées disponibles
Langues : Français (fre) Catégories : Français - Anglais
ChimieTags : Pinaceae Abies numidica Cedrus atlantica diterpènes acides tocotrienoliques flavonoides lignanes activités biologiques diterpenes tocotrienolic acids flavonoids biological activities Index. décimale : 540 Chimie et sciences connexes Résumé : Separations and purifications by chromatographic methods allowed us to isolate 8 abietanediterpene compounds from the cones of Abies numidica de Lannoy and 21 compounds from
the cones of Cedrus atlantica (Endl) Manetti including 3 tocotrienolic acids from wich one is
new, 3 flavonoids from which one is new, 3 neolignanes and 12 abietane-diterpenes. The
structural determination of the isolated compounds from these two Pinaceae was based on the
use of 1D and 2D NMR techniques (1H, 13C, COSY HH, HSQC, HMBC and NOESY), mass
spectrometry (ESI-MS and HRESI-MS ) and on comparison with literature data. Evaluation
of the antioxidant activity of the fractions derived from the VLC of the hydromethanolic
extract of the cones of A. numidica showed a higher activity of the F60:40 fraction in the
ABTS + test, followed by fractions F40:60 and F80:20. Furthermore, the F60:40 fraction of
the hydromethanolic extract of the cones of A. numidica was the best inhibitor of the enzyme
acetylcholinesterase whereas the F80:20 fraction showed the highest activity against
butyrylcholinesterase. The extracts of the two studied plants and the isolated compounds
showed a good antimicrobial activity against a large spectrum of Gram-positive bacteria and
on the tested fungi (Candida)
Diplôme : Doctorat En ligne : ../theses/chimie/BEL7047.pdf Format de la ressource électronique : Permalink : https://bu.umc.edu.dz/md/index.php?lvl=notice_display&id=10552 Etude phytochimique et évaluation des activités biologiques d'Abies numidica de Lannoy et de Cedrus atlantica (Endl) Manetti (Pinaceae) [texte imprimé] / Maya Belhadj-Mostefa, Auteur ; Zahia Kabouche, Directeur de thèse . - [S.l.] : جامعة الإخوة منتوري قسنطينة, 2017 . - 278 f. ; 30 cm.
2 copies imprimées disponibles
Langues : Français (fre)
Catégories : Français - Anglais
ChimieTags : Pinaceae Abies numidica Cedrus atlantica diterpènes acides tocotrienoliques flavonoides lignanes activités biologiques diterpenes tocotrienolic acids flavonoids biological activities Index. décimale : 540 Chimie et sciences connexes Résumé : Separations and purifications by chromatographic methods allowed us to isolate 8 abietanediterpene compounds from the cones of Abies numidica de Lannoy and 21 compounds from
the cones of Cedrus atlantica (Endl) Manetti including 3 tocotrienolic acids from wich one is
new, 3 flavonoids from which one is new, 3 neolignanes and 12 abietane-diterpenes. The
structural determination of the isolated compounds from these two Pinaceae was based on the
use of 1D and 2D NMR techniques (1H, 13C, COSY HH, HSQC, HMBC and NOESY), mass
spectrometry (ESI-MS and HRESI-MS ) and on comparison with literature data. Evaluation
of the antioxidant activity of the fractions derived from the VLC of the hydromethanolic
extract of the cones of A. numidica showed a higher activity of the F60:40 fraction in the
ABTS + test, followed by fractions F40:60 and F80:20. Furthermore, the F60:40 fraction of
the hydromethanolic extract of the cones of A. numidica was the best inhibitor of the enzyme
acetylcholinesterase whereas the F80:20 fraction showed the highest activity against
butyrylcholinesterase. The extracts of the two studied plants and the isolated compounds
showed a good antimicrobial activity against a large spectrum of Gram-positive bacteria and
on the tested fungi (Candida)
Diplôme : Doctorat En ligne : ../theses/chimie/BEL7047.pdf Format de la ressource électronique : Permalink : https://bu.umc.edu.dz/md/index.php?lvl=notice_display&id=10552 Exemplaires (1)
Code-barres Cote Support Localisation Section Disponibilité BEL/7047 BEL/7047 Thèse Bibliothèque principale Thèses Disponible
Exemplaires (1)
Code-barres Cote Support Localisation Section Disponibilité BOU/6714 BOU/6714 Thèse Bibliothèque principale Thèses Disponible
Titre : Etude chimique et biologique des espèces Calligonum azel et Calligonum comosum (Polygonaceae) et une espèce du genre Thymus (Lamiaceae). Type de document : texte imprimé Auteurs : Soumia Belaabed Khalfaoui, Auteur ; Nour-eddine Beghidja, Directeur de thèse Editeur : جامعة الإخوة منتوري قسنطينة Année de publication : 2018 Importance : 250 f. Format : 30 cm. Note générale : 2 copies imprimées disponibles
Langues : Français (fre) Catégories : Français - Anglais
ChimieTags : Calligonum azel Calligonum comosum Thymus ciliatus Polygonaceae Lamiaceae RMN 1D et 2D CLHP HRESIMS activités biologiques huile essentielle NMR 1D and 2D HPLC Biological activities essential oil ??????? ?????? ??????????1D ?2D ????????????? HPLC ??????? ?????? ???????? ?????????? ?????? ???????? Index. décimale : 540 Chimie et sciences connexes Résumé : The phytochemical and biological study concerns the aerial parts of two endemic Saharian species belonging to the polygonaceae family: Calligonum azel and Calligonum comosum and a third one belonging to the Lamiaceae family.
The object of our work focused on the valorization of the Algerian flora. For this, firstly; we carried out a phytochemical study on Calligonum azel and Calligonum comosum which concerned mainly the biologically active compounds then we tested the antioxidant, antibacterial, antifungal and anti-inflammatory properties of all the organic extracts and some isolated compounds. Secondly; we studied the chemical composition and biological activities of Thymus ciliatus essential oil.
The study of aerial parts of C. azel and C. comosum, in order to know the active compounds responsible for their biological activity, leading to purification, chromatographic identification (CC, TLC and HPLC), and characterization using the different spectroscopic methods (1D and 2D NMR, MS and UV) of twenty one pure compounds (21) in which eighteen (18) compounds were identified.
The investigation of the biological activities of the extracts of Calligonum azel and Calligonum comosum showed that the best antioxidant activity was exhibited by the Chloroform and ethyl acetate extracts of C. azel and the Chloroform extract of C. comosum. The chloroform extracts of both species showed the best antibacterial activity. Chloroform extract from C. comosum has better antifungal activity against Candida albicans ATCC 2019 and Candida parapsilosis ATCC 22019.
From the isolated compounds, three have an antioxidant and anti-inflammatory activity. These compounds were: protocatachuic ethyl ester acid, -diamino (4-hydroxy benzene) butanoic acid and tamgernanetin.
The qualitative and quantitative analysis of essential oil of T. ciliatus allows the identification of 25 compounds representing 87.18 % of the total essential oil mainly. The GC and GC-MS analysis showed that this essential oils was mainly rich of thymol (54.26%), carvacrol methyl ether (1,373 %), o-cymene (5.72 %) carvacrol (1.373%)-cymen-7-ol (17.58 %), however it was the first time that -cymen-7-ol (17.58 %) was found as main component in the essential oils of T. ciliatus.
The evaluation of the antibacterial activity was assessed by disc diffusion method against bacterial strains. The essential oil exhibited a good antibacterial activity against Escherichia coli ATCC 25922, Staphylococcus aureus ATCC 43300 and Staphylocossus aureus.
All of our works confirms the medicinal properties of the Saharian species, and contributes to their scientific descriptions.Diplôme : Doctorat En ligne : ../theses/chimie/BEL7311.pdf Format de la ressource électronique : Permalink : https://bu.umc.edu.dz/md/index.php?lvl=notice_display&id=10926 Etude chimique et biologique des espèces Calligonum azel et Calligonum comosum (Polygonaceae) et une espèce du genre Thymus (Lamiaceae). [texte imprimé] / Soumia Belaabed Khalfaoui, Auteur ; Nour-eddine Beghidja, Directeur de thèse . - [S.l.] : جامعة الإخوة منتوري قسنطينة, 2018 . - 250 f. ; 30 cm.
2 copies imprimées disponibles
Langues : Français (fre)
Catégories : Français - Anglais
ChimieTags : Calligonum azel Calligonum comosum Thymus ciliatus Polygonaceae Lamiaceae RMN 1D et 2D CLHP HRESIMS activités biologiques huile essentielle NMR 1D and 2D HPLC Biological activities essential oil ??????? ?????? ??????????1D ?2D ????????????? HPLC ??????? ?????? ???????? ?????????? ?????? ???????? Index. décimale : 540 Chimie et sciences connexes Résumé : The phytochemical and biological study concerns the aerial parts of two endemic Saharian species belonging to the polygonaceae family: Calligonum azel and Calligonum comosum and a third one belonging to the Lamiaceae family.
The object of our work focused on the valorization of the Algerian flora. For this, firstly; we carried out a phytochemical study on Calligonum azel and Calligonum comosum which concerned mainly the biologically active compounds then we tested the antioxidant, antibacterial, antifungal and anti-inflammatory properties of all the organic extracts and some isolated compounds. Secondly; we studied the chemical composition and biological activities of Thymus ciliatus essential oil.
The study of aerial parts of C. azel and C. comosum, in order to know the active compounds responsible for their biological activity, leading to purification, chromatographic identification (CC, TLC and HPLC), and characterization using the different spectroscopic methods (1D and 2D NMR, MS and UV) of twenty one pure compounds (21) in which eighteen (18) compounds were identified.
The investigation of the biological activities of the extracts of Calligonum azel and Calligonum comosum showed that the best antioxidant activity was exhibited by the Chloroform and ethyl acetate extracts of C. azel and the Chloroform extract of C. comosum. The chloroform extracts of both species showed the best antibacterial activity. Chloroform extract from C. comosum has better antifungal activity against Candida albicans ATCC 2019 and Candida parapsilosis ATCC 22019.
From the isolated compounds, three have an antioxidant and anti-inflammatory activity. These compounds were: protocatachuic ethyl ester acid, -diamino (4-hydroxy benzene) butanoic acid and tamgernanetin.
The qualitative and quantitative analysis of essential oil of T. ciliatus allows the identification of 25 compounds representing 87.18 % of the total essential oil mainly. The GC and GC-MS analysis showed that this essential oils was mainly rich of thymol (54.26%), carvacrol methyl ether (1,373 %), o-cymene (5.72 %) carvacrol (1.373%)-cymen-7-ol (17.58 %), however it was the first time that -cymen-7-ol (17.58 %) was found as main component in the essential oils of T. ciliatus.
The evaluation of the antibacterial activity was assessed by disc diffusion method against bacterial strains. The essential oil exhibited a good antibacterial activity against Escherichia coli ATCC 25922, Staphylococcus aureus ATCC 43300 and Staphylocossus aureus.
All of our works confirms the medicinal properties of the Saharian species, and contributes to their scientific descriptions.Diplôme : Doctorat En ligne : ../theses/chimie/BEL7311.pdf Format de la ressource électronique : Permalink : https://bu.umc.edu.dz/md/index.php?lvl=notice_display&id=10926 Exemplaires (1)
Code-barres Cote Support Localisation Section Disponibilité BEL/7311 BEL/7311 Thèse Bibliothèque principale Thèses Disponible
Titre : Etude phytochimique et pharmacologique de plantes médicinales Algériennes Genista ulicina Spach (Fabaceae) et Chrysanthemum macrocarpum (Sch. Bip.) Coss. & Kralik ex Batt (Asteraceae) Type de document : texte imprimé Auteurs : Naima Boutaghane, Auteur ; Zahia Kabouche, Directeur de thèse ; Laurence Voutquenne, Directeur de thèse Editeur : constantine [Algérie] : Université Constantine 1 Année de publication : 2013 Importance : 270 f. Format : 30 cm. Note générale : 2 copies imprimées disponibles Langues : Français (fre) Catégories : Français - Anglais
ChimieTags : Fabaceae Asteraceae Genista ulicina Chrysanthemum macrocarpum cyclitols Saponines flavonoïdes Huile essentielle activités biologiques RMN 1D et 2D Spectrométrie de masse Saponins flavonoids essential oil biological activities NMR 1D and 2D mass spectroscopy ????????? ???????????? ?????? ??????? ??????? ?????? ?????? ?????????? ?????? ? ?????? ????? ??????? ?????? Index. décimale : 540 Chimie et sciences connexes Résumé :
This report is concerning the phytochemical study of two Algerian plants belonging to the Fabaceae family (Genista ulicina Spach) and Asteraceae family (Chrysanthemum macrocarpum Coss. & Kralik ex Batt). This study led to the isolation and identification of 36 compounds from which 10 compounds are new.
The structures of isolated compounds were established particularly by the use of NMR highfield
1D and 2D technics (1H, 13C J-modulated, COSY H-H, HSQC J-modulated, HMBC and NOESY), high resolution mass spectrometry (ESI-MS and HR-ESI-MS), measurement of rotatory power and comparison with literature data.
GC and GC / MS analyses of the essential oil of C. macrocarpum showed that it was mainly represented by: T-cadinol (19.6%), spathulenol (12.5%), caryophyllene oxide (6.5%), and α- cadinol (5.6%).
The chloroform fraction of C. macrocarpum showed a weak antibacterial activity against: E.
coli, S. aureus, P.aeruginosa, E. faecalis and K. pneumoniae.
The same chloroform fraction was evaluated for its antiproliferative activity against human cancer HT-29 cells and human PC3 cells. The results indicate that the chloroform fraction inhibited cell proliferation of both HT-29 and PC-3 cells,The chloroform fraction showed an excellent analegesic, anti-inflammatory and antiulcerogenic activities.
The butanolic fraction of G. ulicina and isolated compounds were investigated for their antibacterial and antiproliferative growth inhibition, but no significant activities were observed.Diplôme : Doctorat en sciences En ligne : ../theses/chimie/BOU6343.pdf Format de la ressource électronique : Permalink : https://bu.umc.edu.dz/md/index.php?lvl=notice_display&id=6313 Etude phytochimique et pharmacologique de plantes médicinales Algériennes Genista ulicina Spach (Fabaceae) et Chrysanthemum macrocarpum (Sch. Bip.) Coss. & Kralik ex Batt (Asteraceae) [texte imprimé] / Naima Boutaghane, Auteur ; Zahia Kabouche, Directeur de thèse ; Laurence Voutquenne, Directeur de thèse . - constantine (Route ain el bey, Algérie) : Université Constantine 1, 2013 . - 270 f. ; 30 cm.
2 copies imprimées disponibles
Langues : Français (fre)
Catégories : Français - Anglais
ChimieTags : Fabaceae Asteraceae Genista ulicina Chrysanthemum macrocarpum cyclitols Saponines flavonoïdes Huile essentielle activités biologiques RMN 1D et 2D Spectrométrie de masse Saponins flavonoids essential oil biological activities NMR 1D and 2D mass spectroscopy ????????? ???????????? ?????? ??????? ??????? ?????? ?????? ?????????? ?????? ? ?????? ????? ??????? ?????? Index. décimale : 540 Chimie et sciences connexes Résumé :
This report is concerning the phytochemical study of two Algerian plants belonging to the Fabaceae family (Genista ulicina Spach) and Asteraceae family (Chrysanthemum macrocarpum Coss. & Kralik ex Batt). This study led to the isolation and identification of 36 compounds from which 10 compounds are new.
The structures of isolated compounds were established particularly by the use of NMR highfield
1D and 2D technics (1H, 13C J-modulated, COSY H-H, HSQC J-modulated, HMBC and NOESY), high resolution mass spectrometry (ESI-MS and HR-ESI-MS), measurement of rotatory power and comparison with literature data.
GC and GC / MS analyses of the essential oil of C. macrocarpum showed that it was mainly represented by: T-cadinol (19.6%), spathulenol (12.5%), caryophyllene oxide (6.5%), and α- cadinol (5.6%).
The chloroform fraction of C. macrocarpum showed a weak antibacterial activity against: E.
coli, S. aureus, P.aeruginosa, E. faecalis and K. pneumoniae.
The same chloroform fraction was evaluated for its antiproliferative activity against human cancer HT-29 cells and human PC3 cells. The results indicate that the chloroform fraction inhibited cell proliferation of both HT-29 and PC-3 cells,The chloroform fraction showed an excellent analegesic, anti-inflammatory and antiulcerogenic activities.
The butanolic fraction of G. ulicina and isolated compounds were investigated for their antibacterial and antiproliferative growth inhibition, but no significant activities were observed.Diplôme : Doctorat en sciences En ligne : ../theses/chimie/BOU6343.pdf Format de la ressource électronique : Permalink : https://bu.umc.edu.dz/md/index.php?lvl=notice_display&id=6313 Exemplaires (1)
Code-barres Cote Support Localisation Section Disponibilité BOU/6343 BOU/6343 Thèse Bibliothèque principale Thèses Disponible
Permalink
