| Titre : |
Etude phytochimique et évaluation des activités biologiques d'Abies numidica de Lannoy et de Cedrus atlantica (Endl) Manetti (Pinaceae) |
| Type de document : |
texte imprimé |
| Auteurs : |
Maya Belhadj-Mostefa, Auteur ; Zahia Kabouche, Directeur de thèse |
| Editeur : |
جامعة الإخوة منتوري قسنطينة |
| Année de publication : |
2017 |
| Importance : |
278 f. |
| Format : |
30 cm. |
| Note générale : |
2 copies imprimées disponibles
|
| Langues : |
Français (fre) |
| Catégories : |
Français - Anglais
Chimie
|
| Tags : |
Pinaceae Abies numidica Cedrus atlantica diterpènes acides tocotrienoliques flavonoides lignanes activités biologiques diterpenes tocotrienolic acids flavonoids biological activities |
| Index. décimale : |
540 Chimie et sciences connexes |
| Résumé : |
Separations and purifications by chromatographic methods allowed us to isolate 8 abietanediterpene compounds from the cones of Abies numidica de Lannoy and 21 compounds from
the cones of Cedrus atlantica (Endl) Manetti including 3 tocotrienolic acids from wich one is
new, 3 flavonoids from which one is new, 3 neolignanes and 12 abietane-diterpenes. The
structural determination of the isolated compounds from these two Pinaceae was based on the
use of 1D and 2D NMR techniques (1H, 13C, COSY HH, HSQC, HMBC and NOESY), mass
spectrometry (ESI-MS and HRESI-MS ) and on comparison with literature data. Evaluation
of the antioxidant activity of the fractions derived from the VLC of the hydromethanolic
extract of the cones of A. numidica showed a higher activity of the F60:40 fraction in the
ABTS + test, followed by fractions F40:60 and F80:20. Furthermore, the F60:40 fraction of
the hydromethanolic extract of the cones of A. numidica was the best inhibitor of the enzyme
acetylcholinesterase whereas the F80:20 fraction showed the highest activity against
butyrylcholinesterase. The extracts of the two studied plants and the isolated compounds
showed a good antimicrobial activity against a large spectrum of Gram-positive bacteria and
on the tested fungi (Candida)
|
| Diplôme : |
Doctorat |
| En ligne : |
../theses/chimie/BEL7047.pdf |
| Format de la ressource électronique : |
pdf |
| Permalink : |
https://bu.umc.edu.dz/md/index.php?lvl=notice_display&id=10552 |
Etude phytochimique et évaluation des activités biologiques d'Abies numidica de Lannoy et de Cedrus atlantica (Endl) Manetti (Pinaceae) [texte imprimé] / Maya Belhadj-Mostefa, Auteur ; Zahia Kabouche, Directeur de thèse . - [S.l.] : جامعة الإخوة منتوري قسنطينة, 2017 . - 278 f. ; 30 cm. 2 copies imprimées disponibles
Langues : Français ( fre)
| Catégories : |
Français - Anglais
Chimie
|
| Tags : |
Pinaceae Abies numidica Cedrus atlantica diterpènes acides tocotrienoliques flavonoides lignanes activités biologiques diterpenes tocotrienolic acids flavonoids biological activities |
| Index. décimale : |
540 Chimie et sciences connexes |
| Résumé : |
Separations and purifications by chromatographic methods allowed us to isolate 8 abietanediterpene compounds from the cones of Abies numidica de Lannoy and 21 compounds from
the cones of Cedrus atlantica (Endl) Manetti including 3 tocotrienolic acids from wich one is
new, 3 flavonoids from which one is new, 3 neolignanes and 12 abietane-diterpenes. The
structural determination of the isolated compounds from these two Pinaceae was based on the
use of 1D and 2D NMR techniques (1H, 13C, COSY HH, HSQC, HMBC and NOESY), mass
spectrometry (ESI-MS and HRESI-MS ) and on comparison with literature data. Evaluation
of the antioxidant activity of the fractions derived from the VLC of the hydromethanolic
extract of the cones of A. numidica showed a higher activity of the F60:40 fraction in the
ABTS + test, followed by fractions F40:60 and F80:20. Furthermore, the F60:40 fraction of
the hydromethanolic extract of the cones of A. numidica was the best inhibitor of the enzyme
acetylcholinesterase whereas the F80:20 fraction showed the highest activity against
butyrylcholinesterase. The extracts of the two studied plants and the isolated compounds
showed a good antimicrobial activity against a large spectrum of Gram-positive bacteria and
on the tested fungi (Candida)
|
| Diplôme : |
Doctorat |
| En ligne : |
../theses/chimie/BEL7047.pdf |
| Format de la ressource électronique : |
pdf |
| Permalink : |
https://bu.umc.edu.dz/md/index.php?lvl=notice_display&id=10552 |
|
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