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Titre : Étude phytochimique et biologique de trois espèces Algériennes : Calendula stellata Cav. (Asteraceae), Scabiosa stellata L. (Caprifoliaceae) et Salvia barrelieri Etl. (Lamiaceae). Type de document : texte imprimé Auteurs : Meryem Lehbili, Auteur ; Ahmed Kabouche, Directeur de thèse ; Abdulmagid Alabdul Magid, Directeur de thèse Editeur : جامعة الإخوة منتوري قسنطينة Année de publication : 2018 Importance : 375 f. Format : 30 cm. Note générale : 2 copies imprimées disponibles
Langues : Français (fre) Catégories : Français - Anglais
ChimieTags : Calendula stellata Scabiosa stellata Salvia barrelieri saponosides iridoïdes triterpenoïdes flavonoïdes activité antioxydante activité antimicrobienne cytotoxicité saponosids iridoids triterpenes flavonoids antioxidant activity antimicrobial activity cytotoxicity ???????? ?????????? ????? ??????? ????? ????????? ???? ????? Index. décimale : 540 Chimie et sciences connexes Résumé : The phytochemical study of three species: Calendula stellata, Scabiosa stellata and Salvia barrelieri led to the isolation of 55 compounds, from which 16 were new, by the use of different chromatographic methods of separation and purification on solid or liquid support.
The isolated compounds were distributed through 27 saponosids, 7 triterpenes, 11 flavonoids, 7 iridoids and 2 chlorogenic acid derivatives. Two mono-iridoids and two flavonoids showed an important antiradical activity (IC50:7-16 µM). Fourteen compounds exhibited a good antibacterial activity (MIC: 15- 125 µg/mL). The new compounds showed a low to moderate cytotoxic activity against all tested cell lines, except for the monodesmoside, obtained from Scabiosa stellata (Scabiostellatoside F) which exhibited a good antiproliferative effect against HT1080 (IC50 = 12 µM).
Diplôme : Doctorat En ligne : ../theses/chimie/LEH7306.pdf Format de la ressource électronique : Permalink : https://bu.umc.edu.dz/md/index.php?lvl=notice_display&id=10921 Étude phytochimique et biologique de trois espèces Algériennes : Calendula stellata Cav. (Asteraceae), Scabiosa stellata L. (Caprifoliaceae) et Salvia barrelieri Etl. (Lamiaceae). [texte imprimé] / Meryem Lehbili, Auteur ; Ahmed Kabouche, Directeur de thèse ; Abdulmagid Alabdul Magid, Directeur de thèse . - [S.l.] : جامعة الإخوة منتوري قسنطينة, 2018 . - 375 f. ; 30 cm.
2 copies imprimées disponibles
Langues : Français (fre)
Catégories : Français - Anglais
ChimieTags : Calendula stellata Scabiosa stellata Salvia barrelieri saponosides iridoïdes triterpenoïdes flavonoïdes activité antioxydante activité antimicrobienne cytotoxicité saponosids iridoids triterpenes flavonoids antioxidant activity antimicrobial activity cytotoxicity ???????? ?????????? ????? ??????? ????? ????????? ???? ????? Index. décimale : 540 Chimie et sciences connexes Résumé : The phytochemical study of three species: Calendula stellata, Scabiosa stellata and Salvia barrelieri led to the isolation of 55 compounds, from which 16 were new, by the use of different chromatographic methods of separation and purification on solid or liquid support.
The isolated compounds were distributed through 27 saponosids, 7 triterpenes, 11 flavonoids, 7 iridoids and 2 chlorogenic acid derivatives. Two mono-iridoids and two flavonoids showed an important antiradical activity (IC50:7-16 µM). Fourteen compounds exhibited a good antibacterial activity (MIC: 15- 125 µg/mL). The new compounds showed a low to moderate cytotoxic activity against all tested cell lines, except for the monodesmoside, obtained from Scabiosa stellata (Scabiostellatoside F) which exhibited a good antiproliferative effect against HT1080 (IC50 = 12 µM).
Diplôme : Doctorat En ligne : ../theses/chimie/LEH7306.pdf Format de la ressource électronique : Permalink : https://bu.umc.edu.dz/md/index.php?lvl=notice_display&id=10921 Exemplaires (1)
Code-barres Cote Support Localisation Section Disponibilité LEH/7306 LEH/7306 Thèse Bibliothèque principale Thèses Disponible Recherche et détermination structurale de métabolites secondaires de trois espèces algériennes. / Amina Bougandoura
Titre : Recherche et détermination structurale de métabolites secondaires de trois espèces algériennes. Type de document : texte imprimé Auteurs : Amina Bougandoura, Auteur ; Ratiba Mekkiou, Directeur de thèse Editeur : جامعة الإخوة منتوري قسنطينة Année de publication : 2018 Importance : 190 f. Format : 30 cm. Note générale : 2 copies imprimées disponibles
Langues : Français (fre) Catégories : Français - Anglais
ChimieTags : Astragalus gombo Genista cinerea ssp. ramosissima Fabaceae Cistanche violacea Orobanchaceae flavonoïdes glycosides Iridoïdes Phenylethanoïde Glycosides Activité antioxydant Activité anti-inflammatoire flavonoid glycosides Iridoids Phenylethanoide Glycosides antioxidant Activity anti-inflammatory Activity Index. décimale : 540 Chimie et sciences connexes Résumé : This work is devoted to the phytochemical and biological study of three species endemic to Algeria. It concerning Astragalus gombo and Genista cinerea ssp. ramosissima, both belong to the Fabaceae family and the third species is Cistanche violacea from the Orobanchaceae family.
The phytochemical investigation of n-butanol extracts from the aerial parts of A. gombo and Genista cinerea ssp. ramosissima allowed the isolation of 8 products and the structural identification of 5 of them. All the identified products present a kaempferol or quercetin skeleton which is glucosided in 3. While, the phytochemical investigation of ethyl acetate and n-butanol extracts of C. violacea allowed the isolation of 15 products and identification of 7 from the EtOAc among which two are new (one iridoid and one phenylethanoid glycoside) and
five others reported for the first time in the Cistanche genus. The structural elucidation of the isolated compounds was carried out by combining the various spectroscopic methods (UV, 1D & 2D NMR) as well as by comparing the results with the literature data.
Quantification of the total polyphenols and total flavonoids of the EtOAc and n-BuOH extracts of G. cinerea ssp. ramosissima was performed by colorimetric methods. This step showed a content of polyphenols and flavonoids more important in the n-BuOH extract. The antioxidant activity of the EtOAc and n-BuOH extracts was evaluated by the free radical scavenging method (DPPH). The n-BuOH extract exhibited the strongest effect with respect to the DPPH
free radical comparing to BHT used as standard.
The EtOAc extract of C. violacea was estimated for its anti-inflammatory activity by using two methods (HRBC membrane stabilization method and Albumin denaturation inhibition). The results showed that this extract can be used as source of new anti-inflammatory agents.
Diplôme : Doctorat En ligne : ../theses/chimie/BOU7284.pdf Format de la ressource électronique : Permalink : https://bu.umc.edu.dz/md/index.php?lvl=notice_display&id=10899 Recherche et détermination structurale de métabolites secondaires de trois espèces algériennes. [texte imprimé] / Amina Bougandoura, Auteur ; Ratiba Mekkiou, Directeur de thèse . - [S.l.] : جامعة الإخوة منتوري قسنطينة, 2018 . - 190 f. ; 30 cm.
2 copies imprimées disponibles
Langues : Français (fre)
Catégories : Français - Anglais
ChimieTags : Astragalus gombo Genista cinerea ssp. ramosissima Fabaceae Cistanche violacea Orobanchaceae flavonoïdes glycosides Iridoïdes Phenylethanoïde Glycosides Activité antioxydant Activité anti-inflammatoire flavonoid glycosides Iridoids Phenylethanoide Glycosides antioxidant Activity anti-inflammatory Activity Index. décimale : 540 Chimie et sciences connexes Résumé : This work is devoted to the phytochemical and biological study of three species endemic to Algeria. It concerning Astragalus gombo and Genista cinerea ssp. ramosissima, both belong to the Fabaceae family and the third species is Cistanche violacea from the Orobanchaceae family.
The phytochemical investigation of n-butanol extracts from the aerial parts of A. gombo and Genista cinerea ssp. ramosissima allowed the isolation of 8 products and the structural identification of 5 of them. All the identified products present a kaempferol or quercetin skeleton which is glucosided in 3. While, the phytochemical investigation of ethyl acetate and n-butanol extracts of C. violacea allowed the isolation of 15 products and identification of 7 from the EtOAc among which two are new (one iridoid and one phenylethanoid glycoside) and
five others reported for the first time in the Cistanche genus. The structural elucidation of the isolated compounds was carried out by combining the various spectroscopic methods (UV, 1D & 2D NMR) as well as by comparing the results with the literature data.
Quantification of the total polyphenols and total flavonoids of the EtOAc and n-BuOH extracts of G. cinerea ssp. ramosissima was performed by colorimetric methods. This step showed a content of polyphenols and flavonoids more important in the n-BuOH extract. The antioxidant activity of the EtOAc and n-BuOH extracts was evaluated by the free radical scavenging method (DPPH). The n-BuOH extract exhibited the strongest effect with respect to the DPPH
free radical comparing to BHT used as standard.
The EtOAc extract of C. violacea was estimated for its anti-inflammatory activity by using two methods (HRBC membrane stabilization method and Albumin denaturation inhibition). The results showed that this extract can be used as source of new anti-inflammatory agents.
Diplôme : Doctorat En ligne : ../theses/chimie/BOU7284.pdf Format de la ressource électronique : Permalink : https://bu.umc.edu.dz/md/index.php?lvl=notice_display&id=10899 Exemplaires (1)
Code-barres Cote Support Localisation Section Disponibilité BOU/7284 BOU/7284 Thèse Bibliothèque principale Thèses Disponible
Exemplaires (1)
Code-barres Cote Support Localisation Section Disponibilité BOU/6714 BOU/6714 Thèse Bibliothèque principale Thèses Disponible
