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Composition chimique et évaluation des activites biologiques des huiles essentielles de Pistacia atlantica Desf.et de Ferula vesceritensis Coss. & Dur. et synthese catalytique de nouveaux dérivés pipéridiniques / Ilhem Labed ep Zouad  

Public ISBD Titre : Composition chimique et évaluation des activites biologiques des huiles essentielles de Pistacia atlantica Desf.et de Ferula vesceritensis Coss. & Dur. et synthese catalytique de nouveaux dérivés pipéridiniques Type de document : texte imprimé Auteurs : Ilhem Labed ep Zouad, Auteur ; Zahia Kabouche, Directeur de thèse Editeur : جامعة الإخوة منتوري قسنطينة Année de publication : 2015 Importance : 211 f. Format : 30 cm. Note générale : 2 copies imprimes disponibles Langues : Français (fre) Catégories : Français - Anglais Chimie Tags : Chimie pharmaceutique  Ferula vesceritensis Coss. & Dur.  antioxydante  anticholinestérase  antibactérienne  couplage oxydant  énamides  pipéridines  hydroboration  hydrogénation  Pistacia atlantica Desf.  antioxidant  anticholinesterase  antibacterial  oxidative coupling  enamides  hydrogenation  hydrobration  piperidines Index. décimale : 540 Chimie et sciences connexes Résumé : In a first part we studied the chemical composition and biological activities of Pistacia atlantica Desf. and Ferula vesceritensis Coss. & Dur. The GC and GC-MS analyses showed that the essential oils of P. atlantica are rich in α-pinene, limonene and spatulenol, while β-phellandrene, α-terpinene, β-elemene, γ-gurjunene and germacrene-B were found as major components, for the first time for the essential oils of the genus Pistacia . α-Pinene and β- pinene were predominant in the essential oils of Ferula vesceritensis; however the first time that α-phellandrene, fenchylacetate, elixene, l'aristolene and cartol were found as main components in the essential oils of the genus Ferula . The both essential oils of P. atlantica . and F. vesceritensis exhibited a good antibacterial activity against clinical isolated bacteria and food borne pathogens. The essential oils of P. atlantica possess an important antioxidant effect which were determined using β-carotene-linoleic acid, DPPH- and ABTS•+ -scavenging activities, metal chelating effect and CUPRAC assays. The essential oils showed a moderate anticholinestérase activity compared with galantamin for the inhibitory activity of principal enzymes of Alzheimer’s disease AChE and BChE. In a second part, we synthesized 12 new piperidine derivatives, which have been achieved through [Cp*Ru]-catalyzed intermolecular coupling of allylic alcohols and propargylic amides with water as the only side product, and demonstrated that the selective oxidativecoupling cinnamyl alcohol derivatives and 2-substituted allylic alcohols. This methodology allows the access to 3,4- and 3,5-disubstituted enamides as valuable scaffolds for the preparation of 3-methylpiperidine derivatives through selective [Cp*Ru] catalyzed alkene hydrogenation. Diplôme : Doctorat En ligne : ../theses/chimie/LAB6834.pdf Format de la ressource électronique : pdf Permalink : https://bu.umc.edu.dz/md/index.php?lvl=notice_display&id=10126 Composition chimique et évaluation des activites biologiques des huiles essentielles de Pistacia atlantica Desf.et de Ferula vesceritensis Coss. & Dur. et synthese catalytique de nouveaux dérivés pipéridiniques [texte imprimé] / Ilhem Labed ep Zouad, Auteur ; Zahia Kabouche, Directeur de thèse . - [S.l.] : جامعة الإخوة منتوري قسنطينة, 2015 . - 211 f. ; 30 cm. 2 copies imprimes disponibles Langues : Français (fre) Catégories : Français - Anglais Chimie Tags : Chimie pharmaceutique  Ferula vesceritensis Coss. & Dur.  antioxydante  anticholinestérase  antibactérienne  couplage oxydant  énamides  pipéridines  hydroboration  hydrogénation  Pistacia atlantica Desf.  antioxidant  anticholinesterase  antibacterial  oxidative coupling  enamides  hydrogenation  hydrobration  piperidines Index. décimale : 540 Chimie et sciences connexes Résumé : In a first part we studied the chemical composition and biological activities of Pistacia atlantica Desf. and Ferula vesceritensis Coss. & Dur. The GC and GC-MS analyses showed that the essential oils of P. atlantica are rich in α-pinene, limonene and spatulenol, while β-phellandrene, α-terpinene, β-elemene, γ-gurjunene and germacrene-B were found as major components, for the first time for the essential oils of the genus Pistacia . α-Pinene and β- pinene were predominant in the essential oils of Ferula vesceritensis; however the first time that α-phellandrene, fenchylacetate, elixene, l'aristolene and cartol were found as main components in the essential oils of the genus Ferula . The both essential oils of P. atlantica . and F. vesceritensis exhibited a good antibacterial activity against clinical isolated bacteria and food borne pathogens. The essential oils of P. atlantica possess an important antioxidant effect which were determined using β-carotene-linoleic acid, DPPH- and ABTS•+ -scavenging activities, metal chelating effect and CUPRAC assays. The essential oils showed a moderate anticholinestérase activity compared with galantamin for the inhibitory activity of principal enzymes of Alzheimer’s disease AChE and BChE. In a second part, we synthesized 12 new piperidine derivatives, which have been achieved through [Cp*Ru]-catalyzed intermolecular coupling of allylic alcohols and propargylic amides with water as the only side product, and demonstrated that the selective oxidativecoupling cinnamyl alcohol derivatives and 2-substituted allylic alcohols. This methodology allows the access to 3,4- and 3,5-disubstituted enamides as valuable scaffolds for the preparation of 3-methylpiperidine derivatives through selective [Cp*Ru] catalyzed alkene hydrogenation. Diplôme : Doctorat En ligne : ../theses/chimie/LAB6834.pdf Format de la ressource électronique : pdf Permalink : https://bu.umc.edu.dz/md/index.php?lvl=notice_display&id=10126

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Code-barres	Cote	Support	Localisation	Section	Disponibilité
LAB/6834	LAB/6834	Thèse	Bibliothèque principale	Thèses	Disponible