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Titre : Etude phytochimique et biologique de deux plantes médicinales Algériennes : Thymus ciliatus (Desf) (Lamiaceae) et Asteriscus graveolens (Forsk.) Dc. (Asteraceae). Type de document : texte imprimé Auteurs : Hanane Achoub, Auteur ; Lahcene Zaiter, Directeur de thèse Mention d'édition : 30/11/2020 Editeur : جامعة الإخوة منتوري قسنطينة Année de publication : 2020 Importance : 267 f. Format : 30 cm. Note générale : 1 copies imprimées disponibles
Langues : Français (fre) Catégories : Français - Anglais
ChimieTags : Chimie organique: Phytochimie Thymus ciliatus (Desf) Asteriscus graveolens (Forsk.) dc. Lamiaceae Asteraceae sesquiterpènes flavonoïdes composés phénoliques monoterpènes activité antioxydante huile essentielle cytotoxicité sesquiterpenes flavonoids phenolic compounds monoterpenes Antioxidant activity essential oil cytotoxic effect سسكويثربينات فلافونويد مركبات فينولية أحادية التربينات نشاط مضادات الأكسدة الزيت الأساسي تأثير السمي للخلايا Index. décimale : 540 Chimie et sciences connexes Résumé :
This work concerned the phytochemical and biological study of two Algerian medicinal plants Thymus ciliatus (Desf) and Asteriscus graveolens (Forsk.) dc. belonging to the families Lamiaceae and Asteraceae ,respectively. This study led to the isolation of twenty seven products from which seventeen were identified including. Among the isolated compounds, 5 sesquiterpenes from which 3 were new, 6 flavonoids which 1 is new, 4 phenolic compounds and 2 monoterpenes. The structures of the isolated products were elucidated mainly by the combination of spectroscopic methods mainly: NMR techniques (1H, 13C, COSY, HSQC and HMBC), UV spectrophotometry, we also used high resolution mass spectrometry methods and comparison with literature data. The quantification of total phenols and total flavonoids contents of the EtOAc, nBuOH extracts of the aerial parts of Thymus ciliatus (Desf) were determined, EtOAc extract had the highest phenolic and flavonoid contents followed by n-butanol extract. This extracts showed an excellent antioxidant activity by DPPH test. The antioxidant activity of AcOEt and n-BuOH extracts of Asteriscus graveolens was estimated by the DPPH test and β-Carotene bleaching assay. The best result was obtained for the ethyl acetate extract, especially in the DPPH method, where its effect is greater than BHT and α-tocopherol used as standards. Both extracts and some isolated compounds of Asteriscus graveolens were tested for their cytotoxic effect in human cancer cell lines (HCT-116, DLD1 and HDFa). The results indicate that EtOAc extract and isolated compounds 9 α-hydroxyparthenolide, 9β-hydroxyparthenolide et 7,12-dihydroxy-6,7- dihydro-5,(6) E-dehydronerolidol showed significant activity compared to the n-BuOH extract and and the two new compounds. The chemical composition of the essential oil of aerial parts of Thymus ciliatus (Desf) Benth studied by GC-FID and GC-MS showed that this oil is mainly composed of elemol (6.80%), carvacrol (5.86%), γ-muurolene (5.18%), β-sesquiphellandrene (5.09%), bicyclogermacrene (5.04%), β-Pinene (4.49%) and curcumene (4.20%).Note de contenu : Annexes. Diplôme : Doctorat en sciences En ligne : ../theses/chimie/ACH7683.pdf Format de la ressource électronique : Permalink : index.php?lvl=notice_display&id=11517 Etude phytochimique et biologique de deux plantes médicinales Algériennes : Thymus ciliatus (Desf) (Lamiaceae) et Asteriscus graveolens (Forsk.) Dc. (Asteraceae). [texte imprimé] / Hanane Achoub, Auteur ; Lahcene Zaiter, Directeur de thèse . - 30/11/2020 . - جامعة الإخوة منتوري قسنطينة, 2020 . - 267 f. ; 30 cm.
1 copies imprimées disponibles
Langues : Français (fre)
Catégories : Français - Anglais
ChimieTags : Chimie organique: Phytochimie Thymus ciliatus (Desf) Asteriscus graveolens (Forsk.) dc. Lamiaceae Asteraceae sesquiterpènes flavonoïdes composés phénoliques monoterpènes activité antioxydante huile essentielle cytotoxicité sesquiterpenes flavonoids phenolic compounds monoterpenes Antioxidant activity essential oil cytotoxic effect سسكويثربينات فلافونويد مركبات فينولية أحادية التربينات نشاط مضادات الأكسدة الزيت الأساسي تأثير السمي للخلايا Index. décimale : 540 Chimie et sciences connexes Résumé :
This work concerned the phytochemical and biological study of two Algerian medicinal plants Thymus ciliatus (Desf) and Asteriscus graveolens (Forsk.) dc. belonging to the families Lamiaceae and Asteraceae ,respectively. This study led to the isolation of twenty seven products from which seventeen were identified including. Among the isolated compounds, 5 sesquiterpenes from which 3 were new, 6 flavonoids which 1 is new, 4 phenolic compounds and 2 monoterpenes. The structures of the isolated products were elucidated mainly by the combination of spectroscopic methods mainly: NMR techniques (1H, 13C, COSY, HSQC and HMBC), UV spectrophotometry, we also used high resolution mass spectrometry methods and comparison with literature data. The quantification of total phenols and total flavonoids contents of the EtOAc, nBuOH extracts of the aerial parts of Thymus ciliatus (Desf) were determined, EtOAc extract had the highest phenolic and flavonoid contents followed by n-butanol extract. This extracts showed an excellent antioxidant activity by DPPH test. The antioxidant activity of AcOEt and n-BuOH extracts of Asteriscus graveolens was estimated by the DPPH test and β-Carotene bleaching assay. The best result was obtained for the ethyl acetate extract, especially in the DPPH method, where its effect is greater than BHT and α-tocopherol used as standards. Both extracts and some isolated compounds of Asteriscus graveolens were tested for their cytotoxic effect in human cancer cell lines (HCT-116, DLD1 and HDFa). The results indicate that EtOAc extract and isolated compounds 9 α-hydroxyparthenolide, 9β-hydroxyparthenolide et 7,12-dihydroxy-6,7- dihydro-5,(6) E-dehydronerolidol showed significant activity compared to the n-BuOH extract and and the two new compounds. The chemical composition of the essential oil of aerial parts of Thymus ciliatus (Desf) Benth studied by GC-FID and GC-MS showed that this oil is mainly composed of elemol (6.80%), carvacrol (5.86%), γ-muurolene (5.18%), β-sesquiphellandrene (5.09%), bicyclogermacrene (5.04%), β-Pinene (4.49%) and curcumene (4.20%).Note de contenu : Annexes. Diplôme : Doctorat en sciences En ligne : ../theses/chimie/ACH7683.pdf Format de la ressource électronique : Permalink : index.php?lvl=notice_display&id=11517 Exemplaires (1)
Code-barres Cote Support Localisation Section Disponibilité ACHO/7683 ACHO/7683 Thèse Bibliothèque principale Thèses Disponible
Titre : Étude phytochimique et biologique de trois espèces Algériennes : Calendula stellata Cav. (Asteraceae), Scabiosa stellata L. (Caprifoliaceae) et Salvia barrelieri Etl. (Lamiaceae). Type de document : texte imprimé Auteurs : Meryem Lehbili, Auteur ; Ahmed Kabouche, Directeur de thèse ; Abdulmagid Alabdul Magid, Directeur de thèse Editeur : جامعة الإخوة منتوري قسنطينة Année de publication : 2018 Importance : 375 f. Format : 30 cm. Note générale : 2 copies imprimées disponibles
Langues : Français (fre) Catégories : Français - Anglais
ChimieTags : Calendula stellata Scabiosa stellata Salvia barrelieri saponosides iridoïdes triterpenoïdes flavonoïdes activité antioxydante activité antimicrobienne cytotoxicité saponosids iridoids triterpenes flavonoids antioxidant activity antimicrobial activity cytotoxicity الفعالیة البیولوجیة مضادة للأكسدة مضادة للبكتیریا سمیة خلویة Index. décimale : 540 Chimie et sciences connexes Résumé : The phytochemical study of three species: Calendula stellata, Scabiosa stellata and Salvia barrelieri led to the isolation of 55 compounds, from which 16 were new, by the use of different chromatographic methods of separation and purification on solid or liquid support.
The isolated compounds were distributed through 27 saponosids, 7 triterpenes, 11 flavonoids, 7 iridoids and 2 chlorogenic acid derivatives. Two mono-iridoids and two flavonoids showed an important antiradical activity (IC50:7-16 µM). Fourteen compounds exhibited a good antibacterial activity (MIC: 15- 125 µg/mL). The new compounds showed a low to moderate cytotoxic activity against all tested cell lines, except for the monodesmoside, obtained from Scabiosa stellata (Scabiostellatoside F) which exhibited a good antiproliferative effect against HT1080 (IC50 = 12 µM).
Diplôme : Doctorat En ligne : ../theses/chimie/LEH7306.pdf Format de la ressource électronique : Permalink : index.php?lvl=notice_display&id=10921 Étude phytochimique et biologique de trois espèces Algériennes : Calendula stellata Cav. (Asteraceae), Scabiosa stellata L. (Caprifoliaceae) et Salvia barrelieri Etl. (Lamiaceae). [texte imprimé] / Meryem Lehbili, Auteur ; Ahmed Kabouche, Directeur de thèse ; Abdulmagid Alabdul Magid, Directeur de thèse . - جامعة الإخوة منتوري قسنطينة, 2018 . - 375 f. ; 30 cm.
2 copies imprimées disponibles
Langues : Français (fre)
Catégories : Français - Anglais
ChimieTags : Calendula stellata Scabiosa stellata Salvia barrelieri saponosides iridoïdes triterpenoïdes flavonoïdes activité antioxydante activité antimicrobienne cytotoxicité saponosids iridoids triterpenes flavonoids antioxidant activity antimicrobial activity cytotoxicity الفعالیة البیولوجیة مضادة للأكسدة مضادة للبكتیریا سمیة خلویة Index. décimale : 540 Chimie et sciences connexes Résumé : The phytochemical study of three species: Calendula stellata, Scabiosa stellata and Salvia barrelieri led to the isolation of 55 compounds, from which 16 were new, by the use of different chromatographic methods of separation and purification on solid or liquid support.
The isolated compounds were distributed through 27 saponosids, 7 triterpenes, 11 flavonoids, 7 iridoids and 2 chlorogenic acid derivatives. Two mono-iridoids and two flavonoids showed an important antiradical activity (IC50:7-16 µM). Fourteen compounds exhibited a good antibacterial activity (MIC: 15- 125 µg/mL). The new compounds showed a low to moderate cytotoxic activity against all tested cell lines, except for the monodesmoside, obtained from Scabiosa stellata (Scabiostellatoside F) which exhibited a good antiproliferative effect against HT1080 (IC50 = 12 µM).
Diplôme : Doctorat En ligne : ../theses/chimie/LEH7306.pdf Format de la ressource électronique : Permalink : index.php?lvl=notice_display&id=10921 Exemplaires (1)
Code-barres Cote Support Localisation Section Disponibilité LEH/7306 LEH/7306 Thèse Bibliothèque principale Thèses Disponible Étude phytochimique et évaluation des activités antioxydante, antibactérienne et cytotoxique de deux plantes du genre Phagnalon (Asteraceae) / Hanene Cherchar ép Saadi
Titre : Étude phytochimique et évaluation des activités antioxydante, antibactérienne et cytotoxique de deux plantes du genre Phagnalon (Asteraceae) Type de document : texte imprimé Auteurs : Hanene Cherchar ép Saadi, Auteur ; Djemaa Berrehal, Directeur de thèse Editeur : جامعة الإخوة منتوري قسنطينة Année de publication : 2018 Importance : 190 f. Format : 30 cm. Note générale : 2 copies imprimées disponibles
Langues : Français (fre) Catégories : Français - Anglais
ChimieTags : Asteraceae Phagnalon saxatile Phagnalon sordidum activité antioxydante activité antibactérienne cytotoxicité antioxidant activity antibacterial activity cytotoxicity فعالية مضادة للأكسدة فعالية مضادة للبكتيريا السمية الخلوية Index. décimale : 540 Chimie et sciences connexes Résumé : Our phytochemical and biological works concerned the aerial parts of two species belonging to Asteraeae family : Phagnalon saxatile (L) Cass. and Phagnalon sordidum L.
Several chromatographic methods allowed us to isolate ten products from the n-butanol and ethyl acetate extracts of Phagnalon saxatile from which one is new, and twenty one products from Phagnalon sordidum.
Structures were determined by different spectral methods: nuclear magnetic resonance with different applications (NMR 1H, NMR 13C, COSY, HSQC and HMBC), the mass spectrometry, UV, acid hydrolysis as well as comparison with literature data.
4 methods were used to evaluate the antioxidant activity of Phagnalon sordidum and Phagnalon saxatile. The latter showed a good activity by the use of 4 methods: DPPH, ABTS, CUPRAC and superoxide radical scavenging activity by alkaline DMSO whereas Phagnalon sordidum exhibited a moderate activity with DPPH and CUPRAC tests.
Furthermore, petroleum ether and chloroform extracts from Phagnalon saxatile showed moderate antibacterial activity against the tested strains. The isolated products (1-O- β-D-glucopyranosyl-1,4-dihydroxy-2-((E) 2-oxo-3-butenyl) benzene, 1-O-β-glucopyranosyl- 2(3’,3’-diméthylallyl) hydroquinone and Potassium 4-hydroxy-3-methoxybenzoique acide
methyl ester-5-sulfate) from Phagnalon saxatile showed a moderate cytotoxic activity by the use of MTT method.
Diplôme : Doctorat En ligne : ../theses/chimie/CHE7249.pdf Format de la ressource électronique : Permalink : index.php?lvl=notice_display&id=10841 Étude phytochimique et évaluation des activités antioxydante, antibactérienne et cytotoxique de deux plantes du genre Phagnalon (Asteraceae) [texte imprimé] / Hanene Cherchar ép Saadi, Auteur ; Djemaa Berrehal, Directeur de thèse . - جامعة الإخوة منتوري قسنطينة, 2018 . - 190 f. ; 30 cm.
2 copies imprimées disponibles
Langues : Français (fre)
Catégories : Français - Anglais
ChimieTags : Asteraceae Phagnalon saxatile Phagnalon sordidum activité antioxydante activité antibactérienne cytotoxicité antioxidant activity antibacterial activity cytotoxicity فعالية مضادة للأكسدة فعالية مضادة للبكتيريا السمية الخلوية Index. décimale : 540 Chimie et sciences connexes Résumé : Our phytochemical and biological works concerned the aerial parts of two species belonging to Asteraeae family : Phagnalon saxatile (L) Cass. and Phagnalon sordidum L.
Several chromatographic methods allowed us to isolate ten products from the n-butanol and ethyl acetate extracts of Phagnalon saxatile from which one is new, and twenty one products from Phagnalon sordidum.
Structures were determined by different spectral methods: nuclear magnetic resonance with different applications (NMR 1H, NMR 13C, COSY, HSQC and HMBC), the mass spectrometry, UV, acid hydrolysis as well as comparison with literature data.
4 methods were used to evaluate the antioxidant activity of Phagnalon sordidum and Phagnalon saxatile. The latter showed a good activity by the use of 4 methods: DPPH, ABTS, CUPRAC and superoxide radical scavenging activity by alkaline DMSO whereas Phagnalon sordidum exhibited a moderate activity with DPPH and CUPRAC tests.
Furthermore, petroleum ether and chloroform extracts from Phagnalon saxatile showed moderate antibacterial activity against the tested strains. The isolated products (1-O- β-D-glucopyranosyl-1,4-dihydroxy-2-((E) 2-oxo-3-butenyl) benzene, 1-O-β-glucopyranosyl- 2(3’,3’-diméthylallyl) hydroquinone and Potassium 4-hydroxy-3-methoxybenzoique acide
methyl ester-5-sulfate) from Phagnalon saxatile showed a moderate cytotoxic activity by the use of MTT method.
Diplôme : Doctorat En ligne : ../theses/chimie/CHE7249.pdf Format de la ressource électronique : Permalink : index.php?lvl=notice_display&id=10841 Exemplaires (1)
Code-barres Cote Support Localisation Section Disponibilité CHE/7249 CHE/7249 Thèse Bibliothèque principale Thèses Disponible
Titre : Etude phytochimique et evaluation biologique de l’espèce senecio delphinifolius Vahl Type de document : texte imprimé Auteurs : Soukaina Tidjani, Auteur ; Salah Rhouati, Directeur de thèse Editeur : جامعة الإخوة منتوري قسنطينة Année de publication : 2016 Importance : 187 f. Format : 30 cm. Langues : Français (fre) Catégories : Français - Anglais
ChimieTags : Asteraceae Senecio delphinifolius Alcaloïdes pyrrolizidiniques Flavonoïdes Furanoeremophilane quinone CGMS Chromatographie activité antioxydante cytotoxicité activité antibactérienne Senecio delphinifolius Vahl Pyrrolizidine alkaloids Flavonoïds GCMS Chromatography antibacterial Antioxidant Cytotoxic قلویدات بیرولزیدنیة فلافونیدیان جلیكوزیة كینونات وكروماتوغرافیا الطور الغازي المقرونة بمطیافیة الكتلة (SM/CG) فعالیة مضادة للاكسدة فعالیة مضادة للبكتیریة Index. décimale : 540 Chimie et sciences connexes Résumé : Although Senecio species are known as sources of potentially toxic pyrrolizidine alkaloids (PAs), some species of this genus are traditionally used as remedies. In this work the evaluation of biological activities and the analysis of PAs of Algerian specimens of Senecio delphinifolius Vahl (its vernacular name in Algeria is ""Hachichetettolba"") are reported. Thus it was possible to identify six APs by GC and GC-MS analysis: (1) senecionine (2) seneciphylline (3) integerrimine (4) senkirkine (5) dehydrosenkirkine and (6) neosenkirkine, this technique is frequently used for complex mixtures of such compounds. The species S.
delphinifolius, contains 140 ppm of PAs belong to the toxic series (1, 2-unsaturation in the pyrrolizidine cycle and macrocyclic diester), the use of S. delphinifolius should be discouraged in traditional medicine.
Our research has also led to the isolation by conventional purification techniques of three compounds from the n-butanol extract of the specie S. delphinifolius Vahl two of them are glycosylated flavonols, (7) Quercetine 3-O-α-(rhamnopyrannosyl (1-6) glucopyrannose) [rutine], (8) Kaempferol 3,7-di-O-α-Lrhamnopyranoside [Kaempferitin], the third is a derivative of 1, 4-benzoquinone that are common in the
genus Senecio (9) 2, 5 Cyclohexadiene-1-acetic acid, 1-methyl-4-oxo, methyl ester. A fourth product was isolated from the dichloromethane extract, the structure is being identified. The structures of the isolated compounds were elucidated through the use of NMR techniques 1D and 2D, mass spectroscopy, UV spectroscopy and acid hydrolysis. (10) Chlorogenic acid was identified by co-chromatography with standards.
Diplôme : Doctorat en sciences En ligne : ../theses/chimie/TID7016.pdf Format de la ressource électronique : Permalink : index.php?lvl=notice_display&id=10395 Etude phytochimique et evaluation biologique de l’espèce senecio delphinifolius Vahl [texte imprimé] / Soukaina Tidjani, Auteur ; Salah Rhouati, Directeur de thèse . - جامعة الإخوة منتوري قسنطينة, 2016 . - 187 f. ; 30 cm.
Langues : Français (fre)
Catégories : Français - Anglais
ChimieTags : Asteraceae Senecio delphinifolius Alcaloïdes pyrrolizidiniques Flavonoïdes Furanoeremophilane quinone CGMS Chromatographie activité antioxydante cytotoxicité activité antibactérienne Senecio delphinifolius Vahl Pyrrolizidine alkaloids Flavonoïds GCMS Chromatography antibacterial Antioxidant Cytotoxic قلویدات بیرولزیدنیة فلافونیدیان جلیكوزیة كینونات وكروماتوغرافیا الطور الغازي المقرونة بمطیافیة الكتلة (SM/CG) فعالیة مضادة للاكسدة فعالیة مضادة للبكتیریة Index. décimale : 540 Chimie et sciences connexes Résumé : Although Senecio species are known as sources of potentially toxic pyrrolizidine alkaloids (PAs), some species of this genus are traditionally used as remedies. In this work the evaluation of biological activities and the analysis of PAs of Algerian specimens of Senecio delphinifolius Vahl (its vernacular name in Algeria is ""Hachichetettolba"") are reported. Thus it was possible to identify six APs by GC and GC-MS analysis: (1) senecionine (2) seneciphylline (3) integerrimine (4) senkirkine (5) dehydrosenkirkine and (6) neosenkirkine, this technique is frequently used for complex mixtures of such compounds. The species S.
delphinifolius, contains 140 ppm of PAs belong to the toxic series (1, 2-unsaturation in the pyrrolizidine cycle and macrocyclic diester), the use of S. delphinifolius should be discouraged in traditional medicine.
Our research has also led to the isolation by conventional purification techniques of three compounds from the n-butanol extract of the specie S. delphinifolius Vahl two of them are glycosylated flavonols, (7) Quercetine 3-O-α-(rhamnopyrannosyl (1-6) glucopyrannose) [rutine], (8) Kaempferol 3,7-di-O-α-Lrhamnopyranoside [Kaempferitin], the third is a derivative of 1, 4-benzoquinone that are common in the
genus Senecio (9) 2, 5 Cyclohexadiene-1-acetic acid, 1-methyl-4-oxo, methyl ester. A fourth product was isolated from the dichloromethane extract, the structure is being identified. The structures of the isolated compounds were elucidated through the use of NMR techniques 1D and 2D, mass spectroscopy, UV spectroscopy and acid hydrolysis. (10) Chlorogenic acid was identified by co-chromatography with standards.
Diplôme : Doctorat en sciences En ligne : ../theses/chimie/TID7016.pdf Format de la ressource électronique : Permalink : index.php?lvl=notice_display&id=10395 Exemplaires (1)
Code-barres Cote Support Localisation Section Disponibilité TID/7016 TID/7016 Thèse Bibliothèque principale Thèses Disponible
Titre : Etude phytochimique et pharmacologique d’espèces de deux familles Lamiacées et Apiacées Salvia phlomoides Asso. et Ferula vesceritensis Coss. et Dur. Type de document : texte imprimé Auteurs : Lamia Benniou ép Gherbi, Auteur ; Samir Benayache, Directeur de thèse ; Fadila Benayache, Directeur de thèse Editeur : جامعة الإخوة منتوري قسنطينة Année de publication : 2018 Importance : 185 f. Format : 30 cm. Note générale : Doctorat 3éme CYCLE LMD.
2 copies imprimées disponibles
Langues : Français (fre) Catégories : Français - Anglais
ChimieTags : Chimie pharmaceutique: Analyses physicochimiques, contrôle de la qualité et synthèse de
substances bioactives Lamiacées Salvia phlomoides triterpènes oléananes cytotoxicité Apaiacées Ferula vesceritensis flavonoides activité antioxydante Lamiaceae oleanane triterpenoids cytotoxicity screening Apaiaceae flavonoids antioxidant activity تريتربين سمية خلوية فلافونويد مضاد الاكسدةIndex. décimale : 540 Chimie et sciences connexes Résumé :
This work deals with phytochemical and pharmacological study of two species Salvia phlomoides Asso. from Lamiaceae family and Ferula vesceritensis Coss. Et Dur. from the Apiaceae family.The separation and purification by chromatographical methods of chloroform and ethyl acetate extract of Salvia phlomoides led to the isolation of nine compounds including four triterpenoids from which three are new, four flavonoids, one phenolic acid, and three flavonoids from the ethyl acetate extract of Ferula vesceritensis. The structural etermination of the isolated compounds was established on the basis of spectral analysis IR; ESI-HR-MS, 1D and 2D NMR (1H NMR, 13C NMR, DEPT-135, HSQC, HMBC, COSY and NOESY), and comparison with literature data. Evaluation of the cytotoxicity of the new triterpenoids showed a selective inhibitory effect against the panel of human tumor cell lines NCI-60 of the National Cancer Institute of the United States of America. Evaluation of the antioxidant activity by different methods of the ethyl acetate and n-butanol extracts of Salvia phlomoides and ethyl acetate extract of Ferula vesceritensis indicates an important antioxidant capacity. The GC and GC-MS analysis of the essential oils of the two species showed that the essential oil of Salvia phlomoides (studied for the first time) was mainly represented by Hexahydrofarnesyl acetone, Dibutyle phtalate, Phytol, α-Humulene, Caryophyllene Oxyde and β-Caryophyllene, and major components of the essential oil of Ferula vesceritensis (South) were Shyobunol, δ-Cadinene, ϒ-Cadinene, Isoledene and Dauca-5,8-diene, while for Ferula vesceritensis (East), D-Carvone and Rotundifolone were found as major components for the first time in the genus Ferula.Note de contenu :
Annexes.Diplôme : Doctorat En ligne : ../theses/chimie/BEN7421.pdf Format de la ressource électronique : Permalink : index.php?lvl=notice_display&id=11074 Etude phytochimique et pharmacologique d’espèces de deux familles Lamiacées et Apiacées Salvia phlomoides Asso. et Ferula vesceritensis Coss. et Dur. [texte imprimé] / Lamia Benniou ép Gherbi, Auteur ; Samir Benayache, Directeur de thèse ; Fadila Benayache, Directeur de thèse . - جامعة الإخوة منتوري قسنطينة, 2018 . - 185 f. ; 30 cm.
Doctorat 3éme CYCLE LMD.
2 copies imprimées disponibles
Langues : Français (fre)
Catégories : Français - Anglais
ChimieTags : Chimie pharmaceutique: Analyses physicochimiques, contrôle de la qualité et synthèse de
substances bioactives Lamiacées Salvia phlomoides triterpènes oléananes cytotoxicité Apaiacées Ferula vesceritensis flavonoides activité antioxydante Lamiaceae oleanane triterpenoids cytotoxicity screening Apaiaceae flavonoids antioxidant activity تريتربين سمية خلوية فلافونويد مضاد الاكسدةIndex. décimale : 540 Chimie et sciences connexes Résumé :
This work deals with phytochemical and pharmacological study of two species Salvia phlomoides Asso. from Lamiaceae family and Ferula vesceritensis Coss. Et Dur. from the Apiaceae family.The separation and purification by chromatographical methods of chloroform and ethyl acetate extract of Salvia phlomoides led to the isolation of nine compounds including four triterpenoids from which three are new, four flavonoids, one phenolic acid, and three flavonoids from the ethyl acetate extract of Ferula vesceritensis. The structural etermination of the isolated compounds was established on the basis of spectral analysis IR; ESI-HR-MS, 1D and 2D NMR (1H NMR, 13C NMR, DEPT-135, HSQC, HMBC, COSY and NOESY), and comparison with literature data. Evaluation of the cytotoxicity of the new triterpenoids showed a selective inhibitory effect against the panel of human tumor cell lines NCI-60 of the National Cancer Institute of the United States of America. Evaluation of the antioxidant activity by different methods of the ethyl acetate and n-butanol extracts of Salvia phlomoides and ethyl acetate extract of Ferula vesceritensis indicates an important antioxidant capacity. The GC and GC-MS analysis of the essential oils of the two species showed that the essential oil of Salvia phlomoides (studied for the first time) was mainly represented by Hexahydrofarnesyl acetone, Dibutyle phtalate, Phytol, α-Humulene, Caryophyllene Oxyde and β-Caryophyllene, and major components of the essential oil of Ferula vesceritensis (South) were Shyobunol, δ-Cadinene, ϒ-Cadinene, Isoledene and Dauca-5,8-diene, while for Ferula vesceritensis (East), D-Carvone and Rotundifolone were found as major components for the first time in the genus Ferula.Note de contenu :
Annexes.Diplôme : Doctorat En ligne : ../theses/chimie/BEN7421.pdf Format de la ressource électronique : Permalink : index.php?lvl=notice_display&id=11074 Exemplaires (1)
Code-barres Cote Support Localisation Section Disponibilité BEN/7421 BEN/7421 Thèse Bibliothèque principale Thèses Disponible
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