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Titre : Etude phytochimique et biologique de deux plantes médicinales Algériennes : Thymus ciliatus (Desf) (Lamiaceae) et Asteriscus graveolens (Forsk.) Dc. (Asteraceae). Type de document : texte imprimé Auteurs : Hanane Achoub, Auteur ; Lahcene Zaiter, Directeur de thèse Mention d'édition : 30/11/2020 Editeur : جامعة الإخوة منتوري قسنطينة Année de publication : 2020 Importance : 267 f. Format : 30 cm. Note générale : 1 copies imprimées disponibles
Langues : Français (fre) Catégories : Français - Anglais
ChimieTags : Chimie organique: Phytochimie Thymus ciliatus (Desf) Asteriscus graveolens (Forsk.) dc. Lamiaceae Asteraceae sesquiterpènes flavonoïdes composés phénoliques monoterpènes activité antioxydante huile essentielle cytotoxicité sesquiterpenes flavonoids phenolic compounds monoterpenes Antioxidant activity essential oil cytotoxic effect سسكويثربينات فلافونويد مركبات فينولية أحادية التربينات نشاط مضادات الأكسدة الزيت الأساسي تأثير السمي للخلايا Index. décimale : 540 Chimie et sciences connexes Résumé :
This work concerned the phytochemical and biological study of two Algerian medicinal plants Thymus ciliatus (Desf) and Asteriscus graveolens (Forsk.) dc. belonging to the families Lamiaceae and Asteraceae ,respectively. This study led to the isolation of twenty seven products from which seventeen were identified including. Among the isolated compounds, 5 sesquiterpenes from which 3 were new, 6 flavonoids which 1 is new, 4 phenolic compounds and 2 monoterpenes. The structures of the isolated products were elucidated mainly by the combination of spectroscopic methods mainly: NMR techniques (1H, 13C, COSY, HSQC and HMBC), UV spectrophotometry, we also used high resolution mass spectrometry methods and comparison with literature data. The quantification of total phenols and total flavonoids contents of the EtOAc, nBuOH extracts of the aerial parts of Thymus ciliatus (Desf) were determined, EtOAc extract had the highest phenolic and flavonoid contents followed by n-butanol extract. This extracts showed an excellent antioxidant activity by DPPH test. The antioxidant activity of AcOEt and n-BuOH extracts of Asteriscus graveolens was estimated by the DPPH test and β-Carotene bleaching assay. The best result was obtained for the ethyl acetate extract, especially in the DPPH method, where its effect is greater than BHT and α-tocopherol used as standards. Both extracts and some isolated compounds of Asteriscus graveolens were tested for their cytotoxic effect in human cancer cell lines (HCT-116, DLD1 and HDFa). The results indicate that EtOAc extract and isolated compounds 9 α-hydroxyparthenolide, 9β-hydroxyparthenolide et 7,12-dihydroxy-6,7- dihydro-5,(6) E-dehydronerolidol showed significant activity compared to the n-BuOH extract and and the two new compounds. The chemical composition of the essential oil of aerial parts of Thymus ciliatus (Desf) Benth studied by GC-FID and GC-MS showed that this oil is mainly composed of elemol (6.80%), carvacrol (5.86%), γ-muurolene (5.18%), β-sesquiphellandrene (5.09%), bicyclogermacrene (5.04%), β-Pinene (4.49%) and curcumene (4.20%).Note de contenu : Annexes. Diplôme : Doctorat en sciences En ligne : ../theses/chimie/ACH7683.pdf Format de la ressource électronique : Permalink : index.php?lvl=notice_display&id=11517 Etude phytochimique et biologique de deux plantes médicinales Algériennes : Thymus ciliatus (Desf) (Lamiaceae) et Asteriscus graveolens (Forsk.) Dc. (Asteraceae). [texte imprimé] / Hanane Achoub, Auteur ; Lahcene Zaiter, Directeur de thèse . - 30/11/2020 . - جامعة الإخوة منتوري قسنطينة, 2020 . - 267 f. ; 30 cm.
1 copies imprimées disponibles
Langues : Français (fre)
Catégories : Français - Anglais
ChimieTags : Chimie organique: Phytochimie Thymus ciliatus (Desf) Asteriscus graveolens (Forsk.) dc. Lamiaceae Asteraceae sesquiterpènes flavonoïdes composés phénoliques monoterpènes activité antioxydante huile essentielle cytotoxicité sesquiterpenes flavonoids phenolic compounds monoterpenes Antioxidant activity essential oil cytotoxic effect سسكويثربينات فلافونويد مركبات فينولية أحادية التربينات نشاط مضادات الأكسدة الزيت الأساسي تأثير السمي للخلايا Index. décimale : 540 Chimie et sciences connexes Résumé :
This work concerned the phytochemical and biological study of two Algerian medicinal plants Thymus ciliatus (Desf) and Asteriscus graveolens (Forsk.) dc. belonging to the families Lamiaceae and Asteraceae ,respectively. This study led to the isolation of twenty seven products from which seventeen were identified including. Among the isolated compounds, 5 sesquiterpenes from which 3 were new, 6 flavonoids which 1 is new, 4 phenolic compounds and 2 monoterpenes. The structures of the isolated products were elucidated mainly by the combination of spectroscopic methods mainly: NMR techniques (1H, 13C, COSY, HSQC and HMBC), UV spectrophotometry, we also used high resolution mass spectrometry methods and comparison with literature data. The quantification of total phenols and total flavonoids contents of the EtOAc, nBuOH extracts of the aerial parts of Thymus ciliatus (Desf) were determined, EtOAc extract had the highest phenolic and flavonoid contents followed by n-butanol extract. This extracts showed an excellent antioxidant activity by DPPH test. The antioxidant activity of AcOEt and n-BuOH extracts of Asteriscus graveolens was estimated by the DPPH test and β-Carotene bleaching assay. The best result was obtained for the ethyl acetate extract, especially in the DPPH method, where its effect is greater than BHT and α-tocopherol used as standards. Both extracts and some isolated compounds of Asteriscus graveolens were tested for their cytotoxic effect in human cancer cell lines (HCT-116, DLD1 and HDFa). The results indicate that EtOAc extract and isolated compounds 9 α-hydroxyparthenolide, 9β-hydroxyparthenolide et 7,12-dihydroxy-6,7- dihydro-5,(6) E-dehydronerolidol showed significant activity compared to the n-BuOH extract and and the two new compounds. The chemical composition of the essential oil of aerial parts of Thymus ciliatus (Desf) Benth studied by GC-FID and GC-MS showed that this oil is mainly composed of elemol (6.80%), carvacrol (5.86%), γ-muurolene (5.18%), β-sesquiphellandrene (5.09%), bicyclogermacrene (5.04%), β-Pinene (4.49%) and curcumene (4.20%).Note de contenu : Annexes. Diplôme : Doctorat en sciences En ligne : ../theses/chimie/ACH7683.pdf Format de la ressource électronique : Permalink : index.php?lvl=notice_display&id=11517 Exemplaires (1)
Code-barres Cote Support Localisation Section Disponibilité ACHO/7683 ACHO/7683 Thèse Bibliothèque principale Thèses Disponible Etude phytochimique et valorisation biologique des deux plantes, Genista quadriflora Munby (Fabaceae) et Convolvulus tricolor L. (Convolvulaceae) / Nassira Kacem
Titre : Etude phytochimique et valorisation biologique des deux plantes, Genista quadriflora Munby (Fabaceae) et Convolvulus tricolor L. (Convolvulaceae) Type de document : texte imprimé Auteurs : Nassira Kacem, Auteur ; Salah Rhouati, Directeur de thèse ; Kurt Hostettmann, Directeur de thèse Editeur : constantine [Algérie] : Université Constantine 1 Année de publication : 2015 Importance : 299 f. Format : 30 cm. Note générale : 2 copies imprimées disponibles
Langues : Français (fre) Catégories : Français - Anglais
ChimieTags : Genista Convolvulus alcaloïdes acides caféoylquiniques sesquiterpènes flavonoïdes HPLC MPLC CPC ESIMS GC/EIMS HR-MS/TOF Q-TRAP MSn RMN-2D leishmanicide antipaludique antibactérienne antifongique antiradicalaire acétylcholinestérase alkaloids caffeoylquinic acids sesquiterpenoids flavonoids antileishmanial antimalarial antibacterial antifungal antiradical acetylcholinesterase قلويدات احماض كافيولكينية سيسكويتربنات فلافونيدات مضاد للأكسدة
الضد ميكروبية الضد فطرية مضاد للإنزيم اسيتلكولنستغاز مضاد للملاريا مضاد للشمانيا،Index. décimale : 540 Chimie et sciences connexes Résumé : This work was focused on two Algerian plants, the endemic species Genista quadriflora Munby (Fabaceae) and the species Convolvulus tricolor (Convolvulaceae). The study of the alkaloid profile of G. quadriflora by GC/EIMS allowed the identification of twenty compounds, among which ten are newly registered for the genus. We indicate the presence of:
• Thirteen quinolizidine alkaloids
• Five piperidine alkaloids
• One nicotinic alkaloid, in addition to a nicotinic acid derivative.
The investigation of the G. quadriflora essential oil has lead to the identification of 222 compounds,of which 197 are reported for the first time in the genus. This oil is mainly composed of terpenoids(66.85%) with a prevalence of sesquiterpenoids (65.18%). The major compounds are cited as:
• Salvial-4 (14) - in-1-one; germacra-4 (15), 5, 10 (14) - trien-1-α-ol; amorpha-4, 9-dien-2-
ol; muurolan-4, 7-peroxide.
Also, twenty two compounds (caffeoylquinic acids, flavonoids, coumarin, phenol acid) were isolated from C. tricolor and G. quadriflora. All these compounds are reported for the first time in the studied species. The structural determination was carried out by mass spectrometry in electronic impact EIMS, by electrospray ESIMS, by high-resolution mass spectrometry HRMS, by time of flight HR-TOFMS, and by mass spectrometry high-resolution tandem MSn. In addition, we used NMR-1D and 2D spectroscopy.
The second part of our work was an in vitro evaluation of the biological activities such as:
• antileishmanial activity, antimalarial activity, antifungal and antibacterial activities, antioxidant activity against the DPPH, and the activity towards the enzyme acetylcholinesterase.
The various tests carried out during this work have leads to tracks quite interesting especially for:
• Samples of Convolvulus tricolor with inhibitions of the parasitic activity going from 89 to 99% by quite low rates of toxicity indicating their good selective activity on the parasites.
• The alkaloids extract resulting from the air parts of Genista quadriflora for which the bacteria type Pseudomonas aeruginosa had a very particular sensitivity.
Diplôme : Doctorat en sciences En ligne : ../theses/chimie/KAC6789.pdf Format de la ressource électronique : Permalink : index.php?lvl=notice_display&id=9979 Etude phytochimique et valorisation biologique des deux plantes, Genista quadriflora Munby (Fabaceae) et Convolvulus tricolor L. (Convolvulaceae) [texte imprimé] / Nassira Kacem, Auteur ; Salah Rhouati, Directeur de thèse ; Kurt Hostettmann, Directeur de thèse . - constantine [Algérie] : Université Constantine 1, 2015 . - 299 f. ; 30 cm.
2 copies imprimées disponibles
Langues : Français (fre)
Catégories : Français - Anglais
ChimieTags : Genista Convolvulus alcaloïdes acides caféoylquiniques sesquiterpènes flavonoïdes HPLC MPLC CPC ESIMS GC/EIMS HR-MS/TOF Q-TRAP MSn RMN-2D leishmanicide antipaludique antibactérienne antifongique antiradicalaire acétylcholinestérase alkaloids caffeoylquinic acids sesquiterpenoids flavonoids antileishmanial antimalarial antibacterial antifungal antiradical acetylcholinesterase قلويدات احماض كافيولكينية سيسكويتربنات فلافونيدات مضاد للأكسدة
الضد ميكروبية الضد فطرية مضاد للإنزيم اسيتلكولنستغاز مضاد للملاريا مضاد للشمانيا،Index. décimale : 540 Chimie et sciences connexes Résumé : This work was focused on two Algerian plants, the endemic species Genista quadriflora Munby (Fabaceae) and the species Convolvulus tricolor (Convolvulaceae). The study of the alkaloid profile of G. quadriflora by GC/EIMS allowed the identification of twenty compounds, among which ten are newly registered for the genus. We indicate the presence of:
• Thirteen quinolizidine alkaloids
• Five piperidine alkaloids
• One nicotinic alkaloid, in addition to a nicotinic acid derivative.
The investigation of the G. quadriflora essential oil has lead to the identification of 222 compounds,of which 197 are reported for the first time in the genus. This oil is mainly composed of terpenoids(66.85%) with a prevalence of sesquiterpenoids (65.18%). The major compounds are cited as:
• Salvial-4 (14) - in-1-one; germacra-4 (15), 5, 10 (14) - trien-1-α-ol; amorpha-4, 9-dien-2-
ol; muurolan-4, 7-peroxide.
Also, twenty two compounds (caffeoylquinic acids, flavonoids, coumarin, phenol acid) were isolated from C. tricolor and G. quadriflora. All these compounds are reported for the first time in the studied species. The structural determination was carried out by mass spectrometry in electronic impact EIMS, by electrospray ESIMS, by high-resolution mass spectrometry HRMS, by time of flight HR-TOFMS, and by mass spectrometry high-resolution tandem MSn. In addition, we used NMR-1D and 2D spectroscopy.
The second part of our work was an in vitro evaluation of the biological activities such as:
• antileishmanial activity, antimalarial activity, antifungal and antibacterial activities, antioxidant activity against the DPPH, and the activity towards the enzyme acetylcholinesterase.
The various tests carried out during this work have leads to tracks quite interesting especially for:
• Samples of Convolvulus tricolor with inhibitions of the parasitic activity going from 89 to 99% by quite low rates of toxicity indicating their good selective activity on the parasites.
• The alkaloids extract resulting from the air parts of Genista quadriflora for which the bacteria type Pseudomonas aeruginosa had a very particular sensitivity.
Diplôme : Doctorat en sciences En ligne : ../theses/chimie/KAC6789.pdf Format de la ressource électronique : Permalink : index.php?lvl=notice_display&id=9979 Exemplaires (1)
Code-barres Cote Support Localisation Section Disponibilité KAC/6789 KAC/6789 Thèse Bibliothèque principale Thèses Disponible
