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Etude phytochimique et valorisation biologique des deux plantes, Genista quadriflora Munby (Fabaceae) et Convolvulus tricolor L. (Convolvulaceae) / Nassira Kacem  

Public ISBD Titre : Etude phytochimique et valorisation biologique des deux plantes, Genista quadriflora Munby (Fabaceae) et Convolvulus tricolor L. (Convolvulaceae) Type de document : texte imprimé Auteurs : Nassira Kacem, Auteur ; Salah Rhouati, Directeur de thèse ; Kurt Hostettmann, Directeur de thèse Editeur : constantine [Algérie] : Université Constantine 1 Année de publication : 2015 Importance : 299 f. Format : 30 cm. Note générale : 2 copies imprimées disponibles Langues : Français (fre) Catégories : Français - Anglais Chimie Tags : Genista  Convolvulus  alcaloïdes  acides caféoylquiniques  sesquiterpènes  flavonoïdes  HPLC  MPLC  CPC  ESIMS  GC/EIMS  HR-MS/TOF  Q-TRAP  MSn  RMN-2D  leishmanicide  antipaludique  antibactérienne  antifongique  antiradicalaire  acétylcholinestérase  alkaloids  caffeoylquinic acids  sesquiterpenoids  flavonoids  antileishmanial  antimalarial  antibacterial  antifungal  antiradical  acetylcholinesterase  قلويدات  احماض كافيولكينية  سيسكويتربنات  فلافونيدات  مضاد للأكسدة الضد ميكروبية  الضد فطرية  مضاد للإنزيم اسيتلكولنستغاز  مضاد للملاريا  مضاد للشمانيا، Index. décimale : 540 Chimie et sciences connexes Résumé : This work was focused on two Algerian plants, the endemic species Genista quadriflora Munby (Fabaceae) and the species Convolvulus tricolor (Convolvulaceae). The study of the alkaloid profile of G. quadriflora by GC/EIMS allowed the identification of twenty compounds, among which ten are newly registered for the genus. We indicate the presence of: • Thirteen quinolizidine alkaloids • Five piperidine alkaloids • One nicotinic alkaloid, in addition to a nicotinic acid derivative. The investigation of the G. quadriflora essential oil has lead to the identification of 222 compounds,of which 197 are reported for the first time in the genus. This oil is mainly composed of terpenoids(66.85%) with a prevalence of sesquiterpenoids (65.18%). The major compounds are cited as: • Salvial-4 (14) - in-1-one; germacra-4 (15), 5, 10 (14) - trien-1-α-ol; amorpha-4, 9-dien-2- ol; muurolan-4, 7-peroxide. Also, twenty two compounds (caffeoylquinic acids, flavonoids, coumarin, phenol acid) were isolated from C. tricolor and G. quadriflora. All these compounds are reported for the first time in the studied species. The structural determination was carried out by mass spectrometry in electronic impact EIMS, by electrospray ESIMS, by high-resolution mass spectrometry HRMS, by time of flight HR-TOFMS, and by mass spectrometry high-resolution tandem MSn. In addition, we used NMR-1D and 2D spectroscopy. The second part of our work was an in vitro evaluation of the biological activities such as: • antileishmanial activity, antimalarial activity, antifungal and antibacterial activities, antioxidant activity against the DPPH, and the activity towards the enzyme acetylcholinesterase. The various tests carried out during this work have leads to tracks quite interesting especially for: • Samples of Convolvulus tricolor with inhibitions of the parasitic activity going from 89 to 99% by quite low rates of toxicity indicating their good selective activity on the parasites. • The alkaloids extract resulting from the air parts of Genista quadriflora for which the bacteria type Pseudomonas aeruginosa had a very particular sensitivity. Diplôme : Doctorat en sciences En ligne : ../theses/chimie/KAC6789.pdf Format de la ressource électronique : pdf Permalink : index.php?lvl=notice_display&id=9979 Etude phytochimique et valorisation biologique des deux plantes, Genista quadriflora Munby (Fabaceae) et Convolvulus tricolor L. (Convolvulaceae) [texte imprimé] / Nassira Kacem, Auteur ; Salah Rhouati, Directeur de thèse ; Kurt Hostettmann, Directeur de thèse . - constantine [Algérie] : Université Constantine 1, 2015 . - 299 f. ; 30 cm. 2 copies imprimées disponibles Langues : Français (fre) Catégories : Français - Anglais Chimie Tags : Genista  Convolvulus  alcaloïdes  acides caféoylquiniques  sesquiterpènes  flavonoïdes  HPLC  MPLC  CPC  ESIMS  GC/EIMS  HR-MS/TOF  Q-TRAP  MSn  RMN-2D  leishmanicide  antipaludique  antibactérienne  antifongique  antiradicalaire  acétylcholinestérase  alkaloids  caffeoylquinic acids  sesquiterpenoids  flavonoids  antileishmanial  antimalarial  antibacterial  antifungal  antiradical  acetylcholinesterase  قلويدات  احماض كافيولكينية  سيسكويتربنات  فلافونيدات  مضاد للأكسدة الضد ميكروبية  الضد فطرية  مضاد للإنزيم اسيتلكولنستغاز  مضاد للملاريا  مضاد للشمانيا، Index. décimale : 540 Chimie et sciences connexes Résumé : This work was focused on two Algerian plants, the endemic species Genista quadriflora Munby (Fabaceae) and the species Convolvulus tricolor (Convolvulaceae). The study of the alkaloid profile of G. quadriflora by GC/EIMS allowed the identification of twenty compounds, among which ten are newly registered for the genus. We indicate the presence of: • Thirteen quinolizidine alkaloids • Five piperidine alkaloids • One nicotinic alkaloid, in addition to a nicotinic acid derivative. The investigation of the G. quadriflora essential oil has lead to the identification of 222 compounds,of which 197 are reported for the first time in the genus. This oil is mainly composed of terpenoids(66.85%) with a prevalence of sesquiterpenoids (65.18%). The major compounds are cited as: • Salvial-4 (14) - in-1-one; germacra-4 (15), 5, 10 (14) - trien-1-α-ol; amorpha-4, 9-dien-2- ol; muurolan-4, 7-peroxide. Also, twenty two compounds (caffeoylquinic acids, flavonoids, coumarin, phenol acid) were isolated from C. tricolor and G. quadriflora. All these compounds are reported for the first time in the studied species. The structural determination was carried out by mass spectrometry in electronic impact EIMS, by electrospray ESIMS, by high-resolution mass spectrometry HRMS, by time of flight HR-TOFMS, and by mass spectrometry high-resolution tandem MSn. In addition, we used NMR-1D and 2D spectroscopy. The second part of our work was an in vitro evaluation of the biological activities such as: • antileishmanial activity, antimalarial activity, antifungal and antibacterial activities, antioxidant activity against the DPPH, and the activity towards the enzyme acetylcholinesterase. The various tests carried out during this work have leads to tracks quite interesting especially for: • Samples of Convolvulus tricolor with inhibitions of the parasitic activity going from 89 to 99% by quite low rates of toxicity indicating their good selective activity on the parasites. • The alkaloids extract resulting from the air parts of Genista quadriflora for which the bacteria type Pseudomonas aeruginosa had a very particular sensitivity. Diplôme : Doctorat en sciences En ligne : ../theses/chimie/KAC6789.pdf Format de la ressource électronique : pdf Permalink : index.php?lvl=notice_display&id=9979

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Code-barres	Cote	Support	Localisation	Section	Disponibilité
KAC/6789	KAC/6789	Thèse	Bibliothèque principale	Thèses	Disponible