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Partager le résultat de cette recherche Interroger des sources externesIdentification par criblage virtuel et analyses biologiques de nouveaux inhibiteurs de l’acétylcholinestérase pour le traitement de la maladie d’Alzheimer. / El-Hassen Mokrani
Titre : Identification par criblage virtuel et analyses biologiques de nouveaux inhibiteurs de l’acétylcholinestérase pour le traitement de la maladie d’Alzheimer. Type de document : texte imprimé Auteurs : El-Hassen Mokrani, Auteur ; Abderrahmane Bensegueni, Directeur de thèse Mention d'édition : 18/10/2020 Editeur : جامعة الإخوة منتوري قسنطينة Année de publication : 2020 Importance : 169 f. Format : 30 cm. Note générale : 1 copies imprimées disponibles
Langues : Français (fre) Catégories : Français - Anglais
BiologieTags : Biochimie et Biologie Cellulaire et Moléculaire: Biochimie Appliquée Acétylcholinestérase Criblage virtuel Inhibiteur Maladie d’Alzheimer vSDC Alzheimer’s disease inhibitory activity Virtual screening أستيل كولينستراز مرض الزهايمر نشاط مثبط فحص افتراضي Index. décimale : 570 Sciences de la vie. Biologie Résumé :
Acetylcholinesterase (AChE) is currently the most favorable target for the symptomatic treatment and reduction of Alzheimer’s disease (AD). In this work, a new structure-based virtual screening strategy was used in order to identify, among 14307 compounds of Institut Curie-CNRS chemical library, new potent AChE inhibitors. The strategy undertaken in this work consisted of the use of several docking programs in SBVS calculations followed by the application of a consensus method (vSDC) and a scrupulous visual analysis. It allowed us to obtain a high degree of success, with a yield of almost 86%, since 12 hits were identified among only 14 molecules tested in vitro. Still more remarkably, 6 of these hits were more active than galantamine, the reference inhibitor. These hits were predicted to have good ADMET properties. Finally, the in vivo study of cytotoxicity undertaken on Artemia salina larvae showed, in particular, through the evaluation of the LC50 / IC50 ratio that the six hits have a greater inhibitory activity than their toxic effect, which can thus be used as starting structures for the optimization and design of new AD drug candidates.
Note de contenu :
Annexes.Diplôme : Doctorat en sciences En ligne : ../theses/biologie/MOK7666.pdf Format de la ressource électronique : Permalink : index.php?lvl=notice_display&id=11500 Identification par criblage virtuel et analyses biologiques de nouveaux inhibiteurs de l’acétylcholinestérase pour le traitement de la maladie d’Alzheimer. [texte imprimé] / El-Hassen Mokrani, Auteur ; Abderrahmane Bensegueni, Directeur de thèse . - 18/10/2020 . - جامعة الإخوة منتوري قسنطينة, 2020 . - 169 f. ; 30 cm.
1 copies imprimées disponibles
Langues : Français (fre)
Catégories : Français - Anglais
BiologieTags : Biochimie et Biologie Cellulaire et Moléculaire: Biochimie Appliquée Acétylcholinestérase Criblage virtuel Inhibiteur Maladie d’Alzheimer vSDC Alzheimer’s disease inhibitory activity Virtual screening أستيل كولينستراز مرض الزهايمر نشاط مثبط فحص افتراضي Index. décimale : 570 Sciences de la vie. Biologie Résumé :
Acetylcholinesterase (AChE) is currently the most favorable target for the symptomatic treatment and reduction of Alzheimer’s disease (AD). In this work, a new structure-based virtual screening strategy was used in order to identify, among 14307 compounds of Institut Curie-CNRS chemical library, new potent AChE inhibitors. The strategy undertaken in this work consisted of the use of several docking programs in SBVS calculations followed by the application of a consensus method (vSDC) and a scrupulous visual analysis. It allowed us to obtain a high degree of success, with a yield of almost 86%, since 12 hits were identified among only 14 molecules tested in vitro. Still more remarkably, 6 of these hits were more active than galantamine, the reference inhibitor. These hits were predicted to have good ADMET properties. Finally, the in vivo study of cytotoxicity undertaken on Artemia salina larvae showed, in particular, through the evaluation of the LC50 / IC50 ratio that the six hits have a greater inhibitory activity than their toxic effect, which can thus be used as starting structures for the optimization and design of new AD drug candidates.
Note de contenu :
Annexes.Diplôme : Doctorat en sciences En ligne : ../theses/biologie/MOK7666.pdf Format de la ressource électronique : Permalink : index.php?lvl=notice_display&id=11500 Exemplaires (1)
Code-barres Cote Support Localisation Section Disponibilité MOK/7666 MOK/7666 Thèse Bibliothèque principale Thèses Disponible
Titre : Etude écophysiologique, développement et importance des plantes médicinales du genre Mentha dans le Parc National d’El-Kala (Nord-Est Algérie). Type de document : texte imprimé Auteurs : Amina Benabdallah, Auteur ; Chaabane Rahmoune, Directeur de thèse Importance : 152 f. Format : 30 cm. Note générale : 2 copies imprimées disponibles
Langues : Français (fre) Catégories : Français - Anglais
BiologieTags : M. aquatica M. arvensis Mx piperita M.pulegium M. rotundifolia M. x villosa NPEK ElKala RAMSAR phenols flavonoids tannins essential oil antioxidant acetylcholinesterase PNEK phénols, flavonoïdes, huile essentielle antioxydant acétylcholinestérase Index. décimale : 570 Sciences de la vie. Biologie Résumé : Mentha species are widely used by native habitants of El-Tarf region, as condiment, flavor or
herb in culinary preparations but also used for therapeutic properties as carminative, sedative,
antispasmodic and well known to treat stomach pain.
The aim of this work was first to inventory and geolocalisate Mentha species of the National
Park of El-Kala and then to investigate the total phenolics, flavonoids and tannins content and
the in-vitro antioxidant activities of methanolic extracts and essential oils, then to evaluate the
chemical composition of essential oils obtained from aerial parts of six wildMentha species:
M. aquatica, M. arvensis, M x piperita, M. pulegium, M. rotundifolia and M x villosa.
Chemical composition was analyzed by GC-MS method and biological activities investigated
by DPPH, B-carotene bleaching and ion chelating assays for the antioxidant activity, as well
as the inhibition of acetycholinesterase. The methanol extracts of mints were rich in phenolic
compounds and exhibited a powerful antioxidant activity ranged from7.5µg/mlto44.66
µg/ml,which varied significantly among species. M. aquatica stands out with an efficient
antioxidant ability which is correlated to the high total phenolics contents, followed by M.
arvensis and M. piperita with very close values, comparing to M. pulegium, M. rotundifolia
and M. villosa with lowest values. Qualitative and quantitative variations were observed
among species. The highest yield of oils, obtained by hydrodistillation, was recorded for M.
pulegium with 1.8%. A total of 27 compounds were identified with the predominance of
oxygenated monoterpenes such as menthofurane (73.38%), rotundifolone (65.99%), pulegone
(59.12%), menthol (49.89%), menthone (20.84%), neomenthol (20.76%), 1.8-cineol (18.16%)
and β-caryophyllene (12.55%). In general, M. aquatica exhibited the strongest antioxidant
level with IC50 of 0.69±0.06 mg/ml assessed by DPPH assay, 0.16±0.02 mg/ml by β-Carotene
bleaching and 1.73±0.17 mg/ml by ferrous ion chelating method. Whereas M. arvensisstood
out with IC50 of 27.5mg/ml for acetylcholinesterase inhibitory.These results show that Mentha
species from NPEK have a great potential of polyphenols which can be used as a natural food
preservative and antioxidant source. Moreover, mints could be exploited for their
pharmacological application in order to prevent induced diseases relied to oxidative stress.Diplôme : Doctorat en sciences En ligne : ../theses/biologie/BEN7087.pdf Format de la ressource électronique : Permalink : index.php?lvl=notice_display&id=10514 Etude écophysiologique, développement et importance des plantes médicinales du genre Mentha dans le Parc National d’El-Kala (Nord-Est Algérie). [texte imprimé] / Amina Benabdallah, Auteur ; Chaabane Rahmoune, Directeur de thèse . - [s.d.] . - 152 f. ; 30 cm.
2 copies imprimées disponibles
Langues : Français (fre)
Catégories : Français - Anglais
BiologieTags : M. aquatica M. arvensis Mx piperita M.pulegium M. rotundifolia M. x villosa NPEK ElKala RAMSAR phenols flavonoids tannins essential oil antioxidant acetylcholinesterase PNEK phénols, flavonoïdes, huile essentielle antioxydant acétylcholinestérase Index. décimale : 570 Sciences de la vie. Biologie Résumé : Mentha species are widely used by native habitants of El-Tarf region, as condiment, flavor or
herb in culinary preparations but also used for therapeutic properties as carminative, sedative,
antispasmodic and well known to treat stomach pain.
The aim of this work was first to inventory and geolocalisate Mentha species of the National
Park of El-Kala and then to investigate the total phenolics, flavonoids and tannins content and
the in-vitro antioxidant activities of methanolic extracts and essential oils, then to evaluate the
chemical composition of essential oils obtained from aerial parts of six wildMentha species:
M. aquatica, M. arvensis, M x piperita, M. pulegium, M. rotundifolia and M x villosa.
Chemical composition was analyzed by GC-MS method and biological activities investigated
by DPPH, B-carotene bleaching and ion chelating assays for the antioxidant activity, as well
as the inhibition of acetycholinesterase. The methanol extracts of mints were rich in phenolic
compounds and exhibited a powerful antioxidant activity ranged from7.5µg/mlto44.66
µg/ml,which varied significantly among species. M. aquatica stands out with an efficient
antioxidant ability which is correlated to the high total phenolics contents, followed by M.
arvensis and M. piperita with very close values, comparing to M. pulegium, M. rotundifolia
and M. villosa with lowest values. Qualitative and quantitative variations were observed
among species. The highest yield of oils, obtained by hydrodistillation, was recorded for M.
pulegium with 1.8%. A total of 27 compounds were identified with the predominance of
oxygenated monoterpenes such as menthofurane (73.38%), rotundifolone (65.99%), pulegone
(59.12%), menthol (49.89%), menthone (20.84%), neomenthol (20.76%), 1.8-cineol (18.16%)
and β-caryophyllene (12.55%). In general, M. aquatica exhibited the strongest antioxidant
level with IC50 of 0.69±0.06 mg/ml assessed by DPPH assay, 0.16±0.02 mg/ml by β-Carotene
bleaching and 1.73±0.17 mg/ml by ferrous ion chelating method. Whereas M. arvensisstood
out with IC50 of 27.5mg/ml for acetylcholinesterase inhibitory.These results show that Mentha
species from NPEK have a great potential of polyphenols which can be used as a natural food
preservative and antioxidant source. Moreover, mints could be exploited for their
pharmacological application in order to prevent induced diseases relied to oxidative stress.Diplôme : Doctorat en sciences En ligne : ../theses/biologie/BEN7087.pdf Format de la ressource électronique : Permalink : index.php?lvl=notice_display&id=10514 Exemplaires (1)
Code-barres Cote Support Localisation Section Disponibilité BEN/7087 BEN/7087 Thèse Bibliothèque principale Thèses Disponible
Titre : Etude phytochimique et valorisation biologique des deux plantes, Genista quadriflora Munby (Fabaceae) et Convolvulus tricolor L. (Convolvulaceae) Type de document : texte imprimé Auteurs : Nassira Kacem, Auteur ; Salah Rhouati, Directeur de thèse ; Kurt Hostettmann, Directeur de thèse Editeur : constantine [Algérie] : Université Constantine 1 Année de publication : 2015 Importance : 299 f. Format : 30 cm. Note générale : 2 copies imprimées disponibles
Langues : Français (fre) Catégories : Français - Anglais
ChimieTags : Genista Convolvulus alcaloïdes acides caféoylquiniques sesquiterpènes flavonoïdes HPLC MPLC CPC ESIMS GC/EIMS HR-MS/TOF Q-TRAP MSn RMN-2D leishmanicide antipaludique antibactérienne antifongique antiradicalaire acétylcholinestérase alkaloids caffeoylquinic acids sesquiterpenoids flavonoids antileishmanial antimalarial antibacterial antifungal antiradical acetylcholinesterase قلويدات احماض كافيولكينية سيسكويتربنات فلافونيدات مضاد للأكسدة
الضد ميكروبية الضد فطرية مضاد للإنزيم اسيتلكولنستغاز مضاد للملاريا مضاد للشمانيا،Index. décimale : 540 Chimie et sciences connexes Résumé : This work was focused on two Algerian plants, the endemic species Genista quadriflora Munby (Fabaceae) and the species Convolvulus tricolor (Convolvulaceae). The study of the alkaloid profile of G. quadriflora by GC/EIMS allowed the identification of twenty compounds, among which ten are newly registered for the genus. We indicate the presence of:
• Thirteen quinolizidine alkaloids
• Five piperidine alkaloids
• One nicotinic alkaloid, in addition to a nicotinic acid derivative.
The investigation of the G. quadriflora essential oil has lead to the identification of 222 compounds,of which 197 are reported for the first time in the genus. This oil is mainly composed of terpenoids(66.85%) with a prevalence of sesquiterpenoids (65.18%). The major compounds are cited as:
• Salvial-4 (14) - in-1-one; germacra-4 (15), 5, 10 (14) - trien-1-α-ol; amorpha-4, 9-dien-2-
ol; muurolan-4, 7-peroxide.
Also, twenty two compounds (caffeoylquinic acids, flavonoids, coumarin, phenol acid) were isolated from C. tricolor and G. quadriflora. All these compounds are reported for the first time in the studied species. The structural determination was carried out by mass spectrometry in electronic impact EIMS, by electrospray ESIMS, by high-resolution mass spectrometry HRMS, by time of flight HR-TOFMS, and by mass spectrometry high-resolution tandem MSn. In addition, we used NMR-1D and 2D spectroscopy.
The second part of our work was an in vitro evaluation of the biological activities such as:
• antileishmanial activity, antimalarial activity, antifungal and antibacterial activities, antioxidant activity against the DPPH, and the activity towards the enzyme acetylcholinesterase.
The various tests carried out during this work have leads to tracks quite interesting especially for:
• Samples of Convolvulus tricolor with inhibitions of the parasitic activity going from 89 to 99% by quite low rates of toxicity indicating their good selective activity on the parasites.
• The alkaloids extract resulting from the air parts of Genista quadriflora for which the bacteria type Pseudomonas aeruginosa had a very particular sensitivity.
Diplôme : Doctorat en sciences En ligne : ../theses/chimie/KAC6789.pdf Format de la ressource électronique : Permalink : index.php?lvl=notice_display&id=9979 Etude phytochimique et valorisation biologique des deux plantes, Genista quadriflora Munby (Fabaceae) et Convolvulus tricolor L. (Convolvulaceae) [texte imprimé] / Nassira Kacem, Auteur ; Salah Rhouati, Directeur de thèse ; Kurt Hostettmann, Directeur de thèse . - constantine [Algérie] : Université Constantine 1, 2015 . - 299 f. ; 30 cm.
2 copies imprimées disponibles
Langues : Français (fre)
Catégories : Français - Anglais
ChimieTags : Genista Convolvulus alcaloïdes acides caféoylquiniques sesquiterpènes flavonoïdes HPLC MPLC CPC ESIMS GC/EIMS HR-MS/TOF Q-TRAP MSn RMN-2D leishmanicide antipaludique antibactérienne antifongique antiradicalaire acétylcholinestérase alkaloids caffeoylquinic acids sesquiterpenoids flavonoids antileishmanial antimalarial antibacterial antifungal antiradical acetylcholinesterase قلويدات احماض كافيولكينية سيسكويتربنات فلافونيدات مضاد للأكسدة
الضد ميكروبية الضد فطرية مضاد للإنزيم اسيتلكولنستغاز مضاد للملاريا مضاد للشمانيا،Index. décimale : 540 Chimie et sciences connexes Résumé : This work was focused on two Algerian plants, the endemic species Genista quadriflora Munby (Fabaceae) and the species Convolvulus tricolor (Convolvulaceae). The study of the alkaloid profile of G. quadriflora by GC/EIMS allowed the identification of twenty compounds, among which ten are newly registered for the genus. We indicate the presence of:
• Thirteen quinolizidine alkaloids
• Five piperidine alkaloids
• One nicotinic alkaloid, in addition to a nicotinic acid derivative.
The investigation of the G. quadriflora essential oil has lead to the identification of 222 compounds,of which 197 are reported for the first time in the genus. This oil is mainly composed of terpenoids(66.85%) with a prevalence of sesquiterpenoids (65.18%). The major compounds are cited as:
• Salvial-4 (14) - in-1-one; germacra-4 (15), 5, 10 (14) - trien-1-α-ol; amorpha-4, 9-dien-2-
ol; muurolan-4, 7-peroxide.
Also, twenty two compounds (caffeoylquinic acids, flavonoids, coumarin, phenol acid) were isolated from C. tricolor and G. quadriflora. All these compounds are reported for the first time in the studied species. The structural determination was carried out by mass spectrometry in electronic impact EIMS, by electrospray ESIMS, by high-resolution mass spectrometry HRMS, by time of flight HR-TOFMS, and by mass spectrometry high-resolution tandem MSn. In addition, we used NMR-1D and 2D spectroscopy.
The second part of our work was an in vitro evaluation of the biological activities such as:
• antileishmanial activity, antimalarial activity, antifungal and antibacterial activities, antioxidant activity against the DPPH, and the activity towards the enzyme acetylcholinesterase.
The various tests carried out during this work have leads to tracks quite interesting especially for:
• Samples of Convolvulus tricolor with inhibitions of the parasitic activity going from 89 to 99% by quite low rates of toxicity indicating their good selective activity on the parasites.
• The alkaloids extract resulting from the air parts of Genista quadriflora for which the bacteria type Pseudomonas aeruginosa had a very particular sensitivity.
Diplôme : Doctorat en sciences En ligne : ../theses/chimie/KAC6789.pdf Format de la ressource électronique : Permalink : index.php?lvl=notice_display&id=9979 Exemplaires (1)
Code-barres Cote Support Localisation Section Disponibilité KAC/6789 KAC/6789 Thèse Bibliothèque principale Thèses Disponible
Titre : Nouvelle procédure de préparation, évaluation de l’activité biologique de molécules de type Betti et nouvelle réaction à quatre composants de la synthèse des dérivés 2,3- dihydrothiophènes. Type de document : texte imprimé Auteurs : Khawla Boudebbous, Auteur ; Abdelmadjid Debache, Directeur de thèse Mention d'édition : 29/07/2021 Editeur : جامعة الإخوة منتوري قسنطينة Année de publication : 2021 Importance : 129 f. Format : 30 cm. Note générale : 1 copies imprimées disponibles
Langues : Français (fre) Catégories : Français - Anglais
ChimieTags : Chimie Organique:Bioactive molecule Amidoalkyl-naphthols 1,3-Oxazine-2-one MCRs Betti acide phénylboronique Acétylcholinestérase α-glucosidase 1,3-thiazolidine-2,4-dione 2,3-dihydrothiophènes carbamate d’éthyl pyridinium p-toluènesulfonate phenylboronic acid Acetylcholinesterase ethyl carbamate pyridinium p-toluenesulfonate 1- الاميدوالكيل- 2-نافطول، 1،3 - اوكزازين- 2- اون، تفاعل المتعدد المكونات بيتي حمض فنيل بورونيك الأستيل كولينإستراز الألفا جلوكوزيداز 1،3 - ثيازوليدين- 2،4 -ديون، 2،3 - ثنائي هيدروثيوفان الإيثيل كاربامات البيريدينيوم براطوليان سيلفونات Index. décimale : 540 Chimie et sciences connexes Résumé :
This manuscript includes two main parts: In the first part, we have reported successfully the use of phenylboronic acid for the Betticyclocondensation reaction. This catalyst has been shown to be very effective to reach the corresponding α-amidoalkyl-β-naphthols and naphtho-1,3-oxazin-3-(2H)-one derivatives with very good yields.
Moreover, various substituted derivatives were evaluated in vitro for their cholinesterase and α-glucosidase inhibitory activities. The obtained results revealed that some of the synthesized compounds are highly active towards both AChE/BChE and α-Glucosidase with IC50 values lower than those of the standards galanthamine and acarbose used as reference drugs. In the second part, with the aim of developing new synthetic methodologies that are more efficient, cleaner, more selective and allowing the rapid production of polyfunctionalized heterocyclic compounds, we have disclosed, for the first time, a method for the synthesis of fused 2,3-dihydrothiophenes with ethyl carbamate moieties via new domino ring opening/recyclization reaction of 1,3 thiazolidinedione.
Diplôme : Doctorat en sciences En ligne : ../theses/chimie/BOU7793.pdf Format de la ressource électronique : Permalink : index.php?lvl=notice_display&id=11625 Nouvelle procédure de préparation, évaluation de l’activité biologique de molécules de type Betti et nouvelle réaction à quatre composants de la synthèse des dérivés 2,3- dihydrothiophènes. [texte imprimé] / Khawla Boudebbous, Auteur ; Abdelmadjid Debache, Directeur de thèse . - 29/07/2021 . - جامعة الإخوة منتوري قسنطينة, 2021 . - 129 f. ; 30 cm.
1 copies imprimées disponibles
Langues : Français (fre)
Catégories : Français - Anglais
ChimieTags : Chimie Organique:Bioactive molecule Amidoalkyl-naphthols 1,3-Oxazine-2-one MCRs Betti acide phénylboronique Acétylcholinestérase α-glucosidase 1,3-thiazolidine-2,4-dione 2,3-dihydrothiophènes carbamate d’éthyl pyridinium p-toluènesulfonate phenylboronic acid Acetylcholinesterase ethyl carbamate pyridinium p-toluenesulfonate 1- الاميدوالكيل- 2-نافطول، 1،3 - اوكزازين- 2- اون، تفاعل المتعدد المكونات بيتي حمض فنيل بورونيك الأستيل كولينإستراز الألفا جلوكوزيداز 1،3 - ثيازوليدين- 2،4 -ديون، 2،3 - ثنائي هيدروثيوفان الإيثيل كاربامات البيريدينيوم براطوليان سيلفونات Index. décimale : 540 Chimie et sciences connexes Résumé :
This manuscript includes two main parts: In the first part, we have reported successfully the use of phenylboronic acid for the Betticyclocondensation reaction. This catalyst has been shown to be very effective to reach the corresponding α-amidoalkyl-β-naphthols and naphtho-1,3-oxazin-3-(2H)-one derivatives with very good yields.
Moreover, various substituted derivatives were evaluated in vitro for their cholinesterase and α-glucosidase inhibitory activities. The obtained results revealed that some of the synthesized compounds are highly active towards both AChE/BChE and α-Glucosidase with IC50 values lower than those of the standards galanthamine and acarbose used as reference drugs. In the second part, with the aim of developing new synthetic methodologies that are more efficient, cleaner, more selective and allowing the rapid production of polyfunctionalized heterocyclic compounds, we have disclosed, for the first time, a method for the synthesis of fused 2,3-dihydrothiophenes with ethyl carbamate moieties via new domino ring opening/recyclization reaction of 1,3 thiazolidinedione.
Diplôme : Doctorat en sciences En ligne : ../theses/chimie/BOU7793.pdf Format de la ressource électronique : Permalink : index.php?lvl=notice_display&id=11625 Exemplaires (1)
Code-barres Cote Support Localisation Section Disponibilité BOU/7793 BOU/7793 Thèse Bibliothèque principale Thèses Disponible
Titre : Modélisation de nouvelles molécules biologiques actives liées au strss oxydant Type de document : texte imprimé Auteurs : Adel Krid ; M. Bencharif, Directeur de thèse ; Univ. de Constantine, Éditeur scientifique Année de publication : 2008 Importance : 73 f. Note générale : 01 Disponible à la salle de recherche 02 Disponibles au magazin de la B.U.C. 01 CD Langues : Français (fre) Catégories : Français - Anglais
ChimieTags : Docking moléculaire Activité biologique Liaison hydrogène Intéraction protéine-ligand Energie d'intéraction Acétylcholinestérase Chalcone Site anionique Intéractionhydrophobique Biodisponibilité Index. décimale : 540 Chimie et sciences connexes En ligne : ../theses/chimie/KRI5162.pdf Permalink : index.php?lvl=notice_display&id=3669 Modélisation de nouvelles molécules biologiques actives liées au strss oxydant [texte imprimé] / Adel Krid ; M. Bencharif, Directeur de thèse ; Univ. de Constantine, Éditeur scientifique . - 2008 . - 73 f.
01 Disponible à la salle de recherche 02 Disponibles au magazin de la B.U.C. 01 CD
Langues : Français (fre)
Catégories : Français - Anglais
ChimieTags : Docking moléculaire Activité biologique Liaison hydrogène Intéraction protéine-ligand Energie d'intéraction Acétylcholinestérase Chalcone Site anionique Intéractionhydrophobique Biodisponibilité Index. décimale : 540 Chimie et sciences connexes En ligne : ../theses/chimie/KRI5162.pdf Permalink : index.php?lvl=notice_display&id=3669 Exemplaires (1)
Code-barres Cote Support Localisation Section Disponibilité KRI/5162 KRI/5162 Thèse Bibliothèque principale Thèses Disponible
