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Partager le résultat de cette recherche Interroger des sources externesEffet des extraits de la plante médicinale Ruta montana) (الفيجلsur la cardiotoxicité induite par la doxorubicine et sur la multi-drug résistances (MDR) des cellules cancéreuses ovarien (A2780) / Wahiba Kara Ali
Titre : Effet des extraits de la plante médicinale Ruta montana) (الفيجلsur la cardiotoxicité induite par la doxorubicine et sur la multi-drug résistances (MDR) des cellules cancéreuses ovarien (A2780) Type de document : texte imprimé Auteurs : Wahiba Kara Ali, Auteur ; N. Abidli, Directeur de thèse Editeur : جامعة الإخوة منتوري قسنطينة Année de publication : 2017 Importance : 160 f. Format : 30 cm. Note générale : 2 copies imprimées disponibles
Langues : Français (fre) Catégories : Français - Anglais
BiologieTags : Ruta montana Doxorubicine Cardiotoxicité Multi-drug résistance Stress oxydant Antioxydant Flavonoides Cardiotoxicity Multidrug resistance Oxidative
stress Antioxidant Flavonoids الدوكسوروبسين السمية القلبية المقاومة المتعددة للأدوية الإجهاد التاكسدي النشاط المضاد للأكسدة الفلافونويداتIndex. décimale : 570 Sciences de la vie. Biologie Résumé : This study was conducted to search for the preventive effect of medicinal plant Ruta montana
extract on oxidative stress induced by doxorubicine (DOX) and its properties to reverse
doxorubicin resistance in ovarian cancer cell line (A2780). Organic extracts were obtained by
maceration with three solvents: petroleum ether, ethyl acetate and butanol. The yields were:
15,04%, 3,55% and 25,14%.respectively. A phytochemical screening in methanol extract
revealed that the plant contain the flavonoids, saponins, tannins, coumarins, reducing component
and the alkaloids. The quantitative study showed that the butanolic extract (BERM) has
significant amount of flavonoids (80.85±0.78mg EQ / g dry extract), followed by ethyl acetate
extract (AEERM) (15.27 ±0.62 EQ / g dry extract) and petroleum ether extract has the lowest
flavonoids content (PEERM) (9.71±1.13 mgEQ/g dry extract). When the total phenolic contents
was: 687.5, 595.83 and 146.33 mg EGA / g dry extract, in the BERM, AEERM and PEERM
respectively. The qualitative analysis of the three methanolic crude extract via thin layer
chromatography (TLC) has shown the presence of the anthocyanidin 3-glycosids, flavons et
flavonols glycosids (hétérosids), flavonols avec 3-OH libre, flavonons ou aurons, isoflavons, the
phénolic acids, Flavonols et 4-OH chalcons. The évaluation of antioxidant activity by the
reduction of free radical DPPH method showed that The highest DPPH radical scavenging
activity was observed with AEERM (IC50 = 0.126 ± 0.002 mg/ ml), followed by BERM (0.135
± 0.0006 mg/ ml) and PEERM (IC50 =0.185± 0.002 mg/ ml). The study of preventive effect of
AEERM on oxidative stress induced by DOX in wistar rats clearly show that DOX (15 mg/kg
i.p) induced animal cardiotoxicity characterized by an increase of cardiac enzyme activity
(CKMB, LDH, l’ALAT et l’ASAT) in serum, the increase in the concentration of
malondialdéhyde (MDA), antioxydant enzyme activity, catalase (CAT) and Glutathion- Stransférase (GST) and a decrease of cardiac cytosolic reduced glutathione (GSH) with a different
pathological changes in the heart. However pretreated animals with EAERM (100 mg/kg orally
during 15 days), showed a decrease of cardiac enzymes activities 24 %, 35, 69%, 21,25 % et
8,10 % respectively to CKMB, LDH, l’ALAT and l’ASAT. The preatretment with the extract
improved antioxidant status in the heart by a decrease in the cardiac MDA concentration by 29,7
% and activity of antioxydants enzymes by 17,91% et 29,78% respectively to CAT et la GST.
In addition, the pretreated rats by the extract showed an increase of GSH level (83,76 %)
compared with DOX-treated animals. Histological study shows that the extract resulted in a
reduction of severe cardiac damages observed in DOX-treated animals. The reversal of
multidrug resistance for DOX in human ovarian adenocarcinoma, cell lines (A2780 DX3) using
MTT assay showed that AEERM was very effective at reversing the resistant in dose dependent
manner with the Reversion Factor (RF =8.62, 05.77 and 02.30 respectively for the
concentrations 40, 10 and 2.5 mg/ml) followed by BERM (FR=05.07 and 02.43 for the
concentrations 40 and 10 mg/ml respectively), then the PEERM had the lowest reversal
resistance effect (RF betwen 1.01 to 1.08). The present study suggests that AEERM can
ameliorate the oxidative stress involved in the pathogenesis of doxorubicine- induced
cardiotoxicity and can reverse the multidrug resistance for DOX.
Diplôme : Doctorat en sciences En ligne : ../theses/biologie/KAR7158.pdf Format de la ressource électronique : Permalink : index.php?lvl=notice_display&id=10435 Effet des extraits de la plante médicinale Ruta montana) (الفيجلsur la cardiotoxicité induite par la doxorubicine et sur la multi-drug résistances (MDR) des cellules cancéreuses ovarien (A2780) [texte imprimé] / Wahiba Kara Ali, Auteur ; N. Abidli, Directeur de thèse . - جامعة الإخوة منتوري قسنطينة, 2017 . - 160 f. ; 30 cm.
2 copies imprimées disponibles
Langues : Français (fre)
Catégories : Français - Anglais
BiologieTags : Ruta montana Doxorubicine Cardiotoxicité Multi-drug résistance Stress oxydant Antioxydant Flavonoides Cardiotoxicity Multidrug resistance Oxidative
stress Antioxidant Flavonoids الدوكسوروبسين السمية القلبية المقاومة المتعددة للأدوية الإجهاد التاكسدي النشاط المضاد للأكسدة الفلافونويداتIndex. décimale : 570 Sciences de la vie. Biologie Résumé : This study was conducted to search for the preventive effect of medicinal plant Ruta montana
extract on oxidative stress induced by doxorubicine (DOX) and its properties to reverse
doxorubicin resistance in ovarian cancer cell line (A2780). Organic extracts were obtained by
maceration with three solvents: petroleum ether, ethyl acetate and butanol. The yields were:
15,04%, 3,55% and 25,14%.respectively. A phytochemical screening in methanol extract
revealed that the plant contain the flavonoids, saponins, tannins, coumarins, reducing component
and the alkaloids. The quantitative study showed that the butanolic extract (BERM) has
significant amount of flavonoids (80.85±0.78mg EQ / g dry extract), followed by ethyl acetate
extract (AEERM) (15.27 ±0.62 EQ / g dry extract) and petroleum ether extract has the lowest
flavonoids content (PEERM) (9.71±1.13 mgEQ/g dry extract). When the total phenolic contents
was: 687.5, 595.83 and 146.33 mg EGA / g dry extract, in the BERM, AEERM and PEERM
respectively. The qualitative analysis of the three methanolic crude extract via thin layer
chromatography (TLC) has shown the presence of the anthocyanidin 3-glycosids, flavons et
flavonols glycosids (hétérosids), flavonols avec 3-OH libre, flavonons ou aurons, isoflavons, the
phénolic acids, Flavonols et 4-OH chalcons. The évaluation of antioxidant activity by the
reduction of free radical DPPH method showed that The highest DPPH radical scavenging
activity was observed with AEERM (IC50 = 0.126 ± 0.002 mg/ ml), followed by BERM (0.135
± 0.0006 mg/ ml) and PEERM (IC50 =0.185± 0.002 mg/ ml). The study of preventive effect of
AEERM on oxidative stress induced by DOX in wistar rats clearly show that DOX (15 mg/kg
i.p) induced animal cardiotoxicity characterized by an increase of cardiac enzyme activity
(CKMB, LDH, l’ALAT et l’ASAT) in serum, the increase in the concentration of
malondialdéhyde (MDA), antioxydant enzyme activity, catalase (CAT) and Glutathion- Stransférase (GST) and a decrease of cardiac cytosolic reduced glutathione (GSH) with a different
pathological changes in the heart. However pretreated animals with EAERM (100 mg/kg orally
during 15 days), showed a decrease of cardiac enzymes activities 24 %, 35, 69%, 21,25 % et
8,10 % respectively to CKMB, LDH, l’ALAT and l’ASAT. The preatretment with the extract
improved antioxidant status in the heart by a decrease in the cardiac MDA concentration by 29,7
% and activity of antioxydants enzymes by 17,91% et 29,78% respectively to CAT et la GST.
In addition, the pretreated rats by the extract showed an increase of GSH level (83,76 %)
compared with DOX-treated animals. Histological study shows that the extract resulted in a
reduction of severe cardiac damages observed in DOX-treated animals. The reversal of
multidrug resistance for DOX in human ovarian adenocarcinoma, cell lines (A2780 DX3) using
MTT assay showed that AEERM was very effective at reversing the resistant in dose dependent
manner with the Reversion Factor (RF =8.62, 05.77 and 02.30 respectively for the
concentrations 40, 10 and 2.5 mg/ml) followed by BERM (FR=05.07 and 02.43 for the
concentrations 40 and 10 mg/ml respectively), then the PEERM had the lowest reversal
resistance effect (RF betwen 1.01 to 1.08). The present study suggests that AEERM can
ameliorate the oxidative stress involved in the pathogenesis of doxorubicine- induced
cardiotoxicity and can reverse the multidrug resistance for DOX.
Diplôme : Doctorat en sciences En ligne : ../theses/biologie/KAR7158.pdf Format de la ressource électronique : Permalink : index.php?lvl=notice_display&id=10435 Exemplaires
Code-barres Cote Support Localisation Section Disponibilité aucun exemplaire
Titre : Etude de l'effet antidiabétique et antioxydant de l'extrait aqueux lyophilisé d'Artemisia herba alba Asso chez des rats sains et des rats rendus diabétiques par streptozotocine Type de document : texte imprimé Auteurs : Univ. de Constantine, Éditeur scientifique Année de publication : 2009 Importance : 90 f. Note générale : 01 Disponible à la salle de recherche 02 Disponibles au magazin de la B.U.C. 01 CD Langues : Français (fre) Catégories : Français - Anglais
BiologieTags : Artemisia herba alba asso Stress oxydant Streptozotocine Antioxydant Hypoglycémie Index. décimale : 570 Sciences de la vie. Biologie En ligne : ../theses/biologie/BOU5495.pdf Permalink : index.php?lvl=notice_display&id=1812 Etude de l'effet antidiabétique et antioxydant de l'extrait aqueux lyophilisé d'Artemisia herba alba Asso chez des rats sains et des rats rendus diabétiques par streptozotocine [texte imprimé] / Univ. de Constantine, Éditeur scientifique . - 2009 . - 90 f.
01 Disponible à la salle de recherche 02 Disponibles au magazin de la B.U.C. 01 CD
Langues : Français (fre)
Catégories : Français - Anglais
BiologieTags : Artemisia herba alba asso Stress oxydant Streptozotocine Antioxydant Hypoglycémie Index. décimale : 570 Sciences de la vie. Biologie En ligne : ../theses/biologie/BOU5495.pdf Permalink : index.php?lvl=notice_display&id=1812 Exemplaires (1)
Code-barres Cote Support Localisation Section Disponibilité BOU/5495 BOU/5495 Thèse Bibliothèque principale Thèses Disponible
Titre : Etude écophysiologique, développement et importance des plantes médicinales du genre Mentha dans le Parc National d’El-Kala (Nord-Est Algérie). Type de document : texte imprimé Auteurs : Amina Benabdallah, Auteur ; Chaabane Rahmoune, Directeur de thèse Importance : 152 f. Format : 30 cm. Note générale : 2 copies imprimées disponibles
Langues : Français (fre) Catégories : Français - Anglais
BiologieTags : M. aquatica M. arvensis Mx piperita M.pulegium M. rotundifolia M. x villosa NPEK ElKala RAMSAR phenols flavonoids tannins essential oil antioxidant acetylcholinesterase PNEK phénols, flavonoïdes, huile essentielle antioxydant acétylcholinestérase Index. décimale : 570 Sciences de la vie. Biologie Résumé : Mentha species are widely used by native habitants of El-Tarf region, as condiment, flavor or
herb in culinary preparations but also used for therapeutic properties as carminative, sedative,
antispasmodic and well known to treat stomach pain.
The aim of this work was first to inventory and geolocalisate Mentha species of the National
Park of El-Kala and then to investigate the total phenolics, flavonoids and tannins content and
the in-vitro antioxidant activities of methanolic extracts and essential oils, then to evaluate the
chemical composition of essential oils obtained from aerial parts of six wildMentha species:
M. aquatica, M. arvensis, M x piperita, M. pulegium, M. rotundifolia and M x villosa.
Chemical composition was analyzed by GC-MS method and biological activities investigated
by DPPH, B-carotene bleaching and ion chelating assays for the antioxidant activity, as well
as the inhibition of acetycholinesterase. The methanol extracts of mints were rich in phenolic
compounds and exhibited a powerful antioxidant activity ranged from7.5µg/mlto44.66
µg/ml,which varied significantly among species. M. aquatica stands out with an efficient
antioxidant ability which is correlated to the high total phenolics contents, followed by M.
arvensis and M. piperita with very close values, comparing to M. pulegium, M. rotundifolia
and M. villosa with lowest values. Qualitative and quantitative variations were observed
among species. The highest yield of oils, obtained by hydrodistillation, was recorded for M.
pulegium with 1.8%. A total of 27 compounds were identified with the predominance of
oxygenated monoterpenes such as menthofurane (73.38%), rotundifolone (65.99%), pulegone
(59.12%), menthol (49.89%), menthone (20.84%), neomenthol (20.76%), 1.8-cineol (18.16%)
and β-caryophyllene (12.55%). In general, M. aquatica exhibited the strongest antioxidant
level with IC50 of 0.69±0.06 mg/ml assessed by DPPH assay, 0.16±0.02 mg/ml by β-Carotene
bleaching and 1.73±0.17 mg/ml by ferrous ion chelating method. Whereas M. arvensisstood
out with IC50 of 27.5mg/ml for acetylcholinesterase inhibitory.These results show that Mentha
species from NPEK have a great potential of polyphenols which can be used as a natural food
preservative and antioxidant source. Moreover, mints could be exploited for their
pharmacological application in order to prevent induced diseases relied to oxidative stress.Diplôme : Doctorat en sciences En ligne : ../theses/biologie/BEN7087.pdf Format de la ressource électronique : Permalink : index.php?lvl=notice_display&id=10514 Etude écophysiologique, développement et importance des plantes médicinales du genre Mentha dans le Parc National d’El-Kala (Nord-Est Algérie). [texte imprimé] / Amina Benabdallah, Auteur ; Chaabane Rahmoune, Directeur de thèse . - [s.d.] . - 152 f. ; 30 cm.
2 copies imprimées disponibles
Langues : Français (fre)
Catégories : Français - Anglais
BiologieTags : M. aquatica M. arvensis Mx piperita M.pulegium M. rotundifolia M. x villosa NPEK ElKala RAMSAR phenols flavonoids tannins essential oil antioxidant acetylcholinesterase PNEK phénols, flavonoïdes, huile essentielle antioxydant acétylcholinestérase Index. décimale : 570 Sciences de la vie. Biologie Résumé : Mentha species are widely used by native habitants of El-Tarf region, as condiment, flavor or
herb in culinary preparations but also used for therapeutic properties as carminative, sedative,
antispasmodic and well known to treat stomach pain.
The aim of this work was first to inventory and geolocalisate Mentha species of the National
Park of El-Kala and then to investigate the total phenolics, flavonoids and tannins content and
the in-vitro antioxidant activities of methanolic extracts and essential oils, then to evaluate the
chemical composition of essential oils obtained from aerial parts of six wildMentha species:
M. aquatica, M. arvensis, M x piperita, M. pulegium, M. rotundifolia and M x villosa.
Chemical composition was analyzed by GC-MS method and biological activities investigated
by DPPH, B-carotene bleaching and ion chelating assays for the antioxidant activity, as well
as the inhibition of acetycholinesterase. The methanol extracts of mints were rich in phenolic
compounds and exhibited a powerful antioxidant activity ranged from7.5µg/mlto44.66
µg/ml,which varied significantly among species. M. aquatica stands out with an efficient
antioxidant ability which is correlated to the high total phenolics contents, followed by M.
arvensis and M. piperita with very close values, comparing to M. pulegium, M. rotundifolia
and M. villosa with lowest values. Qualitative and quantitative variations were observed
among species. The highest yield of oils, obtained by hydrodistillation, was recorded for M.
pulegium with 1.8%. A total of 27 compounds were identified with the predominance of
oxygenated monoterpenes such as menthofurane (73.38%), rotundifolone (65.99%), pulegone
(59.12%), menthol (49.89%), menthone (20.84%), neomenthol (20.76%), 1.8-cineol (18.16%)
and β-caryophyllene (12.55%). In general, M. aquatica exhibited the strongest antioxidant
level with IC50 of 0.69±0.06 mg/ml assessed by DPPH assay, 0.16±0.02 mg/ml by β-Carotene
bleaching and 1.73±0.17 mg/ml by ferrous ion chelating method. Whereas M. arvensisstood
out with IC50 of 27.5mg/ml for acetylcholinesterase inhibitory.These results show that Mentha
species from NPEK have a great potential of polyphenols which can be used as a natural food
preservative and antioxidant source. Moreover, mints could be exploited for their
pharmacological application in order to prevent induced diseases relied to oxidative stress.Diplôme : Doctorat en sciences En ligne : ../theses/biologie/BEN7087.pdf Format de la ressource électronique : Permalink : index.php?lvl=notice_display&id=10514 Exemplaires (1)
Code-barres Cote Support Localisation Section Disponibilité BEN/7087 BEN/7087 Thèse Bibliothèque principale Thèses Disponible
Titre : Etude phytochimique et biologique de six plantes médicinales de l'est Algerien Type de document : texte imprimé Auteurs : Salih Chibani, Auteur ; Zahia Kabouche, Directeur de thèse Editeur : constantine [Algérie] : Université Constantine 1 Année de publication : 2013 Importance : 203 f. Format : 30 cm. Note générale : 2 copies imprimées disponibles Langues : Français (fre) Catégories : Français - Anglais
BiologieTags : Asteraceae flavonoïdes Santolina rosmarinifolia L. antioxydant antibacterien Mentha Artemisia Ferula Senecio flavonoids antioxidant antibacterial ضد الأكسدة ضد البكتيريا Index. décimale : 540 Chimie et sciences connexes Résumé : The Asteraceae family is rich of flavonoids, particularly aglycones and methoxylated. In agreement with this characteristic, our works of extraction and isolation of flavonoids of Santolina rosmarinifolia L. specie (Asteraceae), collected from Batna, led to 3 methoxylated
aglycone flavones, eupatilin, jaceosidin and salvigenin together with luteolin and a flavonol, quercetin and 7-O-glugoside derivatives of the latters.
The butanolic extract showed an excellent antioxidant activity by the use of the DPPH.
In another hand, the essential oils obtained by hydrodistillation of Santolina rosmarinifolia L., Mentha piperita, Artemisia herba-alba, Ferula communis, F. lutea and Senecio giganteus species have been analyzed by GC and GC/MS.
The essential oil of Santolina rosmarinifolia L. showed the best antibacterial activity against Escherichia coli ATCC, Escherichia coli HS, and Enterobacter sp. strains. The essential oil of dry aerial part of Mentha piperita inhibited more strongly the growth of Escherichia coli ATCC and Streptococcus sp. strains.Diplôme : Doctorat en sciences En ligne : ../theses/biologie/CHI6434.pdf Format de la ressource électronique : Permalink : index.php?lvl=notice_display&id=9460 Etude phytochimique et biologique de six plantes médicinales de l'est Algerien [texte imprimé] / Salih Chibani, Auteur ; Zahia Kabouche, Directeur de thèse . - constantine [Algérie] : Université Constantine 1, 2013 . - 203 f. ; 30 cm.
2 copies imprimées disponibles
Langues : Français (fre)
Catégories : Français - Anglais
BiologieTags : Asteraceae flavonoïdes Santolina rosmarinifolia L. antioxydant antibacterien Mentha Artemisia Ferula Senecio flavonoids antioxidant antibacterial ضد الأكسدة ضد البكتيريا Index. décimale : 540 Chimie et sciences connexes Résumé : The Asteraceae family is rich of flavonoids, particularly aglycones and methoxylated. In agreement with this characteristic, our works of extraction and isolation of flavonoids of Santolina rosmarinifolia L. specie (Asteraceae), collected from Batna, led to 3 methoxylated
aglycone flavones, eupatilin, jaceosidin and salvigenin together with luteolin and a flavonol, quercetin and 7-O-glugoside derivatives of the latters.
The butanolic extract showed an excellent antioxidant activity by the use of the DPPH.
In another hand, the essential oils obtained by hydrodistillation of Santolina rosmarinifolia L., Mentha piperita, Artemisia herba-alba, Ferula communis, F. lutea and Senecio giganteus species have been analyzed by GC and GC/MS.
The essential oil of Santolina rosmarinifolia L. showed the best antibacterial activity against Escherichia coli ATCC, Escherichia coli HS, and Enterobacter sp. strains. The essential oil of dry aerial part of Mentha piperita inhibited more strongly the growth of Escherichia coli ATCC and Streptococcus sp. strains.Diplôme : Doctorat en sciences En ligne : ../theses/biologie/CHI6434.pdf Format de la ressource électronique : Permalink : index.php?lvl=notice_display&id=9460 Exemplaires (1)
Code-barres Cote Support Localisation Section Disponibilité CHI/6434 CHI/6434 Thèse Bibliothèque principale Thèses Disponible Documents numériques
texte intégraleAdobe Acrobat PDF
Titre : Etude de la relation du thé vert. Maladies cardiovasculaires et Stress oxydant. Type de document : texte imprimé Auteurs : Samy Kabouche, Auteur ; Djamila Zama, Directeur de thèse Editeur : Constantine : Université Mentouri Constantine Année de publication : 2010 Importance : 136 f. Format : 31 cm Note générale : 2 copies imprimées disponibles Langues : Français (fre) Catégories : Français - Anglais
BiologieTags : Camellia sinensis stress oxydant antioxydant hypolipedimique satins. Biologie Index. décimale : 570 Sciences de la vie. Biologie Diplôme : Magistère En ligne : ../theses/biologie/KAB5938.pdf Format de la ressource électronique : Permalink : index.php?lvl=notice_display&id=5727 Etude de la relation du thé vert. Maladies cardiovasculaires et Stress oxydant. [texte imprimé] / Samy Kabouche, Auteur ; Djamila Zama, Directeur de thèse . - Constantine : Université Mentouri Constantine, 2010 . - 136 f. ; 31 cm.
2 copies imprimées disponibles
Langues : Français (fre)
Catégories : Français - Anglais
BiologieTags : Camellia sinensis stress oxydant antioxydant hypolipedimique satins. Biologie Index. décimale : 570 Sciences de la vie. Biologie Diplôme : Magistère En ligne : ../theses/biologie/KAB5938.pdf Format de la ressource électronique : Permalink : index.php?lvl=notice_display&id=5727 Exemplaires (1)
Code-barres Cote Support Localisation Section Disponibilité KAB/5938 KAB/5938 Thèse Bibliothèque principale Thèses Disponible
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