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Partager le résultat de cette recherche Interroger des sources externesEtude de l'effet de l'extrait de la plante médicinale Artémisia campestris sur les cellules tumorales et son r?le dans la protection du stress oxydatif induit par le cisplatine
Titre : Etude de l'effet de l'extrait de la plante médicinale Artémisia campestris sur les cellules tumorales et son r?le dans la protection du stress oxydatif induit par le cisplatine Type de document : texte imprimé Auteurs : Univ. de Constantine, Éditeur scientifique Année de publication : 2010 Importance : 143 f. Note générale : 01 Disponible à la salle de recherche 01 Disponible au magazin de la B.U.C. 01 CD Langues : Français (fre) Catégories : Français - Anglais
BiologieTags : Stress oxydant Activité antioxydante Cisplatine Néphrotoxicité Artémisia campestris L.ssp.campestris Potentiel cytotoxique Fonction rénale Cancer Chimiothérapie Index. décimale : 570 Sciences de la vie. Biologie En ligne : ../theses/biologie/MOU5723.pdf Permalink : index.php?lvl=notice_display&id=1825 Etude de l'effet de l'extrait de la plante médicinale Artémisia campestris sur les cellules tumorales et son r?le dans la protection du stress oxydatif induit par le cisplatine [texte imprimé] / Univ. de Constantine, Éditeur scientifique . - 2010 . - 143 f.
01 Disponible à la salle de recherche 01 Disponible au magazin de la B.U.C. 01 CD
Langues : Français (fre)
Catégories : Français - Anglais
BiologieTags : Stress oxydant Activité antioxydante Cisplatine Néphrotoxicité Artémisia campestris L.ssp.campestris Potentiel cytotoxique Fonction rénale Cancer Chimiothérapie Index. décimale : 570 Sciences de la vie. Biologie En ligne : ../theses/biologie/MOU5723.pdf Permalink : index.php?lvl=notice_display&id=1825 Exemplaires (1)
Code-barres Cote Support Localisation Section Disponibilité MOU/5723 MOU/5723 Thèse Bibliothèque principale Thèses Disponible
Titre : Etude de la relation du thé vert. Maladies cardiovasculaires et Stress oxydant. Type de document : texte imprimé Auteurs : Samy Kabouche, Auteur ; Djamila Zama, Directeur de thèse Editeur : Constantine : Université Mentouri Constantine Année de publication : 2010 Importance : 136 f. Format : 31 cm Note générale : 2 copies imprimées disponibles Langues : Français (fre) Catégories : Français - Anglais
BiologieTags : Camellia sinensis stress oxydant antioxydant hypolipedimique satins. Biologie Index. décimale : 570 Sciences de la vie. Biologie Diplôme : Magistère En ligne : ../theses/biologie/KAB5938.pdf Format de la ressource électronique : Permalink : index.php?lvl=notice_display&id=5727 Etude de la relation du thé vert. Maladies cardiovasculaires et Stress oxydant. [texte imprimé] / Samy Kabouche, Auteur ; Djamila Zama, Directeur de thèse . - Constantine : Université Mentouri Constantine, 2010 . - 136 f. ; 31 cm.
2 copies imprimées disponibles
Langues : Français (fre)
Catégories : Français - Anglais
BiologieTags : Camellia sinensis stress oxydant antioxydant hypolipedimique satins. Biologie Index. décimale : 570 Sciences de la vie. Biologie Diplôme : Magistère En ligne : ../theses/biologie/KAB5938.pdf Format de la ressource électronique : Permalink : index.php?lvl=notice_display&id=5727 Exemplaires (1)
Code-barres Cote Support Localisation Section Disponibilité KAB/5938 KAB/5938 Thèse Bibliothèque principale Thèses Disponible
Titre : Effet préventif et curatif de l'extrait de la plante médicinale Crataegus oxyacantha L.sur le strss oxydant induit par la Doxorubicine Type de document : texte imprimé Auteurs : Univ. de Constantine, Éditeur scientifique Année de publication : 2009 Importance : 98 f. Note générale : 01 Disponible à la salle de recherche 02 Disponibles au magazin de la B.U.C. 01 CD Langues : Français (fre) Catégories : Français - Anglais
BiologieTags : Stress oxydant Doxorubicine Cardiotoxicité Carataegus oxyacantha L. . Flavonoides Activité antioxydante Effet préventif Effet curatif Index. décimale : 570 Sciences de la vie. Biologie En ligne : ../theses/biologie/BRA5445.pdf Permalink : index.php?lvl=notice_display&id=1361 Effet préventif et curatif de l'extrait de la plante médicinale Crataegus oxyacantha L.sur le strss oxydant induit par la Doxorubicine [texte imprimé] / Univ. de Constantine, Éditeur scientifique . - 2009 . - 98 f.
01 Disponible à la salle de recherche 02 Disponibles au magazin de la B.U.C. 01 CD
Langues : Français (fre)
Catégories : Français - Anglais
BiologieTags : Stress oxydant Doxorubicine Cardiotoxicité Carataegus oxyacantha L. . Flavonoides Activité antioxydante Effet préventif Effet curatif Index. décimale : 570 Sciences de la vie. Biologie En ligne : ../theses/biologie/BRA5445.pdf Permalink : index.php?lvl=notice_display&id=1361 Exemplaires (1)
Code-barres Cote Support Localisation Section Disponibilité BRA/5445 BRA/5445 Thèse Bibliothèque principale Thèses Disponible
Titre : Activité biochimique des extraits flavonoiques de la plante Ranunculus repens L. : effet sur le diabLte expérimental et l'hépatotoxicité induite par l'Epirubicine. Type de document : texte imprimé Auteurs : Mohamed Kebieche, Auteur ; Zahia Meraihi, Directeur de thèse Editeur : Constantine : Université Mentouri Constantine Année de publication : 2009 Importance : 129 f. Format : 30 cm. Note générale : 01 Disponible à la salle de recherche 02 Disponibles au magazin de la B.U.C. 01 CD Langues : Français (fre) Catégories : Français - Anglais
BiologieTags : Biochimie - Microbiologie: Biochimie diabète flavonoïdes Stress oxydant Alloxane Ranunculus repens L. Effet antidiabétique Epirubicine Hépatotoxicité Quercétine Chémoprotecteur stress oxydant flavonoids extract Ranunculus repens L alloxane antidiabetic effect épirubicin Hepatotoxicity Oxidative stress Quercetin Hepatoprotective effect. Index. décimale : 570 Sciences de la vie. Biologie Résumé : In the present study, the antihyperglycemic, anti-diabetic and antioxidant effects of the n-Butanol extract (BE) obtained from air part of Ranunculus repens L plant and quercetin were investigated in normal glucose-fed hyperglycemia, in alloxan induced diabetes and in epirubicin (EPI) toxicity of the rats. The results of this study show antihyperglycemic and antidiabetic activity of the phenolic compounds. And to elucidate a possible mechanism of action of this plant extract, the glycogen liver rate, insulin secretion and the in vitro chelating effect of glucose by plant compounds were also investigated. The flavonoids reduced significantly blood glucose in a dose-dependant manner (200,400,600 mg/kg) in both hyperglycemic and diabetic rats after oral administration as oral hypoglycemic drug, glibenclamide (2.5 mg/kg). We show that flavonoids extracts was able significantly to complex the glucose in vitro, induce insulin secretion of beta cells and to active glycogenesis in liver as shown by the abundance of glycogen granulation in liver histochemical preparation after administration of flavonoids extract. In addition these flavonoids extract and quercetin possess a chemoprotector power against malondialdehyde formation (MDA, lipid peroxidation product) and reduction of antioxidant systems such SOD, CAT and GSH in alloxan-induced diabetic rats. The equilibrium disorder of redox status after alloxan administration is reestablished by flavonoids pretreatment of alloxanised rats. The flavonoids markedly inhibited lipid peroxidation process in pancreatic cells and the proportioning of cytosolic SOD, CAT and GSH showed a significant elevation to establish equilibrium of redox status and consequently protect beta cells and prevent diabetes. The anticancer therapy with EPI produces acute hepatotoxicityby generation of free radicals. However, the oxidative status of the liver cells and mitochondria has been investigated in EPI toxicity of the rats. In this present study, we investigated in first the prooxidant effect of EPI and its implication on both hepatic cells and mitochondria function. EPI injection in rats at dose of 9 mg/kg induced hepatic dysfunction revealed by a significant increase in serum of glutamate oxaloacetate transaminases and glutamate pyruvate transaminases. Oxidative stress in liver cells and mitochondria was provoked by EPI since a statistically significant reduction of CAT, SOD and GSH levels, and significant increase of MDA level, indicator of lipid peroxidation which could perforate the biologic
membranes, were observed. In second, the protective effect of quercetin (33 mg/kg) and flavonoids extract of RRL (100 mg/kg) against oxidative stress induced by EPI was also investigated. Indeed, the pretreatment of rats with flavonoids protected liver cells and mitochondria from oxidative stress permitting, on one hand, the prevention of hepatic dysfunction on maintaining the normal level of serum transaminases following inhibition of their hepatic leakage by preventing lipid peroxidation Thus, the prevention of the cellular membranes perforation, and in the other hand maintaining also antioxidant defense system in mitochondria and cytosol of hepatocytes. Taken together, this data reveal that flavonoids extract of Ranunculus repens L extract and quercetin possess an interesting virtue to be antihyperglycemic and antidiabetic with positive action on liver glycogenesis and insulin secretion. These phenolic compounds have also antiradical and antioxidant power that confers them chemoprotection role against oxidative stress generated in pancreas cells and liver respectively by alloxan and epirubicin.
Note de contenu :
Annexes.Diplôme : Doctorat En ligne : ../theses/biologie/KEB5525.pdf Permalink : index.php?lvl=notice_display&id=1794 Activité biochimique des extraits flavonoiques de la plante Ranunculus repens L. : effet sur le diabLte expérimental et l'hépatotoxicité induite par l'Epirubicine. [texte imprimé] / Mohamed Kebieche, Auteur ; Zahia Meraihi, Directeur de thèse . - Constantine : Université Mentouri Constantine, 2009 . - 129 f. ; 30 cm.
01 Disponible à la salle de recherche 02 Disponibles au magazin de la B.U.C. 01 CD
Langues : Français (fre)
Catégories : Français - Anglais
BiologieTags : Biochimie - Microbiologie: Biochimie diabète flavonoïdes Stress oxydant Alloxane Ranunculus repens L. Effet antidiabétique Epirubicine Hépatotoxicité Quercétine Chémoprotecteur stress oxydant flavonoids extract Ranunculus repens L alloxane antidiabetic effect épirubicin Hepatotoxicity Oxidative stress Quercetin Hepatoprotective effect. Index. décimale : 570 Sciences de la vie. Biologie Résumé : In the present study, the antihyperglycemic, anti-diabetic and antioxidant effects of the n-Butanol extract (BE) obtained from air part of Ranunculus repens L plant and quercetin were investigated in normal glucose-fed hyperglycemia, in alloxan induced diabetes and in epirubicin (EPI) toxicity of the rats. The results of this study show antihyperglycemic and antidiabetic activity of the phenolic compounds. And to elucidate a possible mechanism of action of this plant extract, the glycogen liver rate, insulin secretion and the in vitro chelating effect of glucose by plant compounds were also investigated. The flavonoids reduced significantly blood glucose in a dose-dependant manner (200,400,600 mg/kg) in both hyperglycemic and diabetic rats after oral administration as oral hypoglycemic drug, glibenclamide (2.5 mg/kg). We show that flavonoids extracts was able significantly to complex the glucose in vitro, induce insulin secretion of beta cells and to active glycogenesis in liver as shown by the abundance of glycogen granulation in liver histochemical preparation after administration of flavonoids extract. In addition these flavonoids extract and quercetin possess a chemoprotector power against malondialdehyde formation (MDA, lipid peroxidation product) and reduction of antioxidant systems such SOD, CAT and GSH in alloxan-induced diabetic rats. The equilibrium disorder of redox status after alloxan administration is reestablished by flavonoids pretreatment of alloxanised rats. The flavonoids markedly inhibited lipid peroxidation process in pancreatic cells and the proportioning of cytosolic SOD, CAT and GSH showed a significant elevation to establish equilibrium of redox status and consequently protect beta cells and prevent diabetes. The anticancer therapy with EPI produces acute hepatotoxicityby generation of free radicals. However, the oxidative status of the liver cells and mitochondria has been investigated in EPI toxicity of the rats. In this present study, we investigated in first the prooxidant effect of EPI and its implication on both hepatic cells and mitochondria function. EPI injection in rats at dose of 9 mg/kg induced hepatic dysfunction revealed by a significant increase in serum of glutamate oxaloacetate transaminases and glutamate pyruvate transaminases. Oxidative stress in liver cells and mitochondria was provoked by EPI since a statistically significant reduction of CAT, SOD and GSH levels, and significant increase of MDA level, indicator of lipid peroxidation which could perforate the biologic
membranes, were observed. In second, the protective effect of quercetin (33 mg/kg) and flavonoids extract of RRL (100 mg/kg) against oxidative stress induced by EPI was also investigated. Indeed, the pretreatment of rats with flavonoids protected liver cells and mitochondria from oxidative stress permitting, on one hand, the prevention of hepatic dysfunction on maintaining the normal level of serum transaminases following inhibition of their hepatic leakage by preventing lipid peroxidation Thus, the prevention of the cellular membranes perforation, and in the other hand maintaining also antioxidant defense system in mitochondria and cytosol of hepatocytes. Taken together, this data reveal that flavonoids extract of Ranunculus repens L extract and quercetin possess an interesting virtue to be antihyperglycemic and antidiabetic with positive action on liver glycogenesis and insulin secretion. These phenolic compounds have also antiradical and antioxidant power that confers them chemoprotection role against oxidative stress generated in pancreas cells and liver respectively by alloxan and epirubicin.
Note de contenu :
Annexes.Diplôme : Doctorat En ligne : ../theses/biologie/KEB5525.pdf Permalink : index.php?lvl=notice_display&id=1794 Exemplaires (1)
Code-barres Cote Support Localisation Section Disponibilité KEB/5525 KEB/5525 Thèse Bibliothèque principale Thèses Disponible
Titre : Effet des extraits de la plante médicinale Ruta montana) (الفيجلsur la cardiotoxicité induite par la doxorubicine et sur la multi-drug résistances (MDR) des cellules cancéreuses ovarien (A2780) Type de document : texte imprimé Auteurs : Wahiba Kara Ali, Auteur ; N. Abidli, Directeur de thèse Editeur : جامعة الإخوة منتوري قسنطينة Année de publication : 2017 Importance : 160 f. Format : 30 cm. Note générale : 2 copies imprimées disponibles
Langues : Français (fre) Catégories : Français - Anglais
BiologieTags : Ruta montana Doxorubicine Cardiotoxicité Multi-drug résistance Stress oxydant Antioxydant Flavonoides Cardiotoxicity Multidrug resistance Oxidative
stress Antioxidant Flavonoids الدوكسوروبسين السمية القلبية المقاومة المتعددة للأدوية الإجهاد التاكسدي النشاط المضاد للأكسدة الفلافونويداتIndex. décimale : 570 Sciences de la vie. Biologie Résumé : This study was conducted to search for the preventive effect of medicinal plant Ruta montana
extract on oxidative stress induced by doxorubicine (DOX) and its properties to reverse
doxorubicin resistance in ovarian cancer cell line (A2780). Organic extracts were obtained by
maceration with three solvents: petroleum ether, ethyl acetate and butanol. The yields were:
15,04%, 3,55% and 25,14%.respectively. A phytochemical screening in methanol extract
revealed that the plant contain the flavonoids, saponins, tannins, coumarins, reducing component
and the alkaloids. The quantitative study showed that the butanolic extract (BERM) has
significant amount of flavonoids (80.85±0.78mg EQ / g dry extract), followed by ethyl acetate
extract (AEERM) (15.27 ±0.62 EQ / g dry extract) and petroleum ether extract has the lowest
flavonoids content (PEERM) (9.71±1.13 mgEQ/g dry extract). When the total phenolic contents
was: 687.5, 595.83 and 146.33 mg EGA / g dry extract, in the BERM, AEERM and PEERM
respectively. The qualitative analysis of the three methanolic crude extract via thin layer
chromatography (TLC) has shown the presence of the anthocyanidin 3-glycosids, flavons et
flavonols glycosids (hétérosids), flavonols avec 3-OH libre, flavonons ou aurons, isoflavons, the
phénolic acids, Flavonols et 4-OH chalcons. The évaluation of antioxidant activity by the
reduction of free radical DPPH method showed that The highest DPPH radical scavenging
activity was observed with AEERM (IC50 = 0.126 ± 0.002 mg/ ml), followed by BERM (0.135
± 0.0006 mg/ ml) and PEERM (IC50 =0.185± 0.002 mg/ ml). The study of preventive effect of
AEERM on oxidative stress induced by DOX in wistar rats clearly show that DOX (15 mg/kg
i.p) induced animal cardiotoxicity characterized by an increase of cardiac enzyme activity
(CKMB, LDH, l’ALAT et l’ASAT) in serum, the increase in the concentration of
malondialdéhyde (MDA), antioxydant enzyme activity, catalase (CAT) and Glutathion- Stransférase (GST) and a decrease of cardiac cytosolic reduced glutathione (GSH) with a different
pathological changes in the heart. However pretreated animals with EAERM (100 mg/kg orally
during 15 days), showed a decrease of cardiac enzymes activities 24 %, 35, 69%, 21,25 % et
8,10 % respectively to CKMB, LDH, l’ALAT and l’ASAT. The preatretment with the extract
improved antioxidant status in the heart by a decrease in the cardiac MDA concentration by 29,7
% and activity of antioxydants enzymes by 17,91% et 29,78% respectively to CAT et la GST.
In addition, the pretreated rats by the extract showed an increase of GSH level (83,76 %)
compared with DOX-treated animals. Histological study shows that the extract resulted in a
reduction of severe cardiac damages observed in DOX-treated animals. The reversal of
multidrug resistance for DOX in human ovarian adenocarcinoma, cell lines (A2780 DX3) using
MTT assay showed that AEERM was very effective at reversing the resistant in dose dependent
manner with the Reversion Factor (RF =8.62, 05.77 and 02.30 respectively for the
concentrations 40, 10 and 2.5 mg/ml) followed by BERM (FR=05.07 and 02.43 for the
concentrations 40 and 10 mg/ml respectively), then the PEERM had the lowest reversal
resistance effect (RF betwen 1.01 to 1.08). The present study suggests that AEERM can
ameliorate the oxidative stress involved in the pathogenesis of doxorubicine- induced
cardiotoxicity and can reverse the multidrug resistance for DOX.
Diplôme : Doctorat en sciences En ligne : ../theses/biologie/KAR7158.pdf Format de la ressource électronique : Permalink : index.php?lvl=notice_display&id=10435 Effet des extraits de la plante médicinale Ruta montana) (الفيجلsur la cardiotoxicité induite par la doxorubicine et sur la multi-drug résistances (MDR) des cellules cancéreuses ovarien (A2780) [texte imprimé] / Wahiba Kara Ali, Auteur ; N. Abidli, Directeur de thèse . - جامعة الإخوة منتوري قسنطينة, 2017 . - 160 f. ; 30 cm.
2 copies imprimées disponibles
Langues : Français (fre)
Catégories : Français - Anglais
BiologieTags : Ruta montana Doxorubicine Cardiotoxicité Multi-drug résistance Stress oxydant Antioxydant Flavonoides Cardiotoxicity Multidrug resistance Oxidative
stress Antioxidant Flavonoids الدوكسوروبسين السمية القلبية المقاومة المتعددة للأدوية الإجهاد التاكسدي النشاط المضاد للأكسدة الفلافونويداتIndex. décimale : 570 Sciences de la vie. Biologie Résumé : This study was conducted to search for the preventive effect of medicinal plant Ruta montana
extract on oxidative stress induced by doxorubicine (DOX) and its properties to reverse
doxorubicin resistance in ovarian cancer cell line (A2780). Organic extracts were obtained by
maceration with three solvents: petroleum ether, ethyl acetate and butanol. The yields were:
15,04%, 3,55% and 25,14%.respectively. A phytochemical screening in methanol extract
revealed that the plant contain the flavonoids, saponins, tannins, coumarins, reducing component
and the alkaloids. The quantitative study showed that the butanolic extract (BERM) has
significant amount of flavonoids (80.85±0.78mg EQ / g dry extract), followed by ethyl acetate
extract (AEERM) (15.27 ±0.62 EQ / g dry extract) and petroleum ether extract has the lowest
flavonoids content (PEERM) (9.71±1.13 mgEQ/g dry extract). When the total phenolic contents
was: 687.5, 595.83 and 146.33 mg EGA / g dry extract, in the BERM, AEERM and PEERM
respectively. The qualitative analysis of the three methanolic crude extract via thin layer
chromatography (TLC) has shown the presence of the anthocyanidin 3-glycosids, flavons et
flavonols glycosids (hétérosids), flavonols avec 3-OH libre, flavonons ou aurons, isoflavons, the
phénolic acids, Flavonols et 4-OH chalcons. The évaluation of antioxidant activity by the
reduction of free radical DPPH method showed that The highest DPPH radical scavenging
activity was observed with AEERM (IC50 = 0.126 ± 0.002 mg/ ml), followed by BERM (0.135
± 0.0006 mg/ ml) and PEERM (IC50 =0.185± 0.002 mg/ ml). The study of preventive effect of
AEERM on oxidative stress induced by DOX in wistar rats clearly show that DOX (15 mg/kg
i.p) induced animal cardiotoxicity characterized by an increase of cardiac enzyme activity
(CKMB, LDH, l’ALAT et l’ASAT) in serum, the increase in the concentration of
malondialdéhyde (MDA), antioxydant enzyme activity, catalase (CAT) and Glutathion- Stransférase (GST) and a decrease of cardiac cytosolic reduced glutathione (GSH) with a different
pathological changes in the heart. However pretreated animals with EAERM (100 mg/kg orally
during 15 days), showed a decrease of cardiac enzymes activities 24 %, 35, 69%, 21,25 % et
8,10 % respectively to CKMB, LDH, l’ALAT and l’ASAT. The preatretment with the extract
improved antioxidant status in the heart by a decrease in the cardiac MDA concentration by 29,7
% and activity of antioxydants enzymes by 17,91% et 29,78% respectively to CAT et la GST.
In addition, the pretreated rats by the extract showed an increase of GSH level (83,76 %)
compared with DOX-treated animals. Histological study shows that the extract resulted in a
reduction of severe cardiac damages observed in DOX-treated animals. The reversal of
multidrug resistance for DOX in human ovarian adenocarcinoma, cell lines (A2780 DX3) using
MTT assay showed that AEERM was very effective at reversing the resistant in dose dependent
manner with the Reversion Factor (RF =8.62, 05.77 and 02.30 respectively for the
concentrations 40, 10 and 2.5 mg/ml) followed by BERM (FR=05.07 and 02.43 for the
concentrations 40 and 10 mg/ml respectively), then the PEERM had the lowest reversal
resistance effect (RF betwen 1.01 to 1.08). The present study suggests that AEERM can
ameliorate the oxidative stress involved in the pathogenesis of doxorubicine- induced
cardiotoxicity and can reverse the multidrug resistance for DOX.
Diplôme : Doctorat en sciences En ligne : ../theses/biologie/KAR7158.pdf Format de la ressource électronique : Permalink : index.php?lvl=notice_display&id=10435 Exemplaires
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