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Titre : Etude de la relation du thé vert. Maladies cardiovasculaires et Stress oxydant Type de document : texte imprimé Auteurs : Samy Kabouche, Auteur ; Djamila Zama, Directeur de thèse Editeur : Constantine : Université Mentouri Constantine Année de publication : 2010 Importance : 136 f. Format : 31 cm Note générale : Magister
2 copies imprimées disponiblesLangues : Français (fre) Tags : Camellia sinensis stress oxydant antioxydant hypolipedimique satins. Biologie Index. décimale : 570 Sciences de la vie. Biologie En ligne : ../theses/biologie/KAB5938.pdf Permalink : https://bu.umc.edu.dz/md/index.php?lvl=notice_display&id=5727 Etude de la relation du thé vert. Maladies cardiovasculaires et Stress oxydant [texte imprimé] / Samy Kabouche, Auteur ; Djamila Zama, Directeur de thèse . - Constantine : Université Mentouri Constantine, 2010 . - 136 f. ; 31 cm.
Magister
2 copies imprimées disponibles
Langues : Français (fre)
Tags : Camellia sinensis stress oxydant antioxydant hypolipedimique satins. Biologie Index. décimale : 570 Sciences de la vie. Biologie En ligne : ../theses/biologie/KAB5938.pdf Permalink : https://bu.umc.edu.dz/md/index.php?lvl=notice_display&id=5727 Exemplaires
Code-barres Cote Support Localisation Section Disponibilité aucun exemplaire Effet préventif et curatif de l'extrait de la plante médicinale Crataegus oxyacantha L.sur le strss oxydant induit par la Doxorubicine
Titre : Effet préventif et curatif de l'extrait de la plante médicinale Crataegus oxyacantha L.sur le strss oxydant induit par la Doxorubicine Type de document : texte imprimé Auteurs : Université Mentouri, Editeur scientifique Année de publication : 2009 Importance : 98 f. Note générale : 01 Disponible à la salle de recherche 02 Disponibles au magazin de la B.U.C. 01 CD Langues : Français (fre) Tags : Stress oxydant Doxorubicine Cardiotoxicité Carataegus oxyacantha L. . Flavonoides Activité antioxydante Effet préventif Effet curatif Index. décimale : 570 Sciences de la vie. Biologie En ligne : ../theses/biologie/BRA5445.pdf Permalink : https://bu.umc.edu.dz/md/index.php?lvl=notice_display&id=1361 Effet préventif et curatif de l'extrait de la plante médicinale Crataegus oxyacantha L.sur le strss oxydant induit par la Doxorubicine [texte imprimé] / Université Mentouri, Editeur scientifique . - 2009 . - 98 f.
01 Disponible à la salle de recherche 02 Disponibles au magazin de la B.U.C. 01 CD
Langues : Français (fre)
Tags : Stress oxydant Doxorubicine Cardiotoxicité Carataegus oxyacantha L. . Flavonoides Activité antioxydante Effet préventif Effet curatif Index. décimale : 570 Sciences de la vie. Biologie En ligne : ../theses/biologie/BRA5445.pdf Permalink : https://bu.umc.edu.dz/md/index.php?lvl=notice_display&id=1361 Exemplaires
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Titre : Etude de l'effet de l'extrait de la plante médicinale Artémisia campestris sur les cellules tumorales et son r?le dans la protection du stress oxydatif induit par le cisplatine Type de document : texte imprimé Auteurs : Université Mentouri, Editeur scientifique Année de publication : 2010 Importance : 143 f. Note générale : 01 Disponible à la salle de recherche 01 Disponible au magazin de la B.U.C. 01 CD Langues : Français (fre) Tags : Stress oxydant Activité antioxydante Cisplatine Néphrotoxicité Artémisia campestris L.ssp.campestris Potentiel cytotoxique Fonction rénale Cancer Chimiothérapie Index. décimale : 570 Sciences de la vie. Biologie En ligne : ../theses/biologie/MOU5723.pdf Permalink : https://bu.umc.edu.dz/md/index.php?lvl=notice_display&id=1825 Etude de l'effet de l'extrait de la plante médicinale Artémisia campestris sur les cellules tumorales et son r?le dans la protection du stress oxydatif induit par le cisplatine [texte imprimé] / Université Mentouri, Editeur scientifique . - 2010 . - 143 f.
01 Disponible à la salle de recherche 01 Disponible au magazin de la B.U.C. 01 CD
Langues : Français (fre)
Tags : Stress oxydant Activité antioxydante Cisplatine Néphrotoxicité Artémisia campestris L.ssp.campestris Potentiel cytotoxique Fonction rénale Cancer Chimiothérapie Index. décimale : 570 Sciences de la vie. Biologie En ligne : ../theses/biologie/MOU5723.pdf Permalink : https://bu.umc.edu.dz/md/index.php?lvl=notice_display&id=1825 Exemplaires
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Titre : Effet des extraits de la plante médicinale Ruta montana) (الفيجلsur la cardiotoxicité induite par la doxorubicine et sur la multi-drug résistances (MDR) des cellules cancéreuses ovarien (A2780) Type de document : texte imprimé Auteurs : Wahiba Kara Ali, Auteur ; N. Abidli, Directeur de thèse Editeur : جامعة الإخوة منتوري قسنطينة Année de publication : 2017 Importance : 160 f. Format : 30 cm. Note générale : 2 copies imprimées disponibles
Langues : Français (fre) Tags : Ruta montana Doxorubicine Cardiotoxicité Multi-drug résistance Stress oxydant Antioxydant Flavonoides Cardiotoxicity Multidrug resistance Oxidative
stress Antioxidant Flavonoids ????????????? ?????? ??????? ???????? ???????? ??????? ??????? ???????? ?????? ?????? ???????Index. décimale : 570 Sciences de la vie. Biologie Résumé : This study was conducted to search for the preventive effect of medicinal plant Ruta montana
extract on oxidative stress induced by doxorubicine (DOX) and its properties to reverse
doxorubicin resistance in ovarian cancer cell line (A2780). Organic extracts were obtained by
maceration with three solvents: petroleum ether, ethyl acetate and butanol. The yields were:
15,04%, 3,55% and 25,14%.respectively. A phytochemical screening in methanol extract
revealed that the plant contain the flavonoids, saponins, tannins, coumarins, reducing component
and the alkaloids. The quantitative study showed that the butanolic extract (BERM) has
significant amount of flavonoids (80.85±0.78mg EQ / g dry extract), followed by ethyl acetate
extract (AEERM) (15.27 ±0.62 EQ / g dry extract) and petroleum ether extract has the lowest
flavonoids content (PEERM) (9.71±1.13 mgEQ/g dry extract). When the total phenolic contents
was: 687.5, 595.83 and 146.33 mg EGA / g dry extract, in the BERM, AEERM and PEERM
respectively. The qualitative analysis of the three methanolic crude extract via thin layer
chromatography (TLC) has shown the presence of the anthocyanidin 3-glycosids, flavons et
flavonols glycosids (hétérosids), flavonols avec 3-OH libre, flavonons ou aurons, isoflavons, the
phénolic acids, Flavonols et 4-OH chalcons. The évaluation of antioxidant activity by the
reduction of free radical DPPH method showed that The highest DPPH radical scavenging
activity was observed with AEERM (IC50 = 0.126 ± 0.002 mg/ ml), followed by BERM (0.135
± 0.0006 mg/ ml) and PEERM (IC50 =0.185± 0.002 mg/ ml). The study of preventive effect of
AEERM on oxidative stress induced by DOX in wistar rats clearly show that DOX (15 mg/kg
i.p) induced animal cardiotoxicity characterized by an increase of cardiac enzyme activity
(CKMB, LDH, l’ALAT et l’ASAT) in serum, the increase in the concentration of
malondialdéhyde (MDA), antioxydant enzyme activity, catalase (CAT) and Glutathion- Stransférase (GST) and a decrease of cardiac cytosolic reduced glutathione (GSH) with a different
pathological changes in the heart. However pretreated animals with EAERM (100 mg/kg orally
during 15 days), showed a decrease of cardiac enzymes activities 24 %, 35, 69%, 21,25 % et
8,10 % respectively to CKMB, LDH, l’ALAT and l’ASAT. The preatretment with the extract
improved antioxidant status in the heart by a decrease in the cardiac MDA concentration by 29,7
% and activity of antioxydants enzymes by 17,91% et 29,78% respectively to CAT et la GST.
In addition, the pretreated rats by the extract showed an increase of GSH level (83,76 %)
compared with DOX-treated animals. Histological study shows that the extract resulted in a
reduction of severe cardiac damages observed in DOX-treated animals. The reversal of
multidrug resistance for DOX in human ovarian adenocarcinoma, cell lines (A2780 DX3) using
MTT assay showed that AEERM was very effective at reversing the resistant in dose dependent
manner with the Reversion Factor (RF =8.62, 05.77 and 02.30 respectively for the
concentrations 40, 10 and 2.5 mg/ml) followed by BERM (FR=05.07 and 02.43 for the
concentrations 40 and 10 mg/ml respectively), then the PEERM had the lowest reversal
resistance effect (RF betwen 1.01 to 1.08). The present study suggests that AEERM can
ameliorate the oxidative stress involved in the pathogenesis of doxorubicine- induced
cardiotoxicity and can reverse the multidrug resistance for DOX.
Diplôme : Doctorat en sciences En ligne : ../theses/biologie/KAR7158.pdf Format de la ressource électronique : Permalink : https://bu.umc.edu.dz/md/index.php?lvl=notice_display&id=10435 Effet des extraits de la plante médicinale Ruta montana) (الفيجلsur la cardiotoxicité induite par la doxorubicine et sur la multi-drug résistances (MDR) des cellules cancéreuses ovarien (A2780) [texte imprimé] / Wahiba Kara Ali, Auteur ; N. Abidli, Directeur de thèse . - [S.l.] : جامعة الإخوة منتوري قسنطينة, 2017 . - 160 f. ; 30 cm.
2 copies imprimées disponibles
Langues : Français (fre)
Tags : Ruta montana Doxorubicine Cardiotoxicité Multi-drug résistance Stress oxydant Antioxydant Flavonoides Cardiotoxicity Multidrug resistance Oxidative
stress Antioxidant Flavonoids ????????????? ?????? ??????? ???????? ???????? ??????? ??????? ???????? ?????? ?????? ???????Index. décimale : 570 Sciences de la vie. Biologie Résumé : This study was conducted to search for the preventive effect of medicinal plant Ruta montana
extract on oxidative stress induced by doxorubicine (DOX) and its properties to reverse
doxorubicin resistance in ovarian cancer cell line (A2780). Organic extracts were obtained by
maceration with three solvents: petroleum ether, ethyl acetate and butanol. The yields were:
15,04%, 3,55% and 25,14%.respectively. A phytochemical screening in methanol extract
revealed that the plant contain the flavonoids, saponins, tannins, coumarins, reducing component
and the alkaloids. The quantitative study showed that the butanolic extract (BERM) has
significant amount of flavonoids (80.85±0.78mg EQ / g dry extract), followed by ethyl acetate
extract (AEERM) (15.27 ±0.62 EQ / g dry extract) and petroleum ether extract has the lowest
flavonoids content (PEERM) (9.71±1.13 mgEQ/g dry extract). When the total phenolic contents
was: 687.5, 595.83 and 146.33 mg EGA / g dry extract, in the BERM, AEERM and PEERM
respectively. The qualitative analysis of the three methanolic crude extract via thin layer
chromatography (TLC) has shown the presence of the anthocyanidin 3-glycosids, flavons et
flavonols glycosids (hétérosids), flavonols avec 3-OH libre, flavonons ou aurons, isoflavons, the
phénolic acids, Flavonols et 4-OH chalcons. The évaluation of antioxidant activity by the
reduction of free radical DPPH method showed that The highest DPPH radical scavenging
activity was observed with AEERM (IC50 = 0.126 ± 0.002 mg/ ml), followed by BERM (0.135
± 0.0006 mg/ ml) and PEERM (IC50 =0.185± 0.002 mg/ ml). The study of preventive effect of
AEERM on oxidative stress induced by DOX in wistar rats clearly show that DOX (15 mg/kg
i.p) induced animal cardiotoxicity characterized by an increase of cardiac enzyme activity
(CKMB, LDH, l’ALAT et l’ASAT) in serum, the increase in the concentration of
malondialdéhyde (MDA), antioxydant enzyme activity, catalase (CAT) and Glutathion- Stransférase (GST) and a decrease of cardiac cytosolic reduced glutathione (GSH) with a different
pathological changes in the heart. However pretreated animals with EAERM (100 mg/kg orally
during 15 days), showed a decrease of cardiac enzymes activities 24 %, 35, 69%, 21,25 % et
8,10 % respectively to CKMB, LDH, l’ALAT and l’ASAT. The preatretment with the extract
improved antioxidant status in the heart by a decrease in the cardiac MDA concentration by 29,7
% and activity of antioxydants enzymes by 17,91% et 29,78% respectively to CAT et la GST.
In addition, the pretreated rats by the extract showed an increase of GSH level (83,76 %)
compared with DOX-treated animals. Histological study shows that the extract resulted in a
reduction of severe cardiac damages observed in DOX-treated animals. The reversal of
multidrug resistance for DOX in human ovarian adenocarcinoma, cell lines (A2780 DX3) using
MTT assay showed that AEERM was very effective at reversing the resistant in dose dependent
manner with the Reversion Factor (RF =8.62, 05.77 and 02.30 respectively for the
concentrations 40, 10 and 2.5 mg/ml) followed by BERM (FR=05.07 and 02.43 for the
concentrations 40 and 10 mg/ml respectively), then the PEERM had the lowest reversal
resistance effect (RF betwen 1.01 to 1.08). The present study suggests that AEERM can
ameliorate the oxidative stress involved in the pathogenesis of doxorubicine- induced
cardiotoxicity and can reverse the multidrug resistance for DOX.
Diplôme : Doctorat en sciences En ligne : ../theses/biologie/KAR7158.pdf Format de la ressource électronique : Permalink : https://bu.umc.edu.dz/md/index.php?lvl=notice_display&id=10435 Exemplaires
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Titre : L’effet protecteur de la plante Linaria tingitana (Scrophulariaceae) sur le dysfonctionnement mitochondrial et lysosomal hépatocytaire induit par l’acide valproïque chez le rat. Type de document : texte imprimé Auteurs : Mourad Hanfer, Auteur ; Souad Ameddah, Directeur de thèse ; Didier Morin, Directeur de thèse Editeur : جامعة الإخوة منتوري قسنطينة Année de publication : 2017 Importance : 202 f. Format : 30 cm. Note générale : 2 copies imprimées disponibles
Langues : Français (fre) Tags : Valproïc acid Linaria tingitana LC-MS. Mitochondrial dysfunction Lysosomal dysfunction Rats HepG2 Inflammation Oxidative stress Acide valproïque LC-MS. Dysfonctionnement mitochondrial Dysfonctionnement lysosomal Stress oxydant Index. décimale : 570 Sciences de la vie. Biologie Résumé : This investigation is interested to study the modulator effect of Linaria tingitana in rats
treated by the valproic acid (VPA). The in vitro studies (DPPH◦, FRAP, β-carotene, Chelation, NO◦) showed that Linaria tingitana is endowed with an antioxidant property. The antiinflammatory studies (albumin denaturation, HRBC, NO scavenger, oedema and peritonitis led
by the carrageenan, the rise of MPO and the infiltration of the PN) confirmed that Linaria
tingitana has a beneficial effect in this sense. The in vivo studies made to rats handled by the
VPA revealed that the n-BuOH extract acts by a multitude of mechanisms: conservation of the
hepatic function, the modulation of the steatoses, the neutralization of the oxidative stress and
the reduction of the inflammation hepatocyte elucidated by the decrease of the activity MPO.
Antirrhides molecules isolated of this plant were ineffective at the level of the cell line HepG2
treated with the VPA. The mitochondrial dysfunction led by the VPA is expressed by the decrease of the RCR accompanied by a decrease of the activity of the complex I. The n-BuOH
extract as well as the isolated molecules managed to reduce the mitochondrial H2O2 and to modulate the antioxidant mitochondrial and lysosomal systems. The conservation of the integrity
lysosomal membrane was more pronounced by the n-BuOH extract compared to the vitamin
E. The various modulator ways of L. tingitana delayed the appearance of the complications
linked to the mitochondrial dysfunction, lysosomal, such necrosis. Probably this is due to the
diversified wealth of this plant in term of polyphenols and irridoids revealed by phytochemical
screening and the analysis of the LC-MS and in the synergetic effect of the molecules that it
contains.Diplôme : Doctorat En ligne : ../theses/biologie/HAN7131.pdf Format de la ressource électronique : Permalink : https://bu.umc.edu.dz/md/index.php?lvl=notice_display&id=10471 L’effet protecteur de la plante Linaria tingitana (Scrophulariaceae) sur le dysfonctionnement mitochondrial et lysosomal hépatocytaire induit par l’acide valproïque chez le rat. [texte imprimé] / Mourad Hanfer, Auteur ; Souad Ameddah, Directeur de thèse ; Didier Morin, Directeur de thèse . - [S.l.] : جامعة الإخوة منتوري قسنطينة, 2017 . - 202 f. ; 30 cm.
2 copies imprimées disponibles
Langues : Français (fre)
Tags : Valproïc acid Linaria tingitana LC-MS. Mitochondrial dysfunction Lysosomal dysfunction Rats HepG2 Inflammation Oxidative stress Acide valproïque LC-MS. Dysfonctionnement mitochondrial Dysfonctionnement lysosomal Stress oxydant Index. décimale : 570 Sciences de la vie. Biologie Résumé : This investigation is interested to study the modulator effect of Linaria tingitana in rats
treated by the valproic acid (VPA). The in vitro studies (DPPH◦, FRAP, β-carotene, Chelation, NO◦) showed that Linaria tingitana is endowed with an antioxidant property. The antiinflammatory studies (albumin denaturation, HRBC, NO scavenger, oedema and peritonitis led
by the carrageenan, the rise of MPO and the infiltration of the PN) confirmed that Linaria
tingitana has a beneficial effect in this sense. The in vivo studies made to rats handled by the
VPA revealed that the n-BuOH extract acts by a multitude of mechanisms: conservation of the
hepatic function, the modulation of the steatoses, the neutralization of the oxidative stress and
the reduction of the inflammation hepatocyte elucidated by the decrease of the activity MPO.
Antirrhides molecules isolated of this plant were ineffective at the level of the cell line HepG2
treated with the VPA. The mitochondrial dysfunction led by the VPA is expressed by the decrease of the RCR accompanied by a decrease of the activity of the complex I. The n-BuOH
extract as well as the isolated molecules managed to reduce the mitochondrial H2O2 and to modulate the antioxidant mitochondrial and lysosomal systems. The conservation of the integrity
lysosomal membrane was more pronounced by the n-BuOH extract compared to the vitamin
E. The various modulator ways of L. tingitana delayed the appearance of the complications
linked to the mitochondrial dysfunction, lysosomal, such necrosis. Probably this is due to the
diversified wealth of this plant in term of polyphenols and irridoids revealed by phytochemical
screening and the analysis of the LC-MS and in the synergetic effect of the molecules that it
contains.Diplôme : Doctorat En ligne : ../theses/biologie/HAN7131.pdf Format de la ressource électronique : Permalink : https://bu.umc.edu.dz/md/index.php?lvl=notice_display&id=10471 Exemplaires
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