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Partager le résultat de cette recherche Interroger des sources externesEtude de l'effet de l'extrait de la plante médicinale Artémisia campestris sur les cellules tumorales et son r?le dans la protection du stress oxydatif induit par le cisplatine
Titre : Etude de l'effet de l'extrait de la plante médicinale Artémisia campestris sur les cellules tumorales et son r?le dans la protection du stress oxydatif induit par le cisplatine Type de document : texte imprimé Auteurs : Université Mentouri, Editeur scientifique Année de publication : 2010 Importance : 143 f. Note générale : 01 Disponible à la salle de recherche 01 Disponible au magazin de la B.U.C. 01 CD Langues : Français (fre) Catégories : Français - Anglais
BiologieTags : Stress oxydant Activité antioxydante Cisplatine Néphrotoxicité Artémisia campestris L.ssp.campestris Potentiel cytotoxique Fonction rénale Cancer Chimiothérapie Index. décimale : 570 Sciences de la vie. Biologie En ligne : ../theses/biologie/MOU5723.pdf Permalink : https://bu.umc.edu.dz/md/index.php?lvl=notice_display&id=1825 Etude de l'effet de l'extrait de la plante médicinale Artémisia campestris sur les cellules tumorales et son r?le dans la protection du stress oxydatif induit par le cisplatine [texte imprimé] / Université Mentouri, Editeur scientifique . - 2010 . - 143 f.
01 Disponible à la salle de recherche 01 Disponible au magazin de la B.U.C. 01 CD
Langues : Français (fre)
Catégories : Français - Anglais
BiologieTags : Stress oxydant Activité antioxydante Cisplatine Néphrotoxicité Artémisia campestris L.ssp.campestris Potentiel cytotoxique Fonction rénale Cancer Chimiothérapie Index. décimale : 570 Sciences de la vie. Biologie En ligne : ../theses/biologie/MOU5723.pdf Permalink : https://bu.umc.edu.dz/md/index.php?lvl=notice_display&id=1825 Exemplaires (1)
Code-barres Cote Support Localisation Section Disponibilité MOU/5723 MOU/5723 Thèse Bibliothèque principale Thèses Disponible
Titre : Etude de la relation du thé vert. Maladies cardiovasculaires et Stress oxydant Type de document : texte imprimé Auteurs : Samy Kabouche, Auteur ; Djamila Zama, Directeur de thèse Editeur : Constantine : Université Mentouri Constantine Année de publication : 2010 Importance : 136 f. Format : 31 cm Note générale : Magister
2 copies imprimées disponiblesLangues : Français (fre) Catégories : Français - Anglais
BiologieTags : Camellia sinensis stress oxydant antioxydant hypolipedimique satins. Biologie Index. décimale : 570 Sciences de la vie. Biologie En ligne : ../theses/biologie/KAB5938.pdf Permalink : https://bu.umc.edu.dz/md/index.php?lvl=notice_display&id=5727 Etude de la relation du thé vert. Maladies cardiovasculaires et Stress oxydant [texte imprimé] / Samy Kabouche, Auteur ; Djamila Zama, Directeur de thèse . - Constantine : Université Mentouri Constantine, 2010 . - 136 f. ; 31 cm.
Magister
2 copies imprimées disponibles
Langues : Français (fre)
Catégories : Français - Anglais
BiologieTags : Camellia sinensis stress oxydant antioxydant hypolipedimique satins. Biologie Index. décimale : 570 Sciences de la vie. Biologie En ligne : ../theses/biologie/KAB5938.pdf Permalink : https://bu.umc.edu.dz/md/index.php?lvl=notice_display&id=5727 Exemplaires (1)
Code-barres Cote Support Localisation Section Disponibilité KAB/5938 KAB/5938 Thèse Bibliothèque principale Thèses Disponible
Titre : Effet préventif et curatif de l'extrait de la plante médicinale Crataegus oxyacantha L.sur le strss oxydant induit par la Doxorubicine Type de document : texte imprimé Auteurs : Université Mentouri, Editeur scientifique Année de publication : 2009 Importance : 98 f. Note générale : 01 Disponible à la salle de recherche 02 Disponibles au magazin de la B.U.C. 01 CD Langues : Français (fre) Catégories : Français - Anglais
BiologieTags : Stress oxydant Doxorubicine Cardiotoxicité Carataegus oxyacantha L. . Flavonoides Activité antioxydante Effet préventif Effet curatif Index. décimale : 570 Sciences de la vie. Biologie En ligne : ../theses/biologie/BRA5445.pdf Permalink : https://bu.umc.edu.dz/md/index.php?lvl=notice_display&id=1361 Effet préventif et curatif de l'extrait de la plante médicinale Crataegus oxyacantha L.sur le strss oxydant induit par la Doxorubicine [texte imprimé] / Université Mentouri, Editeur scientifique . - 2009 . - 98 f.
01 Disponible à la salle de recherche 02 Disponibles au magazin de la B.U.C. 01 CD
Langues : Français (fre)
Catégories : Français - Anglais
BiologieTags : Stress oxydant Doxorubicine Cardiotoxicité Carataegus oxyacantha L. . Flavonoides Activité antioxydante Effet préventif Effet curatif Index. décimale : 570 Sciences de la vie. Biologie En ligne : ../theses/biologie/BRA5445.pdf Permalink : https://bu.umc.edu.dz/md/index.php?lvl=notice_display&id=1361 Exemplaires (1)
Code-barres Cote Support Localisation Section Disponibilité BRA/5445 BRA/5445 Thèse Bibliothèque principale Thèses Disponible
Titre : Effet des extraits de la plante médicinale Ruta montana) (الفيجلsur la cardiotoxicité induite par la doxorubicine et sur la multi-drug résistances (MDR) des cellules cancéreuses ovarien (A2780) Type de document : texte imprimé Auteurs : Wahiba Kara Ali, Auteur ; N. Abidli, Directeur de thèse Editeur : جامعة الإخوة منتوري قسنطينة Année de publication : 2017 Importance : 160 f. Format : 30 cm. Note générale : 2 copies imprimées disponibles
Langues : Français (fre) Catégories : Français - Anglais
BiologieTags : Ruta montana Doxorubicine Cardiotoxicité Multi-drug résistance Stress oxydant Antioxydant Flavonoides Cardiotoxicity Multidrug resistance Oxidative
stress Antioxidant Flavonoids ????????????? ?????? ??????? ???????? ???????? ??????? ??????? ???????? ?????? ?????? ???????Index. décimale : 570 Sciences de la vie. Biologie Résumé : This study was conducted to search for the preventive effect of medicinal plant Ruta montana
extract on oxidative stress induced by doxorubicine (DOX) and its properties to reverse
doxorubicin resistance in ovarian cancer cell line (A2780). Organic extracts were obtained by
maceration with three solvents: petroleum ether, ethyl acetate and butanol. The yields were:
15,04%, 3,55% and 25,14%.respectively. A phytochemical screening in methanol extract
revealed that the plant contain the flavonoids, saponins, tannins, coumarins, reducing component
and the alkaloids. The quantitative study showed that the butanolic extract (BERM) has
significant amount of flavonoids (80.85±0.78mg EQ / g dry extract), followed by ethyl acetate
extract (AEERM) (15.27 ±0.62 EQ / g dry extract) and petroleum ether extract has the lowest
flavonoids content (PEERM) (9.71±1.13 mgEQ/g dry extract). When the total phenolic contents
was: 687.5, 595.83 and 146.33 mg EGA / g dry extract, in the BERM, AEERM and PEERM
respectively. The qualitative analysis of the three methanolic crude extract via thin layer
chromatography (TLC) has shown the presence of the anthocyanidin 3-glycosids, flavons et
flavonols glycosids (hétérosids), flavonols avec 3-OH libre, flavonons ou aurons, isoflavons, the
phénolic acids, Flavonols et 4-OH chalcons. The évaluation of antioxidant activity by the
reduction of free radical DPPH method showed that The highest DPPH radical scavenging
activity was observed with AEERM (IC50 = 0.126 ± 0.002 mg/ ml), followed by BERM (0.135
± 0.0006 mg/ ml) and PEERM (IC50 =0.185± 0.002 mg/ ml). The study of preventive effect of
AEERM on oxidative stress induced by DOX in wistar rats clearly show that DOX (15 mg/kg
i.p) induced animal cardiotoxicity characterized by an increase of cardiac enzyme activity
(CKMB, LDH, l’ALAT et l’ASAT) in serum, the increase in the concentration of
malondialdéhyde (MDA), antioxydant enzyme activity, catalase (CAT) and Glutathion- Stransférase (GST) and a decrease of cardiac cytosolic reduced glutathione (GSH) with a different
pathological changes in the heart. However pretreated animals with EAERM (100 mg/kg orally
during 15 days), showed a decrease of cardiac enzymes activities 24 %, 35, 69%, 21,25 % et
8,10 % respectively to CKMB, LDH, l’ALAT and l’ASAT. The preatretment with the extract
improved antioxidant status in the heart by a decrease in the cardiac MDA concentration by 29,7
% and activity of antioxydants enzymes by 17,91% et 29,78% respectively to CAT et la GST.
In addition, the pretreated rats by the extract showed an increase of GSH level (83,76 %)
compared with DOX-treated animals. Histological study shows that the extract resulted in a
reduction of severe cardiac damages observed in DOX-treated animals. The reversal of
multidrug resistance for DOX in human ovarian adenocarcinoma, cell lines (A2780 DX3) using
MTT assay showed that AEERM was very effective at reversing the resistant in dose dependent
manner with the Reversion Factor (RF =8.62, 05.77 and 02.30 respectively for the
concentrations 40, 10 and 2.5 mg/ml) followed by BERM (FR=05.07 and 02.43 for the
concentrations 40 and 10 mg/ml respectively), then the PEERM had the lowest reversal
resistance effect (RF betwen 1.01 to 1.08). The present study suggests that AEERM can
ameliorate the oxidative stress involved in the pathogenesis of doxorubicine- induced
cardiotoxicity and can reverse the multidrug resistance for DOX.
Diplôme : Doctorat en sciences En ligne : ../theses/biologie/KAR7158.pdf Format de la ressource électronique : Permalink : https://bu.umc.edu.dz/md/index.php?lvl=notice_display&id=10435 Effet des extraits de la plante médicinale Ruta montana) (الفيجلsur la cardiotoxicité induite par la doxorubicine et sur la multi-drug résistances (MDR) des cellules cancéreuses ovarien (A2780) [texte imprimé] / Wahiba Kara Ali, Auteur ; N. Abidli, Directeur de thèse . - [S.l.] : جامعة الإخوة منتوري قسنطينة, 2017 . - 160 f. ; 30 cm.
2 copies imprimées disponibles
Langues : Français (fre)
Catégories : Français - Anglais
BiologieTags : Ruta montana Doxorubicine Cardiotoxicité Multi-drug résistance Stress oxydant Antioxydant Flavonoides Cardiotoxicity Multidrug resistance Oxidative
stress Antioxidant Flavonoids ????????????? ?????? ??????? ???????? ???????? ??????? ??????? ???????? ?????? ?????? ???????Index. décimale : 570 Sciences de la vie. Biologie Résumé : This study was conducted to search for the preventive effect of medicinal plant Ruta montana
extract on oxidative stress induced by doxorubicine (DOX) and its properties to reverse
doxorubicin resistance in ovarian cancer cell line (A2780). Organic extracts were obtained by
maceration with three solvents: petroleum ether, ethyl acetate and butanol. The yields were:
15,04%, 3,55% and 25,14%.respectively. A phytochemical screening in methanol extract
revealed that the plant contain the flavonoids, saponins, tannins, coumarins, reducing component
and the alkaloids. The quantitative study showed that the butanolic extract (BERM) has
significant amount of flavonoids (80.85±0.78mg EQ / g dry extract), followed by ethyl acetate
extract (AEERM) (15.27 ±0.62 EQ / g dry extract) and petroleum ether extract has the lowest
flavonoids content (PEERM) (9.71±1.13 mgEQ/g dry extract). When the total phenolic contents
was: 687.5, 595.83 and 146.33 mg EGA / g dry extract, in the BERM, AEERM and PEERM
respectively. The qualitative analysis of the three methanolic crude extract via thin layer
chromatography (TLC) has shown the presence of the anthocyanidin 3-glycosids, flavons et
flavonols glycosids (hétérosids), flavonols avec 3-OH libre, flavonons ou aurons, isoflavons, the
phénolic acids, Flavonols et 4-OH chalcons. The évaluation of antioxidant activity by the
reduction of free radical DPPH method showed that The highest DPPH radical scavenging
activity was observed with AEERM (IC50 = 0.126 ± 0.002 mg/ ml), followed by BERM (0.135
± 0.0006 mg/ ml) and PEERM (IC50 =0.185± 0.002 mg/ ml). The study of preventive effect of
AEERM on oxidative stress induced by DOX in wistar rats clearly show that DOX (15 mg/kg
i.p) induced animal cardiotoxicity characterized by an increase of cardiac enzyme activity
(CKMB, LDH, l’ALAT et l’ASAT) in serum, the increase in the concentration of
malondialdéhyde (MDA), antioxydant enzyme activity, catalase (CAT) and Glutathion- Stransférase (GST) and a decrease of cardiac cytosolic reduced glutathione (GSH) with a different
pathological changes in the heart. However pretreated animals with EAERM (100 mg/kg orally
during 15 days), showed a decrease of cardiac enzymes activities 24 %, 35, 69%, 21,25 % et
8,10 % respectively to CKMB, LDH, l’ALAT and l’ASAT. The preatretment with the extract
improved antioxidant status in the heart by a decrease in the cardiac MDA concentration by 29,7
% and activity of antioxydants enzymes by 17,91% et 29,78% respectively to CAT et la GST.
In addition, the pretreated rats by the extract showed an increase of GSH level (83,76 %)
compared with DOX-treated animals. Histological study shows that the extract resulted in a
reduction of severe cardiac damages observed in DOX-treated animals. The reversal of
multidrug resistance for DOX in human ovarian adenocarcinoma, cell lines (A2780 DX3) using
MTT assay showed that AEERM was very effective at reversing the resistant in dose dependent
manner with the Reversion Factor (RF =8.62, 05.77 and 02.30 respectively for the
concentrations 40, 10 and 2.5 mg/ml) followed by BERM (FR=05.07 and 02.43 for the
concentrations 40 and 10 mg/ml respectively), then the PEERM had the lowest reversal
resistance effect (RF betwen 1.01 to 1.08). The present study suggests that AEERM can
ameliorate the oxidative stress involved in the pathogenesis of doxorubicine- induced
cardiotoxicity and can reverse the multidrug resistance for DOX.
Diplôme : Doctorat en sciences En ligne : ../theses/biologie/KAR7158.pdf Format de la ressource électronique : Permalink : https://bu.umc.edu.dz/md/index.php?lvl=notice_display&id=10435 Exemplaires
Code-barres Cote Support Localisation Section Disponibilité aucun exemplaire
Titre : L'effet préventif des flavonoïdes et des phénols de thé vert (Camellia sinensis (L.) Kuntze) sur le cancer de la prostate chez une population de l'Est Algérien : étude épidémiologique et étude expérimentale in vitro et in humaine Type de document : texte imprimé Auteurs : Somia Lassed, Auteur ; Djamila Zama, Directeur de thèse Editeur : جامعة الإخوة منتوري قسنطينة Année de publication : 2017 Note générale : 2 copies imprimées disponibles
Langues : Français (fre) Catégories : Français - Anglais
BiologieTags : Cancer de la prostate stress oxydant thé vert chimioprévention Algérie Prostate cancer oxidative stress green tea chemoprevention Algeria ????? ?????????? ??????? ???????? ????? ?????? ??????? ????????? ??????? Index. décimale : 570 Sciences de la vie. Biologie Résumé : In Algeria, prostate cancer is the fourth most common cancer and the sixth leading cause of
death in men. The objective of the current study is to determine the relationship between lifestyle
factors, family history, diet including green tea consumption and the risk of prostate cancer and to
evaluate the preventive effect of green tea on prostate cancer in the East Algerian population.
The epidemiological approach carried out on a representative sample of East Algerian
population consists of 90 patients with prostate cancer and 190 controls shows that ageing,
consumption of lamb and beef and high intake of animal fat and dairy products increase the risk
of prostate cancer. Contrary, 7 to 13 servings of vegetables per week and 14 servings or more
decrease 62% and 96% of the risk of prostate cancer respectively. Also, the consumption of 7 to
14 servings of fruit per week decreases 98% of the risk. Consumption of green tea reduced the
risk of prostate cancer, but the results were statistically limited. A high risk has been observed in
men with a family history of prostate cancer. A positive association was also found for alcohol
and smoking intake and a dose-response relationship existed for quantity and history of smoking.
Our intervention study include 70 patients with prostate cancer and 120 controls of East Algerian
population and which precedes by an in vitro study shows that oxidative stress can be associated
with the development and progression of prostate cancer in our population. Also, the consumption
of green tea which is rich in phenols and flavonoids and which exhibits potent antioxidant and
anti-cancer activities in our in vitro study can have a protective effect against this disease via the
reduction of oxidative stress. Consumption of 2 to 3 cups of green tea per day for 6 months
significantly increases the level of GSH, total thiols and catalase and GPx activity and
significantly decreases the level of MDA in the blood of patients with prostate cancer. In addition
it also improves the level of albumin and total protein in plasma.
Faced to the limitations of the treatments currently used for cancer, chemoprevention remains
the only solution. Regular consumption of green tea for a long period may prevent men from
developing prostate cancer or at least delay its progression.Diplôme : Doctorat En ligne : ../theses/biologie/LAS7067.pdf Format de la ressource électronique : Permalink : https://bu.umc.edu.dz/md/index.php?lvl=notice_display&id=10534 L'effet préventif des flavonoïdes et des phénols de thé vert (Camellia sinensis (L.) Kuntze) sur le cancer de la prostate chez une population de l'Est Algérien : étude épidémiologique et étude expérimentale in vitro et in humaine [texte imprimé] / Somia Lassed, Auteur ; Djamila Zama, Directeur de thèse . - [S.l.] : جامعة الإخوة منتوري قسنطينة, 2017.
2 copies imprimées disponibles
Langues : Français (fre)
Catégories : Français - Anglais
BiologieTags : Cancer de la prostate stress oxydant thé vert chimioprévention Algérie Prostate cancer oxidative stress green tea chemoprevention Algeria ????? ?????????? ??????? ???????? ????? ?????? ??????? ????????? ??????? Index. décimale : 570 Sciences de la vie. Biologie Résumé : In Algeria, prostate cancer is the fourth most common cancer and the sixth leading cause of
death in men. The objective of the current study is to determine the relationship between lifestyle
factors, family history, diet including green tea consumption and the risk of prostate cancer and to
evaluate the preventive effect of green tea on prostate cancer in the East Algerian population.
The epidemiological approach carried out on a representative sample of East Algerian
population consists of 90 patients with prostate cancer and 190 controls shows that ageing,
consumption of lamb and beef and high intake of animal fat and dairy products increase the risk
of prostate cancer. Contrary, 7 to 13 servings of vegetables per week and 14 servings or more
decrease 62% and 96% of the risk of prostate cancer respectively. Also, the consumption of 7 to
14 servings of fruit per week decreases 98% of the risk. Consumption of green tea reduced the
risk of prostate cancer, but the results were statistically limited. A high risk has been observed in
men with a family history of prostate cancer. A positive association was also found for alcohol
and smoking intake and a dose-response relationship existed for quantity and history of smoking.
Our intervention study include 70 patients with prostate cancer and 120 controls of East Algerian
population and which precedes by an in vitro study shows that oxidative stress can be associated
with the development and progression of prostate cancer in our population. Also, the consumption
of green tea which is rich in phenols and flavonoids and which exhibits potent antioxidant and
anti-cancer activities in our in vitro study can have a protective effect against this disease via the
reduction of oxidative stress. Consumption of 2 to 3 cups of green tea per day for 6 months
significantly increases the level of GSH, total thiols and catalase and GPx activity and
significantly decreases the level of MDA in the blood of patients with prostate cancer. In addition
it also improves the level of albumin and total protein in plasma.
Faced to the limitations of the treatments currently used for cancer, chemoprevention remains
the only solution. Regular consumption of green tea for a long period may prevent men from
developing prostate cancer or at least delay its progression.Diplôme : Doctorat En ligne : ../theses/biologie/LAS7067.pdf Format de la ressource électronique : Permalink : https://bu.umc.edu.dz/md/index.php?lvl=notice_display&id=10534 Exemplaires (1)
Code-barres Cote Support Localisation Section Disponibilité LAS/7067 LAS/7067 Thèse Bibliothèque principale Thèses Disponible
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