| Titre : |
Corrélations entre le comportement dépressif, le profil lipidique et les paramètres du stress oxydatif au cours du diabète expérimental : Effet protecteur de la mélatonine et de la fluoxétine |
| Type de document : |
texte imprimé |
| Auteurs : |
Redouane Rebai, Auteur ; Abedenacer Boudah, Directeur de thèse |
| Editeur : |
جامعة الإخوة منتوري قسنطينة |
| Année de publication : |
2017 |
| Importance : |
117 f. |
| Format : |
30 cm. |
| Note générale : |
2 copies imprimées disponibles
|
| Langues : |
Français (fre) |
| Catégories : |
Français - Anglais
Biologie
|
| Tags : |
Diabète sucré Dépression Mélatonine Fluoxétine Désordres métaboliques Stress oxydatif Diabetes mellitus Depression Melatonin Fluoxetine Metabolic disorders Oxidative stress داء السكري الميلاتونين الفلوكستين مستوى الدهون الإجهاد التأكسدي |
| Index. décimale : |
570 Sciences de la vie. Biologie |
| Résumé : |
The chronic hyperglycemia is accompanied by excessive production of free radicals by
various mechanisms. This is an indicator of the oxidative stress that is involved in the
worsening of chronic complications related to diabetes mellitus. The objective of this study is
to evaluate the beneficial effects of melatonin and fluoxetine on metabolic disorders induced
by diabetes, as well as on the parameters of oxidative stress that could play a causal role in the
appearance of depressive behavior in rats rendered diabetic following an intraperitoneal
injection of streptozotocin (60 mg / kg). After 72 hours, the diabetic rats were treated with
melatonin and fluoxetine for 4 weeks. Behavioral tests such as the elevated plus maze (EPM),
the open field (OFT) and forced swimming (FST) were performed during the last week of
treatment to verify the antidepressant and anxiolytic effects of these two drugs.
At the end of this experiment, blood samples were taken for the determination of some
biochemical parameters, as well as the determination of oxidative stress markers in
erythrocytes, prefrontal cortex and hippocampus.
Our results showed that treatment with melatonin and fluoxetine significantly improved
anxiety behavior in diabetic rats during EPM and OFT, the same treatment was able to
reverse depressive behavior in the FST.
It was also noted that both treatments exert a regulating effect on blood glucose and lipid
profile parameters, thus these two drugs decrease erythrocyte lipoperoxidation and improve
the antioxidant status in the cerebral structures involved in the pathophysiology of depression
However, all these results clearly show that melatonin is endowed with a more potent
antioxidant activity than that of fluoxetine, and thus it would have an antidepressant effect. |
| Diplôme : |
Doctorat |
| En ligne : |
../theses/biologie/REB7079.pdf |
| Format de la ressource électronique : |
pdf |
| Permalink : |
index.php?lvl=notice_display&id=10522 |
Corrélations entre le comportement dépressif, le profil lipidique et les paramètres du stress oxydatif au cours du diabète expérimental : Effet protecteur de la mélatonine et de la fluoxétine [texte imprimé] / Redouane Rebai, Auteur ; Abedenacer Boudah, Directeur de thèse . - جامعة الإخوة منتوري قسنطينة, 2017 . - 117 f. ; 30 cm. 2 copies imprimées disponibles
Langues : Français ( fre)
| Catégories : |
Français - Anglais
Biologie
|
| Tags : |
Diabète sucré Dépression Mélatonine Fluoxétine Désordres métaboliques Stress oxydatif Diabetes mellitus Depression Melatonin Fluoxetine Metabolic disorders Oxidative stress داء السكري الميلاتونين الفلوكستين مستوى الدهون الإجهاد التأكسدي |
| Index. décimale : |
570 Sciences de la vie. Biologie |
| Résumé : |
The chronic hyperglycemia is accompanied by excessive production of free radicals by
various mechanisms. This is an indicator of the oxidative stress that is involved in the
worsening of chronic complications related to diabetes mellitus. The objective of this study is
to evaluate the beneficial effects of melatonin and fluoxetine on metabolic disorders induced
by diabetes, as well as on the parameters of oxidative stress that could play a causal role in the
appearance of depressive behavior in rats rendered diabetic following an intraperitoneal
injection of streptozotocin (60 mg / kg). After 72 hours, the diabetic rats were treated with
melatonin and fluoxetine for 4 weeks. Behavioral tests such as the elevated plus maze (EPM),
the open field (OFT) and forced swimming (FST) were performed during the last week of
treatment to verify the antidepressant and anxiolytic effects of these two drugs.
At the end of this experiment, blood samples were taken for the determination of some
biochemical parameters, as well as the determination of oxidative stress markers in
erythrocytes, prefrontal cortex and hippocampus.
Our results showed that treatment with melatonin and fluoxetine significantly improved
anxiety behavior in diabetic rats during EPM and OFT, the same treatment was able to
reverse depressive behavior in the FST.
It was also noted that both treatments exert a regulating effect on blood glucose and lipid
profile parameters, thus these two drugs decrease erythrocyte lipoperoxidation and improve
the antioxidant status in the cerebral structures involved in the pathophysiology of depression
However, all these results clearly show that melatonin is endowed with a more potent
antioxidant activity than that of fluoxetine, and thus it would have an antidepressant effect. |
| Diplôme : |
Doctorat |
| En ligne : |
../theses/biologie/REB7079.pdf |
| Format de la ressource électronique : |
pdf |
| Permalink : |
index.php?lvl=notice_display&id=10522 |
|
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