| Titre : |
L'effet préventif des flavonoïdes et des phénols de thé vert (Camellia sinensis (L.) Kuntze) sur le cancer de la prostate chez une population de l'Est Algérien : étude épidémiologique et étude expérimentale in vitro et in humaine |
| Type de document : |
texte imprimé |
| Auteurs : |
Somia Lassed, Auteur ; Djamila Zama, Directeur de thèse |
| Editeur : |
جامعة الإخوة منتوري قسنطينة |
| Année de publication : |
2017 |
| Note générale : |
2 copies imprimées disponibles
|
| Langues : |
Français (fre) |
| Catégories : |
Français - Anglais
Biologie
|
| Tags : |
Cancer de la prostate stress oxydant thé vert chimioprévention Algérie Prostate cancer oxidative stress green tea chemoprevention Algeria سرطان البروستاتا الإجھاد التأكسدي الشاي الأخضر الوقایة الكیماویة الجزائر |
| Index. décimale : |
570 Sciences de la vie. Biologie |
| Résumé : |
In Algeria, prostate cancer is the fourth most common cancer and the sixth leading cause of
death in men. The objective of the current study is to determine the relationship between lifestyle
factors, family history, diet including green tea consumption and the risk of prostate cancer and to
evaluate the preventive effect of green tea on prostate cancer in the East Algerian population.
The epidemiological approach carried out on a representative sample of East Algerian
population consists of 90 patients with prostate cancer and 190 controls shows that ageing,
consumption of lamb and beef and high intake of animal fat and dairy products increase the risk
of prostate cancer. Contrary, 7 to 13 servings of vegetables per week and 14 servings or more
decrease 62% and 96% of the risk of prostate cancer respectively. Also, the consumption of 7 to
14 servings of fruit per week decreases 98% of the risk. Consumption of green tea reduced the
risk of prostate cancer, but the results were statistically limited. A high risk has been observed in
men with a family history of prostate cancer. A positive association was also found for alcohol
and smoking intake and a dose-response relationship existed for quantity and history of smoking.
Our intervention study include 70 patients with prostate cancer and 120 controls of East Algerian
population and which precedes by an in vitro study shows that oxidative stress can be associated
with the development and progression of prostate cancer in our population. Also, the consumption
of green tea which is rich in phenols and flavonoids and which exhibits potent antioxidant and
anti-cancer activities in our in vitro study can have a protective effect against this disease via the
reduction of oxidative stress. Consumption of 2 to 3 cups of green tea per day for 6 months
significantly increases the level of GSH, total thiols and catalase and GPx activity and
significantly decreases the level of MDA in the blood of patients with prostate cancer. In addition
it also improves the level of albumin and total protein in plasma.
Faced to the limitations of the treatments currently used for cancer, chemoprevention remains
the only solution. Regular consumption of green tea for a long period may prevent men from
developing prostate cancer or at least delay its progression. |
| Diplôme : |
Doctorat |
| En ligne : |
../theses/biologie/LAS7067.pdf |
| Format de la ressource électronique : |
pdf |
| Permalink : |
index.php?lvl=notice_display&id=10534 |
L'effet préventif des flavonoïdes et des phénols de thé vert (Camellia sinensis (L.) Kuntze) sur le cancer de la prostate chez une population de l'Est Algérien : étude épidémiologique et étude expérimentale in vitro et in humaine [texte imprimé] / Somia Lassed, Auteur ; Djamila Zama, Directeur de thèse . - جامعة الإخوة منتوري قسنطينة, 2017. 2 copies imprimées disponibles
Langues : Français ( fre)
| Catégories : |
Français - Anglais
Biologie
|
| Tags : |
Cancer de la prostate stress oxydant thé vert chimioprévention Algérie Prostate cancer oxidative stress green tea chemoprevention Algeria سرطان البروستاتا الإجھاد التأكسدي الشاي الأخضر الوقایة الكیماویة الجزائر |
| Index. décimale : |
570 Sciences de la vie. Biologie |
| Résumé : |
In Algeria, prostate cancer is the fourth most common cancer and the sixth leading cause of
death in men. The objective of the current study is to determine the relationship between lifestyle
factors, family history, diet including green tea consumption and the risk of prostate cancer and to
evaluate the preventive effect of green tea on prostate cancer in the East Algerian population.
The epidemiological approach carried out on a representative sample of East Algerian
population consists of 90 patients with prostate cancer and 190 controls shows that ageing,
consumption of lamb and beef and high intake of animal fat and dairy products increase the risk
of prostate cancer. Contrary, 7 to 13 servings of vegetables per week and 14 servings or more
decrease 62% and 96% of the risk of prostate cancer respectively. Also, the consumption of 7 to
14 servings of fruit per week decreases 98% of the risk. Consumption of green tea reduced the
risk of prostate cancer, but the results were statistically limited. A high risk has been observed in
men with a family history of prostate cancer. A positive association was also found for alcohol
and smoking intake and a dose-response relationship existed for quantity and history of smoking.
Our intervention study include 70 patients with prostate cancer and 120 controls of East Algerian
population and which precedes by an in vitro study shows that oxidative stress can be associated
with the development and progression of prostate cancer in our population. Also, the consumption
of green tea which is rich in phenols and flavonoids and which exhibits potent antioxidant and
anti-cancer activities in our in vitro study can have a protective effect against this disease via the
reduction of oxidative stress. Consumption of 2 to 3 cups of green tea per day for 6 months
significantly increases the level of GSH, total thiols and catalase and GPx activity and
significantly decreases the level of MDA in the blood of patients with prostate cancer. In addition
it also improves the level of albumin and total protein in plasma.
Faced to the limitations of the treatments currently used for cancer, chemoprevention remains
the only solution. Regular consumption of green tea for a long period may prevent men from
developing prostate cancer or at least delay its progression. |
| Diplôme : |
Doctorat |
| En ligne : |
../theses/biologie/LAS7067.pdf |
| Format de la ressource électronique : |
pdf |
| Permalink : |
index.php?lvl=notice_display&id=10534 |
|
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