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Titre : Gènes de prédisposition au cancer prostatique. Type de document : texte imprimé Auteurs : Somia Medjani, Auteur ; Djalila Rezgoune-Chellat, Directeur de thèse Mention d'édition : 24/10/2019 Editeur : جامعة الإخوة منتوري قسنطينة Année de publication : 2019 Importance : 145 f. Format : 30 cm. Note générale : Doctorat 3éme CYCLE LMD.
1 copies imprimées disponibles
Langues : Français (fre) Catégories : Français - Anglais
BiologieTags : Biologie Animale:Génétique Moléculaire cancer de la prostate facteurs de risque polymorphisme CYP1A1 T3801C GSTM1 GSTT1 VEGF -2578C/A PCR/RFLP PCR multiplexe prostate cancer risk factors polymorphism multiplex PCR سرطان البروستاتا عوامل الخطر التعدد الأليلي GSTT1
multiplexe PCR. VEGIndex. décimale : 570 Sciences de la vie. Biologie Résumé : Prostate cancer is currently the most frequently diagnosed cancer and is the leading cause of death in men. In this sense, the objective of our work was to identify, through two statistical studies, some risk factors and histopathological parameters, as well as the possible involvement of genes encoding detoxification enzymes (CYP1A1, GSTM1 and GSTT1) and gene encoding a factor of angiogenesis (-2587C/A of VEGF) and the occurrence of prostate cancer after molecular analysis using the PCR/RFLP technique and multiplex PCR. The statistical study demonstrated an increase in the rate of prostate cancer from the age 60 years old with means age of 71.66±7.99. On the other hand, the presence of family history, smoking and occupational exposure (truck driver, builder, painter, farmer….) are recorded as risk factors implicated in this cancer. Also the sporadic form is the most common form in prostates cancers. Furthermore, the most prostate cancer are adenocarcinoma at the prostatic capsule (PSA >10 ng/ml ; Gleason Score8 ≤ GS ≤ 10). Finally, the genetic analysis of patients and controls for the studied genes presented by the pvalue indicates that no association between the deletion of GSTM1 and the CYP1A1 3801T>C variant and prostate carcinogenesis. However, the deletion of GSTT1 and the double deletion of GSTM1/GSTT1 are involved in the development of prostate cancer. Thus the results of the VEGF-2578C/A variant show a significant difference with susceptibility to prostate cancer. Note de contenu : Annexes. Diplôme : Doctorat En ligne : ../theses/biologie/MED7571.pdf Format de la ressource électronique : Permalink : index.php?lvl=notice_display&id=11409 Gènes de prédisposition au cancer prostatique. [texte imprimé] / Somia Medjani, Auteur ; Djalila Rezgoune-Chellat, Directeur de thèse . - 24/10/2019 . - جامعة الإخوة منتوري قسنطينة, 2019 . - 145 f. ; 30 cm.
Doctorat 3éme CYCLE LMD.
1 copies imprimées disponibles
Langues : Français (fre)
Catégories : Français - Anglais
BiologieTags : Biologie Animale:Génétique Moléculaire cancer de la prostate facteurs de risque polymorphisme CYP1A1 T3801C GSTM1 GSTT1 VEGF -2578C/A PCR/RFLP PCR multiplexe prostate cancer risk factors polymorphism multiplex PCR سرطان البروستاتا عوامل الخطر التعدد الأليلي GSTT1
multiplexe PCR. VEGIndex. décimale : 570 Sciences de la vie. Biologie Résumé : Prostate cancer is currently the most frequently diagnosed cancer and is the leading cause of death in men. In this sense, the objective of our work was to identify, through two statistical studies, some risk factors and histopathological parameters, as well as the possible involvement of genes encoding detoxification enzymes (CYP1A1, GSTM1 and GSTT1) and gene encoding a factor of angiogenesis (-2587C/A of VEGF) and the occurrence of prostate cancer after molecular analysis using the PCR/RFLP technique and multiplex PCR. The statistical study demonstrated an increase in the rate of prostate cancer from the age 60 years old with means age of 71.66±7.99. On the other hand, the presence of family history, smoking and occupational exposure (truck driver, builder, painter, farmer….) are recorded as risk factors implicated in this cancer. Also the sporadic form is the most common form in prostates cancers. Furthermore, the most prostate cancer are adenocarcinoma at the prostatic capsule (PSA >10 ng/ml ; Gleason Score8 ≤ GS ≤ 10). Finally, the genetic analysis of patients and controls for the studied genes presented by the pvalue indicates that no association between the deletion of GSTM1 and the CYP1A1 3801T>C variant and prostate carcinogenesis. However, the deletion of GSTT1 and the double deletion of GSTM1/GSTT1 are involved in the development of prostate cancer. Thus the results of the VEGF-2578C/A variant show a significant difference with susceptibility to prostate cancer. Note de contenu : Annexes. Diplôme : Doctorat En ligne : ../theses/biologie/MED7571.pdf Format de la ressource électronique : Permalink : index.php?lvl=notice_display&id=11409 Exemplaires (1)
Code-barres Cote Support Localisation Section Disponibilité MED/7571 MED/7571 Thèse Bibliothèque principale Thèses Disponible
Titre : Cancer de la prostate : gènes de susceptibilité et marqueurs génétiques. Type de document : texte imprimé Auteurs : Samah Tellouche ép Bouhouhou, Auteur ; Djalila Rezgoune-Chellat, Directeur de thèse ; Abderezzak Dahdouh, Directeur de thèse Editeur : جامعة الإخوة منتوري قسنطينة Année de publication : 2019 Importance : 130 f. Format : 30 cm. Note générale : Doctorat 3éme CYCLE.
2 copies imprimées disponibles
Langues : Français (fre) Catégories : Français - Anglais
BiologieTags : Biologie Animale:Génétique Moléculaire cancer de la prostate anatomopathologie polymorphisme MTHFR XRCC4 PCR/RFLP Prostate cancer Anatomopathology Polymorphism سرطان البروستاتا التشريح المرضي للأنسجة التعدد الأليلي PCR Index. décimale : 570 Sciences de la vie. Biologie Résumé : Prostate cancer is one of the most common malignant cancers among men. Age,ethnicity and family history are the established risk factors. The objective of this study was to realize a clinical-pathological study and to examine through molecular analysis of the possible combination between MTHFR C677T and XRCC4 G-1394T polymorphisms with the risk of prostate cancer among Algerian men. Methods: This case control study was conducted on 120 patients with prostate cancer and 101 controls. Clinical-pathological study was conducted using a questionnaire and consulting medical records. Anatomo-pathological study has been carried out by exploring surgical specimens. With regard to molecular analysis, genomic DNA was extracted by NaCl method and identification of polymorphisms in the MTHFR and XRCC4 genes for patients and controls has been carried out by using PCR-RFLP technique. Results: In Algeria, prostate cancer affects men at age the 50 and more. We found that the risk of this cancer increases significantly among alcoholics. 20,83% of patients with a family history of prostate cancer and 47,49% with other pathologies (Hypertention, Diabetes 1 and 2, heart disease). 75% of patients have abnormal RT at diagnosis. More than half of patients (58,33%) with PSA levels above 50 ng/ml. According to Gleason score, there are as many moderately differentiated adenocarcinoma as little or no differentiated adenocarcinoma. 64,16% of patients at a late stage and distant metastasis, underlining delayed diagnosis in our country. For the MTHFR C677T polymorphism, we found that the heterozygotes 677CT could be a risk factor for prostate cancer (p = 0,04; OR= 2,01, 95% IC: 1,02- 3,95). However, no association was observed between XRCC4 G-1394T polymorphism and the risk of prostate cancer (p = 0,26; OR= 0,52, 95% IC: 0,17-1,49). Conclusion: Our results seem to indicate that the risk of prostate cancer increase with alcohol consumption. In addition, genes polymorphisms could play a role in prostate carcinogenesis underscoring the importance of genetic screening. Note de contenu : Annexes. Diplôme : Doctorat En ligne : ../theses/biologie/TEL7479.pdf Format de la ressource électronique : Permalink : index.php?lvl=notice_display&id=11311 Cancer de la prostate : gènes de susceptibilité et marqueurs génétiques. [texte imprimé] / Samah Tellouche ép Bouhouhou, Auteur ; Djalila Rezgoune-Chellat, Directeur de thèse ; Abderezzak Dahdouh, Directeur de thèse . - جامعة الإخوة منتوري قسنطينة, 2019 . - 130 f. ; 30 cm.
Doctorat 3éme CYCLE.
2 copies imprimées disponibles
Langues : Français (fre)
Catégories : Français - Anglais
BiologieTags : Biologie Animale:Génétique Moléculaire cancer de la prostate anatomopathologie polymorphisme MTHFR XRCC4 PCR/RFLP Prostate cancer Anatomopathology Polymorphism سرطان البروستاتا التشريح المرضي للأنسجة التعدد الأليلي PCR Index. décimale : 570 Sciences de la vie. Biologie Résumé : Prostate cancer is one of the most common malignant cancers among men. Age,ethnicity and family history are the established risk factors. The objective of this study was to realize a clinical-pathological study and to examine through molecular analysis of the possible combination between MTHFR C677T and XRCC4 G-1394T polymorphisms with the risk of prostate cancer among Algerian men. Methods: This case control study was conducted on 120 patients with prostate cancer and 101 controls. Clinical-pathological study was conducted using a questionnaire and consulting medical records. Anatomo-pathological study has been carried out by exploring surgical specimens. With regard to molecular analysis, genomic DNA was extracted by NaCl method and identification of polymorphisms in the MTHFR and XRCC4 genes for patients and controls has been carried out by using PCR-RFLP technique. Results: In Algeria, prostate cancer affects men at age the 50 and more. We found that the risk of this cancer increases significantly among alcoholics. 20,83% of patients with a family history of prostate cancer and 47,49% with other pathologies (Hypertention, Diabetes 1 and 2, heart disease). 75% of patients have abnormal RT at diagnosis. More than half of patients (58,33%) with PSA levels above 50 ng/ml. According to Gleason score, there are as many moderately differentiated adenocarcinoma as little or no differentiated adenocarcinoma. 64,16% of patients at a late stage and distant metastasis, underlining delayed diagnosis in our country. For the MTHFR C677T polymorphism, we found that the heterozygotes 677CT could be a risk factor for prostate cancer (p = 0,04; OR= 2,01, 95% IC: 1,02- 3,95). However, no association was observed between XRCC4 G-1394T polymorphism and the risk of prostate cancer (p = 0,26; OR= 0,52, 95% IC: 0,17-1,49). Conclusion: Our results seem to indicate that the risk of prostate cancer increase with alcohol consumption. In addition, genes polymorphisms could play a role in prostate carcinogenesis underscoring the importance of genetic screening. Note de contenu : Annexes. Diplôme : Doctorat En ligne : ../theses/biologie/TEL7479.pdf Format de la ressource électronique : Permalink : index.php?lvl=notice_display&id=11311 Exemplaires (1)
Code-barres Cote Support Localisation Section Disponibilité TEL/7479 TEL/7479 Thèse Bibliothèque principale Thèses Disponible L'effet préventif des flavonoïdes et des phénols de thé vert (Camellia sinensis (L.) Kuntze) sur le cancer de la prostate chez une population de l'Est Algérien / Somia Lassed
Titre : L'effet préventif des flavonoïdes et des phénols de thé vert (Camellia sinensis (L.) Kuntze) sur le cancer de la prostate chez une population de l'Est Algérien : étude épidémiologique et étude expérimentale in vitro et in humaine Type de document : texte imprimé Auteurs : Somia Lassed, Auteur ; Djamila Zama, Directeur de thèse Editeur : جامعة الإخوة منتوري قسنطينة Année de publication : 2017 Note générale : 2 copies imprimées disponibles
Langues : Français (fre) Catégories : Français - Anglais
BiologieTags : Cancer de la prostate stress oxydant thé vert chimioprévention Algérie Prostate cancer oxidative stress green tea chemoprevention Algeria سرطان البروستاتا الإجھاد التأكسدي الشاي الأخضر الوقایة الكیماویة الجزائر Index. décimale : 570 Sciences de la vie. Biologie Résumé : In Algeria, prostate cancer is the fourth most common cancer and the sixth leading cause of
death in men. The objective of the current study is to determine the relationship between lifestyle
factors, family history, diet including green tea consumption and the risk of prostate cancer and to
evaluate the preventive effect of green tea on prostate cancer in the East Algerian population.
The epidemiological approach carried out on a representative sample of East Algerian
population consists of 90 patients with prostate cancer and 190 controls shows that ageing,
consumption of lamb and beef and high intake of animal fat and dairy products increase the risk
of prostate cancer. Contrary, 7 to 13 servings of vegetables per week and 14 servings or more
decrease 62% and 96% of the risk of prostate cancer respectively. Also, the consumption of 7 to
14 servings of fruit per week decreases 98% of the risk. Consumption of green tea reduced the
risk of prostate cancer, but the results were statistically limited. A high risk has been observed in
men with a family history of prostate cancer. A positive association was also found for alcohol
and smoking intake and a dose-response relationship existed for quantity and history of smoking.
Our intervention study include 70 patients with prostate cancer and 120 controls of East Algerian
population and which precedes by an in vitro study shows that oxidative stress can be associated
with the development and progression of prostate cancer in our population. Also, the consumption
of green tea which is rich in phenols and flavonoids and which exhibits potent antioxidant and
anti-cancer activities in our in vitro study can have a protective effect against this disease via the
reduction of oxidative stress. Consumption of 2 to 3 cups of green tea per day for 6 months
significantly increases the level of GSH, total thiols and catalase and GPx activity and
significantly decreases the level of MDA in the blood of patients with prostate cancer. In addition
it also improves the level of albumin and total protein in plasma.
Faced to the limitations of the treatments currently used for cancer, chemoprevention remains
the only solution. Regular consumption of green tea for a long period may prevent men from
developing prostate cancer or at least delay its progression.Diplôme : Doctorat En ligne : ../theses/biologie/LAS7067.pdf Format de la ressource électronique : Permalink : index.php?lvl=notice_display&id=10534 L'effet préventif des flavonoïdes et des phénols de thé vert (Camellia sinensis (L.) Kuntze) sur le cancer de la prostate chez une population de l'Est Algérien : étude épidémiologique et étude expérimentale in vitro et in humaine [texte imprimé] / Somia Lassed, Auteur ; Djamila Zama, Directeur de thèse . - جامعة الإخوة منتوري قسنطينة, 2017.
2 copies imprimées disponibles
Langues : Français (fre)
Catégories : Français - Anglais
BiologieTags : Cancer de la prostate stress oxydant thé vert chimioprévention Algérie Prostate cancer oxidative stress green tea chemoprevention Algeria سرطان البروستاتا الإجھاد التأكسدي الشاي الأخضر الوقایة الكیماویة الجزائر Index. décimale : 570 Sciences de la vie. Biologie Résumé : In Algeria, prostate cancer is the fourth most common cancer and the sixth leading cause of
death in men. The objective of the current study is to determine the relationship between lifestyle
factors, family history, diet including green tea consumption and the risk of prostate cancer and to
evaluate the preventive effect of green tea on prostate cancer in the East Algerian population.
The epidemiological approach carried out on a representative sample of East Algerian
population consists of 90 patients with prostate cancer and 190 controls shows that ageing,
consumption of lamb and beef and high intake of animal fat and dairy products increase the risk
of prostate cancer. Contrary, 7 to 13 servings of vegetables per week and 14 servings or more
decrease 62% and 96% of the risk of prostate cancer respectively. Also, the consumption of 7 to
14 servings of fruit per week decreases 98% of the risk. Consumption of green tea reduced the
risk of prostate cancer, but the results were statistically limited. A high risk has been observed in
men with a family history of prostate cancer. A positive association was also found for alcohol
and smoking intake and a dose-response relationship existed for quantity and history of smoking.
Our intervention study include 70 patients with prostate cancer and 120 controls of East Algerian
population and which precedes by an in vitro study shows that oxidative stress can be associated
with the development and progression of prostate cancer in our population. Also, the consumption
of green tea which is rich in phenols and flavonoids and which exhibits potent antioxidant and
anti-cancer activities in our in vitro study can have a protective effect against this disease via the
reduction of oxidative stress. Consumption of 2 to 3 cups of green tea per day for 6 months
significantly increases the level of GSH, total thiols and catalase and GPx activity and
significantly decreases the level of MDA in the blood of patients with prostate cancer. In addition
it also improves the level of albumin and total protein in plasma.
Faced to the limitations of the treatments currently used for cancer, chemoprevention remains
the only solution. Regular consumption of green tea for a long period may prevent men from
developing prostate cancer or at least delay its progression.Diplôme : Doctorat En ligne : ../theses/biologie/LAS7067.pdf Format de la ressource électronique : Permalink : index.php?lvl=notice_display&id=10534 Exemplaires (1)
Code-barres Cote Support Localisation Section Disponibilité LAS/7067 LAS/7067 Thèse Bibliothèque principale Thèses Disponible
