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Titre : Cancer de la prostate : gènes de susceptibilité et marqueurs génétiques. Type de document : texte imprimé Auteurs : Samah Tellouche ép Bouhouhou, Auteur ; Djalila Rezgoune-Chellat, Directeur de thèse ; Abderezzak Dahdouh, Directeur de thèse Editeur : جامعة الإخوة منتوري قسنطينة Année de publication : 2019 Importance : 130 f. Format : 30 cm. Note générale : Doctorat 3éme CYCLE.
2 copies imprimées disponibles
Langues : Français (fre) Catégories : Français - Anglais
BiologieTags : Biologie Animale:Génétique Moléculaire cancer de la prostate anatomopathologie polymorphisme MTHFR XRCC4 PCR/RFLP Prostate cancer Anatomopathology Polymorphism سرطان البروستاتا التشريح المرضي للأنسجة التعدد الأليلي PCR Index. décimale : 570 Sciences de la vie. Biologie Résumé : Prostate cancer is one of the most common malignant cancers among men. Age,ethnicity and family history are the established risk factors. The objective of this study was to realize a clinical-pathological study and to examine through molecular analysis of the possible combination between MTHFR C677T and XRCC4 G-1394T polymorphisms with the risk of prostate cancer among Algerian men. Methods: This case control study was conducted on 120 patients with prostate cancer and 101 controls. Clinical-pathological study was conducted using a questionnaire and consulting medical records. Anatomo-pathological study has been carried out by exploring surgical specimens. With regard to molecular analysis, genomic DNA was extracted by NaCl method and identification of polymorphisms in the MTHFR and XRCC4 genes for patients and controls has been carried out by using PCR-RFLP technique. Results: In Algeria, prostate cancer affects men at age the 50 and more. We found that the risk of this cancer increases significantly among alcoholics. 20,83% of patients with a family history of prostate cancer and 47,49% with other pathologies (Hypertention, Diabetes 1 and 2, heart disease). 75% of patients have abnormal RT at diagnosis. More than half of patients (58,33%) with PSA levels above 50 ng/ml. According to Gleason score, there are as many moderately differentiated adenocarcinoma as little or no differentiated adenocarcinoma. 64,16% of patients at a late stage and distant metastasis, underlining delayed diagnosis in our country. For the MTHFR C677T polymorphism, we found that the heterozygotes 677CT could be a risk factor for prostate cancer (p = 0,04; OR= 2,01, 95% IC: 1,02- 3,95). However, no association was observed between XRCC4 G-1394T polymorphism and the risk of prostate cancer (p = 0,26; OR= 0,52, 95% IC: 0,17-1,49). Conclusion: Our results seem to indicate that the risk of prostate cancer increase with alcohol consumption. In addition, genes polymorphisms could play a role in prostate carcinogenesis underscoring the importance of genetic screening. Note de contenu : Annexes. Diplôme : Doctorat En ligne : ../theses/biologie/TEL7479.pdf Format de la ressource électronique : Permalink : https://bu.umc.edu.dz/md/index.php?lvl=notice_display&id=11311 Cancer de la prostate : gènes de susceptibilité et marqueurs génétiques. [texte imprimé] / Samah Tellouche ép Bouhouhou, Auteur ; Djalila Rezgoune-Chellat, Directeur de thèse ; Abderezzak Dahdouh, Directeur de thèse . - جامعة الإخوة منتوري قسنطينة, 2019 . - 130 f. ; 30 cm.
Doctorat 3éme CYCLE.
2 copies imprimées disponibles
Langues : Français (fre)
Catégories : Français - Anglais
BiologieTags : Biologie Animale:Génétique Moléculaire cancer de la prostate anatomopathologie polymorphisme MTHFR XRCC4 PCR/RFLP Prostate cancer Anatomopathology Polymorphism سرطان البروستاتا التشريح المرضي للأنسجة التعدد الأليلي PCR Index. décimale : 570 Sciences de la vie. Biologie Résumé : Prostate cancer is one of the most common malignant cancers among men. Age,ethnicity and family history are the established risk factors. The objective of this study was to realize a clinical-pathological study and to examine through molecular analysis of the possible combination between MTHFR C677T and XRCC4 G-1394T polymorphisms with the risk of prostate cancer among Algerian men. Methods: This case control study was conducted on 120 patients with prostate cancer and 101 controls. Clinical-pathological study was conducted using a questionnaire and consulting medical records. Anatomo-pathological study has been carried out by exploring surgical specimens. With regard to molecular analysis, genomic DNA was extracted by NaCl method and identification of polymorphisms in the MTHFR and XRCC4 genes for patients and controls has been carried out by using PCR-RFLP technique. Results: In Algeria, prostate cancer affects men at age the 50 and more. We found that the risk of this cancer increases significantly among alcoholics. 20,83% of patients with a family history of prostate cancer and 47,49% with other pathologies (Hypertention, Diabetes 1 and 2, heart disease). 75% of patients have abnormal RT at diagnosis. More than half of patients (58,33%) with PSA levels above 50 ng/ml. According to Gleason score, there are as many moderately differentiated adenocarcinoma as little or no differentiated adenocarcinoma. 64,16% of patients at a late stage and distant metastasis, underlining delayed diagnosis in our country. For the MTHFR C677T polymorphism, we found that the heterozygotes 677CT could be a risk factor for prostate cancer (p = 0,04; OR= 2,01, 95% IC: 1,02- 3,95). However, no association was observed between XRCC4 G-1394T polymorphism and the risk of prostate cancer (p = 0,26; OR= 0,52, 95% IC: 0,17-1,49). Conclusion: Our results seem to indicate that the risk of prostate cancer increase with alcohol consumption. In addition, genes polymorphisms could play a role in prostate carcinogenesis underscoring the importance of genetic screening. Note de contenu : Annexes. Diplôme : Doctorat En ligne : ../theses/biologie/TEL7479.pdf Format de la ressource électronique : Permalink : https://bu.umc.edu.dz/md/index.php?lvl=notice_display&id=11311 Exemplaires (1)
Code-barres Cote Support Localisation Section Disponibilité TEL/7479 TEL/7479 Thèse Bibliothèque principale Thèses Disponible
Titre : Caractérisation moléculaire des gènes impliqués dans le cancer du rein. Type de document : texte imprimé Auteurs : Fatima Zohra Bensouilah, Auteur ; Djalila Chellat, Directeur de thèse Mention d'édition : 26 / 09 /2021 Editeur : جامعة الإخوة منتوري قسنطينة Année de publication : 2021 Importance : 104 f. Format : 30 cm. Note générale : Doctorat 3éme CYCLE LMD.
1 copies imprimées disponibles
Langues : Français (fre) Catégories : Français - Anglais
BiologieTags : Biologie Animale:Génétique Moléculaire Carcinomes à cellules rénales Polymorphisme Sequenome iPLEX ATM ALDH9A1 VEGF VHL. Renal cell carcinoma Polymorphism سرطان الخلايا الكلوية التعدد الإليلي Index. décimale : 570 Sciences de la vie. Biologie Résumé : Renal Cell Carcinoma (RCC) also called renal adenocarcinoma and accounts for 90 à 95% of primary malignant kidney tumors. It's the 14th most common cancer in the world, and the third of urological malignant tumors after prostate cancer and bladder cancer. Several environmental and genetic risk factors are potentially involved in renal carcinogenesis. Recently, several genome-wide association studies (GWAS) were conducted in the aim to identify additional new risk loci for RCC. In this sense, the objective of our work was to identify, through two statistical studies, some risk factors and histopathological parameters, as well as the possible involvement of genes encoding angiogenesis (VHL, VEGF and EPAS1), DNA repair (ATM, LRRIQ4), metabolism (ALDH9A1), apoptosis (FAF1, RHOBTB and LRRIQ4), chromatin remodeling complex (DPF3), telomere length regulation (OBFC1), and the occurrence of kidney cancer after molecular analysis using the sequenom iPLEX. The statistical study demonstrated an increase in the rate of renal cancer from the age 50years old with means age of 56.37±13.70. Higher incidences were reported in men than women (odds ratio: 1.35). Also, the sporadic form is the most common form in renal cancers. Furthermore, the most common type of RCC is clear cell renal carcinoma. On the other hand, the genetic analysis of patients and controls for the studied genes presented by the p-value indicates that no association between gene polymorphisms (VEGF, VHL, FAF1, LRRIQ4, RHOBTB2, OBFC1, DPF3 and EPSA1) and renal carcinogenesis. However, the results of the ATM rs1800057 variant showed a significant difference with susceptibility to kidney cancer. Thus, the polymorphism rs3845536 of the ALDH9A1 gene seems to have a protective effect against the RCC in our population.
Note de contenu :
Annexes.
Diplôme : Doctorat En ligne : ../theses/biologie/BEN7833.pdf Format de la ressource électronique : Permalink : https://bu.umc.edu.dz/md/index.php?lvl=notice_display&id=11665 Caractérisation moléculaire des gènes impliqués dans le cancer du rein. [texte imprimé] / Fatima Zohra Bensouilah, Auteur ; Djalila Chellat, Directeur de thèse . - 26 / 09 /2021 . - جامعة الإخوة منتوري قسنطينة, 2021 . - 104 f. ; 30 cm.
Doctorat 3éme CYCLE LMD.
1 copies imprimées disponibles
Langues : Français (fre)
Catégories : Français - Anglais
BiologieTags : Biologie Animale:Génétique Moléculaire Carcinomes à cellules rénales Polymorphisme Sequenome iPLEX ATM ALDH9A1 VEGF VHL. Renal cell carcinoma Polymorphism سرطان الخلايا الكلوية التعدد الإليلي Index. décimale : 570 Sciences de la vie. Biologie Résumé : Renal Cell Carcinoma (RCC) also called renal adenocarcinoma and accounts for 90 à 95% of primary malignant kidney tumors. It's the 14th most common cancer in the world, and the third of urological malignant tumors after prostate cancer and bladder cancer. Several environmental and genetic risk factors are potentially involved in renal carcinogenesis. Recently, several genome-wide association studies (GWAS) were conducted in the aim to identify additional new risk loci for RCC. In this sense, the objective of our work was to identify, through two statistical studies, some risk factors and histopathological parameters, as well as the possible involvement of genes encoding angiogenesis (VHL, VEGF and EPAS1), DNA repair (ATM, LRRIQ4), metabolism (ALDH9A1), apoptosis (FAF1, RHOBTB and LRRIQ4), chromatin remodeling complex (DPF3), telomere length regulation (OBFC1), and the occurrence of kidney cancer after molecular analysis using the sequenom iPLEX. The statistical study demonstrated an increase in the rate of renal cancer from the age 50years old with means age of 56.37±13.70. Higher incidences were reported in men than women (odds ratio: 1.35). Also, the sporadic form is the most common form in renal cancers. Furthermore, the most common type of RCC is clear cell renal carcinoma. On the other hand, the genetic analysis of patients and controls for the studied genes presented by the p-value indicates that no association between gene polymorphisms (VEGF, VHL, FAF1, LRRIQ4, RHOBTB2, OBFC1, DPF3 and EPSA1) and renal carcinogenesis. However, the results of the ATM rs1800057 variant showed a significant difference with susceptibility to kidney cancer. Thus, the polymorphism rs3845536 of the ALDH9A1 gene seems to have a protective effect against the RCC in our population.
Note de contenu :
Annexes.
Diplôme : Doctorat En ligne : ../theses/biologie/BEN7833.pdf Format de la ressource électronique : Permalink : https://bu.umc.edu.dz/md/index.php?lvl=notice_display&id=11665 Exemplaires (1)
Code-barres Cote Support Localisation Section Disponibilité BEN/7833 BEN/7833 Thèse Bibliothèque principale Thèses Disponible
Titre : Génétique mitochondriale des infertilités masculines Type de document : texte imprimé Auteurs : Mohamed Larbi Rezgoune, Auteur ; Dalila Satta, Directeur de thèse ; Abdelhamid Slama, Directeur de thèse Editeur : جامعة الإخوة منتوري قسنطينة Année de publication : 2016 Importance : 187 f. Format : 30 cm. Note générale : 2 copies imprimées disponibles
Langues : Français (fre) Catégories : Français - Anglais
BiologieTags : mitochondrie polymorphisme infertilité masculine biologie moléculaire mitochondria polymorphism male infertility molecular biology الميتوكوندري تعدد الاشكال الجيني اصطرابات الخصوبة عند الرجال البيولوجيا الجزيئية Index. décimale : 570 Sciences de la vie. Biologie Résumé : Mitochondria play a central role in energy metabolism, homeostasis and apoptosis.
These functions are in part under the control of a mitochondrial genome, support of cytoplasmic heredity, whose transmission is only maternal. The involvement of these organelles in human reproduction is a relatively new concept that arouses scientific and medical interest. Abnormalities both qualitative and quantitative of mitochondrial DNA (mtDNA) have been associated with male fertility disorders.
Infertility concerns 10 to 15 % of couples wishing to have a child, a male component is found
in almost half of cases. In a significant proportion of these cases, a known genetic basis,
chromosomal or gene, sometimes transmitted from the parents, is involved.
In this work, in a first part, different genetic polymorphisms in humans: (CAG)n POLG1,T3801C CYP1A1 and MTHFR A1298C, and their role as potential risk factors for male infertility in an Algerian population cohort were studied by sequencing or RFLP.
Our results show that the variants described at the MTHFR and CYP1A1 genes are not associated with male infertility unlike that of POLG1 which appears to be involved in this dysfunction.
In the second part of our work, we have prospected qualitative alterations of mitochondrial
genome by analysis of macro-deletions by long PCR and quantitative by quantification of leukocyte mtDNA rate by real-time quantitative PCR (mitochondrial DNA vs nuclear) in idiopathic male infertility. The mtDNA deletion does not appear to be associated with this disorder but the assessment of the level of leukocyte mtDNA likely suggests the involvement of this parameter in male infertility especially in azoospermic and asthenospermic men.
Molecular biology has led to the discovery of unexplored etiologies until now without denigrating the clinical and biological explanatory value of many recognized etiologies.
This mitochondrial molecular appearance misunderstood opens up new perspectives and may in the future introduce profound changes in the genetic approach to male infertility.
Diplôme : Doctorat en sciences En ligne : ../theses/biologie/REZ7000.pdf Format de la ressource électronique : Permalink : https://bu.umc.edu.dz/md/index.php?lvl=notice_display&id=10389 Génétique mitochondriale des infertilités masculines [texte imprimé] / Mohamed Larbi Rezgoune, Auteur ; Dalila Satta, Directeur de thèse ; Abdelhamid Slama, Directeur de thèse . - جامعة الإخوة منتوري قسنطينة, 2016 . - 187 f. ; 30 cm.
2 copies imprimées disponibles
Langues : Français (fre)
Catégories : Français - Anglais
BiologieTags : mitochondrie polymorphisme infertilité masculine biologie moléculaire mitochondria polymorphism male infertility molecular biology الميتوكوندري تعدد الاشكال الجيني اصطرابات الخصوبة عند الرجال البيولوجيا الجزيئية Index. décimale : 570 Sciences de la vie. Biologie Résumé : Mitochondria play a central role in energy metabolism, homeostasis and apoptosis.
These functions are in part under the control of a mitochondrial genome, support of cytoplasmic heredity, whose transmission is only maternal. The involvement of these organelles in human reproduction is a relatively new concept that arouses scientific and medical interest. Abnormalities both qualitative and quantitative of mitochondrial DNA (mtDNA) have been associated with male fertility disorders.
Infertility concerns 10 to 15 % of couples wishing to have a child, a male component is found
in almost half of cases. In a significant proportion of these cases, a known genetic basis,
chromosomal or gene, sometimes transmitted from the parents, is involved.
In this work, in a first part, different genetic polymorphisms in humans: (CAG)n POLG1,T3801C CYP1A1 and MTHFR A1298C, and their role as potential risk factors for male infertility in an Algerian population cohort were studied by sequencing or RFLP.
Our results show that the variants described at the MTHFR and CYP1A1 genes are not associated with male infertility unlike that of POLG1 which appears to be involved in this dysfunction.
In the second part of our work, we have prospected qualitative alterations of mitochondrial
genome by analysis of macro-deletions by long PCR and quantitative by quantification of leukocyte mtDNA rate by real-time quantitative PCR (mitochondrial DNA vs nuclear) in idiopathic male infertility. The mtDNA deletion does not appear to be associated with this disorder but the assessment of the level of leukocyte mtDNA likely suggests the involvement of this parameter in male infertility especially in azoospermic and asthenospermic men.
Molecular biology has led to the discovery of unexplored etiologies until now without denigrating the clinical and biological explanatory value of many recognized etiologies.
This mitochondrial molecular appearance misunderstood opens up new perspectives and may in the future introduce profound changes in the genetic approach to male infertility.
Diplôme : Doctorat en sciences En ligne : ../theses/biologie/REZ7000.pdf Format de la ressource électronique : Permalink : https://bu.umc.edu.dz/md/index.php?lvl=notice_display&id=10389 Exemplaires (1)
Code-barres Cote Support Localisation Section Disponibilité REZ/7000 REZ/7000 Thèse Bibliothèque principale Thèses Disponible
Titre : Seuil de détection du goût des lipides et corpulence. Type de document : texte imprimé Auteurs : Ouassila Allam, Auteur ; Hayet Oulamara, Directeur de thèse ; Naim Akhtar Khan, Directeur de thèse Mention d'édition : 30 /09/ 2021 Editeur : جامعة الإخوة منتوري قسنطينة Année de publication : 2021 Importance : 153 f. Format : 30 cm. Note générale : Doctorat 3éme CYCLE LMD.
1 copies imprimées disponibles
Langues : Français (fre) Catégories : Français - Anglais
Nutrition, Alimentation et Technologies Agro-AlimentairesTags : Nutrition Humaine: Nutrition Humaine goût lipides sensibilité seuil détection IMC apports obésité polymorphisme taste lipids sensitivity detection threshold BMI nutritional intake obesity polymorphism "
الذوق الدهون الحساسية عتبة الكشف مؤشر كتلة الجسم السمنة تعدد الأشكالIndex. décimale : 640 Industrie Alimentaire Résumé : The main objective of this study is to investigate the relationship between fat detection threshold and weight status of adult women The study included 140 women aged from 18 to 50 years old. Exclusion criterias were considered. Weight and height were measured to calculate BMI. Overweight is defined by a BMI 25 and obesity by a BMI 30. The three alternative forced choice (3-AFC) method has been adapted to determine detection thresholds. Individuals were classified DV K\SRVHQVLWLYH mM and hypersensitive < 3 mM. Lipid perception intensity was measured by a gLMS intensity scale. Nutritional intakes were assessed by a 24 hour foodconsumption diaries repeated 3 times. The level of preference towards fatty foods was assessed by a preference questionnaire. Tongue photography was taken to count fungiform papillae. Two polymorphisms of the CD36 gene were studied (rs1761667 and rs1527483) by real-time PCR. The association of the two polymorphisms with obesity has been investigated in 50 women. Statistical analysis is performed with SPSS software. Our results confirm the association between lipid detection thresholds and weight status of women. The anthropometric parameters (BMI, waist circumference, waist circumference / hip circumference ratio and waist circumference / height ratio) are positively associated with the fat detection threshold. Obese participants are the least sensitive to fat taste. Better sensitivity to oleic acid is associated with better intensity of perception and identification of fat in food. Obese subjects have the lowest lipid perception intensity. Impaired lipid detection is possibly related to overweight in adults. Lipids hyposensitivity has been linked to higher intakes of overall energy and fat intake. It is also linked to higher preference for pure fat and salty-fat foods. Reduced taste density is associated with low taste sensitivity and overweight. Obese
people consume more energy and fat and have a greater preference for fat. The study of polymorphism of the two variants-CD36 gene (rs1761667 and rs1527483) confirms its involvement in obesity in our population.
Note de contenu : Annexes. Diplôme : Doctorat En ligne : ../theses/agronomie/ALL7813.pdf Format de la ressource électronique : Permalink : https://bu.umc.edu.dz/md/index.php?lvl=notice_display&id=11645 Seuil de détection du goût des lipides et corpulence. [texte imprimé] / Ouassila Allam, Auteur ; Hayet Oulamara, Directeur de thèse ; Naim Akhtar Khan, Directeur de thèse . - 30 /09/ 2021 . - جامعة الإخوة منتوري قسنطينة, 2021 . - 153 f. ; 30 cm.
Doctorat 3éme CYCLE LMD.
1 copies imprimées disponibles
Langues : Français (fre)
Catégories : Français - Anglais
Nutrition, Alimentation et Technologies Agro-AlimentairesTags : Nutrition Humaine: Nutrition Humaine goût lipides sensibilité seuil détection IMC apports obésité polymorphisme taste lipids sensitivity detection threshold BMI nutritional intake obesity polymorphism "
الذوق الدهون الحساسية عتبة الكشف مؤشر كتلة الجسم السمنة تعدد الأشكالIndex. décimale : 640 Industrie Alimentaire Résumé : The main objective of this study is to investigate the relationship between fat detection threshold and weight status of adult women The study included 140 women aged from 18 to 50 years old. Exclusion criterias were considered. Weight and height were measured to calculate BMI. Overweight is defined by a BMI 25 and obesity by a BMI 30. The three alternative forced choice (3-AFC) method has been adapted to determine detection thresholds. Individuals were classified DV K\SRVHQVLWLYH mM and hypersensitive < 3 mM. Lipid perception intensity was measured by a gLMS intensity scale. Nutritional intakes were assessed by a 24 hour foodconsumption diaries repeated 3 times. The level of preference towards fatty foods was assessed by a preference questionnaire. Tongue photography was taken to count fungiform papillae. Two polymorphisms of the CD36 gene were studied (rs1761667 and rs1527483) by real-time PCR. The association of the two polymorphisms with obesity has been investigated in 50 women. Statistical analysis is performed with SPSS software. Our results confirm the association between lipid detection thresholds and weight status of women. The anthropometric parameters (BMI, waist circumference, waist circumference / hip circumference ratio and waist circumference / height ratio) are positively associated with the fat detection threshold. Obese participants are the least sensitive to fat taste. Better sensitivity to oleic acid is associated with better intensity of perception and identification of fat in food. Obese subjects have the lowest lipid perception intensity. Impaired lipid detection is possibly related to overweight in adults. Lipids hyposensitivity has been linked to higher intakes of overall energy and fat intake. It is also linked to higher preference for pure fat and salty-fat foods. Reduced taste density is associated with low taste sensitivity and overweight. Obese
people consume more energy and fat and have a greater preference for fat. The study of polymorphism of the two variants-CD36 gene (rs1761667 and rs1527483) confirms its involvement in obesity in our population.
Note de contenu : Annexes. Diplôme : Doctorat En ligne : ../theses/agronomie/ALL7813.pdf Format de la ressource électronique : Permalink : https://bu.umc.edu.dz/md/index.php?lvl=notice_display&id=11645 Exemplaires (1)
Code-barres Cote Support Localisation Section Disponibilité ALL/7813 ALL/7813 Thèse Bibliothèque principale Thèses Disponible Comportement alimentaire et signalisation via le récepteur TGR5 de l’homéostasie lipido-glucidique et énergétique et polymorphisme dans l’obésité. / Adel Bensalem
Titre : Comportement alimentaire et signalisation via le récepteur TGR5 de l’homéostasie lipido-glucidique et énergétique et polymorphisme dans l’obésité. Type de document : texte imprimé Auteurs : Adel Bensalem, Auteur ; Abdel-Nacer Agli, Directeur de thèse ; Naim Akhtar Khan, Directeur de thèse Mention d'édition : 10/02/2021 Editeur : جامعة الإخوة منتوري قسنطينة Année de publication : 2021 Importance : 181 f. Format : 30 cm. Note générale : 1 copies imprimées disponibles
Langues : Français (fre) Catégories : Français - Anglais
Nutrition, Alimentation et Technologies Agro-AlimentairesTags : Nutrition Humaine: Sciences Alimentaires obésité comportement alimentaire appétit repas récepteur TGR5 préférences alimentaires polymorphisme obesity eating behavior appetite meals TGR5 receptor dietary preferences polymorphism السمنة سلوك الغذائي الشهية الوجبة مستقبل TGR5التفضيلات الغذائية تعدد الأشكال الجيني Index. décimale : 640 Industrie Alimentaire Résumé :
Our work consists of studying the behavioral determinants of appetite and the involvement of the bile acid receptor TGR5 in the modulation of food preferences and its association with obesity. A survey on eating behavior and assessment of subjective and objective appetite was conducted among 208 young adults. Subjective feelings of appetite were estimated by scores on a visual analog scale and objective appetite was estimated by nutrient intake and interprandial intervals. The identification of a signaling pathway via the TGR5 receptor in lipid-glucidic homeostasis and its implication in the modulation of dietary preferences and in obesity was carried out in WT and TGR5-/- mice. The association of the TGR5 gene polymorphism with obesity has been investigated in 127 children. Food consumption depends on the subjective sensations of appetite, and the preprandial duration. Stress induces overconsumption of energy. Consumption habits and the importance given to meals favored more energy consumption. The subjective satiation score is associated with nutritional intake. The gustatory pleasure score is correlated with protein and lipid intake. Gastric fullness is correlated with fiber intake. The energy density of dishes has a positive influence on satiation and negatively on gastric fullness. Only the sensation of gustatory pleasure is influenced by the pleasantness of the dish served. Postprandial duration is positively correlated with subjective satiation score and gustatory pleasure, but not with gastric fullness.The proteins had presented a satiating effect and a satietogenic power more important, than those of the carbohydrates and the lipids. The deletion of the TGR5 gene associated with a high fat diet, leads to a decrease in energy expenditure, and an imbalance of carbohydrate-lipid and energy homeostasis, as well as a decrease in the secretion of GLP-1. To which are added inflammatory effects and hepatic steatosis. Indeed, TGR5 is also involved in the control of dietary fat intake through its involvement in the physiology of taste buds. The study of the single nucleotide polymorphism of TGR5 (SNP rs11554825) further confirms its involvement in childhood obesity.
Diplôme : Doctorat en sciences En ligne : ../theses/agronomie/BEN7712.pdf Format de la ressource électronique : Permalink : https://bu.umc.edu.dz/md/index.php?lvl=notice_display&id=11546 Comportement alimentaire et signalisation via le récepteur TGR5 de l’homéostasie lipido-glucidique et énergétique et polymorphisme dans l’obésité. [texte imprimé] / Adel Bensalem, Auteur ; Abdel-Nacer Agli, Directeur de thèse ; Naim Akhtar Khan, Directeur de thèse . - 10/02/2021 . - جامعة الإخوة منتوري قسنطينة, 2021 . - 181 f. ; 30 cm.
1 copies imprimées disponibles
Langues : Français (fre)
Catégories : Français - Anglais
Nutrition, Alimentation et Technologies Agro-AlimentairesTags : Nutrition Humaine: Sciences Alimentaires obésité comportement alimentaire appétit repas récepteur TGR5 préférences alimentaires polymorphisme obesity eating behavior appetite meals TGR5 receptor dietary preferences polymorphism السمنة سلوك الغذائي الشهية الوجبة مستقبل TGR5التفضيلات الغذائية تعدد الأشكال الجيني Index. décimale : 640 Industrie Alimentaire Résumé :
Our work consists of studying the behavioral determinants of appetite and the involvement of the bile acid receptor TGR5 in the modulation of food preferences and its association with obesity. A survey on eating behavior and assessment of subjective and objective appetite was conducted among 208 young adults. Subjective feelings of appetite were estimated by scores on a visual analog scale and objective appetite was estimated by nutrient intake and interprandial intervals. The identification of a signaling pathway via the TGR5 receptor in lipid-glucidic homeostasis and its implication in the modulation of dietary preferences and in obesity was carried out in WT and TGR5-/- mice. The association of the TGR5 gene polymorphism with obesity has been investigated in 127 children. Food consumption depends on the subjective sensations of appetite, and the preprandial duration. Stress induces overconsumption of energy. Consumption habits and the importance given to meals favored more energy consumption. The subjective satiation score is associated with nutritional intake. The gustatory pleasure score is correlated with protein and lipid intake. Gastric fullness is correlated with fiber intake. The energy density of dishes has a positive influence on satiation and negatively on gastric fullness. Only the sensation of gustatory pleasure is influenced by the pleasantness of the dish served. Postprandial duration is positively correlated with subjective satiation score and gustatory pleasure, but not with gastric fullness.The proteins had presented a satiating effect and a satietogenic power more important, than those of the carbohydrates and the lipids. The deletion of the TGR5 gene associated with a high fat diet, leads to a decrease in energy expenditure, and an imbalance of carbohydrate-lipid and energy homeostasis, as well as a decrease in the secretion of GLP-1. To which are added inflammatory effects and hepatic steatosis. Indeed, TGR5 is also involved in the control of dietary fat intake through its involvement in the physiology of taste buds. The study of the single nucleotide polymorphism of TGR5 (SNP rs11554825) further confirms its involvement in childhood obesity.
Diplôme : Doctorat en sciences En ligne : ../theses/agronomie/BEN7712.pdf Format de la ressource électronique : Permalink : https://bu.umc.edu.dz/md/index.php?lvl=notice_display&id=11546 Exemplaires (1)
Code-barres Cote Support Localisation Section Disponibilité BEN/7712 BEN/7712 Thèse Bibliothèque principale Thèses Disponible
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