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Partager le résultat de cette recherche Interroger des sources externesContribution à l’étude des facteurs de risque des pathologies dominantes en élevage laitier dans les wilayas de Biskra et de Constantine / Adel Mammeri
Titre : Contribution à l’étude des facteurs de risque des pathologies dominantes en élevage laitier dans les wilayas de Biskra et de Constantine Type de document : texte imprimé Auteurs : Adel Mammeri, Auteur ; Abdelmalek Benmakhlouf, Directeur de thèse Editeur : جامعة الإخوة منتوري قسنطينة Année de publication : 2016 Importance : 259 f. Format : 30 cm. Note générale : 2 copies imprimées disponibles
Langues : Français (fre) Catégories : Français - Anglais
Sciences VétérinairesTags : facteurs de risque pathologies dominantes enquêtes élevage bovin élevage
camelin Biskra Constantine risk factors dominant pathologies investigations cattle breeding camel
breeding عوامل الخطر الأمراض المھیمنة تحقیق تربیة الأبقار تربیة الإبل بسكرة قسنطینةIndex. décimale : 636 Sciences Vétérinaires Résumé : This study that extends from 2012 to 2015, is a contribution to the study of dominant
pathologies risk factors among cattle and camel herds. It is performed via surveys among 62
cattle farms in the wilayas of Biskra (n=56) and Constantine (n=6), and 10 camel herds in the
region of Biskra. Also, physicochemical and microbiological analyses including the detection
and enumeration of (Staphylococcus spp., Salmonella, molds and yeasts) were realized on
samples of milk and animal feeds. Statistical analyses were performed with SPSS 18 and 20. The
investigations either in Biskra, or Constantine, revealed several deficiencies in livestock
hygiene and feeding, the mycological and possibly mycotoxinic risks are very high.The
microbiological quality of analyzed milk and water samples, is generally acceptable concerning
Salmonella and complies with the recommendations of A.O.J.R. (Salmonella = Zero). However,
contamination of milk by the kind Staphylocuccus seems to be high, thus giving evidence of the
existence of several cases of subclinical mastitis in cows and she-camels, and alarms us the
existence of high risk of human contaminations. The improvement of dairy farming in the
regions of Biskra and Constantine, deserves more efforts, either from the competent authorities,
through vulgarization sessions, and register visits, or from the breeders, who should be better
informed on this sector, ask for the support of communal vulgarization officers, and
finally, respect the modern cattle industry standards and enhanced control of the suitable
rationing methods of their livestock. The region of Biskra, is more adequate to expect a
rapid improvement of periurban breeding of camel, but there remains much to control the
dominant camelids pathologies and related risk factors, particularly by stricter
management of herds feeding.
Diplôme : Doctorat en sciences En ligne : ../theses/veterinaire/MAM7090.pdf Format de la ressource électronique : Permalink : index.php?lvl=notice_display&id=10504 Contribution à l’étude des facteurs de risque des pathologies dominantes en élevage laitier dans les wilayas de Biskra et de Constantine [texte imprimé] / Adel Mammeri, Auteur ; Abdelmalek Benmakhlouf, Directeur de thèse . - جامعة الإخوة منتوري قسنطينة, 2016 . - 259 f. ; 30 cm.
2 copies imprimées disponibles
Langues : Français (fre)
Catégories : Français - Anglais
Sciences VétérinairesTags : facteurs de risque pathologies dominantes enquêtes élevage bovin élevage
camelin Biskra Constantine risk factors dominant pathologies investigations cattle breeding camel
breeding عوامل الخطر الأمراض المھیمنة تحقیق تربیة الأبقار تربیة الإبل بسكرة قسنطینةIndex. décimale : 636 Sciences Vétérinaires Résumé : This study that extends from 2012 to 2015, is a contribution to the study of dominant
pathologies risk factors among cattle and camel herds. It is performed via surveys among 62
cattle farms in the wilayas of Biskra (n=56) and Constantine (n=6), and 10 camel herds in the
region of Biskra. Also, physicochemical and microbiological analyses including the detection
and enumeration of (Staphylococcus spp., Salmonella, molds and yeasts) were realized on
samples of milk and animal feeds. Statistical analyses were performed with SPSS 18 and 20. The
investigations either in Biskra, or Constantine, revealed several deficiencies in livestock
hygiene and feeding, the mycological and possibly mycotoxinic risks are very high.The
microbiological quality of analyzed milk and water samples, is generally acceptable concerning
Salmonella and complies with the recommendations of A.O.J.R. (Salmonella = Zero). However,
contamination of milk by the kind Staphylocuccus seems to be high, thus giving evidence of the
existence of several cases of subclinical mastitis in cows and she-camels, and alarms us the
existence of high risk of human contaminations. The improvement of dairy farming in the
regions of Biskra and Constantine, deserves more efforts, either from the competent authorities,
through vulgarization sessions, and register visits, or from the breeders, who should be better
informed on this sector, ask for the support of communal vulgarization officers, and
finally, respect the modern cattle industry standards and enhanced control of the suitable
rationing methods of their livestock. The region of Biskra, is more adequate to expect a
rapid improvement of periurban breeding of camel, but there remains much to control the
dominant camelids pathologies and related risk factors, particularly by stricter
management of herds feeding.
Diplôme : Doctorat en sciences En ligne : ../theses/veterinaire/MAM7090.pdf Format de la ressource électronique : Permalink : index.php?lvl=notice_display&id=10504 Exemplaires (1)
Code-barres Cote Support Localisation Section Disponibilité MAM7090 MAM7090 Thèse Bibliothèque principale Thèses Disponible
Titre : L’obésité de l’adolescent Constantinois : étude épidémiologique, prédisposition génétique, hormonale, et conséquences métaboliques Type de document : texte imprimé Auteurs : Hadjer Daoudi, Auteur ; Leïla Rouabah, Directeur de thèse Editeur : جامعة الإخوة منتوري قسنطينة Année de publication : 2016 Importance : 152 f. Format : 30 cm. Note générale : 2 copies imprimées disponibles
Langues : Français (fre) Catégories : Français - Anglais
BiologieTags : adolescence surpoids obésité puberté fréquence facteurs de risques goût du
gras CD36 overweight obesity puberty frequency risk factors taste of fat المراهقة زٌادة الوزن السمنة سن البلوغ عوامل الخطر الدهونIndex. décimale : 570 Sciences de la vie. Biologie Résumé : Overweight and obesity in adolescence often persist into adulthood and it’s accompanied by risks of increased morbidity and mortality in patients being overweight or obese in adolescence.
A cross-sectional study with single elementary sampling nominative list of all college students enrolled in the academic year 2012/2013 has allowed us to estimate the frequency of overweight and obesity in teenagers of Constantine. For that 457 teenagers were recruited.
The frequency of overweight and obesity according to the 2007 WHO reference z-score, is respectively 18.2% and 13.2%, including 1.8% with severe obesity. Overweight and obesity are more prevalent in boys than in girls. Obesity is more common among adolescents who don’t respect the main meal of the day and those who don’t take their family meals. The obese have low nutritional knowledge and less physical activity compared to leans ones. Birth order may be identified as a risk factor. Obesity is more common among adolescents who have
parents with a higher socio-economic and socio-professional status. Breast feeding plays an essential role in the prevention of overweight in childhood and adolescence. Birth weight would influence the weight at the age of 5 and 10 years and at adolescence, anxiety of obese adolescents associated with poor felt the denial of the image of their own body size may increase overweight and obesity among these. Puberty is a critical period in the development of obesity.
The genotype of CD36 gene lingual, rs1761667 (AA) could be responsible for the low
detection of lipids and encourage teenagers to over-consume fat to have the same appreciation that subjects with the other two AG and GG genotypes.
Obesity in adolescence seems to play an important role in predicting very slight increase in glucose and lipid values, insulin and inflammatory, confirming the deleterious role of excess weight on biological data.
Through measures as dietary and behavioral, we can fight effectively against long-term obesity in adolescents.
Diplôme : Doctorat En ligne : ../theses/biologie/DAO6866.pdf Format de la ressource électronique : Permalink : index.php?lvl=notice_display&id=10180 L’obésité de l’adolescent Constantinois : étude épidémiologique, prédisposition génétique, hormonale, et conséquences métaboliques [texte imprimé] / Hadjer Daoudi, Auteur ; Leïla Rouabah, Directeur de thèse . - جامعة الإخوة منتوري قسنطينة, 2016 . - 152 f. ; 30 cm.
2 copies imprimées disponibles
Langues : Français (fre)
Catégories : Français - Anglais
BiologieTags : adolescence surpoids obésité puberté fréquence facteurs de risques goût du
gras CD36 overweight obesity puberty frequency risk factors taste of fat المراهقة زٌادة الوزن السمنة سن البلوغ عوامل الخطر الدهونIndex. décimale : 570 Sciences de la vie. Biologie Résumé : Overweight and obesity in adolescence often persist into adulthood and it’s accompanied by risks of increased morbidity and mortality in patients being overweight or obese in adolescence.
A cross-sectional study with single elementary sampling nominative list of all college students enrolled in the academic year 2012/2013 has allowed us to estimate the frequency of overweight and obesity in teenagers of Constantine. For that 457 teenagers were recruited.
The frequency of overweight and obesity according to the 2007 WHO reference z-score, is respectively 18.2% and 13.2%, including 1.8% with severe obesity. Overweight and obesity are more prevalent in boys than in girls. Obesity is more common among adolescents who don’t respect the main meal of the day and those who don’t take their family meals. The obese have low nutritional knowledge and less physical activity compared to leans ones. Birth order may be identified as a risk factor. Obesity is more common among adolescents who have
parents with a higher socio-economic and socio-professional status. Breast feeding plays an essential role in the prevention of overweight in childhood and adolescence. Birth weight would influence the weight at the age of 5 and 10 years and at adolescence, anxiety of obese adolescents associated with poor felt the denial of the image of their own body size may increase overweight and obesity among these. Puberty is a critical period in the development of obesity.
The genotype of CD36 gene lingual, rs1761667 (AA) could be responsible for the low
detection of lipids and encourage teenagers to over-consume fat to have the same appreciation that subjects with the other two AG and GG genotypes.
Obesity in adolescence seems to play an important role in predicting very slight increase in glucose and lipid values, insulin and inflammatory, confirming the deleterious role of excess weight on biological data.
Through measures as dietary and behavioral, we can fight effectively against long-term obesity in adolescents.
Diplôme : Doctorat En ligne : ../theses/biologie/DAO6866.pdf Format de la ressource électronique : Permalink : index.php?lvl=notice_display&id=10180 Exemplaires (1)
Code-barres Cote Support Localisation Section Disponibilité DAO/6866 DAO/6866 Thèse Bibliothèque principale Thèses Disponible
Titre : Contribution à l’étude de la fièvre aphteuse en Algérie 2014 : facteurs de risque dans la wilaya d’Oum El Bouaghi Type de document : texte imprimé Auteurs : Abderrahmane Badache, Auteur ; Omar Bennoune, Directeur de thèse Editeur : جامعة الإخوة منتوري قسنطينة Année de publication : 2017 Importance : 97 f. Format : 30 cm. Note générale : 2 copies imprimées disponibles
Langues : Français (fre) Catégories : Français - Anglais
Sciences VétérinairesTags : Enquête cas/témoin fievre aphteuse élevages bovins facteurs de risque facteurs protecteurs Oum El Bouaghi Investigation case / control foot - and - mouth disease cattle farms risk factors protective factors استقصاء الحالة\ الشاهد الحمى القلاعية مربو الابقار عوامل الخطر عوامل الحماية ام البواقي Index. décimale : 636 Sciences Vétérinaires Résumé : A retrospective control case study was carried out on 41 farms belonging to the wilaya of Oum El Bouaghi, with the aim of determining the risk factors and also the protective factors associated with the epidemic of foot and mouth disease of 2014.
The qualitative questions were aimed at collecting general information on farms, risk factors for the introduction of foot-and-mouth disease (the location of the farm, the operation of the farm, the movement of personnel, the movement of animals, Moving vehicles) and health and medical protections factors, as well as questions to get information about farm officials and their skills.
The results of the descriptive study show that several factors are present, the wilaya climate favors the transmission of the foot-and-mouth virus even at short distances, the anarchic distribution of cattle breeding controlled by the nature of the region, and The culture of the population, generates an aspect of agglomeration and farming practices favor the transmission of the disease.
The analytical study shows that common grazing is the most likely risk factor in the transmission of foot-and-mouth disease between farms with an Odds ratio of 5.1944 within an estimated confidence interval between 1.2798 and 21.083; And that vaccination of cattle is a protective factor against infection by this virus with an Odds ratio of 0.0611 and an estimated confidence interval between 0.0068 and 0.5477.
The results also showed that the incrimination of seniority in breeding practice with two opposing categories, the first between 10 and 20 years as a protective factor with an Odds ratio of 0.2051 and a confidence interval between 0.0536 and 0.7847 and The second over 20 years as a risk factor with an Odds ratio of 7.7727 and a confidence interval between 1.4162 and 42.6611.
Diplôme : Magistère En ligne : ../theses/veterinaire/BAD7054.pdf Format de la ressource électronique : Permalink : index.php?lvl=notice_display&id=10546 Contribution à l’étude de la fièvre aphteuse en Algérie 2014 : facteurs de risque dans la wilaya d’Oum El Bouaghi [texte imprimé] / Abderrahmane Badache, Auteur ; Omar Bennoune, Directeur de thèse . - جامعة الإخوة منتوري قسنطينة, 2017 . - 97 f. ; 30 cm.
2 copies imprimées disponibles
Langues : Français (fre)
Catégories : Français - Anglais
Sciences VétérinairesTags : Enquête cas/témoin fievre aphteuse élevages bovins facteurs de risque facteurs protecteurs Oum El Bouaghi Investigation case / control foot - and - mouth disease cattle farms risk factors protective factors استقصاء الحالة\ الشاهد الحمى القلاعية مربو الابقار عوامل الخطر عوامل الحماية ام البواقي Index. décimale : 636 Sciences Vétérinaires Résumé : A retrospective control case study was carried out on 41 farms belonging to the wilaya of Oum El Bouaghi, with the aim of determining the risk factors and also the protective factors associated with the epidemic of foot and mouth disease of 2014.
The qualitative questions were aimed at collecting general information on farms, risk factors for the introduction of foot-and-mouth disease (the location of the farm, the operation of the farm, the movement of personnel, the movement of animals, Moving vehicles) and health and medical protections factors, as well as questions to get information about farm officials and their skills.
The results of the descriptive study show that several factors are present, the wilaya climate favors the transmission of the foot-and-mouth virus even at short distances, the anarchic distribution of cattle breeding controlled by the nature of the region, and The culture of the population, generates an aspect of agglomeration and farming practices favor the transmission of the disease.
The analytical study shows that common grazing is the most likely risk factor in the transmission of foot-and-mouth disease between farms with an Odds ratio of 5.1944 within an estimated confidence interval between 1.2798 and 21.083; And that vaccination of cattle is a protective factor against infection by this virus with an Odds ratio of 0.0611 and an estimated confidence interval between 0.0068 and 0.5477.
The results also showed that the incrimination of seniority in breeding practice with two opposing categories, the first between 10 and 20 years as a protective factor with an Odds ratio of 0.2051 and a confidence interval between 0.0536 and 0.7847 and The second over 20 years as a risk factor with an Odds ratio of 7.7727 and a confidence interval between 1.4162 and 42.6611.
Diplôme : Magistère En ligne : ../theses/veterinaire/BAD7054.pdf Format de la ressource électronique : Permalink : index.php?lvl=notice_display&id=10546 Exemplaires (1)
Code-barres Cote Support Localisation Section Disponibilité BAD/7054 BAD/7054 Thèse Bibliothèque principale Thèses Disponible
Titre : Déterminants de l’état nutritionnel des enfants à Tébessa Type de document : texte imprimé Auteurs : Khalida Abla, Auteur ; Abdel-Nacer Agli, Directeur de thèse Editeur : جامعة الإخوة منتوري قسنطينة Année de publication : 2018 Importance : 296 f. Format : 30 cm. Note générale : 2 copies imprimées disponibles
Langues : Français (fre) Catégories : Français - Anglais
Nutrition, Alimentation et Technologies Agro-AlimentairesTags : Etat nutritionnel Malnutrition Surpoids Obésité facteurs de risque enfants Tébessa " Nutritional status Overweight Obesity risk factors children Tebessa الحالة التغذوية سوء التغذية زيادة الوزن السمنة عوامل الخطر الأطفال تبسة Index. décimale : 640 Industrie Alimentaire Résumé : Our work consists of a retrospective survey, which aims to assess nutritional status and identify risk factors for malnutrition and overweight among children aged from 1 to 24 months in Tebessa.
The study involved 2000 healthy children, aged from 1 to 24 months, randomly selected. For each subject we collected, by questionnaire, information on the characteristics of the child, the mother and the household. Dietary practices including breastfeeding type, age and food diversification foods were sought. Children's dietary intake of energy, macronutrients was estimated by the 24-hour recall. The assessment of nutritional status was performed by calculating anthropometric indices. For the classification of children we have retained the pediatric references of WHO (2006).
The results reveal the simultaneous presence of malnutrition and overweight. Malnutrition is found in 17.55% of children. It is more common in children from 1 to 6 months with 79.48%. Its rate decreases with the age of the children (r = - 0.317, p = 0.027).
Overweight affects 29.65% of the total population. Overweight alone affects 17.95% of children and obesity 11.7% of them. Its rate increases with the age of the children (r = 0.012, p = 0.003). It is more common in children aged 12 to 24 months with 76.21%. The study of the determinants of children's nutritional status shows a significant link between malnutrition and some parental risk factors, including early motherhood, maternal malnutrition and inadequate GWG. With respect to individual risk factors, malnutrition appears to be significantly associated with prematurity and low birth weight. In addition, we noted a significant link with the occurrence of anemia and acute diarrhea. Social factors contribute to child malnutrition, through the low social level, and the low level of education of mothers. For dietary factors, malnutrition appears to be significantly associated with breastfeeding, especially for children with low birth weights. It should also be noted that malnourished children have average daily energy and protein intake, which is significantly lower compared to children of normal nutritional status.
For overweight and childhood obesity, maternal overweight, excessive GWG, and maternal diabetes are the main risk factors for parenting. Among the individual determinants, a significant link was observed with the female sex. High birth weight, such as low birth weight, are also risk factors. Regarding socio-economic factors, overweight is significantly more common in households with high social and educational levels. This link is stronger, as the size of households and the number of children decreas. Artificial breastfeeding and the early age of
introduction of weaning foods are the main dietary risk factors. It should also be noted that overweight children consume more sugary drinks, less dairy products and have average daily energy, carbohydrate and fat intake, significantly higher than normal weight children.
Malnutrition has long been a priority concern in Algeria, as in most developing countries. At present, the nutrition transition process has changed this situation, with a double burden of underweight and overweight. Overweight and obesity have become a public health problem that threatens children in Algeria.
Diplôme : Doctorat en sciences En ligne : ../theses/agronomie/ABL7274.pdf Format de la ressource électronique : Permalink : index.php?lvl=notice_display&id=10889 Déterminants de l’état nutritionnel des enfants à Tébessa [texte imprimé] / Khalida Abla, Auteur ; Abdel-Nacer Agli, Directeur de thèse . - جامعة الإخوة منتوري قسنطينة, 2018 . - 296 f. ; 30 cm.
2 copies imprimées disponibles
Langues : Français (fre)
Catégories : Français - Anglais
Nutrition, Alimentation et Technologies Agro-AlimentairesTags : Etat nutritionnel Malnutrition Surpoids Obésité facteurs de risque enfants Tébessa " Nutritional status Overweight Obesity risk factors children Tebessa الحالة التغذوية سوء التغذية زيادة الوزن السمنة عوامل الخطر الأطفال تبسة Index. décimale : 640 Industrie Alimentaire Résumé : Our work consists of a retrospective survey, which aims to assess nutritional status and identify risk factors for malnutrition and overweight among children aged from 1 to 24 months in Tebessa.
The study involved 2000 healthy children, aged from 1 to 24 months, randomly selected. For each subject we collected, by questionnaire, information on the characteristics of the child, the mother and the household. Dietary practices including breastfeeding type, age and food diversification foods were sought. Children's dietary intake of energy, macronutrients was estimated by the 24-hour recall. The assessment of nutritional status was performed by calculating anthropometric indices. For the classification of children we have retained the pediatric references of WHO (2006).
The results reveal the simultaneous presence of malnutrition and overweight. Malnutrition is found in 17.55% of children. It is more common in children from 1 to 6 months with 79.48%. Its rate decreases with the age of the children (r = - 0.317, p = 0.027).
Overweight affects 29.65% of the total population. Overweight alone affects 17.95% of children and obesity 11.7% of them. Its rate increases with the age of the children (r = 0.012, p = 0.003). It is more common in children aged 12 to 24 months with 76.21%. The study of the determinants of children's nutritional status shows a significant link between malnutrition and some parental risk factors, including early motherhood, maternal malnutrition and inadequate GWG. With respect to individual risk factors, malnutrition appears to be significantly associated with prematurity and low birth weight. In addition, we noted a significant link with the occurrence of anemia and acute diarrhea. Social factors contribute to child malnutrition, through the low social level, and the low level of education of mothers. For dietary factors, malnutrition appears to be significantly associated with breastfeeding, especially for children with low birth weights. It should also be noted that malnourished children have average daily energy and protein intake, which is significantly lower compared to children of normal nutritional status.
For overweight and childhood obesity, maternal overweight, excessive GWG, and maternal diabetes are the main risk factors for parenting. Among the individual determinants, a significant link was observed with the female sex. High birth weight, such as low birth weight, are also risk factors. Regarding socio-economic factors, overweight is significantly more common in households with high social and educational levels. This link is stronger, as the size of households and the number of children decreas. Artificial breastfeeding and the early age of
introduction of weaning foods are the main dietary risk factors. It should also be noted that overweight children consume more sugary drinks, less dairy products and have average daily energy, carbohydrate and fat intake, significantly higher than normal weight children.
Malnutrition has long been a priority concern in Algeria, as in most developing countries. At present, the nutrition transition process has changed this situation, with a double burden of underweight and overweight. Overweight and obesity have become a public health problem that threatens children in Algeria.
Diplôme : Doctorat en sciences En ligne : ../theses/agronomie/ABL7274.pdf Format de la ressource électronique : Permalink : index.php?lvl=notice_display&id=10889 Exemplaires (1)
Code-barres Cote Support Localisation Section Disponibilité ABL/7274 ABL/7274 Thèse Bibliothèque principale Thèses Disponible
Titre : Gènes de prédisposition au cancer prostatique. Type de document : texte imprimé Auteurs : Somia Medjani, Auteur ; Djalila Rezgoune-Chellat, Directeur de thèse Mention d'édition : 24/10/2019 Editeur : جامعة الإخوة منتوري قسنطينة Année de publication : 2019 Importance : 145 f. Format : 30 cm. Note générale : Doctorat 3éme CYCLE LMD.
1 copies imprimées disponibles
Langues : Français (fre) Catégories : Français - Anglais
BiologieTags : Biologie Animale:Génétique Moléculaire cancer de la prostate facteurs de risque polymorphisme CYP1A1 T3801C GSTM1 GSTT1 VEGF -2578C/A PCR/RFLP PCR multiplexe prostate cancer risk factors polymorphism multiplex PCR سرطان البروستاتا عوامل الخطر التعدد الأليلي GSTT1
multiplexe PCR. VEGIndex. décimale : 570 Sciences de la vie. Biologie Résumé : Prostate cancer is currently the most frequently diagnosed cancer and is the leading cause of death in men. In this sense, the objective of our work was to identify, through two statistical studies, some risk factors and histopathological parameters, as well as the possible involvement of genes encoding detoxification enzymes (CYP1A1, GSTM1 and GSTT1) and gene encoding a factor of angiogenesis (-2587C/A of VEGF) and the occurrence of prostate cancer after molecular analysis using the PCR/RFLP technique and multiplex PCR. The statistical study demonstrated an increase in the rate of prostate cancer from the age 60 years old with means age of 71.66±7.99. On the other hand, the presence of family history, smoking and occupational exposure (truck driver, builder, painter, farmer….) are recorded as risk factors implicated in this cancer. Also the sporadic form is the most common form in prostates cancers. Furthermore, the most prostate cancer are adenocarcinoma at the prostatic capsule (PSA >10 ng/ml ; Gleason Score8 ≤ GS ≤ 10). Finally, the genetic analysis of patients and controls for the studied genes presented by the pvalue indicates that no association between the deletion of GSTM1 and the CYP1A1 3801T>C variant and prostate carcinogenesis. However, the deletion of GSTT1 and the double deletion of GSTM1/GSTT1 are involved in the development of prostate cancer. Thus the results of the VEGF-2578C/A variant show a significant difference with susceptibility to prostate cancer. Note de contenu : Annexes. Diplôme : Doctorat En ligne : ../theses/biologie/MED7571.pdf Format de la ressource électronique : Permalink : index.php?lvl=notice_display&id=11409 Gènes de prédisposition au cancer prostatique. [texte imprimé] / Somia Medjani, Auteur ; Djalila Rezgoune-Chellat, Directeur de thèse . - 24/10/2019 . - جامعة الإخوة منتوري قسنطينة, 2019 . - 145 f. ; 30 cm.
Doctorat 3éme CYCLE LMD.
1 copies imprimées disponibles
Langues : Français (fre)
Catégories : Français - Anglais
BiologieTags : Biologie Animale:Génétique Moléculaire cancer de la prostate facteurs de risque polymorphisme CYP1A1 T3801C GSTM1 GSTT1 VEGF -2578C/A PCR/RFLP PCR multiplexe prostate cancer risk factors polymorphism multiplex PCR سرطان البروستاتا عوامل الخطر التعدد الأليلي GSTT1
multiplexe PCR. VEGIndex. décimale : 570 Sciences de la vie. Biologie Résumé : Prostate cancer is currently the most frequently diagnosed cancer and is the leading cause of death in men. In this sense, the objective of our work was to identify, through two statistical studies, some risk factors and histopathological parameters, as well as the possible involvement of genes encoding detoxification enzymes (CYP1A1, GSTM1 and GSTT1) and gene encoding a factor of angiogenesis (-2587C/A of VEGF) and the occurrence of prostate cancer after molecular analysis using the PCR/RFLP technique and multiplex PCR. The statistical study demonstrated an increase in the rate of prostate cancer from the age 60 years old with means age of 71.66±7.99. On the other hand, the presence of family history, smoking and occupational exposure (truck driver, builder, painter, farmer….) are recorded as risk factors implicated in this cancer. Also the sporadic form is the most common form in prostates cancers. Furthermore, the most prostate cancer are adenocarcinoma at the prostatic capsule (PSA >10 ng/ml ; Gleason Score8 ≤ GS ≤ 10). Finally, the genetic analysis of patients and controls for the studied genes presented by the pvalue indicates that no association between the deletion of GSTM1 and the CYP1A1 3801T>C variant and prostate carcinogenesis. However, the deletion of GSTT1 and the double deletion of GSTM1/GSTT1 are involved in the development of prostate cancer. Thus the results of the VEGF-2578C/A variant show a significant difference with susceptibility to prostate cancer. Note de contenu : Annexes. Diplôme : Doctorat En ligne : ../theses/biologie/MED7571.pdf Format de la ressource électronique : Permalink : index.php?lvl=notice_display&id=11409 Exemplaires (1)
Code-barres Cote Support Localisation Section Disponibilité MED/7571 MED/7571 Thèse Bibliothèque principale Thèses Disponible
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